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PRJNA207719: Tissue specific transcriptome profiling

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Results for irx6a

Z-value: 0.34

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Transcription factors associated with irx6a

Gene Symbol Gene ID Gene Info
irx6a
ENSDARG00000034420 iroquois homeobox 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx6adr11_v1_chr7_-_35516251_355162510.632.5e-01Click!

Activity profile of irx6a motif

Sorted Z-values of irx6a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_3827751 0.44 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr16_+_25316973 0.38 ENSDART00000086409
dync1i1
dynein, cytoplasmic 1, intermediate chain 1
chr20_+_35382482 0.37 ENSDART00000135284
vsnl1a
visinin-like 1a
chr13_+_23677949 0.37 ENSDART00000144215
pcnxl2
pecanex-like 2 (Drosophila)
chr17_-_26719821 0.27 ENSDART00000186813
calm1a
calmodulin 1a
chr8_-_6943155 0.27 ENSDART00000139545
ENSDART00000033294
wdr13
WD repeat domain 13
chr7_-_44672095 0.26 ENSDART00000073745
cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr16_+_1803462 0.22 ENSDART00000183974
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr21_-_12036134 0.21 ENSDART00000031658
tpgs2
tubulin polyglutamylase complex subunit 2
chr25_+_7671640 0.21 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr14_-_47963115 0.21 ENSDART00000003826
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr5_-_33460959 0.21 ENSDART00000085636
si:ch211-182d3.1
si:ch211-182d3.1
chr7_+_10701770 0.20 ENSDART00000167323
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr16_+_22649855 0.18 ENSDART00000143043
chrnb2b
cholinergic receptor, nicotinic, beta 2b
chr17_-_14705039 0.16 ENSDART00000154281
ENSDART00000123550
ptp4a2a
protein tyrosine phosphatase type IVA, member 2a
chr18_+_910992 0.16 ENSDART00000161206
ENSDART00000167229
pkma
pyruvate kinase M1/2a
chr13_+_43247936 0.16 ENSDART00000126850
ENSDART00000165331
smoc2
SPARC related modular calcium binding 2
chr9_+_23748342 0.15 ENSDART00000019053
faima
Fas apoptotic inhibitory molecule a
chr18_+_19990412 0.14 ENSDART00000155054
ENSDART00000090310
pias1b
protein inhibitor of activated STAT, 1b
chr23_-_32944796 0.14 ENSDART00000190388
plxna2
plexin A2
chr8_+_29986265 0.13 ENSDART00000148258
ptch1
patched 1
chr22_+_2937485 0.13 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr19_-_17526735 0.12 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr5_-_48268049 0.12 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr4_+_22613625 0.12 ENSDART00000131161
sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr15_-_9419472 0.11 ENSDART00000122117
sacs
sacsin molecular chaperone
chr21_+_20549395 0.11 ENSDART00000181633
efna5a
ephrin-A5a
chr5_+_13427826 0.10 ENSDART00000083359
sec14l8
SEC14-like lipid binding 8
chr14_-_33177935 0.10 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr14_-_26392146 0.10 ENSDART00000037999
b4galt7
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
chr10_-_28117740 0.09 ENSDART00000134491
med13a
mediator complex subunit 13a
chr3_+_18050667 0.09 ENSDART00000035531
mettl26
methyltransferase like 26
chr22_+_2431585 0.09 ENSDART00000167758
zgc:171435
zgc:171435
chr6_-_12788539 0.08 ENSDART00000156415
dock9b
dedicator of cytokinesis 9b
chr15_-_2857961 0.08 ENSDART00000033263
ankrd49
ankyrin repeat domain 49
chr9_+_23748133 0.08 ENSDART00000180758
faima
Fas apoptotic inhibitory molecule a
chr23_-_3721444 0.07 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr3_-_12970418 0.07 ENSDART00000158747
pdgfab
platelet-derived growth factor alpha polypeptide b
chr4_-_75175407 0.06 ENSDART00000180125
CABZ01043953.1

chr8_-_11832771 0.06 ENSDART00000193412
ENSDART00000184720
ENSDART00000139947
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr19_+_27342479 0.06 ENSDART00000184687
ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr4_-_18841071 0.06 ENSDART00000140722
cbll1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr24_-_15263142 0.05 ENSDART00000183176
ENSDART00000006930
rttn
rotatin
chr20_-_38610360 0.05 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr22_-_2937503 0.05 ENSDART00000092991
ENSDART00000131110
pigx
phosphatidylinositol glycan anchor biosynthesis, class X
chr15_-_14375452 0.05 ENSDART00000160675
ENSDART00000164028
ENSDART00000171642
dpf1
D4, zinc and double PHD fingers family 1
chr6_-_131401 0.04 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr4_+_9028819 0.04 ENSDART00000102893
aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr22_+_31207226 0.04 ENSDART00000180016
grip2b
glutamate receptor interacting protein 2b
chr24_-_28229618 0.04 ENSDART00000145290
bcl2a
BCL2, apoptosis regulator a
chr20_-_27190393 0.04 ENSDART00000149024
btbd7
BTB (POZ) domain containing 7
chr22_+_2492397 0.04 ENSDART00000181596
CU570894.2

chr12_+_34854562 0.04 ENSDART00000130366
si:dkey-21c1.4
si:dkey-21c1.4
chr5_-_69538058 0.03 ENSDART00000097251
zgc:153044
zgc:153044
chr24_+_10202718 0.03 ENSDART00000126668
pou6f2
POU class 6 homeobox 2
chr21_+_40498628 0.03 ENSDART00000163454
coro6
coronin 6
chr13_+_12389849 0.03 ENSDART00000086525
atp10d
ATPase phospholipid transporting 10D
chr18_+_5549672 0.02 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr21_-_45871866 0.01 ENSDART00000161716
larp1
La ribonucleoprotein domain family, member 1
chr23_+_29885019 0.01 ENSDART00000167059
aurkaip1
aurora kinase A interacting protein 1
chr13_-_12389748 0.01 ENSDART00000141606
commd8
COMM domain containing 8
chr25_-_17494364 0.01 ENSDART00000154134
lrrc29
leucine rich repeat containing 29
chr24_-_26981848 0.01 ENSDART00000183198
stag1b
stromal antigen 1b
chr20_-_13774826 0.01 ENSDART00000063831
opn8c
opsin 8, group member c
chr19_+_26923274 0.00 ENSDART00000148439
ENSDART00000148877
nelfe
negative elongation factor complex member E

Network of associatons between targets according to the STRING database.

First level regulatory network of irx6a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.1 GO:0003403 optic vesicle formation(GO:0003403)
0.0 0.1 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.0 0.1 GO:0043703 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0 0.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.2 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.2 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.0 0.1 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.0 GO:0042560 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.0 0.1 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.4 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.0 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 0.1 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion