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PRJNA207719: Tissue specific transcriptome profiling

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Results for tp73

Z-value: 0.89

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Transcription factors associated with tp73

Gene Symbol Gene ID Gene Info
tp73
ENSDARG00000017953 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp73dr11_v1_chr8_+_48848200_488482000.197.6e-01Click!

Activity profile of tp73 motif

Sorted Z-values of tp73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_12176327 0.72 ENSDART00000041914
si:ch211-156l18.7
si:ch211-156l18.7
chr3_+_31680592 0.69 ENSDART00000172456
mylk5
myosin, light chain kinase 5
chr3_+_8825382 0.63 ENSDART00000158893
si:dkeyp-30d6.2
si:dkeyp-30d6.2
chr13_-_4707018 0.61 ENSDART00000128422
oit3
oncoprotein induced transcript 3
chr21_+_26612777 0.61 ENSDART00000142667
esrra
estrogen-related receptor alpha
chr19_+_4068134 0.59 ENSDART00000158285
btr26
bloodthirsty-related gene family, member 26
chr2_+_36691771 0.58 ENSDART00000131978
ptx3b
pentraxin 3, long b
chr11_+_14287427 0.54 ENSDART00000180903
si:ch211-262i1.3
si:ch211-262i1.3
chr11_+_14333441 0.53 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr3_+_16229911 0.53 ENSDART00000121728
rpl19
ribosomal protein L19
chr11_+_12175162 0.53 ENSDART00000125446
si:ch211-156l18.7
si:ch211-156l18.7
chr18_-_38270077 0.53 ENSDART00000185546
caprin1b
cell cycle associated protein 1b
chr21_-_27338639 0.52 ENSDART00000130632
hif1al2
hypoxia-inducible factor 1, alpha subunit, like 2
chr3_-_39488639 0.50 ENSDART00000161644
zgc:100868
zgc:100868
chr20_-_30376433 0.49 ENSDART00000190737
rps7
ribosomal protein S7
chr5_+_40837539 0.48 ENSDART00000188279
si:dkey-3h3.3
si:dkey-3h3.3
chr3_-_39488482 0.48 ENSDART00000135192
zgc:100868
zgc:100868
chr8_+_22485956 0.47 ENSDART00000099960
si:ch211-261n11.7
si:ch211-261n11.7
chr19_+_4061699 0.47 ENSDART00000158309
ENSDART00000166512
btr25
btr26
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr12_+_22576404 0.46 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr21_-_20832482 0.42 ENSDART00000191928
c6
complement component 6
chr13_-_17464362 0.41 ENSDART00000145499
lrmda
leucine rich melanocyte differentiation associated
chr25_+_34641536 0.40 ENSDART00000167033
CABZ01079011.1

chr13_-_17464654 0.39 ENSDART00000140312
lrmda
leucine rich melanocyte differentiation associated
chr25_+_36292465 0.36 ENSDART00000152649
bmb
brambleberry
chr14_+_15484544 0.35 ENSDART00000188649
CR382326.1

chr4_-_49607096 0.34 ENSDART00000154381
si:dkey-159n16.4
si:dkey-159n16.4
chr11_+_30303785 0.34 ENSDART00000185610
ENSDART00000126815
ugt1b5
UDP glucuronosyltransferase 1 family, polypeptide B5
chr5_-_26936861 0.34 ENSDART00000191032
htra4
HtrA serine peptidase 4
chr7_-_16596938 0.31 ENSDART00000134548
e2f8
E2F transcription factor 8
chr1_-_53714885 0.29 ENSDART00000026409
cct4
chaperonin containing TCP1, subunit 4 (delta)
chr18_+_20567542 0.29 ENSDART00000182585
bida
BH3 interacting domain death agonist
chr7_-_16597130 0.28 ENSDART00000144118
e2f8
E2F transcription factor 8
chr7_+_41314862 0.28 ENSDART00000185198
zgc:165532
zgc:165532
chr3_+_62219158 0.27 ENSDART00000162354
BX470259.5

chr8_+_30747940 0.27 ENSDART00000098975
p2rx4b
purinergic receptor P2X, ligand-gated ion channel, 4b
chr8_+_25767610 0.25 ENSDART00000062406
cacna1sb
calcium channel, voltage-dependent, L type, alpha 1S subunit, b
chr7_-_73848458 0.25 ENSDART00000041385
zgc:163061
zgc:163061
chr5_+_27898226 0.24 ENSDART00000098604
ENSDART00000180251
adam28
ADAM metallopeptidase domain 28
chr6_+_13046720 0.24 ENSDART00000165896
casp8
caspase 8, apoptosis-related cysteine peptidase
chr11_+_24298432 0.23 ENSDART00000138487
si:dkey-76p14.2
si:dkey-76p14.2
chr24_+_14859238 0.23 ENSDART00000113859
ENSDART00000138227
crispld1a
cysteine-rich secretory protein LCCL domain containing 1a
chr1_-_56363108 0.23 ENSDART00000021878
gcgrb
glucagon receptor b
chr6_-_2154137 0.22 ENSDART00000162656
tgm5l
transglutaminase 5, like
chr20_-_1314355 0.21 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr8_-_34762163 0.21 ENSDART00000114080
setd1bb
SET domain containing 1B, b
chr14_-_16328331 0.21 ENSDART00000111262
pcdh12
protocadherin 12
chr13_-_50546634 0.20 ENSDART00000192127
CU570781.2

chr5_+_6854498 0.20 ENSDART00000148663
elac1
elaC ribonuclease Z 1
chr10_+_2587234 0.20 ENSDART00000126937
wu:fb59d01
wu:fb59d01
chr11_+_16137302 0.19 ENSDART00000164892
pimr204
Pim proto-oncogene, serine/threonine kinase, related 204
chr7_+_19495905 0.19 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
si:ch211-212k18.8
chr1_+_11711503 0.19 ENSDART00000138355
si:dkey-26i13.8
si:dkey-26i13.8
chr2_+_44528255 0.19 ENSDART00000193834
pask
PAS domain containing serine/threonine kinase
chr20_-_13673566 0.18 ENSDART00000181641
TAGAP
si:ch211-122h15.4
chr6_-_10902916 0.17 ENSDART00000122221
nfe2l2b
nuclear factor, erythroid 2-like 2b
chr11_-_8271374 0.17 ENSDART00000168253
pimr202
Pim proto-oncogene, serine/threonine kinase, related 202
chr7_+_19495379 0.17 ENSDART00000180514
si:ch211-212k18.8
si:ch211-212k18.8
chr15_-_35960250 0.16 ENSDART00000186765
col4a4
collagen, type IV, alpha 4
chr12_-_44151296 0.16 ENSDART00000168734
si:ch73-329n5.3
si:ch73-329n5.3
chr1_+_55600504 0.15 ENSDART00000123946
umod
uromodulin
chr4_+_25680480 0.14 ENSDART00000100737
acot17
acyl-CoA thioesterase 17
chr16_-_19568795 0.14 ENSDART00000185141
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr2_+_10771787 0.14 ENSDART00000187782
gfi1aa
growth factor independent 1A transcription repressor a
chr25_+_4581214 0.14 ENSDART00000185552
CABZ01068600.1

chr15_-_4485828 0.14 ENSDART00000062868
tfdp2
transcription factor Dp-2
chr22_+_12477996 0.13 ENSDART00000177704
CR847870.3

chr23_-_20345473 0.13 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr18_+_44768829 0.13 ENSDART00000016271
ilvbl
ilvB (bacterial acetolactate synthase)-like
chr12_+_26608883 0.11 ENSDART00000153094
si:dkey-148d16.5
si:dkey-148d16.5
chr18_+_32916351 0.11 ENSDART00000170387
ENSDART00000161553
olfcg2
olfactory receptor C family, g2
chr20_+_4157815 0.11 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr2_-_48539673 0.10 ENSDART00000168202
CR391991.4

chr20_-_164300 0.08 ENSDART00000183354
si:ch211-241j12.3
si:ch211-241j12.3
chr1_+_54773877 0.07 ENSDART00000129831
nlrc6
NLR family CARD domain containing 6
chr4_+_71018579 0.06 ENSDART00000186727
si:dkeyp-80d11.10
si:dkeyp-80d11.10
chr16_+_54829293 0.05 ENSDART00000024729
pabpc1a
poly(A) binding protein, cytoplasmic 1a
chr7_-_22941472 0.05 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr13_-_9300299 0.05 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr20_-_1314537 0.04 ENSDART00000144288
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr9_-_52847881 0.04 ENSDART00000166407
trpm2
transient receptor potential cation channel, subfamily M, member 2
chr19_-_7525588 0.03 ENSDART00000092256
mrpl9
mitochondrial ribosomal protein L9
chr4_+_25693463 0.03 ENSDART00000132864
acot18
acyl-CoA thioesterase 18
chr6_-_43769332 0.03 ENSDART00000128174
foxp1b
forkhead box P1b
chr3_+_52545400 0.02 ENSDART00000184183
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr8_+_52515188 0.02 ENSDART00000163668
si:ch1073-392o20.2
si:ch1073-392o20.2
chr22_+_30331414 0.01 ENSDART00000133482
BX649448.3

chr22_+_24318131 0.00 ENSDART00000187360
ENSDART00000165618
ccdc50
coiled-coil domain containing 50
chr13_-_36418921 0.00 ENSDART00000135804
dcaf5
ddb1 and cul4 associated factor 5
chr2_-_37837472 0.00 ENSDART00000165347
mettl17
methyltransferase like 17
chr3_+_24577021 0.00 ENSDART00000158449
sp100.3
SP110 nuclear body protein, tandem duplicate 3

Network of associatons between targets according to the STRING database.

First level regulatory network of tp73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.1 0.3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.1 0.2 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.1 0.4 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.0 0.2 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.0 0.1 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.0 0.3 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.1 GO:0097384 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.1 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.0 0.2 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.5 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.3 GO:0033198 response to ATP(GO:0033198)
0.0 0.6 GO:0061035 regulation of cartilage development(GO:0061035)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0019835 cytolysis(GO:0019835)
0.0 0.8 GO:0030318 melanocyte differentiation(GO:0030318)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005948 acetolactate synthase complex(GO:0005948)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 0.2 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.1 0.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.1 GO:0003984 acetolactate synthase activity(GO:0003984)
0.0 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.3 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway