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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Tbr1

Z-value: 0.84

Motif logo

Transcription factors associated with Tbr1

Gene Symbol Gene ID Gene Info
ENSRNOG00000005049 T-box, brain, 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbr1rn6_v1_chr3_+_47677720_476777200.138.3e-01Click!

Activity profile of Tbr1 motif

Sorted Z-values of Tbr1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_109300433 0.71 ENSRNOT00000010712
FBJ osteosarcoma oncogene
chr7_-_82059247 0.36 ENSRNOT00000087177
R-spondin 2
chr1_+_219250265 0.34 ENSRNOT00000024353
double C2-like domains, gamma
chr14_+_63405408 0.30 ENSRNOT00000086658

chr1_-_169513537 0.30 ENSRNOT00000078058
tripartite motif-containing 30C
chr10_+_14136883 0.27 ENSRNOT00000082295

chr6_-_115513354 0.27 ENSRNOT00000005881
stonin 2
chr1_-_82004538 0.27 ENSRNOT00000087572
POU class 2 homeobox 2
chr5_-_74029238 0.26 ENSRNOT00000031432
ferric-chelate reductase 1-like
chr6_+_106039991 0.26 ENSRNOT00000088917
signal-induced proliferation-associated 1 like 1
chr1_-_25839198 0.26 ENSRNOT00000090388
ENSRNOT00000092757
ENSRNOT00000042072
triadin
chr1_-_199655147 0.25 ENSRNOT00000026979
zinc finger protein 239-like
chr3_-_43119159 0.25 ENSRNOT00000041394
nuclear receptor subfamily 4, group A, member 2
chr2_+_251200686 0.25 ENSRNOT00000019210
collagen type XXIV alpha 1 chain
chr9_-_20528879 0.24 ENSRNOT00000085293

chr20_-_22459025 0.24 ENSRNOT00000000792
early growth response 2
chr8_+_58431407 0.24 ENSRNOT00000011974
sarcolipin
chr7_-_144936803 0.23 ENSRNOT00000055279
G protein-coupled receptor 84
chr9_-_81566642 0.23 ENSRNOT00000080345
angio-associated, migratory cell protein
chr13_-_61591139 0.22 ENSRNOT00000005324
regulator of G-protein signaling 18
chr18_+_25613831 0.22 ENSRNOT00000091040
thymic stromal lymphopoietin
chr10_+_64737022 0.21 ENSRNOT00000017071
ENSRNOT00000093232
ENSRNOT00000017042
ENSRNOT00000093244
galectin 9
chr7_-_123892429 0.21 ENSRNOT00000037681
NFAT activating protein with ITAM motif 1
chr8_-_64305330 0.20 ENSRNOT00000030199
transmembrane protein 202
chr1_+_142679345 0.20 ENSRNOT00000034267
zinc finger and SCAN domain containing 2
chr5_+_74727494 0.20 ENSRNOT00000076683

chr15_+_62406873 0.20 ENSRNOT00000047572
olfactomedin 4
chr1_-_219168177 0.20 ENSRNOT00000023789
aldehyde dehydrogenase 3 family, member B1
chr5_-_136098013 0.20 ENSRNOT00000089166
RGD1563714
chr13_+_101790865 0.20 ENSRNOT00000087784
TATA-box binding protein associated factor, RNA polymerase I subunit A
chr2_+_140471690 0.20 ENSRNOT00000017379
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr8_-_45137893 0.19 ENSRNOT00000010743
similar to hypothetical protein FLJ23554
chr1_-_227047290 0.19 ENSRNOT00000037226
membrane spanning 4-domains A15
chrX_+_13117239 0.19 ENSRNOT00000088998

chr1_+_170242846 0.19 ENSRNOT00000023751
cyclic nucleotide gated channel alpha 4
chr1_+_80777014 0.19 ENSRNOT00000079758
predicted gene, 19345
chr10_+_11912543 0.19 ENSRNOT00000045192
zinc finger protein 597
chr16_-_32868680 0.19 ENSRNOT00000015974
ENSRNOT00000082392
aminoadipate aminotransferase
chr20_+_4043741 0.18 ENSRNOT00000000525
RT1 class II, locus Bb
chr11_-_81444375 0.18 ENSRNOT00000058479
ENSRNOT00000078131
ENSRNOT00000080949
ENSRNOT00000080562
ENSRNOT00000084867
kininogen 1
chr1_+_161401527 0.18 ENSRNOT00000015181
teneurin transmembrane protein 4
chr10_-_87541851 0.18 ENSRNOT00000089610
similar to keratin associated protein 2-4
chr3_+_15560712 0.18 ENSRNOT00000010218
prostaglandin-endoperoxide synthase 1
chr9_-_15700235 0.18 ENSRNOT00000088713
ENSRNOT00000035907
transcriptional regulating factor 1
chr8_+_33239139 0.17 ENSRNOT00000011589
Rho GTPase activating protein 32
chr5_+_164808323 0.17 ENSRNOT00000011005
natriuretic peptide A
chr12_-_41448668 0.17 ENSRNOT00000001856
RAS protein activator like 1 (GAP1 like)
chr14_-_92495894 0.17 ENSRNOT00000064483
cordon-bleu WH2 repeat protein
chr5_-_106207126 0.17 ENSRNOT00000015094
MLLT3, super elongation complex subunit
chr15_-_42898150 0.16 ENSRNOT00000030036
protein tyrosine kinase 2 beta
chr7_+_64769089 0.16 ENSRNOT00000088861
glutamate receptor interacting protein 1
chr4_+_171250818 0.16 ENSRNOT00000040576
protein tyrosine phosphatase, receptor type, O
chr12_-_9990284 0.16 ENSRNOT00000001264
RAS-like family 11 member A
chr17_-_10622063 0.16 ENSRNOT00000022980
SUMO-interacting motifs containing 1
chr2_-_25153334 0.16 ENSRNOT00000024191
corticotropin releasing hormone binding protein
chr7_+_121841855 0.15 ENSRNOT00000024673
GRB2-related adaptor protein 2
chr7_-_80457816 0.15 ENSRNOT00000039430

chr15_+_1054937 0.15 ENSRNOT00000008154

chr19_-_56037077 0.15 ENSRNOT00000021968
spermatogenesis associated 2-like
chr13_+_50103189 0.15 ENSRNOT00000004078
ATPase plasma membrane Ca2+ transporting 4
chr14_+_12218553 0.15 ENSRNOT00000003237
protein kinase, cGMP-dependent, type II
chr9_-_104350308 0.15 ENSRNOT00000033958
solute carrier organic anion transporter family, member 4C1
chr4_-_51586881 0.15 ENSRNOT00000064983
IQ motif and ubiquitin domain containing
chr1_+_42169501 0.15 ENSRNOT00000025477
ENSRNOT00000092791
vasoactive intestinal peptide
chr10_+_1622573 0.15 ENSRNOT00000040132
ENSRNOT00000090207
ENSRNOT00000089118

chr19_+_39063998 0.14 ENSRNOT00000081116
hyaluronan synthase 3
chr13_+_50974872 0.14 ENSRNOT00000080768
chitinase 1
chr10_-_57121584 0.14 ENSRNOT00000029421
vitelline membrane outer layer 1 homolog
chr10_-_74119009 0.14 ENSRNOT00000085712
ENSRNOT00000006926
DEAH-box helicase 40
chr15_+_83442144 0.14 ENSRNOT00000039344
bora, aurora kinase A activator
chr1_+_196996581 0.14 ENSRNOT00000021690
interleukin 21 receptor
chr8_+_29453643 0.14 ENSRNOT00000090643
opioid binding protein/cell adhesion molecule-like
chr6_-_25616995 0.14 ENSRNOT00000077894
FOS like 2, AP-1 transcription factor subunit
chr13_-_50509916 0.14 ENSRNOT00000076747
renin
chr1_-_155955173 0.14 ENSRNOT00000079345

chr17_-_1610745 0.14 ENSRNOT00000025850
hydroxysteroid (17-beta) dehydrogenase 3
chr1_+_84584596 0.14 ENSRNOT00000032933
zinc finger protein 60-like
chr4_-_124338176 0.14 ENSRNOT00000016628
prickle planar cell polarity protein 2
chr4_+_2053712 0.14 ENSRNOT00000045086
ring finger protein 32
chr7_+_48867664 0.14 ENSRNOT00000005862
PTPRF interacting protein alpha 2
chr18_-_37096132 0.13 ENSRNOT00000041188
protein phosphatase 2, regulatory subunit B, beta
chr12_+_2534212 0.13 ENSRNOT00000001399
cortexin 1
chr4_+_158224000 0.13 ENSRNOT00000084240
ENSRNOT00000078495
anoctamin 2
chr7_+_15422479 0.13 ENSRNOT00000066520
zinc finger protein 563
chr3_+_71437241 0.13 ENSRNOT00000046112
LRRG00114
chr10_-_91661558 0.13 ENSRNOT00000043156

chr7_-_104801045 0.13 ENSRNOT00000079524
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr1_-_261446570 0.13 ENSRNOT00000020182
secreted frizzled-related protein 5
chrX_-_142248369 0.13 ENSRNOT00000091330
fibroblast growth factor 13
chr18_+_68984051 0.13 ENSRNOT00000002969
StAR-related lipid transfer domain containing 6
chrX_-_70428364 0.13 ENSRNOT00000045907
pyrimidinergic receptor P2Y4
chr13_+_21678512 0.13 ENSRNOT00000047108
contactin associated protein-like 5B
chr1_-_82003691 0.13 ENSRNOT00000084569
POU class 2 homeobox 2
chr13_-_89661150 0.13 ENSRNOT00000058390
ubiquitin specific peptidase 21
chr4_+_62299044 0.13 ENSRNOT00000032077
ATP/GTP binding protein-like 3
chr13_+_80464348 0.13 ENSRNOT00000076324
vesicle-associated membrane protein 4
chr20_+_14578605 0.13 ENSRNOT00000041165
rhabdoid tumor deletion region gene 1
chr17_+_10066187 0.12 ENSRNOT00000091200
ubiquitin interaction motif containing 1
chr1_+_21613148 0.12 ENSRNOT00000018695
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr16_+_39909270 0.12 ENSRNOT00000081994
WD repeat domain 17
chr20_-_45126062 0.12 ENSRNOT00000000720
similar to KIAA1919 protein
chr5_+_2654065 0.12 ENSRNOT00000074957
uncharacterized LOC100912291
chr4_+_78371121 0.12 ENSRNOT00000059157
GTPase, IMAP family member 1
chr1_-_42486035 0.12 ENSRNOT00000025398
mitochondrial translational release factor 1-like
chr5_+_58661049 0.12 ENSRNOT00000078274
unc-13 homolog B
chr2_-_19808937 0.12 ENSRNOT00000044237
ATPase H+ transporting accessory protein 1 like
chr14_-_108658371 0.12 ENSRNOT00000008919
poly(A) polymerase gamma
chr13_-_103080920 0.12 ENSRNOT00000034990

chr1_+_248647170 0.12 ENSRNOT00000015016
tumor protein D52-like 3
chr3_-_6626284 0.12 ENSRNOT00000012494
ficolin B
chr17_-_21739408 0.12 ENSRNOT00000060335
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr1_+_88875375 0.12 ENSRNOT00000028284
Tyro protein tyrosine kinase binding protein
chr20_-_6500523 0.12 ENSRNOT00000000629
copine 5
chr1_-_97785490 0.12 ENSRNOT00000019364
LRRGT00021
chr1_+_87938042 0.12 ENSRNOT00000027837
mitogen activated protein kinase kinase kinase kinase 1
chr13_-_74331214 0.12 ENSRNOT00000006018
FAM20B, glycosaminoglycan xylosylkinase
chr3_+_72080630 0.12 ENSRNOT00000008911
mediator complex subunit 19
chr9_+_61738471 0.12 ENSRNOT00000090305

chr4_+_181103774 0.12 ENSRNOT00000084207
ENSRNOT00000055473
ENSRNOT00000077619
aryl hydrocarbon receptor nuclear translocator-like 2
chr1_+_47942800 0.12 ENSRNOT00000079312
Wilms tumor 1 associated protein
chr7_-_70498992 0.12 ENSRNOT00000067774
ENSRNOT00000079327
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr4_-_118342176 0.11 ENSRNOT00000032477

chr2_-_23289266 0.11 ENSRNOT00000061708
betaine-homocysteine S-methyltransferase 2
chr1_+_73837944 0.11 ENSRNOT00000036413
leukocyte-associated immunoglobulin-like receptor 1
chr7_-_104800536 0.11 ENSRNOT00000085650
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr13_+_48644604 0.11 ENSRNOT00000084259
ENSRNOT00000073669
RAB29, member RAS oncogene family
chr11_-_32508420 0.11 ENSRNOT00000002717
potassium voltage-gated channel subfamily E regulatory subunit 1
chr8_+_113105814 0.11 ENSRNOT00000016749
copine 4
chr8_-_83280888 0.11 ENSRNOT00000052341
GDNF family receptor alpha like
chr8_-_22336794 0.11 ENSRNOT00000066340
adaptor-related protein complex 1, mu 2 subunit
chr6_+_107517668 0.11 ENSRNOT00000013753
acyl-CoA thioesterase 4
chr1_+_48077033 0.11 ENSRNOT00000020100
MAS1 proto-oncogene, G protein-coupled receptor
chr2_+_55835151 0.11 ENSRNOT00000018634
FYN binding protein
chr4_+_114854458 0.11 ENSRNOT00000013312
hypothetical gene supported by BC079424
chr10_+_1920529 0.11 ENSRNOT00000072296
RIKEN cDNA A630010A05 gene
chr3_+_100768637 0.11 ENSRNOT00000083542
brain-derived neurotrophic factor
chr3_-_153321352 0.11 ENSRNOT00000064824
RB transcriptional corepressor like 1
chr9_+_12114977 0.11 ENSRNOT00000073673

chr2_-_52492509 0.11 ENSRNOT00000021964
NIM1 serine/threonine protein kinase
chr18_-_44141865 0.11 ENSRNOT00000083407
NACHT and WD repeat domain-containing protein 2-like
chr2_-_106703401 0.11 ENSRNOT00000043933

chr2_-_211322719 0.11 ENSRNOT00000027493
similar to KIAA1324 protein
chr5_+_104698040 0.11 ENSRNOT00000009127
ADAMTS-like 1
chr7_+_143096874 0.11 ENSRNOT00000010881
similar to RIKEN cDNA 1700011A15
chr7_-_97994586 0.11 ENSRNOT00000077616
WDYHV motif containing 1
chr13_+_113691932 0.11 ENSRNOT00000084709
CD34 molecule
chr3_+_48626038 0.10 ENSRNOT00000009697
grancalcin
chr15_-_33629699 0.10 ENSRNOT00000023302
myosin heavy chain 6
chr10_+_69423086 0.10 ENSRNOT00000000256
C-C motif chemokine ligand 7
chr3_-_123849788 0.10 ENSRNOT00000028869
ring finger protein 24
chr1_+_105094411 0.10 ENSRNOT00000036258
HIV-1 Tat interactive protein 2
chr13_-_70626252 0.10 ENSRNOT00000036947
laminin subunit gamma 2
chr20_+_28572242 0.10 ENSRNOT00000072485
SH3 domain containing ring finger 3
chr2_-_21698937 0.10 ENSRNOT00000080165

chr10_+_53570989 0.10 ENSRNOT00000064764
ENSRNOT00000004516
transmembrane protein 220
chr2_-_198834038 0.10 ENSRNOT00000031484
nudix hydrolase 17
chr9_-_30251388 0.10 ENSRNOT00000035033
succinate dehydrogenase complex assembly factor 4
chr1_-_151106802 0.10 ENSRNOT00000021971
tyrosinase
chr1_-_72377434 0.10 ENSRNOT00000022193
zinc finger protein 524
chr20_-_3401273 0.10 ENSRNOT00000089257
ENSRNOT00000078451
ENSRNOT00000001085
nurim (nuclear envelope membrane protein)
chr6_+_78567970 0.10 ENSRNOT00000032743
tetratricopeptide repeat domain 6
chr7_+_41475163 0.10 ENSRNOT00000037844
dual specificity phosphatase 6
chr3_+_159321310 0.10 ENSRNOT00000045677
ENSRNOT00000063906
l(3)mbt-like 1 (Drosophila)
chr5_+_59228199 0.10 ENSRNOT00000060282
histidine rich carboxyl terminus 1
chr1_-_71290337 0.10 ENSRNOT00000063956
zinc finger protein 667
chr14_-_3462629 0.10 ENSRNOT00000061538
bromodomain testis associated
chr1_+_205706468 0.10 ENSRNOT00000089957
ENSRNOT00000023877
erythroid differentiation regulatory factor 1
chr3_-_67668772 0.10 ENSRNOT00000010247
frizzled-related protein
chr2_-_210766501 0.10 ENSRNOT00000025800
glutathione S-transferase mu 3
chr11_+_27208564 0.10 ENSRNOT00000002158
MAP3K7 C-terminal like
chr7_+_23960378 0.10 ENSRNOT00000006886
PR/SET domain 4
chr10_-_68926264 0.10 ENSRNOT00000008661
prohibitin, pseudogene 1
chr12_-_31629881 0.09 ENSRNOT00000001238
piwi-like RNA-mediated gene silencing 1
chr15_+_27739251 0.09 ENSRNOT00000011840
poly (ADP-ribose) polymerase 2
chr6_-_50923510 0.09 ENSRNOT00000010631
B-cell receptor-associated protein 29
chr10_-_73865364 0.09 ENSRNOT00000005226
ribosomal protein S6 kinase B1
chr10_-_103685844 0.09 ENSRNOT00000064284
Cd300 molecule-like family member F
chrX_+_120859968 0.09 ENSRNOT00000085185
WD repeat domain 44
chr7_-_12899004 0.09 ENSRNOT00000011086
granzyme M
chr16_-_84939323 0.09 ENSRNOT00000022742
myosin XVI
chrX_+_16946207 0.09 ENSRNOT00000003981
similar to cysteine-rich protein 2
chrX_+_104734082 0.09 ENSRNOT00000005020
sushi-repeat-containing protein, X-linked 2
chr7_+_14891001 0.09 ENSRNOT00000041034
cytochrome P450, family 4, subfamily f, polypeptide 4
chr3_-_36660758 0.09 ENSRNOT00000006111
Rho family GTPase 3
chr18_+_69549937 0.09 ENSRNOT00000041227
mex-3 RNA binding family member C
chr2_+_58448917 0.09 ENSRNOT00000082562
RAN binding protein 3-like
chr15_+_48674380 0.09 ENSRNOT00000018762
F-box protein 16
chr1_+_266333440 0.09 ENSRNOT00000071243
sideroflexin 2
chr7_+_116355698 0.09 ENSRNOT00000076693
lymphocyte antigen 6 complex, locus E
chr1_+_89220083 0.09 ENSRNOT00000093144
dermokine
chr19_-_11341863 0.09 ENSRNOT00000025694
metallothionein 4
chr7_+_34326087 0.09 ENSRNOT00000006971
histidine ammonia lyase
chrX_-_68562873 0.09 ENSRNOT00000076193
oligophrenin 1
chr7_-_120744602 0.09 ENSRNOT00000018564
potassium voltage-gated channel subfamily J member 4
chr1_-_128695995 0.09 ENSRNOT00000077020
synemin
chr1_+_88581206 0.09 ENSRNOT00000087931
zinc finger protein 382
chr17_-_21705773 0.09 ENSRNOT00000078010
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr17_+_9595761 0.09 ENSRNOT00000089990
family with sequence similarity 193, member B
chr19_+_9622611 0.09 ENSRNOT00000061498
solute carrier family 38, member 7
chr1_+_248195797 0.09 ENSRNOT00000066891
tumor protein D55-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.1 0.4 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.1 0.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.3 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.1 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 0.3 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.1 0.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 0.2 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.1 0.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.2 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.1 0.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0017143 insecticide metabolic process(GO:0017143)
0.0 0.1 GO:2000041 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:2001038 regulation of cellular response to drug(GO:2001038)
0.0 0.1 GO:1905243 response to 3,3',5-triiodo-L-thyronine(GO:1905242) cellular response to 3,3',5-triiodo-L-thyronine(GO:1905243)
0.0 0.1 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0035759 mesangial cell-matrix adhesion(GO:0035759)
0.0 0.2 GO:0002125 maternal aggressive behavior(GO:0002125)
0.0 0.1 GO:1900106 hyaluranon cable assembly(GO:0036118) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0 0.2 GO:0048669 somite specification(GO:0001757) collateral sprouting in absence of injury(GO:0048669)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0 0.1 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.0 0.3 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:2000426 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
0.0 0.1 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.0 0.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.1 GO:0019556 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) formamide metabolic process(GO:0043606)
0.0 0.1 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.1 GO:0002018 angiotensin maturation(GO:0002003) renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.2 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 0.1 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) renal artery morphogenesis(GO:0061441) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.0 0.2 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.0 0.1 GO:1903116 positive regulation of actin filament-based movement(GO:1903116)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.1 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.0 0.1 GO:0072566 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.1 GO:0032639 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
0.0 0.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.1 GO:2000541 positive regulation of synaptic growth at neuromuscular junction(GO:0045887) regulation of protein geranylgeranylation(GO:2000539) positive regulation of protein geranylgeranylation(GO:2000541)
0.0 0.2 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.2 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.1 GO:0001905 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.0 0.1 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.2 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.1 GO:2000118 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.2 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808) presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.1 GO:2000830 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
0.0 0.0 GO:0090244 planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.0 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0060689 cell differentiation involved in salivary gland development(GO:0060689)
0.0 0.1 GO:2000851 positive regulation of glucocorticoid secretion(GO:2000851)
0.0 0.1 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.0 GO:0033986 response to methanol(GO:0033986)
0.0 0.0 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.1 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.0 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.0 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.1 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 0.1 GO:1903441 protein localization to ciliary membrane(GO:1903441)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799)
0.0 0.1 GO:0061193 taste bud development(GO:0061193)
0.0 0.1 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.1 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.0 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.0 GO:1905073 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0 0.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.0 0.0 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.0 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.0 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.0 GO:2000173 negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0 0.2 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 0.1 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.1 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0035976 AP1 complex(GO:0035976)
0.1 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0036117 hyaluranon cable(GO:0036117)
0.0 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.0 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801)
0.0 0.2 GO:0036396 MIS complex(GO:0036396)
0.0 0.1 GO:0005607 laminin-2 complex(GO:0005607)
0.0 0.1 GO:0032398 MHC class Ib protein complex(GO:0032398)
0.0 0.1 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.0 0.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)
0.0 0.1 GO:0090534 calcium ion-transporting ATPase complex(GO:0090534)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.0 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 0.2 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.0 GO:0016935 glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.0 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.1 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.1 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
0.0 0.0 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.1 GO:0070976 TIR domain binding(GO:0070976)
0.0 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0005148 3-keto sterol reductase activity(GO:0000253) prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.0 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.0 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.1 GO:0043199 sulfate binding(GO:0043199)
0.0 0.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.0 GO:0001847 opsonin receptor activity(GO:0001847)
0.0 0.0 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.0 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.0 GO:1903924 estradiol binding(GO:1903924)
0.0 0.0 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.0 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
0.0 0.0 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
0.0 0.1 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.0 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0015266 protein channel activity(GO:0015266)
0.0 0.0 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.0 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.0 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.0 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021) vascular endothelial growth factor binding(GO:0038085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate