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PRJNA207719: Tissue specific transcriptome profiling

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Results for raraa+rarab

Z-value: 0.51

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Transcription factors associated with raraa+rarab

Gene Symbol Gene ID Gene Info
ENSDARG00000034893 retinoic acid receptor, alpha b
ENSDARG00000056783 retinoic acid receptor, alpha a
ENSDARG00000111757 retinoic acid receptor, alpha b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
raraadr11_v1_chr12_+_10952794_10952794-0.553.3e-01Click!
rarabdr11_v1_chr3_-_33175583_33175583-0.513.8e-01Click!

Activity profile of raraa+rarab motif

Sorted Z-values of raraa+rarab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_38173960 0.49 ENSDART00000010537
ceruloplasmin
chr4_+_1530287 0.45 ENSDART00000067446
solute carrier family 38, member 4
chr14_-_51855047 0.39 ENSDART00000088912
complexin 1
chr18_+_8340886 0.38 ENSDART00000081132
carnitine palmitoyltransferase 1B (muscle)
chr17_+_33340675 0.26 ENSDART00000184396
ENSDART00000077553
xanthine dehydrogenase
chr22_+_21324398 0.22 ENSDART00000168509
SHC (Src homology 2 domain containing) transforming protein 2
chr10_+_19595009 0.20 ENSDART00000112276
zgc:173837
chr11_-_34147205 0.18 ENSDART00000173216
ATPase 13A3
chr3_+_33367954 0.18 ENSDART00000103161
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr13_+_28618086 0.18 ENSDART00000087001
cyclin and CBS domain divalent metal cation transport mediator 2a
chr23_-_3703569 0.15 ENSDART00000143731
protein kinase C and casein kinase substrate in neurons 1a
chr22_+_20208185 0.15 ENSDART00000142748
si:dkey-110c1.7
chr13_+_24834199 0.14 ENSDART00000101274
zgc:153981
chr1_+_59154521 0.12 ENSDART00000130089
ENSDART00000152456
heme-binding protein soul5, like
chr21_+_2506013 0.12 ENSDART00000162351
3-hydroxy-3-methylglutaryl-CoA reductase b
chr6_-_40029423 0.12 ENSDART00000103230
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
chr23_-_21758253 0.10 ENSDART00000046613
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr23_+_25822742 0.09 ENSDART00000184436
R3H domain containing-like
chr14_-_50892442 0.09 ENSDART00000174562
cadherin related family member 2
chr10_-_41450367 0.09 ENSDART00000122682
ENSDART00000189549
calcium binding protein 1b
chr18_+_3338228 0.09 ENSDART00000161520
glycerophosphodiester phosphodiesterase domain containing 4a
chr22_-_31788170 0.08 ENSDART00000170925
Pim proto-oncogene, serine/threonine kinase, related 207
chr7_-_69352424 0.08 ENSDART00000170714
adaptor-related protein complex 1, gamma 1 subunit
chr16_-_22194400 0.08 ENSDART00000186042
interleukin 6 receptor
chr18_+_1145571 0.07 ENSDART00000135055
REC114 meiotic recombination protein
chr8_-_13419049 0.07 ENSDART00000133656
Pim proto-oncogene, serine/threonine kinase, related 101
chr14_+_36497250 0.07 ENSDART00000184727
si:dkey-237h12.3
chr25_+_2263857 0.07 ENSDART00000076439
tyrosyl-tRNA synthetase 2, mitochondrial
chr8_-_13428740 0.07 ENSDART00000131826

chr8_-_13471916 0.07 ENSDART00000146558
Pim proto-oncogene, serine/threonine kinase, related 105
chr12_-_34427909 0.07 ENSDART00000129501
transmembrane protein 235
chr5_-_64823750 0.07 ENSDART00000140305
limb and CNS expressed 1
chr15_+_31735931 0.06 ENSDART00000185681
ENSDART00000149137
relaxin/insulin-like family peptide receptor 2b
chr19_+_5291935 0.06 ENSDART00000141237
si:dkeyp-113d7.10
chr14_+_41518257 0.06 ENSDART00000050037
cholinergic receptor, nicotinic, beta 3b (neuronal)
chr8_-_13486258 0.06 ENSDART00000137459
Pim proto-oncogene, serine/threonine kinase, related 104
chr5_-_3885727 0.06 ENSDART00000143250
MLX interacting protein like
chr8_-_13442871 0.06 ENSDART00000144887
Pim proto-oncogene, serine/threonine kinase, related 106
chr18_+_19842569 0.06 ENSDART00000147470
IQ motif containing H
chr4_-_191736 0.06 ENSDART00000169187
ENSDART00000192054
protein tyrosine phosphatase, receptor type, O
chr8_-_13454281 0.05 ENSDART00000141959

chr24_+_37723362 0.05 ENSDART00000136836
RAB11 family interacting protein 3 (class II)
chr14_-_52552875 0.05 ENSDART00000170107
protein phosphatase 2, regulatory subunit B, beta a
chr8_-_10947205 0.05 ENSDART00000164467
PQ loop repeat containing 2
chr7_-_24838857 0.05 ENSDART00000179766
ENSDART00000180892
family with sequence similarity 113
chr11_+_25111846 0.05 ENSDART00000128705
ENSDART00000190058
ndrg family member 3a
chr4_+_70563225 0.04 ENSDART00000159508
si:dkey-11d20.1
chr14_-_2001386 0.04 ENSDART00000170346
ENSDART00000163975
protocadherin 2 gamma 5
chr25_-_3132060 0.04 ENSDART00000014363
eosinophil peroxidase
chr2_+_31948352 0.04 ENSDART00000192611
ANKH inorganic pyrophosphate transport regulator b
chr2_+_56213694 0.04 ENSDART00000162582
upf1 regulator of nonsense transcripts homolog (yeast)
chr10_+_22890791 0.03 ENSDART00000176011
arrestin, beta 2a
chr17_+_46739693 0.03 ENSDART00000097810
Pim proto-oncogene, serine/threonine kinase, related 22
chr4_+_3980247 0.03 ENSDART00000049194
G protein-coupled receptor 37b
chr22_-_9900378 0.02 ENSDART00000193906
zinc finger protein 991
chr2_+_3696038 0.02 ENSDART00000150499
ENSDART00000136906
ENSDART00000164152
ENSDART00000128514
ENSDART00000108964
epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
chr2_-_55317035 0.02 ENSDART00000169382
ENSDART00000097874
tropomyosin 4b
chr8_+_37168570 0.01 ENSDART00000098636
colony stimulating factor 1b (macrophage)
chr18_+_7073130 0.00 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
chr18_+_43183749 0.00 ENSDART00000151166
nectin cell adhesion molecule 1b
chr19_+_19762183 0.00 ENSDART00000163611
ENSDART00000187604
homeobox A3a
chr10_+_22891126 0.00 ENSDART00000057291
arrestin, beta 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of raraa+rarab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.0 0.2 GO:0016081 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.4 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.2 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.0 0.0 GO:0031701 angiotensin receptor binding(GO:0031701)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation