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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx2.1

Z-value: 0.79

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Transcription factors associated with nkx2.1

Gene Symbol Gene ID Gene Info
ENSDARG00000019835 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.1dr11_v1_chr17_+_38262408_38262408-0.434.7e-01Click!

Activity profile of nkx2.1 motif

Sorted Z-values of nkx2.1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_28674739 0.96 ENSDART00000067073
leucine rich repeat containing 10
chr5_+_51597677 0.81 ENSDART00000048210
ENSDART00000184797
creatine kinase, mitochondrial 2b (sarcomeric)
chr5_+_51594209 0.73 ENSDART00000164668
ENSDART00000058403
ENSDART00000055857
creatine kinase, mitochondrial 2b (sarcomeric)
chr17_+_20605013 0.59 ENSDART00000156878
si:ch73-288o11.5
chr4_-_67799941 0.50 ENSDART00000185830
si:ch211-66c13.1
chr25_+_25124684 0.50 ENSDART00000167542
lactate dehydrogenase A4
chr3_+_24207243 0.49 ENSDART00000023454
ENSDART00000136400
adenylosuccinate lyase
chr2_+_26237322 0.46 ENSDART00000030520
paralemmin 1b
chr7_+_48555400 0.46 ENSDART00000174474
potassium voltage-gated channel, KQT-like subfamily, member 1
chr7_+_48555626 0.43 ENSDART00000125483
ENSDART00000083514
potassium voltage-gated channel, KQT-like subfamily, member 1
chr6_-_39051319 0.35 ENSDART00000155093
tensin 2b
chr22_+_39096911 0.35 ENSDART00000157127
ENSDART00000153841
LIM and cysteine-rich domains 1
chrM_+_10590 0.33 ENSDART00000093615
NADH dehydrogenase 3, mitochondrial
chr23_-_33558161 0.33 ENSDART00000018301
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr2_+_26240339 0.27 ENSDART00000191006
paralemmin 1b
chr7_+_25053331 0.25 ENSDART00000173998
si:dkey-23i12.7
chr18_+_808911 0.25 ENSDART00000172518
cytochrome c oxidase subunit Vab
chr12_+_34953038 0.23 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
QKI, KH domain containing, RNA binding 2
chr1_+_55662491 0.21 ENSDART00000152386
adhesion G protein-coupled receptor E8
chr22_-_24248420 0.21 ENSDART00000165433
regulator of G protein signaling 2
chr7_+_34602991 0.20 ENSDART00000073447
formin homology 2 domain containing 1
chr3_-_31019715 0.18 ENSDART00000156687
ENSDART00000156127
ENSDART00000153945
si:dkeyp-71f10.5
chr8_-_36469117 0.18 ENSDART00000111240
major histocompatibility complex class II DAB gene
chr21_-_2348838 0.17 ENSDART00000160337
si:ch73-299h12.8
chr22_+_38762693 0.16 ENSDART00000015016
ENSDART00000150187
alkaline phosphatase, intestinal, tandem duplicate 1
chr13_-_36579086 0.15 ENSDART00000146671
lectin, galactoside binding soluble 3a
chr12_-_30583668 0.15 ENSDART00000153406
caspase 7, apoptosis-related cysteine peptidase
chr2_-_8609653 0.14 ENSDART00000193354
ENSDART00000189489
ENSDART00000186144
si:ch211-71m22.1
chr11_-_24063196 0.13 ENSDART00000036513
tribbles pseudokinase 3
chr4_-_20314749 0.13 ENSDART00000066894
ENSDART00000188123
decapping mRNA 1B
chr3_+_17933132 0.12 ENSDART00000104299
ENSDART00000162144
ENSDART00000162242
ENSDART00000166289
ENSDART00000171101
ENSDART00000164853
2',3'-cyclic nucleotide 3' phosphodiesterase
chr4_-_14531687 0.12 ENSDART00000182093
ENSDART00000159447
plexin b2a
chr11_-_36040549 0.11 ENSDART00000112684
SET domain and mariner transposase fusion gene
chr7_-_30639385 0.11 ENSDART00000173618
myosin IE, a
chr5_-_35456269 0.11 ENSDART00000051312
tetratricopeptide repeat domain 33
chr6_+_38880166 0.11 ENSDART00000019939
ENSDART00000144286
bridging integrator 2b
chr11_+_43403525 0.10 ENSDART00000180683
vasoactive intestinal peptide b
chr15_-_434503 0.10 ENSDART00000122286

chr3_-_8510201 0.09 ENSDART00000009151

chr10_-_16062565 0.08 ENSDART00000188728
si:dkey-184a18.5
chr2_-_59345920 0.08 ENSDART00000134662
finTRIM family, member 37
chr1_+_46026457 0.08 ENSDART00000132705
si:ch211-138g9.2
chr22_-_5724085 0.08 ENSDART00000110526
ENSDART00000140905
piggyBac transposable element derived 4
chr13_+_27040887 0.08 ENSDART00000132714
heme-binding protein soul2
chr1_+_27977297 0.07 ENSDART00000180692
ENSDART00000166819
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr25_+_19485198 0.06 ENSDART00000156730
glutaminase like
chr1_-_59571758 0.06 ENSDART00000193546
ENSDART00000167087
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr6_-_46875310 0.06 ENSDART00000154442
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr9_+_7724152 0.06 ENSDART00000061716
motor neuron and pancreas homeobox 2a
chr6_+_38879961 0.06 ENSDART00000184798
bridging integrator 2b
chr7_+_48675347 0.06 ENSDART00000157917
ENSDART00000185580
transient receptor potential cation channel, subfamily M, member 5
chr4_+_76748500 0.05 ENSDART00000075607
membrane-spanning 4-domains, subfamily A, member 17A.10
chr18_-_39321484 0.05 ENSDART00000077694
LEO1 homolog, Paf1/RNA polymerase II complex component
chr11_-_8271374 0.05 ENSDART00000168253
Pim proto-oncogene, serine/threonine kinase, related 202
chr21_+_34088377 0.05 ENSDART00000170070
myotubularin related protein 1b
chr7_-_48733662 0.05 ENSDART00000191675
TNF receptor-associated factor 6
chr15_-_23482088 0.04 ENSDART00000185823
ENSDART00000185523
NLR family member X1
chr1_-_43862638 0.04 ENSDART00000145044
tachykinin receptor 3a
chr1_-_58000438 0.04 ENSDART00000163761
si:ch211-114l13.9
chr16_+_5539189 0.04 ENSDART00000178106

chr17_+_23975762 0.03 ENSDART00000155941
exportin 1 (CRM1 homolog, yeast) b
chr11_+_12879635 0.03 ENSDART00000182515
ENSDART00000081296
si:dkey-11m19.5
chr4_-_50926767 0.03 ENSDART00000183430
si:ch211-208f21.3
chr11_+_583725 0.03 ENSDART00000189415
MKRN2 opposite strand, tandem duplicate 2
chr1_-_23294753 0.03 ENSDART00000013263
UDP-glucose 6-dehydrogenase
chr3_+_22335030 0.03 ENSDART00000055676
zgc:103564
chr8_-_44298964 0.03 ENSDART00000098520
frizzled class receptor 10
chr15_-_4053149 0.03 ENSDART00000189076

chr12_+_20506197 0.02 ENSDART00000153010
si:zfos-754c12.2
chr4_-_2052687 0.02 ENSDART00000138291
ENSDART00000150844
cleavage and polyadenylation specific factor 6
chr1_+_55583116 0.02 ENSDART00000152163
adhesion G protein-coupled receptor E19
chr9_-_7089303 0.02 ENSDART00000146609
cytochrome C oxidase assembly factor 5
chr14_-_33478963 0.02 ENSDART00000132813
lysosomal-associated membrane protein 2
chr7_-_59123066 0.02 ENSDART00000175438
DENN/MADD domain containing 4C
chr7_+_42461850 0.02 ENSDART00000190350
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr21_-_2162850 0.02 ENSDART00000159731
expressed sequence AI877918
chr20_+_46255057 0.02 ENSDART00000100536
trace amine associated receptor 14i
chr12_+_30788912 0.02 ENSDART00000160422
aldehyde dehydrogenase 18 family, member A1
chr6_+_18531932 0.01 ENSDART00000165271
SUZ12 polycomb repressive complex 2b subunit
chr7_-_3895071 0.01 ENSDART00000175200
si:dkey-88n24.11
chr20_+_9128829 0.01 ENSDART00000064144
ENSDART00000137450
bisphosphate nucleotidase 1
chr7_+_25825667 0.01 ENSDART00000149835
myotubularin 1
chr11_-_1956204 0.01 ENSDART00000185541
nuclear receptor subfamily 1, group D, member 4b
chr18_-_22701800 0.00 ENSDART00000135098
si:ch73-113g13.3
chr2_-_52020049 0.00 ENSDART00000128198
ENSDART00000135331
sodium channel, voltage gated, type XII, alpha a
chr3_-_7464250 0.00 ENSDART00000159873
zinc finger protein 1001
chr14_-_16476863 0.00 ENSDART00000089021
calnexin
chr17_+_24597001 0.00 ENSDART00000191834
rearranged L-myc fusion

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 1.0 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 0.3 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 0.2 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.2 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.2 GO:0071800 podosome assembly(GO:0071800)
0.0 0.1 GO:0048241 copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 1.5 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1