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PRJNA207719: Tissue specific transcriptome profiling

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Results for pax10+pax6a+pax6b

Z-value: 0.85

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Transcription factors associated with pax10+pax6a+pax6b

Gene Symbol Gene ID Gene Info
ENSDARG00000045936 paired box 6b
ENSDARG00000053364 paired box 10
ENSDARG00000103379 paired box 6a
ENSDARG00000111379 paired box 10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax10dr11_v1_chr3_+_32546499_32546499-0.866.1e-02Click!
pax6bdr11_v1_chr7_+_15872357_15872357-0.829.1e-02Click!
pax6adr11_v1_chr25_-_15040369_15040442-0.761.3e-01Click!

Activity profile of pax10+pax6a+pax6b motif

Sorted Z-values of pax10+pax6a+pax6b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_+_38306010 0.79 ENSDART00000143184
myosin binding protein C, fast type b
chr7_+_38750871 0.75 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
coagulation factor II (thrombin)
chr10_-_8053385 0.64 ENSDART00000142714
si:ch211-251f6.7
chr10_-_8046764 0.60 ENSDART00000099031
zgc:136254
chr21_-_25756119 0.59 ENSDART00000002341
claudin c
chr9_-_32847642 0.56 ENSDART00000121506
hemopexin
chr18_+_62932 0.53 ENSDART00000052638
solute carrier family 27 (fatty acid transporter), member 2a
chr2_+_11031360 0.47 ENSDART00000180020
ENSDART00000145093
acyl-CoA thioesterase 11a
chr25_+_22320738 0.45 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr10_-_8053753 0.44 ENSDART00000162289
si:ch211-251f6.7
chr13_-_20381485 0.43 ENSDART00000131351
si:ch211-270n8.1
chr14_-_1454045 0.41 ENSDART00000161460
phosphoethanolamine methyltransferase
chr23_+_44611864 0.40 ENSDART00000145905
ENSDART00000132361
enolase 3, (beta, muscle)
chr23_+_44614056 0.36 ENSDART00000188379
enolase 3, (beta, muscle)
chr11_+_11175814 0.35 ENSDART00000183864

chr7_-_20582842 0.35 ENSDART00000169750
ENSDART00000111719
si:dkey-19b23.11
chr12_+_4900981 0.35 ENSDART00000171507
CD79b molecule, immunoglobulin-associated beta
chr8_-_8489685 0.32 ENSDART00000131849
ENSDART00000064113
activator of basal transcription 1
chr23_+_17926279 0.32 ENSDART00000012540
chitinase, acidic.4
chr21_-_2322102 0.31 ENSDART00000162867
zgc:66483
chr6_+_23887314 0.31 ENSDART00000163188
zinc finger protein 648
chr8_+_52442622 0.30 ENSDART00000012758
zgc:77112
chr8_-_8489886 0.30 ENSDART00000183334
activator of basal transcription 1
chr25_-_31423493 0.30 ENSDART00000027661
myogenic differentiation 1
chr25_-_27842654 0.30 ENSDART00000154852
ENSDART00000156906
ankyrin repeat and SOCS box containing 15a
chr21_+_27382893 0.29 ENSDART00000005682
actinin alpha 3a
chr1_-_54706039 0.29 ENSDART00000083633
exosome component 1
chr25_-_4148719 0.29 ENSDART00000112880
ENSDART00000023278
fatty acid desaturase 2
chr5_+_57924611 0.27 ENSDART00000050949
B-cell translocation gene 4
chr13_-_10945288 0.27 ENSDART00000114315
ENSDART00000164667
ENSDART00000159482
ATP-binding cassette, sub-family G (WHITE), member 8
chr15_-_12270857 0.26 ENSDART00000170093
si:dkey-36i7.3
chr2_+_6255434 0.26 ENSDART00000139429
zona pellucida glycoprotein 3b
chr7_+_59649746 0.26 ENSDART00000181067
ribosomal protein L34
chr3_+_43086548 0.25 ENSDART00000163579
si:dkey-43p13.5
chr19_+_30990815 0.25 ENSDART00000134645
syncoilin, intermediate filament protein
chr9_+_8365398 0.24 ENSDART00000138713
ENSDART00000136847
si:dkey-90l23.2
chr20_+_2281933 0.24 ENSDART00000137579
si:ch73-18b11.2
chr22_-_5006801 0.24 ENSDART00000106166
retinal homeobox gene 1
chr19_-_15192840 0.24 ENSDART00000151337
phosphatase and actin regulator 4a
chr19_-_11238620 0.24 ENSDART00000148697
ENSDART00000149169
signal sequence receptor, beta
chr4_-_5370468 0.23 ENSDART00000133423
ENSDART00000184963
si:dkey-14d8.1
chr9_-_1970071 0.23 ENSDART00000080608
homeobox D10a
chr2_+_21000334 0.23 ENSDART00000062563
ENSDART00000147809
ras responsive element binding protein 1b
chr16_-_13992646 0.22 ENSDART00000139623
si:dkey-85k15.6
chr15_-_1745408 0.22 ENSDART00000182311
syntaxin 1A (brain)
chr14_-_858985 0.22 ENSDART00000148687
ENSDART00000149375
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr17_+_8799661 0.21 ENSDART00000105326
tonsoku-like, DNA repair protein
chr13_-_22862133 0.21 ENSDART00000138563
phenazine biosynthesis-like protein domain containing 2
chr18_+_45781115 0.21 ENSDART00000151699
ENSDART00000179887
ribosomal protein L35a
chr8_+_37111643 0.21 ENSDART00000061336
renin
chr18_+_45781516 0.21 ENSDART00000168840
ribosomal protein L35a
chr11_+_24298432 0.21 ENSDART00000138487
si:dkey-76p14.2
chr9_+_23003208 0.21 ENSDART00000021060
ELL associated factor 2
chr16_+_13993285 0.21 ENSDART00000139130
ENSDART00000130353
si:dkey-85k15.7
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
chr10_-_17501528 0.21 ENSDART00000144847
solute carrier family 2 (facilitated glucose transporter), member 11-like
chr13_+_10945337 0.20 ENSDART00000091845
ATP-binding cassette, sub-family G (WHITE), member 5
chr6_-_58757131 0.20 ENSDART00000083582
sterol O-acyltransferase 2
chr7_+_59649399 0.20 ENSDART00000123520
ENSDART00000040771
ribosomal protein L34
chr25_-_28926631 0.20 ENSDART00000112850
electron transfer flavoprotein beta subunit lysine methyltransferase
chr20_-_25486384 0.20 ENSDART00000141340
si:dkey-183n20.15
chr9_+_47966167 0.20 ENSDART00000183345
G protein-coupled bile acid receptor 1
chr16_+_11779761 0.20 ENSDART00000140297
si:dkey-250k15.4
chr25_-_37284370 0.20 ENSDART00000103222
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr8_+_41037541 0.20 ENSDART00000129344
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr12_+_25845494 0.20 ENSDART00000170582
glutamate dehydrogenase 1b
chr12_-_35949936 0.20 ENSDART00000192583

chr15_-_14625373 0.20 ENSDART00000171841
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr15_+_9121054 0.19 ENSDART00000193889
prostaglandin I2 receptor
chr5_-_57361594 0.19 ENSDART00000112793
cell division cycle 26 homolog
chr1_+_55239160 0.19 ENSDART00000152318
si:ch211-286b5.2
chr17_-_12196865 0.19 ENSDART00000154694
kinesin family member 28
chr19_-_4793263 0.18 ENSDART00000147510
ENSDART00000141336
ENSDART00000110551
ENSDART00000146684
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr18_-_14901437 0.18 ENSDART00000145842
ENSDART00000008035
TraB domain containing
chr18_-_27897217 0.18 ENSDART00000175259
IQ motif containing G
chr13_-_39160018 0.18 ENSDART00000168795
collagen, type IX, alpha 1b
chr17_+_8799451 0.18 ENSDART00000189814
ENSDART00000191577
tonsoku-like, DNA repair protein
chr23_-_19230627 0.18 ENSDART00000007122
guanylate cyclase activator 1B
chr24_-_38197040 0.17 ENSDART00000137949
ENSDART00000105639
immunoglobulin light iota constant 1, s1
chr5_+_22393501 0.17 ENSDART00000185276
si:dkey-27p18.7
chr23_+_43177290 0.17 ENSDART00000193300
ENSDART00000186065
si:dkey-65j6.2
chr8_+_41038141 0.17 ENSDART00000075620
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr13_-_39159810 0.17 ENSDART00000131508
collagen, type IX, alpha 1b
chr16_-_11766265 0.17 ENSDART00000141547
zgc:158701
chr13_+_12671513 0.17 ENSDART00000010517
eukaryotic translation initiation factor 4eb
chr7_-_41512999 0.17 ENSDART00000173577
si:dkey-10f23.2
chr3_-_49110710 0.17 ENSDART00000160404
tripartite motif containing 35-12
chr4_+_5341592 0.17 ENSDART00000123375
ENSDART00000067371
zgc:113263
chr22_-_3182965 0.17 ENSDART00000158009
lon peptidase 1, mitochondrial
chr18_-_15269272 0.17 ENSDART00000048206
transmembrane protein 263
chr16_+_11779534 0.17 ENSDART00000133497
si:dkey-250k15.4
chr7_+_3357973 0.17 ENSDART00000172853
si:ch211-285c6.5
chr10_-_22497980 0.16 ENSDART00000185549

chr24_+_39186940 0.16 ENSDART00000155817
splA/ryanodine receptor domain and SOCS box containing 3b
chr22_+_9126557 0.16 ENSDART00000190669
si:ch211-156p11.1
chr2_-_32768951 0.16 ENSDART00000004712
beaded filament structural protein 2, phakinin
chr4_+_68939074 0.16 ENSDART00000180232
si:dkey-264f17.2
chr14_-_14659023 0.16 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr25_+_23280220 0.16 ENSDART00000153940
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr10_+_25726694 0.16 ENSDART00000140308
UDP glucuronosyltransferase 5 family, polypeptide D1
chr9_+_40546677 0.16 ENSDART00000132911
von Willebrand factor C domain containing protein 2-like
chr22_+_9429710 0.16 ENSDART00000184089
si:ch211-11p18.6
chr4_+_18804317 0.16 ENSDART00000101043
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr10_-_36254445 0.16 ENSDART00000123571
odorant receptor, family D, subfamily 110, member 2
chr14_+_6423973 0.16 ENSDART00000051556
ATP-binding cassette, sub-family A (ABC1), member 1B
chr25_-_10543682 0.16 ENSDART00000154262
testis expressed metallothionein like protein
chr4_-_18850799 0.16 ENSDART00000151844
malonyl CoA:ACP acyltransferase (mitochondrial)
chr20_+_19119800 0.15 ENSDART00000151881
retinitis pigmentosa 1-like 1b
chr9_-_42873700 0.15 ENSDART00000125953
titin, tandem duplicate 1
chr24_+_37709191 0.15 ENSDART00000066558
2,4-dienoyl CoA reductase 2, peroxisomal
chr23_+_25292147 0.15 ENSDART00000131486
proliferation-associated 2G4, b
chr14_+_20893065 0.15 ENSDART00000079452
lysozyme g-like 1
chr4_+_56477160 0.15 ENSDART00000184152
si:ch211-237a4.2
chr18_+_14277003 0.15 ENSDART00000006628
zgc:173742
chr9_-_2936017 0.15 ENSDART00000102823
sterile alpha motif and leucine zipper containing kinase AZK
chr15_-_41503392 0.15 ENSDART00000169351
si:dkey-230i18.2
chr14_-_12390724 0.15 ENSDART00000131343
magnesium transporter 1
chr21_-_1644414 0.15 ENSDART00000105736
ENSDART00000124904
zgc:152948
chr19_-_20163197 0.15 ENSDART00000148179
ENSDART00000151646
family with sequence similarity 221, member A
chr4_-_17741513 0.15 ENSDART00000141680
myosin binding protein C, slow type
chr7_+_6879534 0.15 ENSDART00000157731
zgc:175248
chr5_-_55914268 0.15 ENSDART00000014049
WD repeat domain 36
chr24_+_28561038 0.15 ENSDART00000147063
ATP-binding cassette, sub-family A (ABC1), member 4a
chr13_-_50200042 0.14 ENSDART00000074230
protein kinase containing Z-DNA binding domains
chr13_-_25196758 0.14 ENSDART00000184722
adenosine kinase a
chr17_-_27266053 0.14 ENSDART00000110903
si:ch211-160f23.5
chr21_+_23108420 0.14 ENSDART00000192394
ENSDART00000088459
5-hydroxytryptamine (serotonin) receptor 3B
chr3_-_23513155 0.14 ENSDART00000170200

chr25_+_30105628 0.14 ENSDART00000187704
si:ch211-147k10.5
chr1_+_51721851 0.14 ENSDART00000040397
peroxiredoxin 2
chr20_-_33959815 0.14 ENSDART00000133081
selectin P
chr10_-_31015535 0.14 ENSDART00000146116
pannexin 3
chr24_-_2381143 0.14 ENSDART00000144307
ras responsive element binding protein 1a
chr13_+_25412674 0.14 ENSDART00000113410
calcium homeostasis modulator 1
chr4_+_40383229 0.13 ENSDART00000126906
ENSDART00000191198
si:ch211-218h8.1
chr24_-_26479841 0.13 ENSDART00000079984
ribosomal protein L22-like 1
chr14_+_30762131 0.13 ENSDART00000145039
si:ch211-145o7.3
chr18_-_24988645 0.13 ENSDART00000136434
ENSDART00000085735
chromodomain helicase DNA binding protein 2
chr2_+_21048661 0.13 ENSDART00000156876
ras responsive element binding protein 1b
chr15_-_41390410 0.13 ENSDART00000136164
si:dkey-121n8.7
chr10_+_18557102 0.13 ENSDART00000160157

chr2_+_6991208 0.13 ENSDART00000182239
discoidin domain receptor tyrosine kinase 2b
chr22_+_8365905 0.13 ENSDART00000105945
si:dkey-19a16.11
chr16_-_21888047 0.13 ENSDART00000162282
ENSDART00000124099
diverse immunoglobulin domain-containing protein 3.3
chr10_-_25823258 0.13 ENSDART00000064327
finTRIM family, member 54
chr24_-_36727922 0.13 ENSDART00000135142
si:ch73-334d15.1
chr20_-_3238110 0.13 ENSDART00000008077
serine peptidase inhibitor, Kunitz type 1 b
chr23_+_25291891 0.13 ENSDART00000016248
proliferation-associated 2G4, b
chr2_-_22569488 0.13 ENSDART00000158608

chr12_-_44072716 0.12 ENSDART00000162509
si:ch73-329n5.3
chr21_+_21713531 0.12 ENSDART00000140501
odorant receptor, family E, subfamily 123, member 1
chr5_+_23242370 0.12 ENSDART00000051532
angiotensin II receptor, type 2
chr20_+_51833030 0.12 ENSDART00000074330
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A
chr4_-_38519671 0.12 ENSDART00000183414
ENSDART00000187075
si:ch211-209n20.3
chr11_-_11336986 0.12 ENSDART00000016677
zgc:77929
chr1_+_55239710 0.12 ENSDART00000174846
si:ch211-286b5.2
chr25_+_13620555 0.12 ENSDART00000163642
si:ch211-172l8.4
chr4_-_71551644 0.12 ENSDART00000168064
si:dkey-27n6.1
chr25_-_14637660 0.12 ENSDART00000143666
neuron navigator 2b
chr2_+_38731696 0.12 ENSDART00000181733

chr4_+_33871518 0.12 ENSDART00000185054
si:dkey-28i19.3
chr21_-_3700334 0.12 ENSDART00000137844
ATPase phospholipid transporting 8B1
chr8_+_52415603 0.12 ENSDART00000021604
ENSDART00000191424
GINS complex subunit 4 (Sld5 homolog)
chr3_-_33961589 0.12 ENSDART00000151533
immunoglobulin heavy constant delta
chr13_+_25455319 0.12 ENSDART00000145948
polycystic kidney disease 2-like 1
chr9_-_53666031 0.12 ENSDART00000126314
protocadherin 8
chr21_-_37194839 0.12 ENSDART00000175126
fibroblast growth factor receptor 4
chr2_+_17569644 0.12 ENSDART00000135823
Pim proto-oncogene, serine/threonine kinase, related 196
chr24_+_38208823 0.11 ENSDART00000187538
ENSDART00000190189

chr18_-_16792561 0.11 ENSDART00000145546
adenosine monophosphate deaminase 3b
chr5_+_38619813 0.11 ENSDART00000133314
si:ch211-271e10.3
chr7_+_48555400 0.11 ENSDART00000174474
potassium voltage-gated channel, KQT-like subfamily, member 1
chr3_-_50139860 0.11 ENSDART00000101563
bloodthirsty-related gene family, member 2
chr23_+_44049509 0.11 ENSDART00000102003
TXK tyrosine kinase
chr6_-_8399486 0.11 ENSDART00000189496
prostaglandin E receptor 1a (subtype EP1)
chr5_-_4204580 0.11 ENSDART00000049197
ENSDART00000132130
si:ch211-283g2.1
chr12_-_4424424 0.11 ENSDART00000152314
si:ch211-173d10.1
chr1_+_15204633 0.11 ENSDART00000188410
intelectin 1
chr25_+_11008419 0.11 ENSDART00000156589
major histocompatibility complex class I LIA
chr21_-_43992027 0.11 ENSDART00000188612
caudal type homeobox 1 b
chr22_+_9091913 0.11 ENSDART00000186598

chr24_-_6671549 0.11 ENSDART00000114700
un-named sa821
chr9_-_5337515 0.11 ENSDART00000192701
TNF superfamily member 13b
chr6_+_54187643 0.11 ENSDART00000056830
protein kinase C and casein kinase substrate in neurons 1b
chr15_+_37972671 0.11 ENSDART00000166764
si:dkey-238d18.9
chr25_+_37285737 0.11 ENSDART00000126879
transmembrane p24 trafficking protein 6
chr22_+_22438783 0.11 ENSDART00000147825
kinesin family member 14
chr22_+_9917007 0.10 ENSDART00000063318
bloody fingers
chr10_+_8688678 0.10 ENSDART00000147568
si:dkey-27b3.4
chr12_-_4408828 0.10 ENSDART00000152447
si:ch211-173d10.1
chr1_-_2075529 0.10 ENSDART00000109983
oxoglutarate (alpha-ketoglutarate) receptor 1a, tandem duplicate 2
chr23_+_36052944 0.10 ENSDART00000103149
homeobox C13a
chr7_+_26545911 0.10 ENSDART00000135313
tyrosine kinase, non-receptor, 1
chr3_-_25118777 0.10 ENSDART00000188222
chondroadherin-like a
chr3_-_4303262 0.10 ENSDART00000112819
si:dkey-73p2.2
chr2_-_22575851 0.10 ENSDART00000182932

chr7_+_4620586 0.10 ENSDART00000108797
zgc:162060
chr16_-_47465777 0.10 ENSDART00000190202
ENSDART00000181240
collagen triple helix repeat containing 1b
chr13_-_46882267 0.10 ENSDART00000161322
solute carrier family 29 (equilibrative nucleoside transporter), member 1a
chr18_+_45542981 0.10 ENSDART00000140357
kinesin family member C3
chr14_+_36454087 0.10 ENSDART00000180247
si:dkey-237h12.3

Network of associatons between targets according to the STRING database.

First level regulatory network of pax10+pax6a+pax6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.1 0.8 GO:0006953 acute-phase response(GO:0006953) positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.1 0.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.8 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.5 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.1 0.3 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.1 0.2 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.1 0.4 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0046099 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.0 0.2 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0009109 coenzyme catabolic process(GO:0009109)
0.0 0.2 GO:0033700 phospholipid efflux(GO:0033700)
0.0 0.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.3 GO:0006032 chitin catabolic process(GO:0006032)
0.0 0.2 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.0 0.2 GO:0048660 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 0.1 GO:0030890 B cell homeostasis(GO:0001782) positive regulation of B cell proliferation(GO:0030890)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.1 GO:0060879 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.0 0.1 GO:0044209 AMP salvage(GO:0044209)
0.0 0.1 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.0 0.2 GO:0034433 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.0 0.1 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.0 0.1 GO:0010359 regulation of anion channel activity(GO:0010359)
0.0 0.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.4 GO:0031297 replication fork processing(GO:0031297)
0.0 0.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.5 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.4 GO:0016233 telomere capping(GO:0016233)
0.0 0.3 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.0 GO:0006500 N-terminal protein palmitoylation(GO:0006500) regulation of lipoprotein metabolic process(GO:0050746) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) regulation of protein lipidation(GO:1903059) negative regulation of protein lipidation(GO:1903060)
0.0 0.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.1 GO:0000303 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.3 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0 0.1 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.1 GO:0032261 purine nucleotide salvage(GO:0032261)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.3 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.4 GO:0070187 telosome(GO:0070187)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.1 0.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.2 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 1.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.2 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.4 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.3 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.1 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.0 0.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.0 0.3 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0004001 adenosine kinase activity(GO:0004001)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.3 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048) cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:2001069 glycogen binding(GO:2001069)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.0 GO:0004061 arylformamidase activity(GO:0004061)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.2 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation