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PRJNA207719: Tissue specific transcriptome profiling

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Results for wt1a+wt1b

Z-value: 1.32

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Transcription factors associated with wt1a+wt1b

Gene Symbol Gene ID Gene Info
ENSDARG00000007990 WT1 transcription factor b
ENSDARG00000031420 WT1 transcription factor a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
wt1bdr11_v1_chr18_-_45617146_456171460.118.7e-01Click!
wt1adr11_v1_chr25_-_15214161_15214161-0.059.4e-01Click!

Activity profile of wt1a+wt1b motif

Sorted Z-values of wt1a+wt1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_22535 3.06 ENSDART00000157877

chr2_+_58221163 2.01 ENSDART00000157939

chr11_-_97817 1.76 ENSDART00000092903
engulfment and cell motility 2
chr16_-_44399335 1.45 ENSDART00000165058
regulating synaptic membrane exocytosis 2a
chr16_-_44349845 1.41 ENSDART00000170932
regulating synaptic membrane exocytosis 2a
chr25_+_34984333 1.41 ENSDART00000154760
coiled-coil domain containing 136b
chr2_+_59015878 1.34 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
chr19_+_31771270 1.33 ENSDART00000147474
stathmin 2b
chr2_-_44282796 1.32 ENSDART00000163040
ENSDART00000166923
ENSDART00000056372
ENSDART00000109251
ENSDART00000132682
myelin protein zero
chr19_+_33701558 1.29 ENSDART00000147226
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr23_+_28731379 1.27 ENSDART00000047378
cortistatin
chr1_+_54677173 1.14 ENSDART00000114705
G protein-coupled receptor, class C, group 5, member Bb
chr8_+_23165749 1.11 ENSDART00000063057
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr2_-_9646857 1.11 ENSDART00000056901
zgc:153615
chr10_+_32561317 1.07 ENSDART00000109029
microtubule-associated protein 6a
chr23_-_637347 1.05 ENSDART00000132175
L1 cell adhesion molecule, paralog b
chr5_+_36614196 1.04 ENSDART00000150574
neuro-oncological ventral antigen 1
chr2_+_38924975 1.02 ENSDART00000109219
RAS (RAD and GEM)-like GTP binding 2
chr9_-_54840124 0.97 ENSDART00000137214
ENSDART00000085693
glycoprotein M6Bb
chr19_+_233143 0.96 ENSDART00000175273
synaptic Ras GTPase activating protein 1a
chr6_-_13408680 0.96 ENSDART00000151566
formin-like 2b
chr8_-_22739757 0.96 ENSDART00000182167
ENSDART00000171891
IQ motif and Sec7 domain 2a
chr23_-_3703569 0.95 ENSDART00000143731
protein kinase C and casein kinase substrate in neurons 1a
chr7_+_48460239 0.92 ENSDART00000052113
leucine rich repeat and Ig domain containing 1b
chr7_-_6592142 0.92 ENSDART00000160137
potassium inwardly-rectifying channel, subfamily J, member 10a
chr13_-_638485 0.90 ENSDART00000066080
ENSDART00000128969
slit homolog 1a (Drosophila)
chr19_+_33701366 0.89 ENSDART00000162517
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr20_-_54462551 0.88 ENSDART00000171769
ENSDART00000169692
Enah/Vasp-like b
chr21_-_22114625 0.87 ENSDART00000177426
ENSDART00000135410
ELMO/CED-12 domain containing 1
chr9_-_54001502 0.86 ENSDART00000085253
midline 1
chr1_-_14234076 0.83 ENSDART00000040049
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr21_+_11468642 0.81 ENSDART00000041869
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr21_+_11468934 0.78 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr23_+_44732863 0.78 ENSDART00000160044
ENSDART00000172268
ATPase Na+/K+ transporting subunit beta 2a
chr21_+_13861589 0.78 ENSDART00000015629
ENSDART00000171306
syntaxin binding protein 1a
chr7_+_73630751 0.78 ENSDART00000159745
si:dkey-46i9.1
chr10_-_1718395 0.77 ENSDART00000137620
si:ch73-46j18.5
chr11_-_103136 0.77 ENSDART00000173308
ENSDART00000162982
engulfment and cell motility 2
chr12_+_18606140 0.77 ENSDART00000161128
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b
chr3_+_7617353 0.77 ENSDART00000165551
zgc:109949
chr13_-_27767330 0.76 ENSDART00000131631
ENSDART00000112553
ENSDART00000189911
regulating synaptic membrane exocytosis 1a
chr16_-_12953739 0.76 ENSDART00000103894
calcium channel, voltage-dependent, gamma subunit 8b
chr1_-_14233815 0.75 ENSDART00000044896
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr14_-_12837052 0.75 ENSDART00000165004
ENSDART00000043180
glutamate receptor, ionotropic, AMPA 3b
chr14_+_42172257 0.74 ENSDART00000074362
protocadherin 18b
chr14_+_22172047 0.74 ENSDART00000114750
ENSDART00000148259
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr6_+_59808677 0.73 ENSDART00000164469
calcium/calmodulin-dependent serine protein kinase b
chr13_+_12739283 0.73 ENSDART00000102279
leucine rich repeat and Ig domain containing 2b
chr14_-_12837432 0.73 ENSDART00000178444
glutamate receptor, ionotropic, AMPA 3b
chr13_+_421231 0.73 ENSDART00000188212
ENSDART00000017854
leucine-rich, glioma inactivated 1a
chr15_-_33925851 0.72 ENSDART00000187807
ENSDART00000187780
myelin associated glycoprotein
chr17_-_20711735 0.72 ENSDART00000150056
ankyrin 3b
chr10_+_45128375 0.72 ENSDART00000164805
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr14_+_42172677 0.71 ENSDART00000148544
protocadherin 18b
chr23_-_19953089 0.70 ENSDART00000153828
ATPase plasma membrane Ca2+ transporting 3b
chr12_+_9880493 0.69 ENSDART00000055019
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4
chr8_-_54223316 0.69 ENSDART00000018054
thyrotropin-releasing hormone
chr5_-_46273938 0.69 ENSDART00000080033
si:ch211-130m23.3
chr11_+_6819050 0.69 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr19_+_33701734 0.69 ENSDART00000123270
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_-_10298162 0.69 ENSDART00000007520
leucine rich repeat containing 4.2
chr21_+_28958471 0.68 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr10_-_24343507 0.68 ENSDART00000002974
phosphatidylinositol transfer protein, alpha b
chr12_+_48511605 0.66 ENSDART00000168389
Rho GTPase activating protein 44
chr5_+_64739762 0.65 ENSDART00000161112
ENSDART00000135610
ENSDART00000002908
olfactomedin 1a
chr3_-_62380146 0.64 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr25_+_35706493 0.64 ENSDART00000176741
kinesin family member 21A
chr11_-_32723851 0.63 ENSDART00000155592
protocadherin 17
chr11_+_40649412 0.63 ENSDART00000043016
ENSDART00000134560
solute carrier family 45, member 1
chr6_-_60031693 0.62 ENSDART00000160275

chr19_+_41701660 0.61 ENSDART00000033362
GATA zinc finger domain containing 2B
chr7_-_57949117 0.61 ENSDART00000138803
ankyrin 2b, neuronal
chr1_+_54908895 0.61 ENSDART00000145652
golgin A7 family, member Ba
chr16_+_23600041 0.61 ENSDART00000186918
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr1_-_625875 0.60 ENSDART00000167331
amyloid beta (A4) precursor protein a
chr2_-_44183613 0.60 ENSDART00000079596
cell adhesion molecule 3
chr19_-_867071 0.59 ENSDART00000122257
eomesodermin homolog a
chr17_-_43466317 0.59 ENSDART00000155313
heat shock protein 4 like
chr13_-_31435137 0.58 ENSDART00000057441
reticulon 1a
chr3_+_50312422 0.58 ENSDART00000157689
growth arrest-specific 7a
chr16_+_1803462 0.58 ENSDART00000183974
glutamate ionotropic receptor kainate type subunit 2
chr6_-_52428826 0.57 ENSDART00000047399
matrix metallopeptidase 24
chr8_-_9118958 0.57 ENSDART00000037922
solute carrier family 6 (neurotransmitter transporter), member 8
chr2_-_11912347 0.57 ENSDART00000023851
abhydrolase domain containing 3
chr6_+_6491013 0.57 ENSDART00000140827
B cell CLL/lymphoma 11Ab
chr17_-_22048233 0.57 ENSDART00000155203
tau tubulin kinase 1b
chr11_-_44030962 0.56 ENSDART00000171910

chr16_-_12914288 0.56 ENSDART00000184221
calcium channel, voltage-dependent, gamma subunit 8b
chr4_-_16124417 0.56 ENSDART00000128079
ENSDART00000077664
ATPase plasma membrane Ca2+ transporting 1a
chr10_+_37500234 0.56 ENSDART00000132096
ENSDART00000099473
musashi RNA-binding protein 2a
chr2_-_44183451 0.56 ENSDART00000111246
cell adhesion molecule 3
chr3_-_22829710 0.54 ENSDART00000055659
cytochrome b561
chr12_+_5189776 0.54 ENSDART00000081298
leucine-rich, glioma inactivated 1b
chr8_-_4618653 0.54 ENSDART00000025535
septin 5a
chr5_-_63109232 0.54 ENSDART00000115128
ubiquitin specific peptidase 2b
chr5_+_42912966 0.54 ENSDART00000039973
RUN and FYVE domain containing 3
chr13_+_13693722 0.52 ENSDART00000110509
si:ch211-194c3.5
chr22_-_18112374 0.52 ENSDART00000191154
neurocan b
chr2_+_3595333 0.52 ENSDART00000041052
complement component 1, q subcomponent-like 3b
chr19_+_30633453 0.52 ENSDART00000052124
family with sequence similarity 49, member A-like
chr18_-_15373620 0.51 ENSDART00000031752
regulatory factor X, 4
chr1_+_29858032 0.50 ENSDART00000054066
zic family member 2 (odd-paired homolog, Drosophila) b
chr23_+_19564392 0.50 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr12_+_41510492 0.50 ENSDART00000170976
ENSDART00000176164
kinesin family member 5B, b
chr24_+_41931585 0.50 ENSDART00000130310
erythrocyte membrane protein band 4.1-like 3a
chr2_+_26303627 0.50 ENSDART00000040278
ephrin-A2a
chr21_-_24865217 0.50 ENSDART00000101136
immunoglobulin superfamily, member 9Bb
chr5_-_6433577 0.49 ENSDART00000160439

chr7_+_38762043 0.49 ENSDART00000036461
Rho GTPase activating protein 1
chr5_-_52277643 0.48 ENSDART00000010757
repulsive guidance molecule family member b
chr11_+_41560792 0.48 ENSDART00000127292
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr7_+_10701770 0.48 ENSDART00000167323
aryl-hydrocarbon receptor nuclear translocator 2
chr14_+_11103718 0.48 ENSDART00000161311
neurite extension and migration factor b
chr2_-_52550135 0.48 ENSDART00000044411
guanine nucleotide binding protein (G protein), alpha 11b (Gq class)
chr4_+_6840223 0.48 ENSDART00000161329
dedicator of cytokinesis 4b
chr25_-_19395476 0.47 ENSDART00000182622
microtubule-associated protein 1Ab
chr5_-_31928913 0.46 ENSDART00000142919
slingshot protein phosphatase 1b
chr17_+_11507131 0.46 ENSDART00000013170
kinesin family member 26Ba
chr2_-_48753873 0.46 ENSDART00000189556

chr22_-_34872533 0.45 ENSDART00000167176
slit homolog 1b (Drosophila)
chr10_-_35542071 0.45 ENSDART00000162139
si:ch211-244c8.4
chr8_-_39977026 0.44 ENSDART00000141707
aspartate beta-hydroxylase domain containing 2
chr13_+_25428677 0.44 ENSDART00000186284
si:dkey-51a16.9
chr14_-_52552875 0.42 ENSDART00000170107
protein phosphatase 2, regulatory subunit B, beta a
chr7_+_10701938 0.41 ENSDART00000158162
aryl-hydrocarbon receptor nuclear translocator 2
chr22_+_12366516 0.41 ENSDART00000157802
R3H domain containing 1
chr14_-_45346558 0.41 ENSDART00000090844
zgc:153018
chr6_-_58828113 0.40 ENSDART00000180934
kinesin family member 5A, b
chr23_+_6752828 0.40 ENSDART00000105179
zgc:158254
chr2_+_1001560 0.40 ENSDART00000134656
calcium channel, voltage-dependent, R type, alpha 1E subunit b
chr22_-_600016 0.40 ENSDART00000086434
transmembrane and coiled-coil domain family 2
chr15_+_1397811 0.40 ENSDART00000102125
schwannomin interacting protein 1
chr20_-_39219537 0.40 ENSDART00000005764
cytochrome P450, family 39, subfamily A, polypeptide 1
chr13_-_36184476 0.40 ENSDART00000057185
mitogen-activated protein kinase kinase kinase 9
chr25_-_19395156 0.40 ENSDART00000155335
microtubule-associated protein 1Ab
chr15_-_14486534 0.40 ENSDART00000179368
numb homolog (Drosophila)-like
chr3_-_6767440 0.39 ENSDART00000156174
microtubule associated serine/threonine kinase 1b
chr14_-_2369849 0.39 ENSDART00000180422
ENSDART00000189731
ENSDART00000111748
protocadherin b
chr23_+_27912079 0.39 ENSDART00000171859

chr9_-_30363770 0.38 ENSDART00000147030
synaptotagmin-like 5
chr12_-_48943467 0.38 ENSDART00000191829

chr17_+_6793001 0.38 ENSDART00000030773
forkhead box O3A
chr16_+_14710436 0.38 ENSDART00000027982
collagen, type XIV, alpha 1a
chr3_-_36944749 0.38 ENSDART00000154501
contactin associated protein 1
chr7_-_51627019 0.37 ENSDART00000174111
NHS-like 2
chr10_-_32851847 0.37 ENSDART00000134255
tripartite motif containing 37
chr25_+_24250247 0.37 ENSDART00000064646
transmembrane protein 86A
chr14_+_2243 0.37 ENSDART00000191193
cytokine like 1
chr4_-_2525916 0.37 ENSDART00000134123
ENSDART00000132581
ENSDART00000019508
cysteine and glycine-rich protein 2
chr2_-_364839 0.36 ENSDART00000155651
SHANK-associated RH domain interacting protein
chr21_-_24865454 0.36 ENSDART00000142907
immunoglobulin superfamily, member 9Bb
chr15_+_47418565 0.36 ENSDART00000155709
ClpB homolog, mitochondrial AAA ATPase chaperonin
chr13_+_1100197 0.36 ENSDART00000139560
protein phosphatase 3, regulatory subunit B, alpha a
chr9_+_22632126 0.35 ENSDART00000139434
ets variant 5a
chr21_-_11054876 0.35 ENSDART00000146576
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_41602 0.35 ENSDART00000159640
putative homeodomain transcription factor 2
chr18_+_3169579 0.35 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
p21 protein (Cdc42/Rac)-activated kinase 1
chr7_+_74141297 0.35 ENSDART00000164992
RNA binding protein with multiple splicing
chr4_-_789645 0.35 ENSDART00000164441
microtubule-associated protein, RP/EB family, member 3b
chr21_-_39058490 0.34 ENSDART00000114885
aldehyde dehydrogenase 3 family, member A2b
chr3_+_12322170 0.34 ENSDART00000161227
GLIS family zinc finger 2b
chr2_-_7431590 0.34 ENSDART00000185699
agouti signaling protein, nonagouti homolog (mouse) 2b
chr5_+_51443009 0.34 ENSDART00000083350
Ras protein-specific guanine nucleotide-releasing factor 2b
chr24_-_25364775 0.34 ENSDART00000151915
patched domain containing 1
chr1_-_59422880 0.33 ENSDART00000167244
si:ch211-188p14.2
chr23_+_44665230 0.33 ENSDART00000144958
calmodulin binding transcription activator 2
chr7_+_31051213 0.33 ENSDART00000148347
tight junction protein 1a
chr10_+_1849874 0.33 ENSDART00000158897
ENSDART00000149956
adenomatous polyposis coli
chr10_-_28835771 0.33 ENSDART00000192220
ENSDART00000188436
activated leukocyte cell adhesion molecule a
chr3_-_30861177 0.33 ENSDART00000154811
SH3 and multiple ankyrin repeat domains 1
chr6_-_57655030 0.32 ENSDART00000155438
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr6_+_2271559 0.32 ENSDART00000165223
pre-B-cell leukemia homeobox 1b
chr9_-_33725972 0.32 ENSDART00000028225
monoamine oxidase
chr7_-_18168493 0.31 ENSDART00000127428
pellino E3 ubiquitin protein ligase family member 3
chr16_+_13822137 0.31 ENSDART00000163251
folliculin
chr4_-_5018705 0.31 ENSDART00000154025
striatin interacting protein 2
chr8_+_26868105 0.31 ENSDART00000005337
ribosomal modification protein rimK-like family member A
chr15_-_42736433 0.31 ENSDART00000154379
si:ch211-181d7.1
chr5_-_18446483 0.31 ENSDART00000180027
si:dkey-215k6.1
chr19_+_1097393 0.31 ENSDART00000168218

chr17_+_52822422 0.31 ENSDART00000158273
ENSDART00000161414
Meis homeobox 2a
chr3_+_32789605 0.30 ENSDART00000171895
TBC1 domain family, member 10b
chr14_-_2933185 0.30 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
chr14_-_21218891 0.30 ENSDART00000158294
protein phosphatase 2, regulatory subunit B, gamma b
chr16_-_46766153 0.30 ENSDART00000115244
mex-3 RNA binding family member A
chr22_+_10713713 0.30 ENSDART00000122349
hippocampus abundant transcript 1b
chr5_+_43458304 0.30 ENSDART00000051114
Rho-related BTB domain containing 2a
chr5_-_41142467 0.30 ENSDART00000129415
zinc finger RNA binding protein
chr21_+_38312549 0.30 ENSDART00000065159
zgc:158291
chr11_+_1796426 0.29 ENSDART00000173330
low density lipoprotein receptor-related protein 1Aa
chr9_+_13714379 0.29 ENSDART00000017593
ENSDART00000145503
transmembrane protein 237a
chr3_-_11624694 0.29 ENSDART00000127157
hepatic leukemia factor a
chr1_+_57371447 0.29 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
chr15_+_47582207 0.29 ENSDART00000159388

chr19_+_63567 0.29 ENSDART00000165657
ENSDART00000165183
zinc fingers and homeoboxes 2b
chr5_-_14390445 0.29 ENSDART00000026120
adaptor-related protein complex 3, mu 2 subunit
chr9_+_51891 0.28 ENSDART00000163529
zgc:158316
chr22_-_21676364 0.28 ENSDART00000183668
transducin like enhancer of split 2b
chr3_+_22079219 0.28 ENSDART00000122782
KAT8 regulatory NSL complex subunit 1b
chr10_+_4874542 0.28 ENSDART00000101431
paralemmin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of wt1a+wt1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:1903792 negative regulation of anion transport(GO:1903792)
0.3 0.3 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.3 1.5 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.2 0.7 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.2 0.6 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 3.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.6 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.1 0.9 GO:0036268 swimming(GO:0036268)
0.1 0.6 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.5 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.6 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 0.3 GO:0032369 negative regulation of lipid transport(GO:0032369)
0.1 0.6 GO:0034505 tooth mineralization(GO:0034505)
0.1 1.4 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.3 GO:1904969 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.1 1.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.3 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.1 2.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 1.3 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.5 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 0.9 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.1 1.9 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 0.6 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.6 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1 0.5 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.1 0.4 GO:0008206 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.1 0.5 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.1 0.3 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 0.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.4 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 0.5 GO:1904861 excitatory synapse assembly(GO:1904861)
0.1 0.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.4 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.2 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.1 0.2 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
0.0 0.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 2.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 0.3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.5 GO:0098900 regulation of action potential(GO:0098900)
0.0 0.8 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.2 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.2 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.4 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.3 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 0.2 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.4 GO:0032288 myelin assembly(GO:0032288)
0.0 0.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.3 GO:0043363 nucleate erythrocyte differentiation(GO:0043363)
0.0 0.3 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.3 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.0 0.3 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.3 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 2.5 GO:0042552 myelination(GO:0042552)
0.0 0.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.2 GO:1904019 epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035)
0.0 0.3 GO:0006868 glutamine transport(GO:0006868)
0.0 0.2 GO:0060855 venous endothelial cell migration involved in lymph vessel development(GO:0060855)
0.0 0.7 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.5 GO:0030316 osteoclast differentiation(GO:0030316)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.4 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.4 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.3 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.1 GO:0015884 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.0 0.6 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 0.4 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.3 GO:1902307 positive regulation of sodium ion transport(GO:0010765) positive regulation of potassium ion transport(GO:0043268) positive regulation of potassium ion transmembrane transport(GO:1901381) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 2.8 GO:0006909 phagocytosis(GO:0006909)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.5 GO:0021602 cranial nerve morphogenesis(GO:0021602)
0.0 0.1 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.6 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.6 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.2 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.1 GO:0003139 secondary heart field specification(GO:0003139)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:0060349 bone morphogenesis(GO:0060349)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.2 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.1 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 0.3 GO:0050890 cognition(GO:0050890)
0.0 0.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.1 GO:0031274 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.7 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.2 GO:0097120 receptor localization to synapse(GO:0097120)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0070062 extracellular exosome(GO:0070062)
0.1 3.6 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.0 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.6 GO:0043209 myelin sheath(GO:0043209)
0.1 0.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 0.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 2.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.4 GO:0033010 paranodal junction(GO:0033010)
0.1 0.4 GO:0016234 inclusion body(GO:0016234)
0.0 0.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.6 GO:0030315 T-tubule(GO:0030315)
0.0 1.3 GO:0030426 growth cone(GO:0030426)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0044545 NSL complex(GO:0044545)
0.0 0.1 GO:1990879 CST complex(GO:1990879)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.5 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0005844 polysome(GO:0005844)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0030141 secretory granule(GO:0030141)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0016586 RSC complex(GO:0016586)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 0.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 0.5 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.7 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.3 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.1 1.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 1.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.6 GO:0015157 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 4.3 GO:0044325 ion channel binding(GO:0044325)
0.1 0.3 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 0.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.2 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.0 2.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 2.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 0.4 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 1.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.0 0.7 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.8 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.4 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.1 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 1.9 GO:0016247 channel regulator activity(GO:0016247)
0.0 0.5 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0015350 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.0 0.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 3.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0004061 arylformamidase activity(GO:0004061)
0.0 0.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 1.2 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.2 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.0 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 2.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0004970 ionotropic glutamate receptor activity(GO:0004970)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway
0.0 0.4 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction