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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx1.2lb

Z-value: 0.90

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Transcription factors associated with nkx1.2lb

Gene Symbol Gene ID Gene Info
nkx1.2lb
ENSDARG00000099427 NK1 transcription factor related 2-like,b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx1.2lbdr11_v1_chr14_+_15064870_15064870-0.974.8e-03Click!

Activity profile of nkx1.2lb motif

Sorted Z-values of nkx1.2lb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_34002185 1.18 ENSDART00000046599
zar1l
zygote arrest 1-like
chr23_-_44965582 0.85 ENSDART00000163367
tfr2
transferrin receptor 2
chr6_-_7720332 0.85 ENSDART00000135945
rpsa
ribosomal protein SA
chr8_-_23780334 0.80 ENSDART00000145179
ENSDART00000145894
zgc:195245
zgc:195245
chr22_-_17458070 0.62 ENSDART00000139658
si:ch211-197g15.10
si:ch211-197g15.10
chr12_-_4249000 0.60 ENSDART00000059298
zgc:92313
zgc:92313
chr17_-_15189397 0.58 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr24_-_32582378 0.52 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr20_-_37813863 0.50 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr13_-_36798204 0.50 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr20_+_14114258 0.50 ENSDART00000044937
kcns3b
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
chr19_-_18313303 0.47 ENSDART00000164644
ENSDART00000167480
ENSDART00000163104
si:dkey-208k4.2
si:dkey-208k4.2
chr10_+_39212898 0.45 ENSDART00000159501
stt3a
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr4_-_9891874 0.45 ENSDART00000067193
adm2a
adrenomedullin 2a
chr20_-_14114078 0.44 ENSDART00000168434
ENSDART00000104032
si:ch211-223m11.2
si:ch211-223m11.2
chr25_+_36312459 0.43 ENSDART00000182484
CR354435.5

chr6_+_28051978 0.43 ENSDART00000143218
si:ch73-194h10.2
si:ch73-194h10.2
chr25_+_469855 0.42 ENSDART00000104717
rsl24d1
ribosomal L24 domain containing 1
chr1_-_48933 0.42 ENSDART00000171162
ildr1a
immunoglobulin-like domain containing receptor 1a
chr23_+_43255328 0.41 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr16_-_11798994 0.41 ENSDART00000135408
cnfn
cornifelin
chr8_-_20243389 0.41 ENSDART00000184904
acer1
alkaline ceramidase 1
chr4_+_306036 0.41 ENSDART00000103659
msgn1
mesogenin 1
chr13_-_17723417 0.40 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr6_-_54179860 0.39 ENSDART00000164283
rps10
ribosomal protein S10
chr9_+_1313418 0.39 ENSDART00000191361
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr7_-_64971839 0.38 ENSDART00000164682
sinhcafl
SIN3-HDAC complex associated factor, like
chr8_-_29658171 0.37 ENSDART00000147755
mpeg1.3
macrophage expressed 1, tandem duplicate 3
chr1_-_8140763 0.37 ENSDART00000091508
FAM83G
si:dkeyp-9d4.4
chr1_-_17715493 0.36 ENSDART00000133027
si:dkey-256e7.8
si:dkey-256e7.8
chr17_+_24821627 0.35 ENSDART00000112389
wdr43
WD repeat domain 43
chr12_-_43685802 0.34 ENSDART00000170723
zgc:112964
zgc:112964
chr23_-_24263474 0.33 ENSDART00000160312
hspb7
heat shock protein family, member 7 (cardiovascular)
chr13_-_9236905 0.32 ENSDART00000142597
ENSDART00000147176
ENSDART00000181670
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-33c12.12
si:dkey-112g5.12
chr21_+_4348600 0.30 ENSDART00000138463
HTRA2 (1 of many)
si:dkey-84o3.2
chr21_+_4429001 0.29 ENSDART00000134520
HTRA2 (1 of many)
si:dkey-84o3.6
chr21_+_4410733 0.28 ENSDART00000136831
ENSDART00000131612
HTRA2 (1 of many)
si:dkey-84o3.7
chr4_+_6032640 0.28 ENSDART00000157487
tfec
transcription factor EC
chr20_+_36812368 0.28 ENSDART00000062931
abracl
ABRA C-terminal like
chr13_-_9070754 0.27 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
si:dkey-112g5.12
chr16_+_16849220 0.25 ENSDART00000047409
ENSDART00000142155
myh14
myosin, heavy chain 14, non-muscle
chr8_+_22472584 0.25 ENSDART00000138303
si:dkey-23c22.9
si:dkey-23c22.9
chr7_+_26173751 0.25 ENSDART00000065131
si:ch211-196f2.7
si:ch211-196f2.7
chr20_-_16972351 0.25 ENSDART00000148312
ENSDART00000186702
si:ch73-74h11.1
si:ch73-74h11.1
chr4_+_73215536 0.24 ENSDART00000174290
LO018260.2
Danio rerio protein NLRC3-like (LOC101883187), mRNA.
chr5_-_22052852 0.24 ENSDART00000002938
mtmr8
myotubularin related protein 8
chr5_-_3991655 0.24 ENSDART00000159368
myo19
myosin XIX
chr13_+_9468535 0.23 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
HTRA2 (1 of many)
si:dkey-265c15.6
chr7_+_24881680 0.23 ENSDART00000058843
krcp
kelch repeat-containing protein
chr2_+_10007113 0.23 ENSDART00000155213
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr7_+_34453185 0.22 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr2_+_19522082 0.22 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr6_+_6924637 0.21 ENSDART00000065551
ENSDART00000151393
zak
sterile alpha motif and leucine zipper containing kinase AZK
chr1_-_44812014 0.21 ENSDART00000139044
si:dkey-9i23.8
si:dkey-9i23.8
chr21_+_4368735 0.20 ENSDART00000182817
CT027677.1

chr9_-_50000144 0.20 ENSDART00000123416
scn1a
sodium channel, voltage-gated, type I, alpha
chr2_+_10006839 0.20 ENSDART00000160304
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr7_+_20384408 0.20 ENSDART00000173809
si:dkey-33c9.6
si:dkey-33c9.6
chr13_+_35955562 0.20 ENSDART00000137377
si:ch211-67f13.7
si:ch211-67f13.7
chr25_+_20272145 0.20 ENSDART00000109605
si:dkey-219c3.2
si:dkey-219c3.2
chr21_+_4328348 0.20 ENSDART00000131658
ENSDART00000143799
HTRA2 (1 of many)
si:dkey-84o3.7
chr12_+_3078221 0.19 ENSDART00000148835
ENSDART00000149427
sgca
sarcoglycan, alpha
chr19_-_3255725 0.19 ENSDART00000105165
illr1
immune-related, lectin-like receptor 1
chr6_+_31368071 0.19 ENSDART00000038990
jak1
Janus kinase 1
chr13_+_9496748 0.19 ENSDART00000147050
ENSDART00000102120
CR848040.4

chr13_-_9184132 0.18 ENSDART00000135289
ENSDART00000136309
ENSDART00000132630
HTRA2 (1 of many)
si:dkey-33c12.10
chr13_-_9111927 0.18 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-19p15.4
si:dkey-112g5.12
chr13_+_9521629 0.18 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
si:dkey-19p15.4
chr11_+_31864921 0.18 ENSDART00000180252
diaph3
diaphanous-related formin 3
chr2_-_52020049 0.18 ENSDART00000128198
ENSDART00000135331
scn12aa
sodium channel, voltage gated, type XII, alpha a
chr13_-_9257728 0.17 ENSDART00000145985
ENSDART00000169991
ENSDART00000132764
HTRA2 (1 of many)
zgc:173425
chr4_+_63790028 0.17 ENSDART00000160964
si:dkey-92j16.2
si:dkey-92j16.2
chr19_-_9662958 0.17 ENSDART00000041094
clcn1a
chloride channel, voltage-sensitive 1a
chr18_+_9171778 0.16 ENSDART00000101192
sema3d
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr21_+_6751760 0.16 ENSDART00000135914
olfm1b
olfactomedin 1b
chr21_+_16145980 0.16 ENSDART00000135119
qrfpr4
pyroglutamylated RFamide peptide receptor 4
chr9_-_21912227 0.16 ENSDART00000145576
lmo7a
LIM domain 7a
chr20_+_43925266 0.15 ENSDART00000037379
clic5b
chloride intracellular channel 5b
chr2_+_25315591 0.15 ENSDART00000161386
fndc3ba
fibronectin type III domain containing 3Ba
chr13_-_9159852 0.15 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
HTRA2 (1 of many)
si:dkey-112g5.16
chr25_-_27819838 0.14 ENSDART00000067106
lmod2a
leiomodin 2 (cardiac) a
chr13_-_6279684 0.14 ENSDART00000092105
agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr9_+_35015747 0.14 ENSDART00000140110
gabpa
GA binding protein transcription factor, alpha subunit
chr23_-_31913069 0.13 ENSDART00000135526
mtfr2
mitochondrial fission regulator 2
chr5_-_67629263 0.13 ENSDART00000133753
zbtb20
zinc finger and BTB domain containing 20
chr4_-_42408339 0.13 ENSDART00000172612
si:ch211-59d8.3
si:ch211-59d8.3
chr13_-_9045879 0.11 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
si:dkey-112g5.11
chr24_-_28245872 0.11 ENSDART00000167861
cox4i1l
cytochrome c oxidase subunit IV isoform 1, like
chr22_-_35330532 0.11 ENSDART00000172654
FO818743.1

chr1_-_50791280 0.10 ENSDART00000181224
CABZ01031870.1

chr2_+_19578079 0.10 ENSDART00000144413
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr2_+_6253246 0.09 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr17_-_53329704 0.09 ENSDART00000193895
exd1
exonuclease 3'-5' domain containing 1
chr13_-_9213207 0.09 ENSDART00000139861
ENSDART00000140524
HTRA2 (1 of many)
si:dkey-33c12.11
chr13_-_30142087 0.09 ENSDART00000110157
tysnd1
trypsin domain containing 1
chr19_-_10810006 0.08 ENSDART00000151157
si:dkey-3n22.9
si:dkey-3n22.9
chr7_+_20383841 0.08 ENSDART00000052906
si:dkey-33c9.6
si:dkey-33c9.6
chr6_+_24420523 0.08 ENSDART00000185461
tgfbr3
transforming growth factor, beta receptor III
chr16_+_4078240 0.08 ENSDART00000160890
inpp5b
inositol polyphosphate-5-phosphatase B
chr7_+_54642005 0.07 ENSDART00000171864
fgf19
fibroblast growth factor 19
chr2_-_55298075 0.07 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr21_+_6751405 0.07 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr2_+_35728033 0.06 ENSDART00000002094
ankrd45
ankyrin repeat domain 45
chr14_+_918287 0.06 ENSDART00000167066
CU462913.1

chr4_-_45115963 0.06 ENSDART00000137248
si:dkey-51d8.6
si:dkey-51d8.6
chr23_-_1348933 0.05 ENSDART00000168981
CABZ01078120.1

chr3_+_17537352 0.05 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr4_-_44611273 0.04 ENSDART00000156793
znf1115
zinc finger protein 1115
chr17_+_16429826 0.04 ENSDART00000136078
efcab11
EF-hand calcium binding domain 11
chr4_-_68868700 0.03 ENSDART00000187985
si:dkey-264f17.5
si:dkey-264f17.5
chr7_-_59123066 0.03 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr4_+_42419522 0.03 ENSDART00000135737
si:dkey-16p6.1
si:dkey-16p6.1
chr23_-_35064785 0.03 ENSDART00000172240
BX294434.1

chr1_+_55758257 0.02 ENSDART00000139312
tecrb
trans-2,3-enoyl-CoA reductase b
chr15_-_25518084 0.02 ENSDART00000158594
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr8_-_16697615 0.02 ENSDART00000187929
rpe65b
retinal pigment epithelium-specific protein 65b
chr18_+_28106139 0.01 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr6_+_4255319 0.00 ENSDART00000170351
nbeal1
neurobeachin-like 1
chr8_-_39822917 0.00 ENSDART00000067843
zgc:162025
zgc:162025
chr23_+_29358188 0.00 ENSDART00000189242
tardbpl
TAR DNA binding protein, like
chr21_-_26071773 0.00 ENSDART00000141382
rab34b
RAB34, member RAS oncogene family b

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2lb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0015682 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.1 0.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.4 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.0 0.4 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.2 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508)
0.0 0.4 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279) post-translational protein modification(GO:0043687)
0.0 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0071871 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.3 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.7 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.1 GO:0042755 eating behavior(GO:0042755)
0.0 0.2 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.2 GO:0086010 membrane depolarization during action potential(GO:0086010)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.4 GO:0046930 pore complex(GO:0046930)
0.0 0.6 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 0.5 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.4 GO:0015288 porin activity(GO:0015288)
0.1 0.4 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.9 GO:0043236 laminin binding(GO:0043236)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis