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PRJNA207719: Tissue specific transcriptome profiling

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Results for tfap2a+tfap2c

Z-value: 0.71

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Transcription factors associated with tfap2a+tfap2c

Gene Symbol Gene ID Gene Info
tfap2c
ENSDARG00000040606 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
tfap2a
ENSDARG00000059279 transcription factor AP-2 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2adr11_v1_chr24_-_8729716_87297160.563.3e-01Click!
tfap2cdr11_v1_chr6_+_56141852_56141852-0.385.2e-01Click!

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_16098531 1.31 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr19_-_9472893 1.04 ENSDART00000045565
ENSDART00000137505
vamp1
vesicle-associated membrane protein 1
chr23_+_37323962 0.97 ENSDART00000102881
fam43b
family with sequence similarity 43, member B
chr7_-_23563092 0.89 ENSDART00000132275
gpr185b
G protein-coupled receptor 185 b
chr15_-_44512461 0.82 ENSDART00000155456
gria4a
glutamate receptor, ionotropic, AMPA 4a
chr16_-_29458806 0.77 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr2_+_27010439 0.66 ENSDART00000030547
cdh7a
cadherin 7a
chr9_+_32358514 0.62 ENSDART00000144608
plcl1
phospholipase C like 1
chr24_-_6898302 0.61 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr5_-_37933983 0.55 ENSDART00000185364
scn4bb
sodium channel, voltage-gated, type IV, beta b
chr12_-_4781801 0.53 ENSDART00000167490
ENSDART00000121718
mapta
microtubule-associated protein tau a
chr1_-_45888608 0.49 ENSDART00000139219
pnpla6
patatin-like phospholipase domain containing 6
chr21_-_21089781 0.46 ENSDART00000144361
ank1b
ankyrin 1, erythrocytic b
chr10_+_21793670 0.44 ENSDART00000168918
pcdh1gc6
protocadherin 1 gamma c 6
chr10_-_8032885 0.42 ENSDART00000188619
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr8_-_13210959 0.42 ENSDART00000142224
si:ch73-61d6.3
si:ch73-61d6.3
chr8_+_49149907 0.41 ENSDART00000138746
snpha
syntaphilin a
chr6_-_10320676 0.40 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr11_+_30253968 0.39 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr8_-_13211527 0.38 ENSDART00000090541
si:ch73-61d6.3
si:ch73-61d6.3
chr22_-_20105969 0.36 ENSDART00000088687
rxfp3.2b
relaxin/insulin-like family peptide receptor 3.2b
chr10_+_21797276 0.36 ENSDART00000169105
pcdh1g29
protocadherin 1 gamma 29
chr1_+_49878000 0.32 ENSDART00000047876
lef1
lymphoid enhancer-binding factor 1
chr8_-_26792912 0.32 ENSDART00000139787
kazna
kazrin, periplakin interacting protein a
chr25_-_20378721 0.30 ENSDART00000181707
kctd15a
potassium channel tetramerization domain containing 15a
chr7_+_39011852 0.30 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr2_+_28995776 0.27 ENSDART00000138733
cdh12a
cadherin 12, type 2a (N-cadherin 2)
chr3_+_36160979 0.26 ENSDART00000038525
si:ch211-234h8.7
si:ch211-234h8.7
chr10_-_36927594 0.26 ENSDART00000162046
sez6a
seizure related 6 homolog a
chr14_+_29609245 0.26 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr5_+_21100356 0.24 ENSDART00000051586
hs3st1l2
heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2
chr23_-_35347714 0.23 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr14_-_28001986 0.22 ENSDART00000054115
tsc22d3
TSC22 domain family, member 3
chr1_+_42225060 0.22 ENSDART00000138740
ENSDART00000101306
ctnna2
catenin (cadherin-associated protein), alpha 2
chr11_-_26180714 0.19 ENSDART00000173597
kaznb
kazrin, periplakin interacting protein b
chr23_+_2760573 0.18 ENSDART00000129719
top1
DNA topoisomerase I
chr11_+_31323746 0.17 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr5_+_16580739 0.16 ENSDART00000135140
htr7c
5-hydroxytryptamine (serotonin) receptor 7c
chr15_-_24960730 0.16 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr19_-_30510930 0.15 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr20_-_20312789 0.14 ENSDART00000114779
si:ch211-212g7.6
si:ch211-212g7.6
chr16_-_46393154 0.14 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr19_+_10799929 0.12 ENSDART00000159152
lipea
lipase, hormone-sensitive a
chr14_+_29200772 0.11 ENSDART00000166608
TENM2
si:dkey-34l15.2
chr16_+_26601364 0.11 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr17_-_15149192 0.11 ENSDART00000180511
ENSDART00000103405
gch1
GTP cyclohydrolase 1
chr5_+_25736979 0.10 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr1_+_33328857 0.10 ENSDART00000137151
mxra5a
matrix-remodelling associated 5a
chr23_-_27152866 0.09 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr10_+_5135842 0.09 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr1_+_58990121 0.08 ENSDART00000171654
CABZ01083166.1

chr2_+_11205795 0.07 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr14_-_572742 0.07 ENSDART00000168951
fgf2
fibroblast growth factor 2
chr3_-_61592417 0.06 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr8_+_48943009 0.06 ENSDART00000180763
rer1
retention in endoplasmic reticulum sorting receptor 1
chr5_+_61799629 0.06 ENSDART00000113508
hnrnpul1l
heterogeneous nuclear ribonucleoprotein U-like 1 like
chr3_-_35865040 0.05 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr25_+_36405021 0.05 ENSDART00000152801
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr18_-_15551360 0.04 ENSDART00000159915
ENSDART00000172690
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr5_+_63302660 0.03 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr18_+_34181655 0.03 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr5_-_62801879 0.03 ENSDART00000191749
adora2b
adenosine A2b receptor
chr8_-_11004726 0.03 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr8_+_48942470 0.03 ENSDART00000005464
ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr11_-_8782871 0.02 ENSDART00000158546
si:ch211-51h4.2
si:ch211-51h4.2
chr2_+_43750899 0.02 ENSDART00000135836
arhgap12a
Rho GTPase activating protein 12a
chr1_+_16548733 0.02 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr7_+_56651759 0.01 ENSDART00000073600
kcng4b
potassium voltage-gated channel, subfamily G, member 4b
chr13_-_28674422 0.00 ENSDART00000122754
ENSDART00000057574
nt5c2a
5'-nucleotidase, cytosolic IIa
chr14_+_918287 0.00 ENSDART00000167066
CU462913.1

chr22_+_30839702 0.00 ENSDART00000139849
ENSDART00000135775
si:dkey-49n23.3
si:dkey-49n23.3

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.4 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 1.0 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.6 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.1 0.3 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.1 0.2 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.5 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.4 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.7 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.6 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.8 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.9 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.0 GO:0031201 SNARE complex(GO:0031201)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.4 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.2 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1