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PRJNA207719: Tissue specific transcriptome profiling

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Results for prdm14

Z-value: 0.97

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Transcription factors associated with prdm14

Gene Symbol Gene ID Gene Info
prdm14
ENSDARG00000045371 PR domain containing 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prdm14dr11_v1_chr24_+_14451404_144514040.894.1e-02Click!

Activity profile of prdm14 motif

Sorted Z-values of prdm14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_30642819 1.29 ENSDART00000078154
npas4a
neuronal PAS domain protein 4a
chr21_-_43949208 1.28 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr20_+_27020201 1.24 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr4_-_22207873 1.12 ENSDART00000142140
ppfia2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr5_+_49744713 0.97 ENSDART00000133384
nr2f1a
nuclear receptor subfamily 2, group F, member 1a
chr11_-_23080970 0.92 ENSDART00000127791
atp2b2
ATPase plasma membrane Ca2+ transporting 2
chr25_-_8030113 0.83 ENSDART00000104674
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr21_-_21089781 0.78 ENSDART00000144361
ank1b
ankyrin 1, erythrocytic b
chr21_+_44300689 0.74 ENSDART00000186298
ENSDART00000142810
gabra3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr25_-_8030425 0.73 ENSDART00000014964
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr12_+_39685485 0.73 ENSDART00000163403
LO017650.1

chr7_+_13418812 0.70 ENSDART00000191905
ENSDART00000091567
dagla
diacylglycerol lipase, alpha
chr3_-_2593859 0.68 ENSDART00000143826
si:dkey-217f16.5
si:dkey-217f16.5
chr22_-_11137268 0.65 ENSDART00000178882
atp6ap2
ATPase H+ transporting accessory protein 2
chr5_-_45877387 0.64 ENSDART00000183714
ENSDART00000041503
slc4a4a
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr1_+_41849152 0.61 ENSDART00000053685
smox
spermine oxidase
chr25_-_1235457 0.61 ENSDART00000093093
coro2bb
coronin, actin binding protein, 2Bb
chr22_-_11136625 0.59 ENSDART00000016873
ENSDART00000125561
atp6ap2
ATPase H+ transporting accessory protein 2
chr12_-_6818676 0.57 ENSDART00000106391
pcdh15b
protocadherin-related 15b
chr22_-_26323893 0.56 ENSDART00000105099
capn1b
calpain 1, (mu/I) large subunit b
chr23_+_39558508 0.46 ENSDART00000017902
camk1gb
calcium/calmodulin-dependent protein kinase IGb
chr22_+_39074688 0.44 ENSDART00000153547
ip6k1
inositol hexakisphosphate kinase 1
chr25_+_16043246 0.44 ENSDART00000186663
sb:cb470
sb:cb470
chr7_+_48806420 0.44 ENSDART00000083431
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr11_-_18791834 0.42 ENSDART00000156431
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr1_+_46509176 0.41 ENSDART00000166028
mcf2la
mcf.2 cell line derived transforming sequence-like a
chr5_-_69482891 0.41 ENSDART00000109487
CABZ01032476.1

chr7_+_48805534 0.41 ENSDART00000145375
ENSDART00000148744
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr22_-_20342260 0.40 ENSDART00000161610
ENSDART00000165667
tcf3b
transcription factor 3b
chr7_+_48805725 0.39 ENSDART00000166543
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr15_-_42760110 0.39 ENSDART00000152490
si:ch211-181d7.3
si:ch211-181d7.3
chr8_+_35172594 0.37 ENSDART00000177146
BX897670.1

chr5_+_26079178 0.36 ENSDART00000145920
si:dkey-201c13.2
si:dkey-201c13.2
chr9_+_33261330 0.36 ENSDART00000135384
usp9
ubiquitin specific peptidase 9
chr10_-_32877348 0.32 ENSDART00000018977
ENSDART00000133421
rabgef1
RAB guanine nucleotide exchange factor (GEF) 1
chr16_-_26255877 0.32 ENSDART00000146214
erfl1
Ets2 repressor factor like 1
chr5_-_67115872 0.31 ENSDART00000065262
rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr20_-_46467280 0.30 ENSDART00000060702
rmdn3
regulator of microtubule dynamics 3
chr9_-_33477588 0.27 ENSDART00000144150
caska
calcium/calmodulin-dependent serine protein kinase a
chr6_+_518979 0.25 ENSDART00000151012
CACNA1I (1 of many)
si:ch73-379f7.5
chr20_+_22220988 0.25 ENSDART00000049204
kdr
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr21_-_14692119 0.25 ENSDART00000123047
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr24_+_26402110 0.25 ENSDART00000133684
si:ch211-230g15.5
si:ch211-230g15.5
chr23_+_21261313 0.23 ENSDART00000104268
ENSDART00000159046
emc1
ER membrane protein complex subunit 1
chr16_-_24135508 0.22 ENSDART00000171819
ENSDART00000103176
bcam
basal cell adhesion molecule (Lutheran blood group)
chr5_+_37903790 0.22 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr23_+_9522781 0.22 ENSDART00000136486
osbpl2b
oxysterol binding protein-like 2b
chr6_-_21988375 0.21 ENSDART00000161257
plxnb1b
plexin b1b
chr13_+_4871886 0.20 ENSDART00000132301
micu1
mitochondrial calcium uptake 1
chr13_+_23157053 0.18 ENSDART00000162359
sorbs1
sorbin and SH3 domain containing 1
chr10_-_33343244 0.18 ENSDART00000164191
c2cd2
C2 calcium-dependent domain containing 2
chr2_-_36819624 0.16 ENSDART00000140844
slitrk3b
SLIT and NTRK-like family, member 3b
chr16_+_32014552 0.16 ENSDART00000047570
mboat7
membrane bound O-acyltransferase domain containing 7
chr15_-_21837207 0.16 ENSDART00000089953
sik2b
salt-inducible kinase 2b
chr7_+_16806473 0.15 ENSDART00000113332
ENSDART00000173541
nav2a
neuron navigator 2a
chr17_+_27162367 0.15 ENSDART00000193345
rps6ka1
ribosomal protein S6 kinase a, polypeptide 1
chr15_+_19293744 0.15 ENSDART00000184994
ENSDART00000123815
jam3a
junctional adhesion molecule 3a
chr18_+_27926839 0.15 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr2_-_32826108 0.14 ENSDART00000098834
prpf4ba
pre-mRNA processing factor 4Ba
chr10_-_43721530 0.13 ENSDART00000025366
cetn3
centrin 3
chr14_-_30897177 0.13 ENSDART00000087918
slc7a3b
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3b
chr5_-_65081600 0.12 ENSDART00000160850
inpp5e
inositol polyphosphate-5-phosphatase E
chr5_-_57898008 0.12 ENSDART00000050945
layna
layilin a
chr8_-_25566347 0.11 ENSDART00000138289
ENSDART00000078022
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr9_-_34945566 0.10 ENSDART00000131908
ENSDART00000059861
dcun1d2a
DCN1, defective in cullin neddylation 1, domain containing 2a
chr19_-_4851411 0.10 ENSDART00000110398
fbxl20
F-box and leucine-rich repeat protein 20
chr18_+_19883325 0.10 ENSDART00000182625
zgc:162898
zgc:162898
chr23_+_9522942 0.09 ENSDART00000137751
osbpl2b
oxysterol binding protein-like 2b
chr15_+_20363859 0.09 ENSDART00000166846
supt5h
SPT5 homolog, DSIF elongation factor subunit
chr6_-_24384654 0.08 ENSDART00000164723
brdt
bromodomain, testis-specific
chr17_+_28675120 0.08 ENSDART00000159067
hectd1
HECT domain containing 1
chr20_-_51727860 0.08 ENSDART00000147044
brox
BRO1 domain and CAAX motif containing
chr21_-_27272657 0.07 ENSDART00000040754
ENSDART00000175009
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr17_+_12075805 0.07 ENSDART00000155329
cnsta
consortin, connexin sorting protein a
chr5_+_51833132 0.06 ENSDART00000167491
papd4
PAP associated domain containing 4
chr20_+_51061695 0.05 ENSDART00000134416
im:7140055
im:7140055
chr17_+_25871304 0.05 ENSDART00000185143
wapla
WAPL cohesin release factor a
chr23_-_2448234 0.05 ENSDART00000082097
LO018513.1

chr6_-_21534301 0.05 ENSDART00000126186
psmd12
proteasome 26S subunit, non-ATPase 12
chr7_+_51324834 0.04 ENSDART00000114429
usp12b
ubiquitin specific peptidase 12b
chr5_+_51833305 0.04 ENSDART00000165276
ENSDART00000166443
papd4
PAP associated domain containing 4
chr7_-_17780048 0.01 ENSDART00000183336
si:dkey-106g10.7
si:dkey-106g10.7
chr1_+_27690 0.01 ENSDART00000162928
eed
embryonic ectoderm development
chr2_-_37458527 0.01 ENSDART00000146820
si:dkey-57k2.7
si:dkey-57k2.7
chr21_-_45878872 0.00 ENSDART00000029763
sap30l
sap30-like

Network of associatons between targets according to the STRING database.

First level regulatory network of prdm14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.3 1.3 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.2 0.7 GO:0098921 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 1.2 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 1.0 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.1 0.5 GO:0045475 locomotor rhythm(GO:0045475)
0.1 0.3 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.6 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.2 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.2 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.2 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.7 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.4 GO:0001881 receptor recycling(GO:0001881)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0051039 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.0 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.1 GO:1902765 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 1.3 GO:0003146 heart jogging(GO:0003146)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.1 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.2 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.7 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.9 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 1.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.6 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 3.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.8 GO:0030507 spectrin binding(GO:0030507)
0.1 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1