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PRJNA207719: Tissue specific transcriptome profiling

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Results for klf5l+klf6a+klf6b

Z-value: 0.60

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Transcription factors associated with klf5l+klf6a+klf6b

Gene Symbol Gene ID Gene Info
klf5l
ENSDARG00000018757 Kruppel-like factor 5 like
klf6a
ENSDARG00000029072 Kruppel-like factor 6a
klf6b
ENSDARG00000038561 Kruppel-like factor 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf6adr11_v1_chr24_-_4148914_4148915-0.652.4e-01Click!
klf5ldr11_v1_chr21_-_38153824_381538240.385.3e-01Click!
klf6bdr11_v1_chr2_+_48073972_480739720.335.9e-01Click!

Activity profile of klf5l+klf6a+klf6b motif

Sorted Z-values of klf5l+klf6a+klf6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_9952103 0.48 ENSDART00000065475
zp2l2
zona pellucida glycoprotein 2, like 2
chr17_-_2584423 0.48 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr22_+_1006573 0.42 ENSDART00000123458
pparda
peroxisome proliferator-activated receptor delta a
chr21_-_30293224 0.41 ENSDART00000101051
slbp2
stem-loop binding protein 2
chr13_-_12021566 0.38 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr22_+_344763 0.30 ENSDART00000181934
CU914780.1

chr19_+_7636941 0.26 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cgnb
cingulin b
chr17_-_12712776 0.25 ENSDART00000064511
il17a/f1
interleukin 17a/f1
chr6_-_60104628 0.25 ENSDART00000057463
ENSDART00000169188
pmepa1
prostate transmembrane protein, androgen induced 1
chr21_-_5056812 0.22 ENSDART00000139713
ENSDART00000140859
zgc:77838
zgc:77838
chr7_-_23768234 0.22 ENSDART00000173981
si:ch211-200p22.4
si:ch211-200p22.4
chr21_+_43253538 0.22 ENSDART00000179940
ENSDART00000164806
ENSDART00000147026
shroom1
shroom family member 1
chr20_-_49889111 0.21 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr13_+_33688474 0.21 ENSDART00000161465
CABZ01087953.1

chr5_-_23800376 0.20 ENSDART00000134184
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr4_+_57093908 0.20 ENSDART00000170198
si:ch211-238e22.5
si:ch211-238e22.5
chr1_+_59538755 0.19 ENSDART00000166354
sp6
Sp6 transcription factor
chr19_+_4892281 0.19 ENSDART00000150969
cdk12
cyclin-dependent kinase 12
chr7_-_32980017 0.18 ENSDART00000113744
pkp3b
plakophilin 3b
chr16_+_34111919 0.18 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr1_-_59232267 0.17 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr16_-_51254694 0.17 ENSDART00000148894
serpinb14
serpin peptidase inhibitor, clade B (ovalbumin), member 14
chr7_-_46019756 0.15 ENSDART00000162583
zgc:162297
zgc:162297
chr1_-_10647307 0.15 ENSDART00000103548
si:dkey-31e10.1
si:dkey-31e10.1
chr13_-_50200042 0.14 ENSDART00000074230
pkz
protein kinase containing Z-DNA binding domains
chr7_-_45852270 0.13 ENSDART00000170224
shcbp1
SHC SH2-domain binding protein 1
chr24_+_24726956 0.13 ENSDART00000144574
ENSDART00000066628
mtfr1
mitochondrial fission regulator 1
chr13_-_23611960 0.13 ENSDART00000146216
prim2
DNA primase subunit 2
chr19_+_19756425 0.12 ENSDART00000167606
hoxa3a
homeobox A3a
chr23_+_42338325 0.12 ENSDART00000169660
cyp2aa7
cytochrome P450, family 2, subfamily AA, polypeptide 7
chr4_+_53119675 0.12 ENSDART00000167470
si:dkey-8o9.2
si:dkey-8o9.2
chr17_-_27273296 0.11 ENSDART00000077087
id3
inhibitor of DNA binding 3
chr11_+_807153 0.11 ENSDART00000173289
vgll4b
vestigial-like family member 4b
chr3_-_30909487 0.11 ENSDART00000025046
ppp1caa
protein phosphatase 1, catalytic subunit, alpha isozyme a
chr19_+_24324967 0.11 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr9_+_13999620 0.10 ENSDART00000143229
cd28l
cd28-like molecule
chr20_+_2039518 0.10 ENSDART00000043157
CABZ01088134.1

chr15_-_38202630 0.10 ENSDART00000183772
rhoga
ras homolog family member Ga
chr16_-_7793457 0.10 ENSDART00000113483
trim71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr20_+_18703108 0.10 ENSDART00000181188
eif5
eukaryotic translation initiation factor 5
chr9_-_34842414 0.09 ENSDART00000126348
BX601644.1
Danio rerio cytokine receptor-like factor 2 (crlf2), mRNA.
chr8_-_4100365 0.09 ENSDART00000142846
cux2b
cut-like homeobox 2b
chr22_+_35089031 0.09 ENSDART00000076040
srfa
serum response factor a
chr22_+_30496360 0.09 ENSDART00000189145
BX649490.4

chr13_+_23093743 0.09 ENSDART00000148034
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr2_+_38225427 0.08 ENSDART00000141614
si:ch211-14a17.11
si:ch211-14a17.11
chr25_+_2229301 0.08 ENSDART00000180198
pparab
peroxisome proliferator-activated receptor alpha b
chr18_-_127558 0.07 ENSDART00000149556
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr1_-_10647484 0.07 ENSDART00000164541
ENSDART00000188958
ENSDART00000190904
si:dkey-31e10.1
si:dkey-31e10.1
chr6_-_10788065 0.07 ENSDART00000190968
wipf1b
WAS/WASL interacting protein family, member 1b
chr5_-_37252111 0.06 ENSDART00000185110
lrch2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr10_-_44026369 0.06 ENSDART00000185456
crybb1
crystallin, beta B1
chr2_-_38225388 0.06 ENSDART00000146485
ENSDART00000128043
acin1a
apoptotic chromatin condensation inducer 1a
chr3_+_17634952 0.06 ENSDART00000191833
rab5c
RAB5C, member RAS oncogene family
chr8_+_43056153 0.05 ENSDART00000186377
prnpa
prion protein a
chr24_-_41180149 0.05 ENSDART00000019975
acvr2ba
activin A receptor type 2Ba
chr21_-_22325124 0.05 ENSDART00000142100
gdpd4b
glycerophosphodiester phosphodiesterase domain containing 4b
chr8_+_36621598 0.04 ENSDART00000180389
magixb
MAGI family member, X-linked b
chr9_-_3496548 0.04 ENSDART00000102876
cybrd1
cytochrome b reductase 1
chr12_-_47648538 0.04 ENSDART00000108477
fh
fumarate hydratase
chr6_+_27514465 0.04 ENSDART00000128985
ENSDART00000079397
ryk
receptor-like tyrosine kinase
chr18_+_6641542 0.04 ENSDART00000160379
c2cd5
C2 calcium-dependent domain containing 5
chr6_-_13891727 0.04 ENSDART00000065356
desmb
desmin b
chr4_+_357810 0.03 ENSDART00000163436
ENSDART00000103645
tmem181
transmembrane protein 181
chr7_-_25126212 0.03 ENSDART00000173588
MAJIN
si:dkey-23i12.11
chr4_+_3438510 0.02 ENSDART00000155320
atxn7l1
ataxin 7-like 1
chr22_+_1786230 0.02 ENSDART00000169318
ENSDART00000164948
znf1154
zinc finger protein 1154
chr6_+_12503849 0.02 ENSDART00000149529
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr16_-_563235 0.02 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr11_-_11965033 0.02 ENSDART00000193683
abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr14_+_46291022 0.02 ENSDART00000074099
cabp2b
calcium binding protein 2b
chr22_+_465269 0.02 ENSDART00000145767
celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr21_+_6613772 0.02 ENSDART00000159645
col5a1
procollagen, type V, alpha 1
chr21_-_37733571 0.01 ENSDART00000176214
mpp1
membrane protein, palmitoylated 1
chr21_+_30293564 0.00 ENSDART00000007412
zmat2
zinc finger, matrin-type 2
chr14_-_237130 0.00 ENSDART00000164988
bod1l1
biorientation of chromosomes in cell division 1-like 1
chr4_+_71018579 0.00 ENSDART00000186727
si:dkeyp-80d11.10
si:dkeyp-80d11.10
chr4_+_14343706 0.00 ENSDART00000142845
prl2
prolactin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of klf5l+klf6a+klf6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0040016 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) embryonic cleavage(GO:0040016)
0.1 0.5 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.2 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0010586 miRNA metabolic process(GO:0010586)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.0 GO:0010039 response to iron ion(GO:0010039)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990077 primosome complex(GO:1990077)
0.0 0.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 0.2 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling