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PRJNA207719: Tissue specific transcriptome profiling

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Results for tp53

Z-value: 2.78

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Transcription factors associated with tp53

Gene Symbol Gene ID Gene Info
ENSDARG00000035559 tumor protein p53
ENSDARG00000115148 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp53dr11_v1_chr5_+_24087035_240870350.884.9e-02Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_31428763 3.53 ENSDART00000053545
zgc:153284
chr3_-_28828242 2.91 ENSDART00000151445
si:ch211-76l23.4
chr3_-_28828569 2.30 ENSDART00000167679
si:ch211-76l23.4
chr7_-_2430286 2.29 ENSDART00000129312
zgc:66473
chr13_+_24755049 2.28 ENSDART00000134102
collagen, type XVII, alpha 1b
chr5_+_29831235 2.22 ENSDART00000109660
F11 receptor, tandem duplicate 1
chr12_+_22576404 2.22 ENSDART00000172053
capping protein (actin filament), gelsolin-like b
chr22_-_6404807 2.21 ENSDART00000149399
ENSDART00000063420
si:rp71-1i20.2
chr5_+_27404946 2.19 ENSDART00000121886
ENSDART00000005025
hematopoietic death receptor
chr5_+_24089334 2.09 ENSDART00000183748
tumor protein p53
chr7_-_2292403 2.03 ENSDART00000075856
zgc:66473
chr14_+_36889893 1.97 ENSDART00000124159
si:ch211-132p1.3
chr23_+_23232136 1.89 ENSDART00000126479
ENSDART00000187764
pleckstrin homology domain containing, family N member 1
chr12_-_5505205 1.88 ENSDART00000092319
ABI family, member 3b
chr8_+_32406885 1.80 ENSDART00000167600
epithelial mitogen homolog (mouse)
chr16_+_38201840 1.70 ENSDART00000044971
myosin IE, b
chr2_-_51316187 1.63 ENSDART00000163362
ENSDART00000166871
ENSDART00000160262
polymeric immunoglobulin receptor-like 3.5
chr6_+_43450221 1.62 ENSDART00000075521
zgc:113054
chr19_+_48176745 1.60 ENSDART00000164963
PR domain containing 1b, with ZNF domain
chr22_-_15693085 1.59 ENSDART00000141861
si:ch1073-396h14.1
chr7_-_8438657 1.59 ENSDART00000173054
si:dkeyp-32g11.8
chr3_+_16229911 1.54 ENSDART00000121728
ribosomal protein L19
chr20_+_7398090 1.54 ENSDART00000108649
proprotein convertase subtilisin/kexin type 9
chr6_-_42983843 1.52 ENSDART00000130666
tumor necrosis factor receptor superfamily, member 18
chr20_-_26929685 1.51 ENSDART00000132556
finTRIM family, member 79
chr19_+_2835240 1.49 ENSDART00000190838
CUB domain containing protein 1
chr5_+_57924611 1.49 ENSDART00000050949
B-cell translocation gene 4
chr25_+_34641536 1.46 ENSDART00000167033

chr3_+_30922947 1.38 ENSDART00000184060
claudin i
chr13_+_25422009 1.36 ENSDART00000057686
calcium homeostasis modulator 2
chr17_-_10838434 1.32 ENSDART00000064597
lectin, galactoside binding soluble 3b
chr11_+_10975481 1.30 ENSDART00000160488
integrin, beta 6
chr16_+_34111919 1.29 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
transcription elongation factor A (SII), 3
chr23_-_33775145 1.28 ENSDART00000132147
ENSDART00000027959
ENSDART00000160116
Rac GTPase activating protein 1
chr17_+_25849332 1.26 ENSDART00000191994
acyl-CoA synthetase short chain family member 1
chr21_+_25688388 1.25 ENSDART00000125709
bicaudal-D-related protein 2
chr5_-_37959874 1.22 ENSDART00000031719
myelin protein zero-like 2b
chr8_+_25629941 1.21 ENSDART00000186925
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
chr11_+_10975012 1.15 ENSDART00000192872
integrin, beta 6
chr2_-_37743834 1.11 ENSDART00000088040
ENSDART00000191057
myosin IXb
chr18_+_35861930 1.09 ENSDART00000185223
protein phosphatase 1, regulatory subunit 13 like
chr13_-_25774183 1.09 ENSDART00000046981
PDZ and LIM domain 1 (elfin)
chr2_-_24068848 1.09 ENSDART00000145526
solute carrier family 12 (potassium/chloride transporter), member 7a
chr10_-_4980150 1.07 ENSDART00000093228
methionine adenosyltransferase II, alpha-like
chr23_+_11285662 1.05 ENSDART00000111028
cell adhesion molecule L1-like a
chr6_+_13046720 1.04 ENSDART00000165896
caspase 8, apoptosis-related cysteine peptidase
chr13_-_45201300 1.03 ENSDART00000074750
ENSDART00000180265
runt-related transcription factor 3
chr20_-_43663494 1.03 ENSDART00000144564

chr8_+_25629722 1.01 ENSDART00000026807
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
chr23_-_1017605 1.00 ENSDART00000138290
cadherin 26, tandem duplicate 1
chr10_+_8554929 1.00 ENSDART00000190849
TBC1 domain family, member 10Ab
chr18_+_2554666 0.98 ENSDART00000167218
purinergic receptor P2Y2, tandem duplicate 1
chr16_-_30903930 0.98 ENSDART00000143996
DENN/MADD domain containing 3b
chr19_+_43780970 0.98 ENSDART00000063870
ribosomal protein L11
chr1_-_11596829 0.97 ENSDART00000140725
si:dkey-26i13.7
chr22_+_37888249 0.97 ENSDART00000076082
fetuin B
chr11_+_25328199 0.96 ENSDART00000141478
ENSDART00000112209
family with sequence similarity 83, member D
chr25_+_36292465 0.95 ENSDART00000152649
brambleberry
chr23_-_1017428 0.94 ENSDART00000110588
ENSDART00000183158
cadherin 26, tandem duplicate 1
chr6_-_19168640 0.94 ENSDART00000163183
si:ch211-188c18.1
chr5_+_27898226 0.93 ENSDART00000098604
ENSDART00000180251
ADAM metallopeptidase domain 28
chr7_+_54260004 0.93 ENSDART00000171909
protein kinase C and casein kinase substrate in neurons 3
chr20_-_13673566 0.92 ENSDART00000181641
si:ch211-122h15.4
chr8_+_7322465 0.91 ENSDART00000192380
ssu-2 homolog, related sequence 1
chr6_-_19270484 0.88 ENSDART00000186894
ENSDART00000188709
zgc:174863
chr22_+_9854088 0.87 ENSDART00000122678

chr3_-_50147160 0.86 ENSDART00000191341
bloodthirsty-related gene family, member 2
chr25_+_26441054 0.85 ENSDART00000158607
death-associated protein kinase 2b
chr23_+_11347313 0.84 ENSDART00000135406
cell adhesion molecule L1-like a
chr5_-_57686487 0.83 ENSDART00000074264
cytokine receptor family member B12
chr12_-_33789218 0.83 ENSDART00000193258
lethal giant larvae homolog 2 (Drosophila)
chr20_+_52546186 0.82 ENSDART00000110777
ENSDART00000153377
ENSDART00000153013
ENSDART00000042704
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr19_-_27570333 0.81 ENSDART00000146562
ENSDART00000179060
si:dkeyp-46h3.5
si:dkeyp-46h3.8
chr1_+_58375871 0.81 ENSDART00000166736

chr11_+_38429319 0.79 ENSDART00000029157
major facilitator superfamily domain containing 4Aa
chr20_-_26936887 0.78 ENSDART00000160827
finTRIM family, member 79
chr12_-_16435150 0.77 ENSDART00000086211
polycomb group ring finger 5b
chr13_-_50200042 0.76 ENSDART00000074230
protein kinase containing Z-DNA binding domains
chr25_-_35136267 0.76 ENSDART00000109751
zgc:173585
chr3_+_35812040 0.76 ENSDART00000075903
ENSDART00000147712
cytokine receptor-like factor 3
chr12_-_33789006 0.75 ENSDART00000034550
lethal giant larvae homolog 2 (Drosophila)
chr16_-_48400639 0.73 ENSDART00000159372
eukaryotic translation initiation factor 3, subunit H, a
chr4_-_70050522 0.72 ENSDART00000100252
si:ch211-171l17.14
chr7_-_26049282 0.72 ENSDART00000136389
ENSDART00000101124
ribonuclease, RNase K a
chr4_-_40589466 0.72 ENSDART00000133295
ENSDART00000124872
si:dkey-207m2.4
chr4_-_71311438 0.72 ENSDART00000168021
si:dkeyp-123a12.2
chr6_-_43283122 0.70 ENSDART00000186022
FERM domain containing 4Ba
chr10_+_4987766 0.70 ENSDART00000121959
si:ch73-234b20.5
chr13_+_25421531 0.68 ENSDART00000158093
calcium homeostasis modulator 2
chr24_-_17039638 0.68 ENSDART00000048823
complement component 8, gamma polypeptide
chr7_+_24520518 0.67 ENSDART00000173604
bloodthirsty-related gene family, member 9
chr15_-_25093680 0.67 ENSDART00000062695
exonuclease 5
chr17_-_27200025 0.61 ENSDART00000192699
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr1_-_9134045 0.61 ENSDART00000142132
partner and localizer of BRCA2
chr3_+_24595922 0.60 ENSDART00000169405
si:dkey-68o6.5
chr15_-_25094026 0.59 ENSDART00000129154
exonuclease 5
chr21_-_19919020 0.59 ENSDART00000147396
protein phosphatase 1, regulatory subunit 3B
chr6_+_59913147 0.59 ENSDART00000156543
angio-associated, migratory cell protein
chr18_+_14619544 0.58 ENSDART00000010821
UTP4, small subunit processome component
chr8_-_4694458 0.58 ENSDART00000019828
zgc:63587
chr23_-_5783421 0.58 ENSDART00000131521
ENSDART00000019455
cysteine and glycine-rich protein 1a
chr9_+_50110763 0.58 ENSDART00000162990
cordon-bleu WH2 repeat protein-like 1b
chr16_-_33806390 0.58 ENSDART00000160671
R-spondin 1
chr25_-_36292346 0.57 ENSDART00000073399
Fanconi anemia core complex associated protein 24
chr7_+_26049818 0.57 ENSDART00000173611
si:dkey-6n21.12
chr6_+_49095646 0.55 ENSDART00000103385
solute carrier family 25, member 55a
chr1_+_58282449 0.54 ENSDART00000131475
si:dkey-222h21.7
chr5_-_63286077 0.54 ENSDART00000131274
tubulin folding cofactor E-like b
chr5_-_33039670 0.53 ENSDART00000141361
GLI pathogenesis-related 2
chr3_-_47294365 0.53 ENSDART00000191039
TNF superfamily member 18
chr13_-_50200348 0.52 ENSDART00000038391
protein kinase containing Z-DNA binding domains
chr6_+_27315173 0.51 ENSDART00000108831
espin like a
chr19_+_41551543 0.51 ENSDART00000112364
si:ch211-57n23.4
chr10_+_8629275 0.49 ENSDART00000129643
apelin receptor b
chr11_+_42641404 0.48 ENSDART00000172641
ENSDART00000169938
interleukin 17 receptor D
chr4_-_49607096 0.46 ENSDART00000154381
si:dkey-159n16.4
chr11_-_37693019 0.46 ENSDART00000102898
zgc:158258
chr5_+_9408901 0.46 ENSDART00000193364

chr15_+_44053244 0.45 ENSDART00000059550
leucine rich repeat containing 51
chr3_+_23692462 0.45 ENSDART00000145934
homeobox B7a
chr3_-_11040575 0.45 ENSDART00000159802

chr18_+_44769027 0.44 ENSDART00000145190
ilvB (bacterial acetolactate synthase)-like
chr4_-_71554068 0.44 ENSDART00000167414
si:dkey-27n6.1
chr15_+_6109861 0.44 ENSDART00000185154
Purkinje cell protein 4
chr3_+_61420079 0.43 ENSDART00000168990

chr3_-_58046319 0.42 ENSDART00000155968
si:ch211-256e16.10
chr4_+_59246094 0.42 ENSDART00000160587
si:dkey-105i14.1
chr3_-_50146854 0.42 ENSDART00000157047
si:dkey-120c6.5
chr2_-_27900518 0.42 ENSDART00000109561
ENSDART00000077720
zgc:163121
chr3_-_58205045 0.42 ENSDART00000130740
si:ch211-256e16.11
chr5_-_1999417 0.42 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
chr3_+_3992590 0.41 ENSDART00000180211
ENSDART00000054840

chr22_+_9793923 0.41 ENSDART00000063323
si:dkey-102c8.2
chr12_+_27537357 0.41 ENSDART00000136212
ets variant 4
chr16_-_30931651 0.39 ENSDART00000132643
solute carrier family 45, member 4
chr14_+_22132896 0.39 ENSDART00000138274
cyclin G1
chr18_+_5172848 0.38 ENSDART00000190642

chr25_-_35147698 0.38 ENSDART00000121963
zgc:165555
chr22_-_6801876 0.38 ENSDART00000135726
si:ch1073-188e1.1
chr22_-_10110959 0.38 ENSDART00000031005
ENSDART00000147580
glutaminase 2b (liver, mitochondrial)
chr3_-_34082283 0.38 ENSDART00000151264
immunoglobulin heavy variable 4-3
chr13_-_50567658 0.38 ENSDART00000132281
B cell linker
chr12_+_29236274 0.37 ENSDART00000006505
mix-type homeobox gene 2
chr11_+_6281647 0.37 ENSDART00000002459
cystinosin, lysosomal cystine transporter
chr14_+_36869273 0.36 ENSDART00000111674
si:ch211-132p1.2
chr16_+_35595312 0.36 ENSDART00000170438
si:ch211-1i11.3
chr23_-_31512496 0.36 ENSDART00000158755
ENSDART00000143425
EYA transcriptional coactivator and phosphatase 4
chr5_-_29570141 0.35 ENSDART00000043259
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr3_-_22359119 0.35 ENSDART00000168184
interferon phi 2
chr25_-_36044294 0.35 ENSDART00000182207
retinoblastoma-like 2 (p130)
chr14_+_29941266 0.35 ENSDART00000112757
family with sequence similarity 149 member A
chr18_-_22717565 0.35 ENSDART00000142185
ENSDART00000059945
si:ch73-113g13.1
chr11_+_14295011 0.34 ENSDART00000060226
si:ch211-262i1.4
chr4_-_13931508 0.34 ENSDART00000067174
zinc finger CCHC-type and RNA binding motif 1
chr7_-_66877058 0.33 ENSDART00000155954
adrenomedullin a
chr16_-_34195002 0.33 ENSDART00000054026
regulator of chromosome condensation 1
chr7_-_20464133 0.33 ENSDART00000078192
canopy4
chr16_-_40459104 0.33 ENSDART00000032389
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr22_+_5959984 0.32 ENSDART00000179378
ENSDART00000178985
ENSDART00000174635

chr22_+_24770744 0.32 ENSDART00000142882
si:rp71-23d18.4
chr13_-_9300299 0.31 ENSDART00000144142
si:dkey-33c12.12
chr5_-_69804433 0.31 ENSDART00000028954
Rab interacting lysosomal protein-like 2
chr6_-_18960105 0.31 ENSDART00000185278
ENSDART00000162968
septin 9b
chr11_+_2434262 0.31 ENSDART00000166445
casein kinase 2, alpha 4 polypeptide
chr5_+_66170479 0.30 ENSDART00000172117
glycine dehydrogenase (decarboxylating)
chr6_-_7109063 0.29 ENSDART00000148548
nonhomologous end-joining factor 1
chr4_-_44508975 0.29 ENSDART00000180528
si:dkeyp-100h4.1
chr13_+_21600946 0.28 ENSDART00000144045
SH2 domain containing 4Ba
chr4_+_59245846 0.28 ENSDART00000104921
si:dkey-105i14.1
chr7_+_4583139 0.28 ENSDART00000143777
si:dkey-83f18.4
chr4_-_13931293 0.27 ENSDART00000067172
zinc finger CCHC-type and RNA binding motif 1
chr22_+_8365905 0.27 ENSDART00000105945
si:dkey-19a16.11
chr4_-_16833518 0.26 ENSDART00000179867
lactate dehydrogenase Ba
chr25_+_35058088 0.26 ENSDART00000156838
zgc:112234
chr8_+_15277874 0.26 ENSDART00000146965
deoxynucleotidyltransferase, terminal, interacting protein 2
chr4_+_25607743 0.26 ENSDART00000028297
acyl-CoA thioesterase 14
chr23_+_4483083 0.26 ENSDART00000092389
nucleoporin 210
chr3_-_7940522 0.26 ENSDART00000159710
ENSDART00000167201
tripartite motif containing 35-25
chr3_-_41795917 0.25 ENSDART00000182662
galectin-related inter-fiber protein
chr9_+_29671553 0.24 ENSDART00000015377
ribonuclease H2, subunit B
chr9_+_51882534 0.24 ENSDART00000165493

chr4_+_34418211 0.24 ENSDART00000160070
si:ch211-246b8.2
chr1_-_18592068 0.24 ENSDART00000082063
family with sequence similarity 114, member A1
chr24_+_12200260 0.23 ENSDART00000181391

chr20_+_42537768 0.23 ENSDART00000134066
ENSDART00000153434
si:dkeyp-93d12.1
chr11_-_13618412 0.23 ENSDART00000137289
secreted immunoglobulin domain 1
chr22_+_2598998 0.22 ENSDART00000176665

chr21_+_11139175 0.22 ENSDART00000169024
alanine--glyoxylate aminotransferase 2
chr16_+_20496691 0.22 ENSDART00000182737
ENSDART00000078984
carboxypeptidase, vitellogenic-like
chr25_+_19095231 0.21 ENSDART00000154066
interferon stimulated exonuclease gene
chr8_-_17926620 0.21 ENSDART00000187864
LIM homeobox 8b
chr21_-_41065369 0.21 ENSDART00000143749
leucyl-tRNA synthetase b
chr15_+_29362714 0.21 ENSDART00000099916
ENSDART00000126196
guanylate cyclase 2F, retinal
chr24_+_22485710 0.21 ENSDART00000146058
si:dkey-40h20.1
chr4_-_62206968 0.20 ENSDART00000193074
si:dkeyp-35e5.5
chr16_-_30931468 0.20 ENSDART00000187838
solute carrier family 45, member 4
chr7_+_4194055 0.19 ENSDART00000105073
si:dkey-28d5.14
chr4_-_44509477 0.19 ENSDART00000102949
ENSDART00000135262
si:dkeyp-100h4.1
chr18_-_16924221 0.19 ENSDART00000122102
WEE1 G2 checkpoint kinase
chr3_+_24556640 0.19 ENSDART00000159405
SP110 nuclear body protein, tandem duplicate 2

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0032197 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.5 2.2 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.5 1.9 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.3 1.0 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.3 1.6 GO:0010719 photoreceptor cell morphogenesis(GO:0008594) negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.3 1.3 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.3 1.7 GO:0070254 mucus secretion(GO:0070254)
0.3 1.3 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.2 0.5 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.2 1.3 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.2 1.8 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.2 0.6 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.2 1.0 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.2 2.2 GO:0050892 intestinal absorption(GO:0050892)
0.2 1.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 2.2 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.6 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.1 0.4 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.1 0.9 GO:0014028 notochord formation(GO:0014028)
0.1 2.4 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 0.3 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 2.2 GO:0051014 actin filament severing(GO:0051014)
0.1 1.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.0 GO:0051310 metaphase plate congression(GO:0051310)
0.1 0.4 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.1 2.1 GO:0003094 glomerular filtration(GO:0003094)
0.1 1.8 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.8 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.6 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 1.6 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.5 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.4 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.3 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 1.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.1 GO:0002407 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.5 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 1.1 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.4 GO:0016576 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 2.2 GO:0006414 translational elongation(GO:0006414)
0.0 1.5 GO:0045785 positive regulation of cell adhesion(GO:0045785)
0.0 1.4 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.4 GO:0035108 limb morphogenesis(GO:0035108)
0.0 0.7 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.9 GO:0042476 odontogenesis(GO:0042476)
0.0 0.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.3 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.3 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.5 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 1.1 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 1.0 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.3 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.6 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.9 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 1.5 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.9 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 1.3 GO:0001772 immunological synapse(GO:0001772)
0.1 0.4 GO:0005948 acetolactate synthase complex(GO:0005948)
0.1 0.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.9 GO:0016342 catenin complex(GO:0016342)
0.0 0.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 1.7 GO:0005902 microvillus(GO:0005902)
0.0 4.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 3.8 GO:0030027 lamellipodium(GO:0030027)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.9 GO:0005884 actin filament(GO:0005884)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.6 GO:0030686 90S preribosome(GO:0030686)
0.0 5.5 GO:0000785 chromatin(GO:0000785)
0.0 6.7 GO:0009986 cell surface(GO:0009986)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:1901612 cardiolipin binding(GO:1901612)
0.4 1.3 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.3 1.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3 1.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.3 1.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.3 1.3 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.2 1.3 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.4 GO:0003984 acetolactate synthase activity(GO:0003984)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 3.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.5 GO:0060182 apelin receptor activity(GO:0060182)
0.1 1.6 GO:0045159 myosin II binding(GO:0045159)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.2 GO:0048030 disaccharide binding(GO:0048030)
0.1 1.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 1.0 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 1.6 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 1.7 GO:0042805 actinin binding(GO:0042805)
0.1 0.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 2.8 GO:0000146 microfilament motor activity(GO:0000146)
0.0 2.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.8 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 1.1 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 2.4 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.6 GO:2001069 glycogen binding(GO:2001069)
0.0 0.7 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 1.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0005542 folic acid binding(GO:0005542)
0.0 0.3 GO:0016594 glycine binding(GO:0016594)
0.0 0.1 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 2.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 2.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.3 PID AURORA B PATHWAY Aurora B signaling
0.0 1.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 3.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.0 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 2.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1