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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Egr4

Z-value: 0.43

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Transcription factors associated with Egr4

Gene Symbol Gene ID Gene Info
Egr4
ENSRNOG00000015719 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr4rn6_v1_chr4_-_117296082_1172960820.396.5e-13Click!

Activity profile of Egr4 motif

Sorted Z-values of Egr4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_22478752 12.71 ENSRNOT00000089392
ENSRNOT00000086915
Ache
acetylcholinesterase
chr13_+_51958834 10.42 ENSRNOT00000007833
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr11_-_55044581 9.93 ENSRNOT00000046330
Morc1
MORC family CW-type zinc finger 1
chr10_-_105552986 8.48 ENSRNOT00000014699
Ube2o
ubiquitin-conjugating enzyme E2O
chr10_-_27179254 8.37 ENSRNOT00000004619
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr7_-_59514939 8.34 ENSRNOT00000085579
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr15_-_61772516 7.07 ENSRNOT00000015605
ENSRNOT00000093399
Wbp4
WW domain binding protein 4
chr1_-_103256823 6.93 ENSRNOT00000018860
Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr1_+_256955652 6.46 ENSRNOT00000020411
Lgi1
leucine-rich, glioma inactivated 1
chr8_+_22050222 6.33 ENSRNOT00000028096
Icam5
intercellular adhesion molecule 5
chr8_-_48762342 6.26 ENSRNOT00000049125
Foxr1
forkhead box R1
chr10_-_85517683 6.12 ENSRNOT00000016070
Srcin1
SRC kinase signaling inhibitor 1
chr10_+_13836128 5.81 ENSRNOT00000012720
Pgp
phosphoglycolate phosphatase
chr13_+_101181994 5.52 ENSRNOT00000052407
Susd4
sushi domain containing 4
chr8_-_48564722 5.38 ENSRNOT00000067902
Cbl
Cbl proto-oncogene
chr3_+_155103150 4.82 ENSRNOT00000020720
Slc32a1
solute carrier family 32 member 1
chrX_-_73360204 4.61 ENSRNOT00000091278
LOC100360296
BRCA2-interacting protein-like
chr3_+_80833272 4.60 ENSRNOT00000023583
Chrm4
cholinergic receptor, muscarinic 4
chr5_-_135472116 4.15 ENSRNOT00000022170
Nasp
nuclear autoantigenic sperm protein
chr15_+_86153628 3.96 ENSRNOT00000012842
Uchl3
ubiquitin C-terminal hydrolase L3
chr8_-_110813000 3.61 ENSRNOT00000010634
Ephb1
Eph receptor B1
chr3_+_71210301 3.59 ENSRNOT00000006504
Fam171b
family with sequence similarity 171, member B
chr1_+_243477493 3.34 ENSRNOT00000021779
ENSRNOT00000085356
Dmrt1
doublesex and mab-3 related transcription factor 1
chr8_+_22189600 3.29 ENSRNOT00000061100
Pde4a
phosphodiesterase 4A
chr1_-_220644636 3.16 ENSRNOT00000027632
Pacs1
phosphofurin acidic cluster sorting protein 1
chr5_+_147246037 3.11 ENSRNOT00000089457
Rnf19b
ring finger protein 19B
chr8_+_53295222 3.01 ENSRNOT00000009724
ENSRNOT00000067420
Usp28
ubiquitin specific peptidase 28
chr10_-_102200596 2.74 ENSRNOT00000081519
Fam104a
family with sequence similarity 104, member A
chr11_+_34051993 2.72 ENSRNOT00000076473
ENSRNOT00000064751
Morc3
MORC family CW-type zinc finger 3
chr7_+_12820840 2.48 ENSRNOT00000012317
Rnf126
ring finger protein 126
chr10_-_102200400 2.20 ENSRNOT00000004001
Fam104a
family with sequence similarity 104, member A
chr1_+_82480195 2.18 ENSRNOT00000028051
Tgfb1
transforming growth factor, beta 1
chr10_+_102199837 2.18 ENSRNOT00000037371
MGC95210
hypothetical LOC287798
chrX_+_136466779 2.07 ENSRNOT00000093268
ENSRNOT00000068717
Arhgap36
Rho GTPase activating protein 36
chr14_+_11198896 1.92 ENSRNOT00000079767
Hnrnpdl
heterogeneous nuclear ribonucleoprotein D-like
chrX_+_120860178 1.74 ENSRNOT00000088661
Wdr44
WD repeat domain 44
chr15_+_57891680 1.66 ENSRNOT00000001383
Tpt1
tumor protein, translationally-controlled 1
chr3_-_57192125 1.66 ENSRNOT00000032528
RGD1565767
similar to ribosomal protein L15
chrX_+_120859968 1.63 ENSRNOT00000085185
Wdr44
WD repeat domain 44
chr5_+_166464252 1.60 ENSRNOT00000055562
Ctnnbip1
catenin, beta-interacting protein 1
chr10_+_13854339 1.40 ENSRNOT00000004486
ENSRNOT00000043951
Caskin1
CASK interacting protein 1
chr8_+_122743189 1.39 ENSRNOT00000014532
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr5_-_136112344 1.00 ENSRNOT00000050195
RGD1563714
RGD1563714
chr10_+_56610051 0.95 ENSRNOT00000024348
Dvl2
dishevelled segment polarity protein 2
chr4_-_152835182 0.95 ENSRNOT00000036721
B4galnt3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr2_-_197971456 0.84 ENSRNOT00000063866
ENSRNOT00000085971
Prpf3
pre-mRNA processing factor 3
chrX_+_122808605 0.77 ENSRNOT00000017567
Zcchc12
zinc finger CCHC-type containing 12
chr10_+_88536626 0.69 ENSRNOT00000077568
ENSRNOT00000024543
Nkiras2
NFKB inhibitor interacting Ras-like 2
chr20_-_10407554 0.66 ENSRNOT00000074081
U2af1
U2 small nuclear RNA auxiliary factor 1
chr1_+_214278296 0.63 ENSRNOT00000024137
Drd4
dopamine receptor D4
chr7_+_2643288 0.61 ENSRNOT00000047241
Timeless
timeless circadian clock
chr4_+_133286114 0.57 ENSRNOT00000084158
Ppp4r2
protein phosphatase 4, regulatory subunit 2
chr7_+_12179203 0.54 ENSRNOT00000049170
Mbd3
methyl-CpG binding domain protein 3
chr3_+_33641616 0.47 ENSRNOT00000051953
Epc2
enhancer of polycomb homolog 2
chr8_+_117126692 0.36 ENSRNOT00000083046
ENSRNOT00000085609
Usp4
ubiquitin specific peptidase 4
chr4_+_149261044 0.28 ENSRNOT00000066670
Cxcl12
C-X-C motif chemokine ligand 12
chr3_+_11554457 0.18 ENSRNOT00000073087
Fam102a
family with sequence similarity 102, member A
chr8_-_71533459 0.16 ENSRNOT00000085745
Trip4
thyroid hormone receptor interactor 4
chr4_+_133285552 0.11 ENSRNOT00000029115
Ppp4r2
protein phosphatase 4, regulatory subunit 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0045959 negative regulation of complement activation, classical pathway(GO:0045959)
1.6 11.5 GO:2000143 negative regulation of DNA-templated transcription, initiation(GO:2000143)
1.5 5.8 GO:0006114 glycerol biosynthetic process(GO:0006114)
1.4 12.7 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
1.2 6.9 GO:2001025 positive regulation of response to drug(GO:2001025)
0.9 4.6 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.7 3.3 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.6 8.4 GO:0071420 cellular response to histamine(GO:0071420)
0.6 1.7 GO:2000384 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.5 2.2 GO:0043932 ossification involved in bone remodeling(GO:0043932) embryonic liver development(GO:1990402)
0.5 4.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.5 5.4 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.5 8.3 GO:0005513 detection of calcium ion(GO:0005513)
0.3 7.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.3 3.6 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.3 4.1 GO:0043486 histone exchange(GO:0043486)
0.2 11.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.2 6.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 0.6 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.2 0.6 GO:1904976 cellular response to bleomycin(GO:1904976)
0.2 3.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 1.4 GO:0090232 positive regulation of spindle checkpoint(GO:0090232) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.2 2.7 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.2 1.0 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.2 3.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.2 0.8 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 3.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 4.0 GO:0042755 eating behavior(GO:0042755)
0.1 9.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.3 GO:1990478 response to ultrasound(GO:1990478)
0.1 3.0 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 6.3 GO:0006909 phagocytosis(GO:0006909)
0.0 6.5 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.0 1.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.7 GO:1903146 regulation of mitophagy(GO:1903146)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0044316 cone cell pedicle(GO:0044316)
0.8 12.7 GO:0043083 synaptic cleft(GO:0043083)
0.6 6.9 GO:1990635 proximal dendrite(GO:1990635)
0.4 1.7 GO:0045298 tubulin complex(GO:0045298)
0.4 3.1 GO:0044194 cytolytic granule(GO:0044194)
0.4 4.5 GO:0016600 flotillin complex(GO:0016600)
0.4 8.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 4.6 GO:0032279 asymmetric synapse(GO:0032279)
0.2 3.6 GO:0032433 filopodium tip(GO:0032433)
0.2 1.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 3.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.7 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.1 0.7 GO:0089701 U2AF(GO:0089701)
0.1 0.8 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 8.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 6.1 GO:0030175 filopodium(GO:0030175)
0.1 1.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 10.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 7.1 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.7 GO:0016605 PML body(GO:0016605)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 1.7 GO:0005902 microvillus(GO:0005902)
0.0 11.4 GO:0016604 nuclear body(GO:0016604)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.4 GO:0010008 endosome membrane(GO:0010008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0003990 acetylcholinesterase activity(GO:0003990)
1.0 4.8 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.9 4.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.8 4.7 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.6 3.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.6 8.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.4 2.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 8.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.3 5.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3 8.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 1.9 GO:0034046 poly(G) binding(GO:0034046)
0.2 7.1 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 3.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 6.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 1.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.7 GO:0050733 RS domain binding(GO:0050733)
0.1 4.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 7.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 10.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 2.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 6.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.0 0.9 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 5.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.2 12.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 6.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.5 8.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 5.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 3.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 8.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 4.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 8.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases