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PRJNA207719: Tissue specific transcriptome profiling

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Results for her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4

Z-value: 0.60

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Transcription factors associated with her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4

Gene Symbol Gene ID Gene Info
her11
ENSDARG00000002707 hairy-related 11
her5
ENSDARG00000008796 hairy-related 5
her1
ENSDARG00000014722 hairy-related 1
her4.4
ENSDARG00000009822 hairy-related 4, tandem duplicate 4
her12
ENSDARG00000032963 hairy-related 12
her2
ENSDARG00000038205 hairy-related 2
her15.2
ENSDARG00000054560 hairy and enhancer of split-related 15, tandem duplicate 2
her15.1
ENSDARG00000054562 hairy and enhancer of split-related 15, tandem duplicate 1
her4.2
ENSDARG00000056729 hairy-related 4, tandem duplicate 2
her4.1
ENSDARG00000056732 hairy-related 4, tandem duplicate 1
her4.3
ENSDARG00000070770 hairy-related 4, tandem duplicate 3
her4.2
ENSDARG00000094426 hairy-related 4, tandem duplicate 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
her4.3dr11_v1_chr23_+_21459263_214592630.961.0e-02Click!
her4.2dr11_v1_chr23_-_21471022_214710220.961.1e-02Click!
her4.4dr11_v1_chr23_-_21463788_214637880.951.1e-02Click!
her4.1dr11_v1_chr23_-_21453614_214536140.941.6e-02Click!
her12dr11_v1_chr23_-_21446985_214469850.828.7e-02Click!
her2dr11_v1_chr11_-_41966854_419668540.829.2e-02Click!
her15.1dr11_v1_chr11_+_41981959_419819590.642.5e-01Click!
her15.2dr11_v1_chr11_-_41996957_419969570.622.7e-01Click!
her11dr11_v1_chr14_-_30540967_30540967-0.593.0e-01Click!
her1dr11_v1_chr5_-_68795063_687950630.001.0e+00Click!

Activity profile of her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4 motif

Sorted Z-values of her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_60147517 1.82 ENSDART00000083453
slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
chr7_-_40993456 1.00 ENSDART00000031700
en2a
engrailed homeobox 2a
chr9_-_44295071 0.93 ENSDART00000011837
neurod1
neuronal differentiation 1
chr23_-_21463788 0.67 ENSDART00000079265
her4.4
hairy-related 4, tandem duplicate 4
chr2_+_29976419 0.61 ENSDART00000056748
en2b
engrailed homeobox 2b
chr6_+_39184236 0.59 ENSDART00000156187
tac3b
tachykinin 3b
chr18_+_6126506 0.57 ENSDART00000125725
si:ch1073-390k14.1
si:ch1073-390k14.1
chr16_-_45069882 0.46 ENSDART00000058384
gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr8_+_21146262 0.45 ENSDART00000045684
porcn
porcupine O-acyltransferase
chr23_+_21459263 0.44 ENSDART00000104209
her4.3
hairy-related 4, tandem duplicate 3
chr23_+_22819971 0.36 ENSDART00000111345
rerea
arginine-glutamic acid dipeptide (RE) repeats a
chr10_-_27566481 0.33 ENSDART00000078920
auts2a
autism susceptibility candidate 2a
chr15_-_14469704 0.32 ENSDART00000185077
numbl
numb homolog (Drosophila)-like
chr5_-_45894802 0.32 ENSDART00000097648
crfb6
cytokine receptor family member b6
chr20_-_27733683 0.32 ENSDART00000103317
ENSDART00000138139
zgc:153157
zgc:153157
chr12_+_33038757 0.27 ENSDART00000153146
rbfox3a
RNA binding fox-1 homolog 3a
chr19_+_42469058 0.26 ENSDART00000076915
si:dkey-166k12.1
si:dkey-166k12.1
chr11_-_3959889 0.25 ENSDART00000159683
pbrm1
polybromo 1
chr15_-_20731297 0.24 ENSDART00000114464
tpst1
tyrosylprotein sulfotransferase 1
chr5_-_38342992 0.23 ENSDART00000140337
mink1
misshapen-like kinase 1
chr7_+_32021669 0.23 ENSDART00000173976
mettl15
methyltransferase like 15
chr20_+_19212962 0.20 ENSDART00000063706
fndc4a
fibronectin type III domain containing 4a
chr11_-_3959477 0.16 ENSDART00000045971
pbrm1
polybromo 1
chr5_-_18897482 0.16 ENSDART00000010101
ENSDART00000099434
aacs
acetoacetyl-CoA synthetase
chr18_-_25855263 0.16 ENSDART00000042074
sema4ba
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ba
chr5_-_46329880 0.15 ENSDART00000156577
si:ch211-130m23.5
si:ch211-130m23.5
chr4_-_1818315 0.15 ENSDART00000067433
ube2nb
ubiquitin-conjugating enzyme E2Nb
chr8_+_39760258 0.12 ENSDART00000037914
cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr23_-_31969786 0.11 ENSDART00000134550
ormdl2
ORMDL sphingolipid biosynthesis regulator 2
chr17_-_37195354 0.10 ENSDART00000190963
asxl2
additional sex combs like transcriptional regulator 2
chr21_-_38730557 0.09 ENSDART00000150984
ENSDART00000111885
taf9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr17_-_37195163 0.09 ENSDART00000108514
asxl2
additional sex combs like transcriptional regulator 2
chr9_+_45789887 0.09 ENSDART00000135202
si:dkey-34f9.3
si:dkey-34f9.3
chr12_+_30046320 0.09 ENSDART00000179904
ENSDART00000153394
ablim1b
actin binding LIM protein 1b
chr3_+_32425202 0.08 ENSDART00000156464
prr12b
proline rich 12b
chr21_+_1586379 0.08 ENSDART00000150961
wdr91
WD repeat domain 91
chr23_+_24989387 0.06 ENSDART00000172299
ENSDART00000145307
arhgap4a
Rho GTPase activating protein 4a
chr18_+_30370559 0.06 ENSDART00000165450
gse1
Gse1 coiled-coil protein
chr18_+_30370339 0.06 ENSDART00000158871
gse1
Gse1 coiled-coil protein
chr25_-_8625601 0.05 ENSDART00000155280
GDPGP1
zgc:153343
chr1_+_5576151 0.03 ENSDART00000109756
cpo
carboxypeptidase O
chr4_-_8093753 0.02 ENSDART00000133434
wnk1b
WNK lysine deficient protein kinase 1b
chr19_-_35596207 0.01 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr22_-_38951128 0.01 ENSDART00000085685
ENSDART00000104422
rbbp9
retinoblastoma binding protein 9

Network of associatons between targets according to the STRING database.

First level regulatory network of her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 0.5 GO:0061355 Wnt protein secretion(GO:0061355)
0.1 0.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 1.0 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 1.1 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.4 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 1.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.1 GO:2000303 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.2 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.6 GO:0030901 midbrain development(GO:0030901)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.4 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0015295 solute:proton symporter activity(GO:0015295)
0.1 0.5 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.2 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0005246 calcium channel regulator activity(GO:0005246)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis