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PRJNA207719: Tissue specific transcriptome profiling

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Results for glis2a+glis2b

Z-value: 0.75

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Transcription factors associated with glis2a+glis2b

Gene Symbol Gene ID Gene Info
glis2a
ENSDARG00000078388 GLIS family zinc finger 2a
glis2b
ENSDARG00000100232 GLIS family zinc finger 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glis2adr11_v1_chr22_-_26558166_265581660.642.5e-01Click!
glis2bdr11_v1_chr3_+_12322170_123221700.583.0e-01Click!

Activity profile of glis2a+glis2b motif

Sorted Z-values of glis2a+glis2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_18364176 0.65 ENSDART00000171606
ENSDART00000186368
cd248a
CD248 molecule, endosialin a
chr23_-_45705525 0.53 ENSDART00000148959
ednrab
endothelin receptor type Ab
chr20_+_25340814 0.53 ENSDART00000063028
ctgfa
connective tissue growth factor a
chr15_-_97205 0.51 ENSDART00000158734
BACE1
beta-secretase 1
chr10_+_33982010 0.47 ENSDART00000180431
fryb
furry homolog b (Drosophila)
chr24_+_25471196 0.46 ENSDART00000066625
smpx
small muscle protein, X-linked
chr13_-_638485 0.40 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr12_-_4070058 0.40 ENSDART00000042200
aldoab
aldolase a, fructose-bisphosphate, b
chr17_-_20717845 0.39 ENSDART00000150037
ank3b
ankyrin 3b
chr23_+_42810055 0.39 ENSDART00000186647
myl9a
myosin, light chain 9a, regulatory
chr2_-_30987538 0.26 ENSDART00000148157
emilin2a
elastin microfibril interfacer 2a
chr3_-_31804481 0.24 ENSDART00000028270
gfap
glial fibrillary acidic protein
chr18_+_17827149 0.22 ENSDART00000190237
ENSDART00000189345
ZNF423
si:ch211-216l23.1
chr10_+_21701568 0.21 ENSDART00000090748
pcdh1g9
protocadherin 1 gamma 9
chr23_-_29004753 0.21 ENSDART00000002812
casz1
castor zinc finger 1
chr23_+_43668756 0.20 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr19_-_42928979 0.20 ENSDART00000086659
cyhr1
cysteine/histidine-rich 1
chr16_+_3004422 0.20 ENSDART00000189969
CABZ01043952.1

chr10_-_34976812 0.20 ENSDART00000170625
smad9
SMAD family member 9
chr6_+_37625787 0.19 ENSDART00000065122
tubgcp5
tubulin, gamma complex associated protein 5
chr13_-_24880525 0.17 ENSDART00000136624
kat6b
K(lysine) acetyltransferase 6B
chr2_+_13721888 0.17 ENSDART00000089618
zbtb41
zinc finger and BTB domain containing 41
chr23_-_29003864 0.17 ENSDART00000148257
casz1
castor zinc finger 1
chr19_-_15281996 0.16 ENSDART00000103784
edn2
endothelin 2
chr5_-_42272517 0.16 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr16_-_26435431 0.15 ENSDART00000187526
megf8
multiple EGF-like-domains 8
chr5_-_71995108 0.15 ENSDART00000124587
fam78ab
family with sequence similarity 78, member Ab
chr24_-_9960290 0.14 ENSDART00000143390
ENSDART00000092975
ENSDART00000184953
vps41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr12_-_41619257 0.14 ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr8_-_53926228 0.14 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr7_+_38509333 0.13 ENSDART00000153482
slc7a9
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr5_-_22001003 0.12 ENSDART00000134393
ENSDART00000143878
arhgef9a
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr25_+_13191391 0.12 ENSDART00000109937
si:ch211-147m6.2
si:ch211-147m6.2
chr25_+_13191615 0.11 ENSDART00000168849
si:ch211-147m6.2
si:ch211-147m6.2
chr21_+_25643880 0.10 ENSDART00000192392
ENSDART00000145091
tmem151a
transmembrane protein 151A
chr2_+_13722116 0.10 ENSDART00000155015
zbtb41
zinc finger and BTB domain containing 41
chr24_-_35707552 0.10 ENSDART00000165199
mapre2
microtubule-associated protein, RP/EB family, member 2
chr23_-_36934944 0.10 ENSDART00000109976
ENSDART00000162179
acap3a
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a
chr7_-_19642417 0.10 ENSDART00000160936
si:ch211-212k18.4
si:ch211-212k18.4
chr6_+_38845697 0.09 ENSDART00000053187
stk35l
serine/threonine kinase 35, like
chr3_+_34220194 0.09 ENSDART00000145859
slc25a23b
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23b
chr4_-_59152337 0.09 ENSDART00000156770
znf1149
zinc finger protein 1149
chr6_+_38845848 0.08 ENSDART00000184907
stk35l
serine/threonine kinase 35, like
chr17_-_44968177 0.07 ENSDART00000075510
ngb
neuroglobin
chr4_-_4756349 0.07 ENSDART00000057507
ssbp1
single-stranded DNA binding protein 1
chr17_-_23674495 0.07 ENSDART00000122209
ptena
phosphatase and tensin homolog A
chr11_+_27968834 0.07 ENSDART00000147984
alpl
alkaline phosphatase, liver/bone/kidney
chr5_-_1047222 0.06 ENSDART00000181112
mbd2
methyl-CpG binding domain protein 2
chr12_+_2676878 0.06 ENSDART00000185909
antxr1c
anthrax toxin receptor 1c
chr20_-_1239596 0.05 ENSDART00000049063
ENSDART00000140650
ankrd6b
ankyrin repeat domain 6b
chr24_+_37723362 0.05 ENSDART00000136836
rab11fip3
RAB11 family interacting protein 3 (class II)
chr9_+_54158387 0.04 ENSDART00000171315
ENSDART00000180570
TLR8
toll like receptor 8
chr7_+_11390462 0.04 ENSDART00000114383
tlnrd1
talin rod domain containing 1
chr13_+_39208542 0.04 ENSDART00000147971
fam135a
family with sequence similarity 135, member A
chr3_+_40409100 0.03 ENSDART00000103486
tnrc18
trinucleotide repeat containing 18
chr22_-_18116635 0.03 ENSDART00000005724
ncanb
neurocan b
chr2_-_9744081 0.03 ENSDART00000097732
dvl3a
dishevelled segment polarity protein 3a
chr17_-_3291369 0.03 ENSDART00000181840
CABZ01007222.1

chr17_-_49275690 0.02 ENSDART00000150172
tfb1m
transcription factor B1, mitochondrial
chr16_-_16590780 0.02 ENSDART00000059841
si:ch211-257p13.3
si:ch211-257p13.3
chr25_+_30196039 0.02 ENSDART00000005299
hsd17b12a
hydroxysteroid (17-beta) dehydrogenase 12a
chr2_+_24867534 0.01 ENSDART00000158050
rab3aa
RAB3A, member RAS oncogene family, a
chr13_+_1928361 0.01 ENSDART00000164764
hmgcll1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chr10_-_1961576 0.01 ENSDART00000042441
tdgf1
teratocarcinoma-derived growth factor 1
chr22_+_26853254 0.01 ENSDART00000182487
tmem186
transmembrane protein 186

Network of associatons between targets according to the STRING database.

First level regulatory network of glis2a+glis2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.2 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0071498 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.0 0.1 GO:0051095 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0098809 nitrite reductase activity(GO:0098809)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling