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PRJNA207719: Tissue specific transcriptome profiling

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Results for isl2a+isl2b

Z-value: 0.83

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Transcription factors associated with isl2a+isl2b

Gene Symbol Gene ID Gene Info
ENSDARG00000003971 ISL LIM homeobox 2a
ENSDARG00000053499 ISL LIM homeobox 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
isl2bdr11_v1_chr7_+_29992889_299928890.523.7e-01Click!
isl2adr11_v1_chr25_-_32751982_32751982-0.385.3e-01Click!

Activity profile of isl2a+isl2b motif

Sorted Z-values of isl2a+isl2b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_24573721 0.66 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
chr13_-_2010191 0.59 ENSDART00000161021
ENSDART00000124134
GDNF family receptor alpha like
chr2_-_38284648 0.45 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr15_-_2640966 0.42 ENSDART00000063320
claudin e
chr21_+_11385031 0.39 ENSDART00000040598
carboxyl ester lipase, tandem duplicate 2
chr8_-_50147948 0.36 ENSDART00000149010
haptoglobin
chr5_+_58550291 0.36 ENSDART00000184983
ENSDART00000044803
POU class 2 homeobox 3
chr22_-_16154771 0.30 ENSDART00000009464
solute carrier family 30 (zinc transporter), member 7
chr22_-_17482282 0.30 ENSDART00000105453
si:ch211-197g15.7
chr25_+_22320738 0.29 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr6_+_39905021 0.28 ENSDART00000064904
endonuclease, polyU-specific
chr3_+_28939759 0.27 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr15_+_46356879 0.27 ENSDART00000154388
wu:fb18f06
chr19_-_5769728 0.27 ENSDART00000133106
si:ch211-264f5.6
chr5_+_69785990 0.26 ENSDART00000162057
ENSDART00000166893
lysine methyltransferase 5Ab
chr21_-_10886709 0.26 ENSDART00000134408
si:dkey-277m11.2
chr7_+_60079302 0.25 ENSDART00000051524
ethanolamine-phosphate phospho-lyase
chr21_+_25236297 0.24 ENSDART00000112783
transmembrane protein 45B
chr15_+_46357080 0.24 ENSDART00000155571
ENSDART00000156541
wu:fb18f06
chr21_-_44081540 0.24 ENSDART00000130833

chr5_+_69786215 0.23 ENSDART00000165956
lysine methyltransferase 5Ab
chr12_-_4532066 0.22 ENSDART00000092687
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr1_-_25966068 0.22 ENSDART00000137869
ENSDART00000134192
synaptopodin 2b
chr3_+_3681116 0.22 ENSDART00000109618
ADP-ribosyltransferase 4 (Dombrock blood group)
chr15_-_46779934 0.22 ENSDART00000085136
chloride channel 2c
chr23_-_31645760 0.21 ENSDART00000035031
serum/glucocorticoid regulated kinase 1
chr10_+_44956660 0.21 ENSDART00000169225
ENSDART00000189298
interleukin 1, beta
chr1_+_52792439 0.21 ENSDART00000123972
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr20_-_33507458 0.21 ENSDART00000140287
papilin b, proteoglycan-like sulfated glycoprotein
chr8_+_24747865 0.21 ENSDART00000078656
solute carrier family 16, member 4
chr11_-_1400507 0.20 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
ribosomal protein L29
chr16_-_48400639 0.20 ENSDART00000159372
eukaryotic translation initiation factor 3, subunit H, a
chr10_+_29850330 0.19 ENSDART00000168898
heat shock protein 8
chr7_-_66868543 0.19 ENSDART00000149680
adenosine monophosphate deaminase 3a
chr23_-_16485190 0.19 ENSDART00000155038
si:dkeyp-100a5.4
chr16_-_45094599 0.19 ENSDART00000155479
si:rp71-77l1.1
chr19_-_5125663 0.18 ENSDART00000005547
ENSDART00000132642
guanine nucleotide binding protein (G protein), beta polypeptide 3b
chr22_-_10165446 0.18 ENSDART00000142012
RanBP-type and C3HC4-type zinc finger containing 1
chr15_-_21702317 0.18 ENSDART00000155824
si:dkey-40g16.6
chr13_-_42560662 0.18 ENSDART00000124898

chr22_-_22147375 0.18 ENSDART00000149304
cell division cycle 34 homolog (S. cerevisiae) a
chr11_-_10456553 0.17 ENSDART00000169509
ENSDART00000185574
ENSDART00000188276
epithelial cell transforming 2
chr11_-_10456387 0.17 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr2_-_10877765 0.17 ENSDART00000100607
cell division cycle 7 homolog (S. cerevisiae)
chr16_+_23303859 0.17 ENSDART00000006093
solute carrier family 50 (sugar efflux transporter), member 1
chr21_+_11749097 0.17 ENSDART00000102408
ENSDART00000102404
elongation factor, RNA polymerase II, 2
chr18_-_48547564 0.16 ENSDART00000138607
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr16_-_16761164 0.16 ENSDART00000135872
si:dkey-27n14.1
chr3_+_26342768 0.16 ENSDART00000163832
si:ch211-156b7.4
chr22_-_10470663 0.16 ENSDART00000143352
osteomodulin
chr6_-_52788213 0.16 ENSDART00000179880
recombination signal binding protein for immunoglobulin kappa J region-like
chr11_+_31324335 0.16 ENSDART00000088093
signal-induced proliferation-associated 1 like 2
chr19_-_20403845 0.16 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
deleted in azoospermia-like
chr14_-_4145594 0.16 ENSDART00000077348
caspase 3, apoptosis-related cysteine peptidase b
chr20_+_41021054 0.16 ENSDART00000146052
mannosidase, alpha, class 1A, member 1
chr2_+_56657804 0.16 ENSDART00000113964
RNA polymerase II subunit E
chr1_+_55608520 0.16 ENSDART00000152307
adhesion G protein-coupled receptor E18
chr18_+_30847237 0.16 ENSDART00000012374
forkhead box F1
chr18_+_13275735 0.15 ENSDART00000148127
phospholipase C, gamma 2
chr22_-_17482810 0.15 ENSDART00000171293
si:ch211-197g15.7
chr13_+_646700 0.15 ENSDART00000006892
tumor protein p53 binding protein, 2a
chr11_+_24002503 0.15 ENSDART00000164702
chitinase, acidic.2
chr12_+_17154655 0.15 ENSDART00000028003
ankyrin repeat domain 22
chr25_-_21031007 0.15 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr3_-_25268751 0.15 ENSDART00000139423
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase a
chr18_-_15932704 0.15 ENSDART00000127769
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr9_-_394088 0.15 ENSDART00000169014
si:dkey-11f4.7
chr20_-_5291012 0.14 ENSDART00000122892
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr23_+_32426954 0.14 ENSDART00000192529
ENSDART00000172313
si:ch211-66i15.5
chr6_-_35046735 0.14 ENSDART00000143649
UDP-N-acetylglucosamine pyrophosphorylase 1
chr6_+_54538948 0.14 ENSDART00000149270
tubby like protein 1b
chr23_+_32406461 0.14 ENSDART00000179878
si:ch211-66i15.5
chr17_-_14815557 0.14 ENSDART00000154473
nidogen 2a (osteonidogen)
chr6_-_54486410 0.13 ENSDART00000064679

chr23_-_33350990 0.13 ENSDART00000144831
si:ch211-226m16.2
chr1_-_9641845 0.13 ENSDART00000121490
ENSDART00000159411
UDP glucuronosyltransferase 5 family, polypeptide B2
UDP glucuronosyltransferase 5 family, polypeptide B3
chr24_+_16985181 0.13 ENSDART00000135580
eukaryotic translation initiation factor 2, subunit 3 gamma
chr2_+_20605925 0.13 ENSDART00000191510
olfactomedin-like 2Bb
chr22_+_19552987 0.13 ENSDART00000105315
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr24_-_26310854 0.13 ENSDART00000080113
apolipoprotein Db
chr2_+_36112273 0.13 ENSDART00000191315
T-cell receptor alpha joining 35
chr20_+_11731039 0.12 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
chr11_+_24001993 0.12 ENSDART00000168215
chitinase, acidic.2
chr1_+_51721851 0.12 ENSDART00000040397
peroxiredoxin 2
chr3_+_32553714 0.12 ENSDART00000165638
paired box 10
chr12_+_16168342 0.12 ENSDART00000079326
ENSDART00000170024
low density lipoprotein receptor-related protein 2b
chr23_-_3511630 0.12 ENSDART00000019667
ring finger protein 114
chr6_-_12588044 0.12 ENSDART00000047896
solute carrier family 15 (oligopeptide transporter), member 1b
chr5_-_42894068 0.12 ENSDART00000169606
chemokine (C-X-C motif) ligand 11, duplicate 1
chr10_-_34916208 0.12 ENSDART00000187371
cyclin A1
chr9_+_24008879 0.12 ENSDART00000190419
ENSDART00000191843
ENSDART00000148226
melanophilin b
chr12_-_28363111 0.12 ENSDART00000016283
ENSDART00000164156
proteasome 26S subunit, non-ATPase 11b
chr21_-_35419486 0.11 ENSDART00000138529
si:dkeyp-23e4.3
chr15_+_34988148 0.11 ENSDART00000076269
coiled-coil domain containing 105
chr3_+_14388010 0.11 ENSDART00000171726
ENSDART00000165452
transmembrane protein 56b
chr3_-_54846444 0.11 ENSDART00000074010
UBA-like domain containing 1b
chr21_-_19314618 0.11 ENSDART00000188744
glycerol-3-phosphate acyltransferase 3
chr7_+_59020972 0.11 ENSDART00000157873
3-hydroxyacyl-CoA dehydratase 1
chr3_-_19368435 0.11 ENSDART00000132987
sphingosine-1-phosphate receptor 5a
chr22_-_9183944 0.11 ENSDART00000188599
si:ch211-213a13.5
chr24_+_13869092 0.10 ENSDART00000176492
EYA transcriptional coactivator and phosphatase 1
chr16_+_11660839 0.10 ENSDART00000193911
ENSDART00000143683
si:dkey-250k15.10
chr23_+_36460239 0.10 ENSDART00000172441
LIM domain and actin binding 1a
chr2_-_59205393 0.10 ENSDART00000056417
ENSDART00000182452
ENSDART00000141876
finTRIM family, member 30
chr2_+_19633493 0.10 ENSDART00000147989
Pim proto-oncogene, serine/threonine kinase, related 54
chr19_+_16015881 0.10 ENSDART00000187135
CTP synthase 1a
chr3_+_23029934 0.10 ENSDART00000110343
N-acetylglutamate synthase
chr19_+_16016038 0.10 ENSDART00000131319
CTP synthase 1a
chr23_+_39695827 0.10 ENSDART00000113893
ENSDART00000186679
transmembrane and coiled-coil domains 4
chr8_-_53044300 0.10 ENSDART00000191653
nuclear receptor subfamily 6, group A, member 1a
chr19_-_47323267 0.09 ENSDART00000190077

chr9_+_48761455 0.09 ENSDART00000139631
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr19_+_31904836 0.09 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tumor protein D52
chr23_-_16484383 0.09 ENSDART00000187839
si:dkeyp-100a5.4
chr13_+_9468535 0.09 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
si:dkey-265c15.6
chr19_+_1688727 0.09 ENSDART00000115136
ENSDART00000166744
DENN/MADD domain containing 3a
chr17_-_4245902 0.09 ENSDART00000151851
growth differentiation factor 3
chr13_-_9450210 0.08 ENSDART00000133768
Pim proto-oncogene, serine/threonine kinase, related 152
chr24_+_19415124 0.08 ENSDART00000186931
sulfatase 1
chr22_-_36530902 0.08 ENSDART00000056188
info polymerase (RNA) II (DNA directed) polypeptide H
chr24_-_3477103 0.08 ENSDART00000143723
isopentenyl-diphosphate delta isomerase 1
chr11_-_29737088 0.08 ENSDART00000159828
si:ch211-218g23.6
chr5_-_42083363 0.08 ENSDART00000162596
chemokine (C-X-C motif) ligand 11, duplicate 5
chr15_+_25438714 0.08 ENSDART00000154164
apoptosis-inducing factor, mitochondrion-associated, 4
chr12_-_6880694 0.08 ENSDART00000171846
protocadherin-related 15b
chr19_+_9186175 0.08 ENSDART00000039325
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr3_+_23029484 0.08 ENSDART00000187900
N-acetylglutamate synthase
chr2_+_19522082 0.08 ENSDART00000146098
Pim proto-oncogene, serine/threonine kinase, related 49
chr6_-_49510553 0.08 ENSDART00000166238
ribosomal protein, large P2
chr10_-_17083180 0.08 ENSDART00000170083
family with sequence similarity 166, member B
chr13_+_9046473 0.08 ENSDART00000136557
Pim proto-oncogene, serine/threonine kinase, related 152
chr2_-_48512450 0.08 ENSDART00000160132

chr16_-_17072440 0.08 ENSDART00000002493
ENSDART00000178443
tumor necrosis factor receptor superfamily, member 1a
chr22_-_12745589 0.07 ENSDART00000136841
phospholipase C, delta 4a
chr8_-_7475917 0.07 ENSDART00000082157
GATA binding protein 1b
chr3_-_13068189 0.07 ENSDART00000167180
protein kinase, cAMP-dependent, regulatory, type I, beta
chr17_-_12407106 0.07 ENSDART00000183540
ankyrin repeat and EF-hand domain containing 1b
chr20_+_25586099 0.07 ENSDART00000063122
ENSDART00000134047
cytochrome P450, family 2, subfamily P, polypeptide 10
chr7_+_66822229 0.07 ENSDART00000112109
lymphatic vessel endothelial hyaluronic receptor 1a
chr8_-_13046089 0.07 ENSDART00000137784
si:dkey-208b23.5
chr13_-_9467944 0.07 ENSDART00000136582
Pim proto-oncogene, serine/threonine kinase, related 152
chr14_+_21722235 0.07 ENSDART00000183667
syntaxin 3A
chr17_-_2834764 0.07 ENSDART00000024027
bradykinin receptor B1
chr5_+_55225497 0.06 ENSDART00000144087
transmembrane channel-like 2a
chr6_+_9175886 0.06 ENSDART00000165333
si:ch211-207l14.1
chr13_-_33639050 0.06 ENSDART00000133073
ribosome binding protein 1a
chr2_-_19520690 0.06 ENSDART00000133559
Pim proto-oncogene, serine/threonine kinase, related 52
chr25_+_13406069 0.06 ENSDART00000010495
zinc and ring finger 1
chr23_-_18024543 0.06 ENSDART00000139695
peptidase M20 domain containing 1, tandem duplicate 1
chr4_-_77218637 0.06 ENSDART00000174325
proteasome subunit beta 10
chr8_+_31717175 0.06 ENSDART00000013434
3-oxoacid CoA transferase 1a
chr10_+_31248036 0.06 ENSDART00000193574
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr1_+_45002971 0.06 ENSDART00000021336
DnaJ (Hsp40) homolog, subfamily A, member 1
chr11_-_45138857 0.06 ENSDART00000166501
calcium activated nucleotidase 1b
chr13_-_30996072 0.06 ENSDART00000181661
WDFY family member 4
chr2_-_22927958 0.06 ENSDART00000141621
myosin VIIBb
chr7_-_7692723 0.05 ENSDART00000183352
aminoadipate aminotransferase
chr21_+_45841731 0.05 ENSDART00000038657
fatty acid hydroxylase domain containing 2
chr16_-_10223741 0.05 ENSDART00000188099
si:rp71-15i12.1
chr22_-_34995333 0.05 ENSDART00000110900
Kv channel interacting protein 2
chr3_-_25119839 0.05 ENSDART00000154724
chondroadherin-like a
chr19_+_7424347 0.05 ENSDART00000004622
splicing factor 3b, subunit 4
chr7_-_7692992 0.05 ENSDART00000192619
aminoadipate aminotransferase
chr8_+_31716872 0.05 ENSDART00000161121
3-oxoacid CoA transferase 1a
chr13_-_9045879 0.05 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
chr3_-_59297532 0.05 ENSDART00000187991

chr24_+_12894282 0.05 ENSDART00000061301
si:dkeyp-28d2.4
chr9_+_32069989 0.05 ENSDART00000139540
si:dkey-83m22.7
chr7_+_20512419 0.05 ENSDART00000173907
si:dkey-19b23.14
chr2_+_10771787 0.05 ENSDART00000187782
growth factor independent 1A transcription repressor a
chr24_-_12770357 0.05 ENSDART00000060826
importin 4
chr9_+_51147380 0.04 ENSDART00000003913
interferon induced with helicase C domain 1
chr17_-_24353462 0.04 ENSDART00000191021
WD repeat containing planar cell polarity effector
chr6_+_12527725 0.04 ENSDART00000149328
serine/threonine kinase 24b (STE20 homolog, yeast)
chr22_-_17844117 0.04 ENSDART00000159363

chr7_-_48665305 0.04 ENSDART00000190507
cyclin-dependent kinase inhibitor 1Ca
chr10_-_40964739 0.04 ENSDART00000076359
neuropeptide FF receptor 1 like 1
chr5_-_19861766 0.04 ENSDART00000088904
glycolipid transfer protein a
chr12_+_18899396 0.04 ENSDART00000105858
X-ray repair complementing defective repair in Chinese hamster cells 6
chr2_+_19578446 0.04 ENSDART00000164758
Pim proto-oncogene, serine/threonine kinase, related 50
chr8_+_52637507 0.04 ENSDART00000163830
si:dkey-90l8.3
chr21_+_43172506 0.03 ENSDART00000121725
zinc finger, CCHC domain containing 10
chr19_+_24872159 0.03 ENSDART00000158490
si:ch211-195b13.1
chr6_+_7533601 0.03 ENSDART00000057823
proliferation-associated 2G4, a
chr19_+_45962016 0.03 ENSDART00000169710
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr2_+_10878406 0.03 ENSDART00000091497
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr13_+_7049823 0.03 ENSDART00000178997
ENSDART00000161443
ribonuclease T2
chr2_-_19520324 0.03 ENSDART00000079877
Pim proto-oncogene, serine/threonine kinase, related 52
chr3_+_38540411 0.03 ENSDART00000154943
si:dkey-7f16.3
chr18_+_3579829 0.03 ENSDART00000158763
ENSDART00000182850
ENSDART00000162754
ENSDART00000178789
ENSDART00000172656
leucine-rich repeats and calponin homology (CH) domain containing 3
chr24_+_2495197 0.03 ENSDART00000146887
coagulation factor XIII, A1 polypeptide a, tandem duplicate 1
chr4_-_49582758 0.03 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
chr6_+_9204099 0.03 ENSDART00000150167
ENSDART00000115394
T-box 19
chr8_-_22273819 0.03 ENSDART00000121513
nephronophthisis 4
chr18_-_8398972 0.03 ENSDART00000136512
si:ch211-220f12.4
chr2_-_7845110 0.02 ENSDART00000091987
si:ch211-38m6.7
chr24_-_6078222 0.02 ENSDART00000146830
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr17_+_12285285 0.02 ENSDART00000154336
Pim proto-oncogene, serine/threonine kinase, related 174
chr17_+_43595692 0.02 ENSDART00000156271
cilia and flagella associated protein 99
chr1_-_52210950 0.02 ENSDART00000083946
phospholipase D family, member 6

Network of associatons between targets according to the STRING database.

First level regulatory network of isl2a+isl2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002369 T cell cytokine production(GO:0002369)
0.1 0.3 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.1 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.4 GO:0006032 chitin catabolic process(GO:0006032)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.4 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.0 0.3 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.2 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.0 0.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0002544 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.0 0.1 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.1 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.2 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.0 0.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.1 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.1 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.1 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.1 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0 0.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.1 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.1 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.1 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.0 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097268 cytoophidium(GO:0097268)
0.0 0.1 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.0 GO:0097541 axonemal basal plate(GO:0097541)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.0 GO:0043202 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.3 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.1 0.2 GO:0034618 arginine binding(GO:0034618)
0.0 0.2 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.0 0.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.1 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.5 GO:0032190 acrosin binding(GO:0032190)
0.0 0.2 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 0.1 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.2 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.0 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.0 0.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation