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PRJNA207719: Tissue specific transcriptome profiling

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Results for phox2a

Z-value: 0.56

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Transcription factors associated with phox2a

Gene Symbol Gene ID Gene Info
phox2a
ENSDARG00000007406 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phox2adr11_v1_chr15_+_47440477_474404770.791.2e-01Click!

Activity profile of phox2a motif

Sorted Z-values of phox2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_21129752 0.75 ENSDART00000169764
syt1a
synaptotagmin Ia
chr8_+_16025554 0.73 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr2_+_50608099 0.60 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr10_-_22918214 0.58 ENSDART00000163908
rnasekb
ribonuclease, RNase K b
chr20_+_41756996 0.55 ENSDART00000186393
fam184a
family with sequence similarity 184, member A
chr9_-_43538328 0.52 ENSDART00000140526
znf385b
zinc finger protein 385B
chr20_-_29864390 0.48 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr21_-_42100471 0.41 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr11_-_42554290 0.39 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr17_+_15433518 0.34 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_-_200316 0.34 ENSDART00000190561
CABZ01083778.1

chr17_+_15433671 0.33 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr4_-_1801519 0.32 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr16_-_25568512 0.31 ENSDART00000149411
atxn1b
ataxin 1b
chr5_+_4054704 0.28 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr3_-_20040636 0.28 ENSDART00000104118
atxn7l3
ataxin 7-like 3
chr10_+_42423318 0.24 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr21_-_13123176 0.24 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr21_+_32820175 0.23 ENSDART00000076903
adra2db
adrenergic, alpha-2D-, receptor b
chr12_-_33357655 0.21 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr19_+_5480327 0.21 ENSDART00000148794
jupb
junction plakoglobin b
chr18_+_34362608 0.18 ENSDART00000131478
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr1_-_44704261 0.17 ENSDART00000133210
si:dkey-28b4.8
si:dkey-28b4.8
chr20_-_28642061 0.16 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr6_-_35779348 0.15 ENSDART00000191159
brinp3a.1
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 1
chr9_-_32177117 0.14 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr2_+_2223837 0.14 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr24_+_28953089 0.14 ENSDART00000153761
rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr7_-_30174882 0.12 ENSDART00000110409
frmd5
FERM domain containing 5
chr15_-_43284021 0.11 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr1_-_19502322 0.10 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr5_+_19933356 0.10 ENSDART00000088819
ankrd13a
ankyrin repeat domain 13A
chr1_-_15797663 0.09 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr15_-_14552101 0.09 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr13_+_31211050 0.09 ENSDART00000111705
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr5_+_60590796 0.08 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr10_-_11261565 0.07 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr15_-_22074315 0.07 ENSDART00000149830
drd2a
dopamine receptor D2a
chr5_+_37903790 0.05 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr2_-_9818640 0.05 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr3_-_56541723 0.04 ENSDART00000156398
ENSDART00000050576
ENSDART00000184874
si:ch211-189a21.1
cyth1a
si:ch211-189a21.1
cytohesin 1a
chr19_+_2631565 0.03 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr6_+_13117598 0.03 ENSDART00000104744
casp8l1
caspase 8, apoptosis-related cysteine peptidase, like 1
chr16_+_28994709 0.03 ENSDART00000088023
gon4l
gon-4-like (C. elegans)
chr6_+_24420523 0.03 ENSDART00000185461
tgfbr3
transforming growth factor, beta receptor III
chr12_+_26877381 0.02 ENSDART00000087329
znf438
zinc finger protein 438
chr18_+_28106139 0.01 ENSDART00000089615
kiaa1549lb
KIAA1549-like b

Network of associatons between targets according to the STRING database.

First level regulatory network of phox2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.3 GO:1901908 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.2 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.2 GO:1901380 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.0 0.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.4 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.7 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.4 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters