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PRJNA207719: Tissue specific transcriptome profiling

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Results for hoxb1a+hoxb1b-2

Z-value: 1.27

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Transcription factors associated with hoxb1a+hoxb1b-2

Gene Symbol Gene ID Gene Info
ENSDARG00000008174 homeobox B1a
ENSDARG00000112663 homeobox B1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb1adr11_v1_chr3_+_23768898_237688980.059.3e-01Click!

Activity profile of hoxb1a+hoxb1b-2 motif

Sorted Z-values of hoxb1a+hoxb1b-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_36378494 1.85 ENSDART00000058503
glycoprotein M6Aa
chr14_-_7888748 1.75 ENSDART00000166293
protein phosphatase 3, catalytic subunit, beta isozyme
chr7_-_13381129 1.72 ENSDART00000164326
si:ch73-119p20.1
chr1_-_38709551 1.60 ENSDART00000128794
glycoprotein M6Ab
chr4_+_21129752 1.53 ENSDART00000169764
synaptotagmin Ia
chr10_+_466926 1.52 ENSDART00000145220
ARVCF, delta catenin family member a
chr25_+_7461624 1.51 ENSDART00000170569
synaptotagmin XII
chr3_+_29714775 1.42 ENSDART00000041388
calcium channel, voltage-dependent, gamma subunit 2a
chr12_-_25916530 1.39 ENSDART00000186386
synuclein, gamma b (breast cancer-specific protein 1)
chr10_-_27049170 1.33 ENSDART00000143451
cornichon family AMPA receptor auxiliary protein 2
chr1_-_8428736 1.29 ENSDART00000138435
ENSDART00000121823
synaptogyrin 3b
chr2_+_27010439 1.27 ENSDART00000030547
cadherin 7a
chr4_+_26496489 1.21 ENSDART00000160652
IQ motif and Sec7 domain 3a
chr20_-_35841570 1.10 ENSDART00000037855
tumor necrosis factor receptor superfamily, member 21
chr1_-_20911297 1.09 ENSDART00000078271
carboxypeptidase E
chr15_-_16704417 1.07 ENSDART00000155163
calneuron 1
chr18_+_28102620 1.05 ENSDART00000132342
KIAA1549-like b
chr22_-_13544244 1.02 ENSDART00000110136
contactin associated protein-like 5b
chr25_-_13842618 1.00 ENSDART00000160258
mitogen-activated protein kinase 8 interacting protein 1a
chr12_-_10220036 0.99 ENSDART00000134619
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr24_-_40009446 0.97 ENSDART00000087422
amine oxidase, copper containing 1
chr16_+_46111849 0.94 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr17_-_7436766 0.93 ENSDART00000162002
glutamate receptor, metabotropic 1b
chr8_-_39903803 0.92 ENSDART00000012391
calcium binding protein 1a
chr23_-_11870962 0.90 ENSDART00000143481
si:dkey-178k16.1
chr2_+_29249204 0.87 ENSDART00000168957
cadherin 18, type 2a
chr16_-_31188715 0.84 ENSDART00000058829
scratch family zinc finger 1b
chr11_+_30817943 0.82 ENSDART00000150130
ENSDART00000159997
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr19_-_867071 0.81 ENSDART00000122257
eomesodermin homolog a
chr10_-_2527342 0.79 ENSDART00000184168

chr7_-_52842007 0.79 ENSDART00000182710
microtubule-associated protein 1Aa
chr22_+_3223489 0.75 ENSDART00000082011
lens intrinsic membrane protein 2.2
chr3_-_35800221 0.74 ENSDART00000031390
CASK interacting protein 1
chr10_+_7563755 0.74 ENSDART00000165877
purine-rich element binding protein G
chr1_+_34181581 0.71 ENSDART00000146042
eph receptor A6
chr21_-_28920245 0.71 ENSDART00000132884
CXXC finger protein 5a
chr3_+_37824268 0.68 ENSDART00000137038
acid-sensing (proton-gated) ion channel 2
chr17_+_19626479 0.62 ENSDART00000044993
ENSDART00000131863
regulator of G protein signaling 7a
chr5_-_52277643 0.62 ENSDART00000010757
repulsive guidance molecule family member b
chr16_-_37964325 0.61 ENSDART00000148801
melanocortin 2 receptor accessory protein 2a
chr8_-_44015210 0.59 ENSDART00000186879
ENSDART00000188965
ENSDART00000001313
ENSDART00000188902
ENSDART00000185935
ENSDART00000147869
RIMS binding protein 2
RIMS binding protein 2
chr10_+_7564106 0.59 ENSDART00000159042
purine-rich element binding protein G
chr4_+_4272622 0.56 ENSDART00000164810
anoctamin 2
chr6_-_13401133 0.56 ENSDART00000151206
formin-like 2b
chr3_+_15805917 0.55 ENSDART00000055834
phosphatase, orphan 1
chr18_+_24922125 0.53 ENSDART00000180385
repulsive guidance molecule family member a
chr22_-_600016 0.52 ENSDART00000086434
transmembrane and coiled-coil domain family 2
chr10_+_37182626 0.49 ENSDART00000137636
kinase suppressor of ras 1a
chr19_+_4463389 0.48 ENSDART00000168805
potassium channel, subfamily K, member 9
chr24_+_32472155 0.45 ENSDART00000098859
neuronal differentiation 6a
chr11_-_27702778 0.45 ENSDART00000045942
ENSDART00000125352
PHD finger protein 2
chr17_-_20897250 0.44 ENSDART00000088106
ankyrin 3b
chr6_-_4214297 0.44 ENSDART00000191433
trafficking protein, kinesin binding 2
chr14_+_34547554 0.43 ENSDART00000074819
gamma-aminobutyric acid (GABA) A receptor, pi
chr17_-_20394566 0.43 ENSDART00000154667
sortilin related VPS10 domain containing receptor 3b
chr7_+_29952719 0.43 ENSDART00000173737
alpha-tropomyosin
chr3_-_51109286 0.42 ENSDART00000172010
si:ch211-148f13.1
chr7_+_7151832 0.38 ENSDART00000109485
galactose-3-O-sulfotransferase 3
chr2_-_16216568 0.37 ENSDART00000173758
Rho guanine nucleotide exchange factor (GEF) 4
chr9_-_53537989 0.37 ENSDART00000114022
SLIT and NTRK-like family, member 5b
chr2_+_2223837 0.37 ENSDART00000101038
ENSDART00000129354
transmembrane inner ear
chr17_+_51764310 0.36 ENSDART00000157171
si:ch211-168d23.3
chr21_-_25395223 0.35 ENSDART00000016219
protein phosphatase methylesterase 1
chr3_+_40409100 0.33 ENSDART00000103486
trinucleotide repeat containing 18
chr3_-_55650771 0.33 ENSDART00000162413
axin 2 (conductin, axil)
chr9_+_32073606 0.33 ENSDART00000184170
ENSDART00000180355
ENSDART00000110204
ENSDART00000123278
phosphoinositide kinase, FYVE finger containing
chr17_-_50233493 0.31 ENSDART00000172266
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr8_+_6410933 0.31 ENSDART00000168789
leucine rich repeat transmembrane neuronal 4 like 2
chr25_+_2668892 0.30 ENSDART00000122929
Bardet-Biedl syndrome 4
chr3_-_21062706 0.29 ENSDART00000155605
ENSDART00000153686
ENSDART00000157168
ENSDART00000156614
ENSDART00000155743
ENSDART00000156275
family with sequence similarity 57, member Ba
chr6_+_19383267 0.29 ENSDART00000166549
melanin-concentrating hormone receptor 1a
chr14_-_26377044 0.29 ENSDART00000022236
empty spiracles homeobox 3
chr3_-_6417328 0.28 ENSDART00000160979
Jupiter microtubule associated homolog 1b
chr7_+_13464878 0.28 ENSDART00000172969
diacylglycerol lipase, alpha
chr7_-_37547889 0.28 ENSDART00000193359
cylindromatosis (turban tumor syndrome), a
chr7_+_36898850 0.28 ENSDART00000113342
TOX high mobility group box family member 3
chr3_-_21118969 0.28 ENSDART00000129016
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr15_-_33304133 0.27 ENSDART00000186092
neurobeachin b
chr10_+_32646402 0.27 ENSDART00000137244
zinc finger and BTB domain containing 21
chr13_-_31829786 0.26 ENSDART00000138667
SERTA domain containing 4
chr18_-_18875308 0.26 ENSDART00000127182
ADP-ribosylation factor-like 2 binding protein
chr6_-_53143667 0.25 ENSDART00000079694
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr22_+_35089031 0.24 ENSDART00000076040
serum response factor a
chr25_+_20215964 0.24 ENSDART00000139235
troponin T2d, cardiac
chr3_-_55650417 0.23 ENSDART00000171441
axin 2 (conductin, axil)
chr5_-_16791223 0.23 ENSDART00000192744
ATPase family, AAA domain containing 1a
chr4_-_13255700 0.22 ENSDART00000162277
ENSDART00000026593
glutamate receptor interacting protein 1
chr14_-_24101897 0.22 ENSDART00000143695
cytoplasmic polyadenylation element binding protein 4a
chr2_+_25657958 0.22 ENSDART00000161407
TRAF2 and NCK interacting kinase a
chr5_-_37881345 0.22 ENSDART00000084819
Rho GTPase activating protein 35b
chr5_-_22544151 0.21 ENSDART00000006474
glycine receptor, alpha 4b
chr18_+_40354998 0.20 ENSDART00000098791
ENSDART00000049171
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr24_-_39518599 0.18 ENSDART00000145606
ENSDART00000031486
LYR motif containing 1
chr10_-_31175744 0.18 ENSDART00000191728
pbx/knotted 1 homeobox 2
chr2_+_25658112 0.17 ENSDART00000051234
TRAF2 and NCK interacting kinase a
chr9_+_21795917 0.16 ENSDART00000169069
REV1, polymerase (DNA directed)
chr11_+_2600612 0.16 ENSDART00000173442
DnaJ (Hsp40) homolog, subfamily C, member 14
chr22_-_16997475 0.16 ENSDART00000090237
nuclear factor I/A
chr23_+_27782071 0.16 ENSDART00000131379
lysine (K)-specific methyltransferase 2D
chr24_+_27548474 0.15 ENSDART00000105774
ENSDART00000123368
eph-like kinase 1
chr24_+_39518774 0.15 ENSDART00000132939
defective in cullin neddylation 1 domain containing 3
chr23_+_20408227 0.15 ENSDART00000134727
si:rp71-17i16.4
chr1_-_10577945 0.14 ENSDART00000179237
ENSDART00000040502
ENSDART00000186876
transient receptor potential cation channel, subfamily C, member 5a
chr2_-_16217344 0.13 ENSDART00000152031
Rho guanine nucleotide exchange factor (GEF) 4
chr3_-_1283247 0.12 ENSDART00000149814
transcription factor 20
chr7_+_16835218 0.12 ENSDART00000173580
neuron navigator 2a
chr10_-_44305180 0.12 ENSDART00000187552
cyclin dependent kinase 2 associated protein 1
chr4_-_17642168 0.11 ENSDART00000007030
kelch-like family, member 42
chr1_+_26626824 0.11 ENSDART00000158193
coronin, actin binding protein, 2A
chr18_-_18874921 0.10 ENSDART00000193332
ADP-ribosylation factor-like 2 binding protein
chr17_-_28101880 0.09 ENSDART00000149458
ENSDART00000149226
ENSDART00000085758
lysine (K)-specific demethylase 1a
chr17_-_20897407 0.09 ENSDART00000149481
ankyrin 3b
chr17_-_19626357 0.08 ENSDART00000011432
receptor accessory protein 3a
chr9_+_35017702 0.08 ENSDART00000193640
GA binding protein transcription factor, alpha subunit
chr22_-_16997246 0.07 ENSDART00000090242
nuclear factor I/A
chr10_-_25591194 0.07 ENSDART00000131640
T cell lymphoma invasion and metastasis 1a
chr16_-_32582798 0.05 ENSDART00000137936
F-box and leucine-rich repeat protein 4
chr24_+_34113424 0.03 ENSDART00000105572
gastrulation brain homeobox 1
chr18_+_41542542 0.02 ENSDART00000087445
TSEN34 tRNA splicing endonuclease subunit
chr19_+_13994563 0.01 ENSDART00000164696
transmembrane protein 222b
chr16_+_10422836 0.00 ENSDART00000161568
INO80 complex subunit E
chr2_-_45630823 0.00 ENSDART00000183553

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb1a+hoxb1b-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0031642 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.3 0.8 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.5 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 1.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 3.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.3 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 0.4 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 0.3 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 1.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 1.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.6 GO:0034394 protein localization to cell surface(GO:0034394) energy homeostasis(GO:0097009)
0.1 1.4 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.6 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 1.5 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 1.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.5 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.8 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 1.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0001973 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.4 GO:0072595 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) maintenance of protein localization in organelle(GO:0072595)
0.0 1.8 GO:0021549 cerebellum development(GO:0021549)
0.0 1.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.2 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 1.0 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 0.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0048041 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.3 1.8 GO:0005955 calcineurin complex(GO:0005955)
0.3 3.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.8 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.4 GO:0043679 axon terminus(GO:0043679)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.9 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1903136 cuprous ion binding(GO:1903136)
0.3 1.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.6 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.9 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.3 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.1 3.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.1 GO:0015026 coreceptor activity(GO:0015026)
0.1 0.7 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 0.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 3.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.5 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 1.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK