ISMARA results: Nkx6-1_Evx1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx6-1_Evx1_Hesx1

Z-value: 1.04

Motif logo

Transcription factors associated with Nkx6-1_Evx1_Hesx1

Gene Symbol	Gene ID	Gene Info
Nkx6-1 NCBI RGD Ensembl	ENSRNOG00000002149	NK6 homeobox 1
Hesx1 NCBI RGD Ensembl	ENSRNOG00000014133	HESX homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nkx6-1	rn6_v1_chr14_+_9555264_9555264	0.27	8.2e-07	Click!
Hesx1	rn6_v1_chr16_+_2634603_2634603	-0.09	1.0e-01	Click!

Activity profile of Nkx6-1_Evx1_Hesx1 motif

Sorted Z-values of Nkx6-1_Evx1_Hesx1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_84506328 Show fit	55.75	ENSRNOT00000064754	Mlip NCBI RGD Ensembl Show fit	muscular LMNA-interacting protein
chr9_-_30844199 Show fit	50.39	ENSRNOT00000017169	Col19a1 NCBI RGD Ensembl Show fit	collagen type XIX alpha 1 chain
chr16_+_29674793 Show fit	40.79	ENSRNOT00000059724	Anxa10 NCBI RGD Ensembl Show fit	annexin A10
chr1_+_198383201 Show fit	36.36	ENSRNOT00000037405	Sez6l2 NCBI RGD Ensembl Show fit	seizure related 6 homolog like 2
chr3_-_52447622 Show fit	34.74	ENSRNOT00000083552	Scn1a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 1
chr7_-_69982592 Show fit	34.29	ENSRNOT00000040010	RGD1564306 NCBI RGD Ensembl Show fit	similar to developmental pluripotency associated 5
chrX_+_118197217 Show fit	31.44	ENSRNOT00000090922	Htr2c NCBI RGD Ensembl Show fit	5-hydroxytryptamine receptor 2C
chr4_-_55011415 Show fit	28.68	ENSRNOT00000056996	Grm8 NCBI RGD Ensembl Show fit	glutamate metabotropic receptor 8
chr15_+_11298478 Show fit	28.45	ENSRNOT00000007672	Lrrc3b NCBI RGD Ensembl Show fit	leucine rich repeat containing 3B
chr8_+_33239139 Show fit	28.24	ENSRNOT00000011589	Arhgap32 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 32
chr11_+_58624198 Show fit	28.21	ENSRNOT00000002091	Gap43 NCBI RGD Ensembl Show fit	growth associated protein 43
chr17_+_63635086 Show fit	26.56	ENSRNOT00000020634	Dip2c NCBI RGD Ensembl Show fit	disco-interacting protein 2 homolog C
chr7_-_76488216 Show fit	25.80	ENSRNOT00000080024	Ncald NCBI RGD Ensembl Show fit	neurocalcin delta
chr2_-_45518502 Show fit	25.36	ENSRNOT00000014627	Hspb3 NCBI RGD Ensembl Show fit	heat shock protein family B (small) member 3
chr6_+_58468155 Show fit	25.29	ENSRNOT00000091263	Etv1 NCBI RGD Ensembl Show fit	ets variant 1
chr17_+_11683862 Show fit	24.75	ENSRNOT00000024766	Msx2 NCBI RGD Ensembl Show fit	msh homeobox 2
chr2_-_158156444 Show fit	24.59	ENSRNOT00000088559	Veph1 NCBI RGD Ensembl Show fit	ventricular zone expressed PH domain-containing 1
chr3_+_48106099 Show fit	23.25	ENSRNOT00000007218	Slc4a10 NCBI RGD Ensembl Show fit	solute carrier family 4 member 10
chr1_+_13595295 Show fit	23.01	ENSRNOT00000079250	Nhsl1 NCBI RGD Ensembl Show fit	NHS-like 1
chr3_-_63568464 Show fit	22.87	ENSRNOT00000068494	AABR07052585.2 NCBI RGD Ensembl Show fit
chrM_+_11736 Show fit	22.72	ENSRNOT00000048767	Mt-nd5 NCBI RGD Ensembl Show fit	mitochondrially encoded NADH dehydrogenase 5
chr3_-_66417741 Show fit	22.27	ENSRNOT00000007662	Neurod1 NCBI RGD Ensembl Show fit	neuronal differentiation 1
chr1_-_215033460 Show fit	21.80	ENSRNOT00000044565	Dusp8 NCBI RGD Ensembl Show fit	dual specificity phosphatase 8
chr2_+_23289374 Show fit	21.77	ENSRNOT00000090666 ENSRNOT00000032783	Dmgdh NCBI RGD Ensembl Show fit	dimethylglycine dehydrogenase
chr18_+_30592794 Show fit	21.04	ENSRNOT00000027133	Pcdhb22 NCBI RGD Ensembl Show fit	protocadherin beta 22
chr11_-_32550539 Show fit	20.40	ENSRNOT00000002715	Rcan1 NCBI RGD Ensembl Show fit	regulator of calcineurin 1
chrM_+_9451 Show fit	20.18	ENSRNOT00000041241	Mt-nd3 NCBI RGD Ensembl Show fit	mitochondrially encoded NADH dehydrogenase 3
chr10_+_54352270 Show fit	20.00	ENSRNOT00000036752	Dhrs7c NCBI RGD Ensembl Show fit	dehydrogenase/reductase 7C
chrM_+_10160 Show fit	19.82	ENSRNOT00000042928	Mt-nd4 NCBI RGD Ensembl Show fit	mitochondrially encoded NADH dehydrogenase 4
chr3_-_63836017 Show fit	19.68	ENSRNOT00000030978	AABR07052585.1 NCBI RGD Ensembl Show fit
chr17_+_72160735 Show fit	19.33	ENSRNOT00000038817	Itih2 NCBI RGD Ensembl Show fit	inter-alpha-trypsin inhibitor heavy chain 2
chr20_-_25826658 Show fit	18.94	ENSRNOT00000057950 ENSRNOT00000084660	Ctnna3 NCBI RGD Ensembl Show fit	catenin alpha 3
chr8_-_78233430 Show fit	18.65	ENSRNOT00000083220	Cgnl1 NCBI RGD Ensembl Show fit	cingulin-like 1
chr2_-_231409988 Show fit	18.60	ENSRNOT00000080637 ENSRNOT00000037255 ENSRNOT00000074002	Ank2 NCBI RGD Ensembl Show fit	ankyrin 2
chr7_-_52404774 Show fit	18.12	ENSRNOT00000082100	Nav3 NCBI RGD Ensembl Show fit	neuron navigator 3
chr17_+_47721977 Show fit	18.03	ENSRNOT00000080800	LOC100910792 NCBI RGD Ensembl Show fit	amphiphysin-like
chr3_-_51612397 Show fit	17.80	ENSRNOT00000081401	Scn3a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 3
chr18_-_31343797 Show fit	17.76	ENSRNOT00000081850	Pcdh1 NCBI RGD Ensembl Show fit	protocadherin 1
chr12_-_2174131 Show fit	17.59	ENSRNOT00000001313	Pcp2 NCBI RGD Ensembl Show fit	Purkinje cell protein 2
chr7_+_136182224 Show fit	17.45	ENSRNOT00000008159	Tmem117 NCBI RGD Ensembl Show fit	transmembrane protein 117
chr5_+_6373583 Show fit	17.36	ENSRNOT00000084749	AABR07046778.1 NCBI RGD Ensembl Show fit
chr2_-_231409496 Show fit	17.32	ENSRNOT00000055615 ENSRNOT00000015386 ENSRNOT00000068415	Ank2 NCBI RGD Ensembl Show fit	ankyrin 2
chrM_+_9870 Show fit	17.19	ENSRNOT00000044582	Mt-nd4l NCBI RGD Ensembl Show fit	mitochondrially encoded NADH 4L dehydrogenase
chr3_+_48096954 Show fit	17.05	ENSRNOT00000068238 ENSRNOT00000064344 ENSRNOT00000044638	Slc4a10 NCBI RGD Ensembl Show fit	solute carrier family 4 member 10
chr14_-_19072677 Show fit	16.84	ENSRNOT00000060548	LOC360919 NCBI RGD Ensembl Show fit	similar to alpha-fetoprotein
chr1_-_67065797 Show fit	16.73	ENSRNOT00000048152	Vom1r46 NCBI RGD Ensembl Show fit	vomeronasal 1 receptor 46
chr6_-_7058314 Show fit	16.66	ENSRNOT00000045996	Haao NCBI RGD Ensembl Show fit	3-hydroxyanthranilate 3,4-dioxygenase
chrM_+_7919 Show fit	16.48	ENSRNOT00000046108	Mt-atp6 NCBI RGD Ensembl Show fit	mitochondrially encoded ATP synthase 6
chr5_-_93244202 Show fit	15.85	ENSRNOT00000075474	Ptprd NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, D
chr4_+_88694583 Show fit	15.59	ENSRNOT00000009202	Ppm1k NCBI RGD Ensembl Show fit	protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr9_+_73378057 Show fit	15.25	ENSRNOT00000043627 ENSRNOT00000045766 ENSRNOT00000092445 ENSRNOT00000037974	Map2 NCBI RGD Ensembl Show fit	microtubule-associated protein 2
chr3_+_54253949 Show fit	15.14	ENSRNOT00000010018	B3galt1 NCBI RGD Ensembl Show fit	Beta-1,3-galactosyltransferase 1
chr2_+_248398917 Show fit	15.11	ENSRNOT00000045855	Gbp1 NCBI RGD Ensembl Show fit	guanylate binding protein 1
chr17_-_9762813 Show fit	15.00	ENSRNOT00000033749	Slc34a1 NCBI RGD Ensembl Show fit	solute carrier family 34 member 1
chr5_-_133959447 Show fit	14.96	ENSRNOT00000011985	Cyp4x1 NCBI RGD Ensembl Show fit	cytochrome P450, family 4, subfamily x, polypeptide 1
chrM_+_7006 Show fit	14.92	ENSRNOT00000043693	Mt-co2 NCBI RGD Ensembl Show fit	mitochondrially encoded cytochrome c oxidase II
chr1_+_59156251 Show fit	14.51	ENSRNOT00000017442	Lix1 NCBI RGD Ensembl Show fit	limb and CNS expressed 1
chr7_+_78558701 Show fit	14.45	ENSRNOT00000006393	Rims2 NCBI RGD Ensembl Show fit	regulating synaptic membrane exocytosis 2
chr15_+_56666012 Show fit	14.33	ENSRNOT00000013408	Htr2a NCBI RGD Ensembl Show fit	5-hydroxytryptamine receptor 2A
chr20_+_25990656 Show fit	14.07	ENSRNOT00000081254	Lrrtm3 NCBI RGD Ensembl Show fit	leucine rich repeat transmembrane neuronal 3
chr3_-_15278645 Show fit	13.88	ENSRNOT00000032204	Ttll11 NCBI RGD Ensembl Show fit	tubulin tyrosine ligase like11
chr6_+_43234526 Show fit	13.85	ENSRNOT00000086808	Asap2 NCBI RGD Ensembl Show fit	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr18_+_30435119 Show fit	13.80	ENSRNOT00000027190	Pcdhb8 NCBI RGD Ensembl Show fit	protocadherin beta 8
chr5_+_33784715 Show fit	13.61	ENSRNOT00000035685	Slc7a13 NCBI RGD Ensembl Show fit	solute carrier family 7 member 13
chr14_-_115052450 Show fit	13.59	ENSRNOT00000067998	Acyp2 NCBI RGD Ensembl Show fit	acylphosphatase 2
chr9_+_81566074 Show fit	13.28	ENSRNOT00000074131 ENSRNOT00000046229 ENSRNOT00000090383	Pnkd NCBI RGD Ensembl Show fit	paroxysmal nonkinesigenic dyskinesia
chr13_-_76049363 Show fit	13.04	ENSRNOT00000075865 ENSRNOT00000007455	Brinp2 NCBI RGD Ensembl Show fit	BMP/retinoic acid inducible neural specific 2
chr12_-_19167015 Show fit	12.97	ENSRNOT00000001797	Gjc3 NCBI RGD Ensembl Show fit	gap junction protein, gamma 3
chrM_+_7758 Show fit	12.77	ENSRNOT00000046201	Mt-atp8 NCBI RGD Ensembl Show fit	mitochondrially encoded ATP synthase 8
chr19_+_53044379 Show fit	12.73	ENSRNOT00000072369	Foxc2 NCBI RGD Ensembl Show fit	forkhead box C2
chr2_-_88763733 Show fit	12.50	ENSRNOT00000059424	LOC688389 NCBI RGD Ensembl Show fit	similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr5_-_17061837 Show fit	12.49	ENSRNOT00000011892	Penk NCBI RGD Ensembl Show fit	proenkephalin
chr5_-_164714145 Show fit	12.45	ENSRNOT00000055680	LOC100911485 NCBI RGD Ensembl Show fit	mitofusin-2-like
chr2_-_158156150 Show fit	11.99	ENSRNOT00000016621	Veph1 NCBI RGD Ensembl Show fit	ventricular zone expressed PH domain-containing 1
chr6_+_29977797 Show fit	11.97	ENSRNOT00000071784	Fkbp1b NCBI RGD Ensembl Show fit	FK506 binding protein 1B
chr3_-_25212049 Show fit	11.94	ENSRNOT00000040023	Lrp1b NCBI RGD Ensembl Show fit	LDL receptor related protein 1B
chr5_-_136965191 Show fit	11.90	ENSRNOT00000056842	St3gal3 NCBI RGD Ensembl Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
chr5_-_17061361 Show fit	11.84	ENSRNOT00000089318	Penk NCBI RGD Ensembl Show fit	proenkephalin
chr2_+_145174876 Show fit	11.80	ENSRNOT00000040631	Mab21l1 NCBI RGD Ensembl Show fit	mab-21 like 1
chr6_-_23316962 Show fit	11.79	ENSRNOT00000065421	Clip4 NCBI RGD Ensembl Show fit	CAP-GLY domain containing linker protein family, member 4
chr3_+_95715193 Show fit	11.78	ENSRNOT00000089525	Pax6 NCBI RGD Ensembl Show fit	paired box 6
chr6_+_8284878 Show fit	11.62	ENSRNOT00000009581	Slc3a1 NCBI RGD Ensembl Show fit	solute carrier family 3 member 1
chr18_-_26656879 Show fit	11.57	ENSRNOT00000086729	Epb41l4a NCBI RGD Ensembl Show fit	erythrocyte membrane protein band 4.1 like 4A
chrX_+_84064427 Show fit	11.55	ENSRNOT00000046364	Zfp711 NCBI RGD Ensembl Show fit	zinc finger protein 711
chr13_+_87986240 Show fit	11.54	ENSRNOT00000003705	Rgs5 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 5
chr3_-_45169118 Show fit	11.51	ENSRNOT00000086371	Ccdc148 NCBI RGD Ensembl Show fit	coiled-coil domain containing 148
chr11_+_80742467 Show fit	11.42	ENSRNOT00000002507	Masp1 NCBI RGD Ensembl Show fit	mannan-binding lectin serine peptidase 1
chr8_-_82533689 Show fit	11.34	ENSRNOT00000014124	Tmod2 NCBI RGD Ensembl Show fit	tropomodulin 2
chr7_+_6644643 Show fit	11.22	ENSRNOT00000051670	Olr962 NCBI RGD Ensembl Show fit	olfactory receptor 962
chr2_+_42829413 Show fit	11.15	ENSRNOT00000065528	Actbl2 NCBI RGD Ensembl Show fit	actin, beta-like 2
chr8_-_87315955 Show fit	11.13	ENSRNOT00000081437	Filip1 NCBI RGD Ensembl Show fit	filamin A interacting protein 1
chrX_-_142248369 Show fit	11.05	ENSRNOT00000091330	Fgf13 NCBI RGD Ensembl Show fit	fibroblast growth factor 13
chr13_-_93307199 Show fit	10.95	ENSRNOT00000065041	Rgs7 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 7
chr20_+_40769586 Show fit	10.79	ENSRNOT00000001079	Fabp7 NCBI RGD Ensembl Show fit	fatty acid binding protein 7
chr5_-_22765429 Show fit	10.78	ENSRNOT00000079432	Asph NCBI RGD Ensembl Show fit	aspartate-beta-hydroxylase
chr16_+_2706428 Show fit	10.77	ENSRNOT00000077117	Il17rd NCBI RGD Ensembl Show fit	interleukin 17 receptor D
chr18_+_17043903 Show fit	10.50	ENSRNOT00000068139	Fhod3 NCBI RGD Ensembl Show fit	formin homology 2 domain containing 3
chr18_+_59748444 Show fit	10.48	ENSRNOT00000024752	St8sia3 NCBI RGD Ensembl Show fit	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr16_-_10802512 Show fit	10.42	ENSRNOT00000079554	Bmpr1a NCBI RGD Ensembl Show fit	bone morphogenetic protein receptor type 1A
chr10_+_90230711 Show fit	10.42	ENSRNOT00000055185	Tmub2 NCBI RGD Ensembl Show fit	transmembrane and ubiquitin-like domain containing 2
chr10_-_87248572 Show fit	10.38	ENSRNOT00000066637 ENSRNOT00000085677	Krt26 NCBI RGD Ensembl Show fit	keratin 26
chr12_+_47179664 Show fit	10.38	ENSRNOT00000001551	Cabp1 NCBI RGD Ensembl Show fit	calcium binding protein 1
chr18_-_53181503 Show fit	10.35	ENSRNOT00000066548	Fbn2 NCBI RGD Ensembl Show fit	fibrillin 2
chr6_+_101532518 Show fit	10.29	ENSRNOT00000075054	Gphn NCBI RGD Ensembl Show fit	gephyrin
chr20_+_34633157 Show fit	10.29	ENSRNOT00000000469	Pln NCBI RGD Ensembl Show fit	phospholamban
chr16_+_54319377 Show fit	10.23	ENSRNOT00000090266	Mtus1 NCBI RGD Ensembl Show fit	microtubule associated tumor suppressor 1
chr3_+_56125924 Show fit	10.20	ENSRNOT00000011380	Ubr3 NCBI RGD Ensembl Show fit	ubiquitin protein ligase E3 component n-recognin 3
chr10_-_83898527 Show fit	10.11	ENSRNOT00000009815	Atp5g1 NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr3_-_51643140 Show fit	10.10	ENSRNOT00000006646	Scn3a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 3
chr4_-_176909075 Show fit	10.09	ENSRNOT00000067489	Abcc9 NCBI RGD Ensembl Show fit	ATP binding cassette subfamily C member 9
chr1_+_217345545 Show fit	10.08	ENSRNOT00000071741	Shank2 NCBI RGD Ensembl Show fit	SH3 and multiple ankyrin repeat domains 2
chr2_-_35104963 Show fit	10.08	ENSRNOT00000018058	Rgs7bp NCBI RGD Ensembl Show fit	regulator of G-protein signaling 7-binding protein
chr7_-_8060373 Show fit	9.94	ENSRNOT00000071699	Olfr798 NCBI RGD Ensembl Show fit	olfactory receptor 798
chr18_+_14471213 Show fit	9.70	ENSRNOT00000045224	Dtna NCBI RGD Ensembl Show fit	dystrobrevin, alpha
chr16_-_49820235 Show fit	9.65	ENSRNOT00000029628	Sorbs2 NCBI RGD Ensembl Show fit	sorbin and SH3 domain containing 2
chr17_-_84247038 Show fit	9.59	ENSRNOT00000068553	Nebl NCBI RGD Ensembl Show fit	nebulette
chrM_+_8599 Show fit	9.53	ENSRNOT00000049683	Mt-cox3 NCBI RGD Ensembl Show fit	mitochondrially encoded cytochrome C oxidase III
chr10_+_56445647 Show fit	9.48	ENSRNOT00000056870	Tmem256 NCBI RGD Ensembl Show fit	transmembrane protein 256
chr16_+_10267482 Show fit	9.27	ENSRNOT00000085255	Gdf2 NCBI RGD Ensembl Show fit	growth differentiation factor 2
chr10_-_91661558 Show fit	9.23	ENSRNOT00000043156	AABR07030521.1 NCBI RGD Ensembl Show fit
chr8_+_57983556 Show fit	9.21	ENSRNOT00000009562	RGD1311251 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA 4930550C14
chr3_-_102672294 Show fit	9.14	ENSRNOT00000030909	Olr760 NCBI RGD Ensembl Show fit	olfactory receptor 760
chr3_-_101547478 Show fit	9.07	ENSRNOT00000006203	Fibin NCBI RGD Ensembl Show fit	fin bud initiation factor homolog (zebrafish)
chrX_-_32153794 Show fit	9.06	ENSRNOT00000005348	Tmem27 NCBI RGD Ensembl Show fit	transmembrane protein 27
chrM_+_2740 Show fit	9.01	ENSRNOT00000047550	Mt-nd1 NCBI RGD Ensembl Show fit	mitochondrially encoded NADH dehydrogenase 1
chr12_+_18679789 Show fit	9.00	ENSRNOT00000001863	Cyp3a9 NCBI RGD Ensembl Show fit	cytochrome P450, family 3, subfamily a, polypeptide 9
chr10_-_51778939 Show fit	8.96	ENSRNOT00000078675 ENSRNOT00000057562	Myocd NCBI RGD Ensembl Show fit	myocardin
chr17_-_87826421 Show fit	8.96	ENSRNOT00000068156	Arhgap21 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 21
chrX_+_111735820 Show fit	8.89	ENSRNOT00000086948	Frmpd3 NCBI RGD Ensembl Show fit	FERM and PDZ domain containing 3
chr2_-_188559882 Show fit	8.88	ENSRNOT00000088199	Trim46 NCBI RGD Ensembl Show fit	tripartite motif-containing 46
chr18_+_81694808 Show fit	8.88	ENSRNOT00000020446	Cyb5a NCBI RGD Ensembl Show fit	cytochrome b5 type A
chr11_-_782954 Show fit	8.83	ENSRNOT00000040065	Epha3 NCBI RGD Ensembl Show fit	Eph receptor A3
chr9_-_105693357 Show fit	8.78	ENSRNOT00000066968	Nudt12 NCBI RGD Ensembl Show fit	nudix hydrolase 12
chrM_-_14061 Show fit	8.74	ENSRNOT00000051268	Mt-nd6 NCBI RGD Ensembl Show fit	mitochondrially encoded NADH dehydrogenase 6
chr4_+_94696965 Show fit	8.74	ENSRNOT00000064696	Grid2 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor delta type subunit 2
chr6_-_106971250 Show fit	8.72	ENSRNOT00000010926	Dpf3 NCBI RGD Ensembl Show fit	double PHD fingers 3
chr19_+_39229754 Show fit	8.70	ENSRNOT00000050612	Vps4a NCBI RGD Ensembl Show fit	vacuolar protein sorting 4 homolog A
chr1_+_80141630 Show fit	8.69	ENSRNOT00000029552	Opa3 NCBI RGD Ensembl Show fit	optic atrophy 3
chr8_+_49441106 Show fit	8.66	ENSRNOT00000030152	Scn4b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 4
chr4_-_161850875 Show fit	8.66	ENSRNOT00000009467	Pzp NCBI RGD Ensembl Show fit	pregnancy-zone protein
chr2_-_89310946 Show fit	8.50	ENSRNOT00000015195	Ralyl NCBI RGD Ensembl Show fit	RALY RNA binding protein-like
chr3_+_53563194 Show fit	8.50	ENSRNOT00000048300	Xirp2 NCBI RGD Ensembl Show fit	xin actin-binding repeat containing 2
chr18_+_51523758 Show fit	8.48	ENSRNOT00000078518	Gramd3 NCBI RGD Ensembl Show fit	GRAM domain containing 3
chr5_-_168734296 Show fit	8.43	ENSRNOT00000066120	Camta1 NCBI RGD Ensembl Show fit	calmodulin binding transcription activator 1
chr8_+_122076759 Show fit	8.41	ENSRNOT00000012545	Clasp2 NCBI RGD Ensembl Show fit	cytoplasmic linker associated protein 2
chrX_+_77065397 Show fit	8.40	ENSRNOT00000090007	Cox7b NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 7B
chr12_-_35979193 Show fit	8.29	ENSRNOT00000071104	Tmem132b NCBI RGD Ensembl Show fit	transmembrane protein 132B
chr9_+_95501778 Show fit	8.23	ENSRNOT00000086805	Spp2 NCBI RGD Ensembl Show fit	secreted phosphoprotein 2
chr17_+_8489266 Show fit	8.22	ENSRNOT00000016252	Lect2 NCBI RGD Ensembl Show fit	leukocyte cell-derived chemotaxin 2
chr5_-_65073012 Show fit	8.10	ENSRNOT00000007957	Grin3a NCBI RGD Ensembl Show fit	glutamate ionotropic receptor NMDA type subunit 3A
chr5_-_156105867 Show fit	8.07	ENSRNOT00000078851	Alpl NCBI RGD Ensembl Show fit	alkaline phosphatase, liver/bone/kidney
chr14_+_37116492 Show fit	8.07	ENSRNOT00000002921	Sgcb NCBI RGD Ensembl Show fit	sarcoglycan, beta
chr13_-_82005741 Show fit	8.06	ENSRNOT00000076404	Mettl11b NCBI RGD Ensembl Show fit	methyltransferase like 11B
chr8_+_117906014 Show fit	8.05	ENSRNOT00000056180	Spink8 NCBI RGD Ensembl Show fit	serine peptidase inhibitor, Kazal type 8
chr8_+_85503224 Show fit	8.01	ENSRNOT00000012348	Gsta4 NCBI RGD Ensembl Show fit	glutathione S-transferase alpha 4
chr9_-_85243001 Show fit	7.98	ENSRNOT00000020219	Scg2 NCBI RGD Ensembl Show fit	secretogranin II
chr18_-_24057917 Show fit	7.96	ENSRNOT00000023874	Rit2 NCBI RGD Ensembl Show fit	Ras-like without CAAX 2
chr16_+_46731403 Show fit	7.93	ENSRNOT00000017624	Tenm3 NCBI RGD Ensembl Show fit	teneurin transmembrane protein 3
chr17_-_32158538 Show fit	7.93	ENSRNOT00000024141	Nqo2 NCBI RGD Ensembl Show fit	NAD(P)H quinone dehydrogenase 2
chr1_-_275882444 Show fit	7.91	ENSRNOT00000083215	Gpam NCBI RGD Ensembl Show fit	glycerol-3-phosphate acyltransferase, mitochondrial
chr9_+_10941613 Show fit	7.88	ENSRNOT00000070794	Sema6b NCBI RGD Ensembl Show fit	semaphorin 6B
chrM_+_14136 Show fit	7.87	ENSRNOT00000042098	Mt-cyb NCBI RGD Ensembl Show fit	mitochondrially encoded cytochrome b
chr12_-_10335499 Show fit	7.84	ENSRNOT00000071567	Wasf3 NCBI RGD Ensembl Show fit	WAS protein family, member 3
chr9_-_63641400 Show fit	7.82	ENSRNOT00000087684	Satb2 NCBI RGD Ensembl Show fit	SATB homeobox 2
chr13_-_82006005 Show fit	7.80	ENSRNOT00000039581	Mettl11b NCBI RGD Ensembl Show fit	methyltransferase like 11B
chr8_-_87419564 Show fit	7.80	ENSRNOT00000015365	Filip1 NCBI RGD Ensembl Show fit	filamin A interacting protein 1
chr5_+_22392732 Show fit	7.78	ENSRNOT00000087182	Clvs1 NCBI RGD Ensembl Show fit	clavesin 1
chr16_-_39476025 Show fit	7.75	ENSRNOT00000014312	Gpm6a NCBI RGD Ensembl Show fit	glycoprotein m6a
chr2_+_66940057 Show fit	7.63	ENSRNOT00000043050	Cdh9 NCBI RGD Ensembl Show fit	cadherin 9
chr8_-_63750531 Show fit	7.62	ENSRNOT00000009496	Neo1 NCBI RGD Ensembl Show fit	neogenin 1
chr2_-_261337163 Show fit	7.60	ENSRNOT00000030341	Tnni3k NCBI RGD Ensembl Show fit	TNNI3 interacting kinase
chr3_+_69549673 Show fit	7.54	ENSRNOT00000043974	Zfp804a NCBI RGD Ensembl Show fit	zinc finger protein 804A
chr4_+_33638709 Show fit	7.43	ENSRNOT00000009888 ENSRNOT00000034719 ENSRNOT00000052333	Tac1 NCBI RGD Ensembl Show fit	tachykinin, precursor 1
chr7_-_76294663 Show fit	7.41	ENSRNOT00000064513	Ncald NCBI RGD Ensembl Show fit	neurocalcin delta
chr6_-_1003905 Show fit	7.36	ENSRNOT00000082071 ENSRNOT00000042735	Fez2 NCBI RGD Ensembl Show fit	fasciculation and elongation protein zeta 2
chr4_+_29978739 Show fit	7.32	ENSRNOT00000011756	Ppp1r9a NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 9A
chr10_-_29450644 Show fit	7.31	ENSRNOT00000087937	Adra1b NCBI RGD Ensembl Show fit	adrenoceptor alpha 1B
chr2_+_206314213 Show fit	7.28	ENSRNOT00000056068	Bcl2l15 NCBI RGD Ensembl Show fit	BCL2-like 15
chr2_+_143475323 Show fit	7.22	ENSRNOT00000044028 ENSRNOT00000015437	Trpc4 NCBI RGD Ensembl Show fit	transient receptor potential cation channel, subfamily C, member 4
chr9_+_73418607 Show fit	7.21	ENSRNOT00000092547	Map2 NCBI RGD Ensembl Show fit	microtubule-associated protein 2
chr3_-_138683318 Show fit	7.12	ENSRNOT00000029701	Dzank1 NCBI RGD Ensembl Show fit	double zinc ribbon and ankyrin repeat domains 1
chr16_+_50049828 Show fit	7.09	ENSRNOT00000034448	Fam149a NCBI RGD Ensembl Show fit	family with sequence similarity 149, member A
chr4_-_17594598 Show fit	7.06	ENSRNOT00000008936	Sema3e NCBI RGD Ensembl Show fit	semaphorin 3E
chr3_-_14229067 Show fit	7.05	ENSRNOT00000025534 ENSRNOT00000092865	C5 NCBI RGD Ensembl Show fit	complement C5
chr18_+_32336102 Show fit	7.04	ENSRNOT00000018577	Fgf1 NCBI RGD Ensembl Show fit	fibroblast growth factor 1
chr3_+_151335292 Show fit	7.02	ENSRNOT00000073642	Mmp24 NCBI RGD Ensembl Show fit	matrix metallopeptidase 24
chr13_+_44424689 Show fit	6.97	ENSRNOT00000005206	Acmsd NCBI RGD Ensembl Show fit	aminocarboxymuconate semialdehyde decarboxylase
chr16_-_8885797 Show fit	6.95	ENSRNOT00000073370	RGD1564899 NCBI RGD Ensembl Show fit	similar to chromosome 10 open reading frame 71
chr4_+_180062799 Show fit	6.89	ENSRNOT00000021623	Rassf8 NCBI RGD Ensembl Show fit	Ras association domain family member 8
chrX_+_74200972 Show fit	6.87	ENSRNOT00000076956	Chic1 NCBI RGD Ensembl Show fit	cysteine-rich hydrophobic domain 1
chr2_+_72006099 Show fit	6.87	ENSRNOT00000034044	Cdh12 NCBI RGD Ensembl Show fit	cadherin 12
chr2_+_144861455 Show fit	6.80	ENSRNOT00000093284 ENSRNOT00000019748 ENSRNOT00000072110	Dclk1 NCBI RGD Ensembl Show fit	doublecortin-like kinase 1
chr8_-_8524643 Show fit	6.78	ENSRNOT00000009418	Cntn5 NCBI RGD Ensembl Show fit	contactin 5
chrX_+_110789269 Show fit	6.75	ENSRNOT00000086014	Rnf128 NCBI RGD Ensembl Show fit	ring finger protein 128, E3 ubiquitin protein ligase
chr1_-_104166367 Show fit	6.71	ENSRNOT00000092211	Csrp3 NCBI RGD Ensembl Show fit	cysteine and glycine rich protein 3
chr2_-_26699333 Show fit	6.70	ENSRNOT00000024459	Sv2c NCBI RGD Ensembl Show fit	synaptic vesicle glycoprotein 2c
chr7_-_6971557 Show fit	6.69	ENSRNOT00000050153	Olr960 NCBI RGD Ensembl Show fit	olfactory receptor 960
chr9_-_4876023 Show fit	6.68	ENSRNOT00000065839	RGD1559960 NCBI RGD Ensembl Show fit	similar to Sulfotransferase K1 (rSULT1C2)
chr17_-_43537293 Show fit	6.66	ENSRNOT00000091749	Slc17a3 NCBI RGD Ensembl Show fit	solute carrier family 17 member 3
chr1_+_107344904 Show fit	6.65	ENSRNOT00000082582	Gas2 NCBI RGD Ensembl Show fit	growth arrest-specific 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-1_Evx1_Hesx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.3	45.8	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
9.0	35.9	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
8.2	24.7	GO:2001055	embryonic nail plate morphogenesis(GO:0035880) positive regulation of mesenchymal cell apoptotic process(GO:2001055)
8.1	24.3	GO:0051867	general adaptation syndrome, behavioral process(GO:0051867)
7.3	21.8	GO:0006579	amino-acid betaine catabolic process(GO:0006579)
5.3	15.9	GO:0006480	N-terminal protein amino acid methylation(GO:0006480)
5.2	15.5	GO:0071691	cardiac muscle thin filament assembly(GO:0071691)
5.0	15.0	GO:0097187	dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
4.5	22.3	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
4.2	16.7	GO:0019805	quinolinate biosynthetic process(GO:0019805)
4.0	27.9	GO:0046684	response to pyrethroid(GO:0046684)
3.9	11.8	GO:1904937	pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
3.8	15.1	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
3.6	46.7	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
3.5	10.5	GO:1990743	protein sialylation(GO:1990743)
3.5	7.0	GO:0046874	quinolinate metabolic process(GO:0046874)
3.5	10.4	GO:0048378	lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) regulation of cardiac ventricle development(GO:1904412)
3.5	3.5	GO:0009441	glycolate metabolic process(GO:0009441)
3.2	12.7	GO:1902256	apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of vascular wound healing(GO:0035470) glomerular endothelium development(GO:0072011) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
3.1	33.9	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
3.1	30.5	GO:0016198	axon choice point recognition(GO:0016198)
3.0	9.0	GO:2000721	regulation of cell growth by extracellular stimulus(GO:0001560) phenotypic switching(GO:0036166) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
2.9	8.8	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
2.9	14.6	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529) gamma-aminobutyric acid receptor clustering(GO:0097112) receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
2.9	8.8	GO:0019677	NADP catabolic process(GO:0006742) NAD catabolic process(GO:0019677)
2.9	8.7	GO:1903774	multivesicular body assembly(GO:0036258) positive regulation of viral budding via host ESCRT complex(GO:1903774)
2.8	5.6	GO:0061034	olfactory bulb mitral cell layer development(GO:0061034)
2.7	8.1	GO:0071529	cementum mineralization(GO:0071529)
2.7	13.3	GO:0051596	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
2.5	7.5	GO:0098939	dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
2.4	7.3	GO:0045819	baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) positive regulation of glycogen catabolic process(GO:0045819)
2.4	40.3	GO:0021860	pyramidal neuron development(GO:0021860)
2.4	18.9	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
2.3	11.5	GO:0042264	peptidyl-aspartic acid hydroxylation(GO:0042264)
2.2	9.0	GO:0009822	lipid hydroxylation(GO:0002933) alkaloid catabolic process(GO:0009822)
2.2	6.7	GO:1903919	regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
2.2	10.8	GO:0021780	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
2.1	25.3	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.1	16.4	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
2.0	10.1	GO:0060327	cytoplasmic actin-based contraction involved in cell motility(GO:0060327)
2.0	20.0	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
2.0	55.8	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
2.0	15.8	GO:0097105	presynaptic membrane assembly(GO:0097105)
2.0	17.7	GO:0010459	negative regulation of heart rate(GO:0010459)
1.9	36.0	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
1.9	20.8	GO:0009642	response to light intensity(GO:0009642)
1.8	7.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
1.7	27.6	GO:0060134	prepulse inhibition(GO:0060134)
1.7	6.9	GO:0034334	adherens junction maintenance(GO:0034334)
1.7	5.1	GO:0033306	phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
1.7	21.8	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
1.7	3.3	GO:0035566	regulation of metanephros size(GO:0035566)
1.6	6.6	GO:0072709	cellular response to sorbitol(GO:0072709)
1.6	11.4	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
1.6	20.4	GO:0007614	short-term memory(GO:0007614) negative regulation of smooth muscle cell differentiation(GO:0051151)
1.6	4.7	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.6	42.1	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.5	10.4	GO:0010649	regulation of cell communication by electrical coupling(GO:0010649)
1.5	4.4	GO:0042360	vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210)
1.5	93.1	GO:0042773	ATP synthesis coupled electron transport(GO:0042773)
1.4	5.8	GO:0050955	thermoception(GO:0050955)
1.4	5.8	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
1.4	5.7	GO:1904428	negative regulation of tubulin deacetylation(GO:1904428)
1.4	11.3	GO:0051694	pointed-end actin filament capping(GO:0051694)
1.4	4.3	GO:0060221	retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
1.4	4.2	GO:0035928	rRNA import into mitochondrion(GO:0035928)
1.4	5.6	GO:0021965	spinal cord ventral commissure morphogenesis(GO:0021965)
1.4	13.9	GO:0018095	protein polyglutamylation(GO:0018095)
1.4	8.3	GO:0002035	brain renin-angiotensin system(GO:0002035)
1.4	5.4	GO:0051643	endoplasmic reticulum localization(GO:0051643)
1.3	5.3	GO:0051684	maintenance of Golgi location(GO:0051684)
1.3	3.8	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
1.2	10.0	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
1.2	8.7	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.2	13.3	GO:0099612	protein localization to axon(GO:0099612)
1.2	3.6	GO:0042357	thiamine diphosphate metabolic process(GO:0042357)
1.2	7.0	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
1.1	5.7	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
1.1	5.7	GO:0071694	protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
1.1	8.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
1.1	6.8	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
1.1	12.3	GO:0055091	phospholipid homeostasis(GO:0055091)
1.1	3.4	GO:0032978	protein insertion into membrane from inner side(GO:0032978)
1.1	4.4	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
1.1	3.3	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
1.1	1.1	GO:0006649	phospholipid transfer to membrane(GO:0006649)
1.1	8.7	GO:0086016	AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
1.1	15.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
1.1	3.2	GO:0002125	maternal aggressive behavior(GO:0002125) hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
1.1	4.2	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
1.0	10.2	GO:0042048	olfactory behavior(GO:0042048)
1.0	9.1	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
1.0	4.0	GO:0035494	SNARE complex disassembly(GO:0035494)
1.0	11.0	GO:0015747	urate transport(GO:0015747)
1.0	20.6	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
1.0	2.9	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
1.0	16.4	GO:1902358	sulfate transmembrane transport(GO:1902358)
1.0	15.3	GO:0099558	maintenance of synapse structure(GO:0099558)
0.9	0.9	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.9	8.4	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.9	4.6	GO:0021553	olfactory nerve development(GO:0021553)
0.9	3.7	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.9	2.7	GO:1901143	insulin catabolic process(GO:1901143)
0.9	8.1	GO:0097084	vascular smooth muscle cell development(GO:0097084)
0.9	3.5	GO:1903375	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375)
0.8	4.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.8	1.6	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.8	9.7	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.8	5.6	GO:0035726	common myeloid progenitor cell proliferation(GO:0035726)
0.8	6.4	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.8	12.9	GO:0097503	sialylation(GO:0097503)
0.7	4.5	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.7	2.2	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.7	22.5	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.7	5.0	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.7	4.2	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.7	10.5	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.7	7.6	GO:0086069	bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.7	3.5	GO:0097688	glutamate receptor clustering(GO:0097688)
0.7	4.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.7	3.3	GO:2000852	regulation of corticosterone secretion(GO:2000852)
0.7	3.9	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.6	7.0	GO:0044331	cell-cell adhesion mediated by cadherin(GO:0044331)
0.6	25.1	GO:1902475	L-alpha-amino acid transmembrane transport(GO:1902475)
0.6	4.3	GO:1901529	positive regulation of anion channel activity(GO:1901529)
0.6	1.8	GO:0072092	ureteric bud invasion(GO:0072092)
0.6	7.6	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.6	9.3	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.6	7.9	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.6	17.2	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.6	5.6	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.5	4.3	GO:0070417	cellular response to cold(GO:0070417)
0.5	74.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5	10.2	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.5	8.0	GO:0009635	response to herbicide(GO:0009635)
0.5	3.7	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.5	4.7	GO:1904116	response to vasopressin(GO:1904116)
0.5	7.8	GO:0031643	positive regulation of myelination(GO:0031643)
0.5	1.6	GO:0009227	nucleotide-sugar catabolic process(GO:0009227)
0.5	4.2	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.5	13.3	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.5	8.1	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.5	1.0	GO:0007172	signal complex assembly(GO:0007172)
0.5	4.5	GO:0007210	serotonin receptor signaling pathway(GO:0007210)
0.5	2.9	GO:0060721	regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.5	9.8	GO:1900003	regulation of serine-type endopeptidase activity(GO:1900003) regulation of serine-type peptidase activity(GO:1902571)
0.5	8.7	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.5	3.3	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.5	8.4	GO:0006828	manganese ion transport(GO:0006828)
0.5	1.4	GO:0006421	asparaginyl-tRNA aminoacylation(GO:0006421)
0.5	3.2	GO:0006824	cobalt ion transport(GO:0006824)
0.5	1.4	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.5	4.5	GO:0035721	intraciliary retrograde transport(GO:0035721)
0.5	4.5	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.4	4.5	GO:0070995	NADPH oxidation(GO:0070995)
0.4	8.4	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.4	1.3	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.4	17.7	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.4	4.7	GO:0071474	cellular hyperosmotic response(GO:0071474)
0.4	1.7	GO:1904923	regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.4	4.6	GO:0060539	diaphragm development(GO:0060539)
0.4	12.5	GO:0008053	mitochondrial fusion(GO:0008053)
0.4	1.2	GO:0002397	MHC class I protein complex assembly(GO:0002397)
0.4	4.4	GO:1904181	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.4	8.4	GO:0003298	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4	2.0	GO:0031443	fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.4	1.6	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.4	1.5	GO:0030242	pexophagy(GO:0030242)
0.4	4.2	GO:0051546	keratinocyte migration(GO:0051546)
0.4	3.4	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.4	0.7	GO:1903758	regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.4	1.1	GO:1990168	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
0.3	2.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.3	7.7	GO:0033194	response to hydroperoxide(GO:0033194)
0.3	2.7	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.3	4.8	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.3	2.0	GO:0051660	establishment of centrosome localization(GO:0051660)
0.3	7.1	GO:0001953	negative regulation of cell-matrix adhesion(GO:0001953)
0.3	3.3	GO:0007097	nuclear migration(GO:0007097)
0.3	0.7	GO:0065001	specification of axis polarity(GO:0065001)
0.3	2.6	GO:0030647	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.3	1.6	GO:0045218	zonula adherens maintenance(GO:0045218)
0.3	5.1	GO:0007602	phototransduction(GO:0007602)
0.3	4.8	GO:0060294	cilium movement involved in cell motility(GO:0060294)
0.3	1.6	GO:0060137	maternal process involved in parturition(GO:0060137)
0.3	2.8	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3	1.2	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.3	8.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3	3.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.3	1.5	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.3	2.0	GO:0000711	meiotic DNA repair synthesis(GO:0000711)
0.3	9.6	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.3	2.5	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
0.3	2.3	GO:0097461	ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.3	2.8	GO:0051197	positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.3	5.0	GO:0060992	response to fungicide(GO:0060992)
0.3	6.9	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.3	2.2	GO:0006751	glutathione catabolic process(GO:0006751)
0.3	1.4	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.3	5.8	GO:0007202	activation of phospholipase C activity(GO:0007202)
0.3	2.6	GO:0042135	neurotransmitter catabolic process(GO:0042135)
0.3	0.8	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174)
0.3	2.6	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.3	1.5	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.3	0.8	GO:0009082	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2	1.0	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471)
0.2	0.7	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527) epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2	2.9	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.2	8.5	GO:0055008	cardiac muscle tissue morphogenesis(GO:0055008)
0.2	0.5	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.2	0.5	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.2	0.7	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.2	6.2	GO:0060292	long term synaptic depression(GO:0060292)
0.2	13.0	GO:0042220	response to cocaine(GO:0042220)
0.2	4.7	GO:0002053	positive regulation of mesenchymal cell proliferation(GO:0002053)
0.2	5.6	GO:0072661	protein targeting to plasma membrane(GO:0072661)
0.2	3.0	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.2	6.7	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.2	3.8	GO:0043248	proteasome assembly(GO:0043248)
0.2	0.7	GO:0019086	late viral transcription(GO:0019086)
0.2	6.0	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.2	9.5	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2	13.0	GO:0071300	cellular response to retinoic acid(GO:0071300)
0.2	15.3	GO:0003073	regulation of systemic arterial blood pressure(GO:0003073)
0.2	5.3	GO:0042036	negative regulation of cytokine biosynthetic process(GO:0042036)
0.2	35.8	GO:0007519	skeletal muscle tissue development(GO:0007519)
0.2	2.2	GO:1902259	regulation of delayed rectifier potassium channel activity(GO:1902259)
0.2	5.4	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2	0.4	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.2	1.9	GO:0042448	progesterone metabolic process(GO:0042448)
0.2	0.8	GO:0010991	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.2	4.4	GO:0007528	neuromuscular junction development(GO:0007528)
0.2	2.3	GO:0006968	cellular defense response(GO:0006968)
0.2	0.5	GO:0009812	flavonoid metabolic process(GO:0009812)
0.2	1.8	GO:0031034	myosin filament assembly(GO:0031034)
0.2	3.4	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.2	3.2	GO:0039694	viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.2	0.7	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.2	2.2	GO:0097062	dendritic spine maintenance(GO:0097062)
0.2	2.8	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.2	204.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2	4.4	GO:0045773	positive regulation of axon extension(GO:0045773)
0.2	3.6	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.1	0.7	GO:0002154	thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.1	1.9	GO:0007625	grooming behavior(GO:0007625)
0.1	7.8	GO:0007040	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1	1.4	GO:0016048	detection of temperature stimulus(GO:0016048) sensory perception of temperature stimulus(GO:0050951)
0.1	0.4	GO:0071400	cellular response to oleic acid(GO:0071400)
0.1	2.5	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.1	1.1	GO:0006488	dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1	1.7	GO:0006833	water transport(GO:0006833)
0.1	0.7	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1	2.5	GO:0006471	protein ADP-ribosylation(GO:0006471)
0.1	14.7	GO:0007605	sensory perception of sound(GO:0007605)
0.1	0.8	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.1	2.8	GO:1901016	regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.1	0.1	GO:0010034	response to acetate(GO:0010034)
0.1	5.9	GO:0030032	lamellipodium assembly(GO:0030032)
0.1	1.4	GO:0006880	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1	2.1	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.1	10.8	GO:0048813	dendrite morphogenesis(GO:0048813)
0.1	1.7	GO:0035404	histone-serine phosphorylation(GO:0035404)
0.1	1.5	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1	0.4	GO:0032930	positive regulation of superoxide anion generation(GO:0032930)
0.1	2.7	GO:2001240	negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1	16.5	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
0.1	1.3	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.1	4.0	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.1	0.9	GO:0050974	detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1	3.9	GO:0035690	cellular response to drug(GO:0035690)
0.1	1.7	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.1	0.4	GO:0036233	glycine import(GO:0036233)
0.1	1.0	GO:0019985	translesion synthesis(GO:0019985)
0.1	0.2	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.1	2.6	GO:0014909	smooth muscle cell migration(GO:0014909)
0.1	3.9	GO:0046849	bone remodeling(GO:0046849)
0.1	0.6	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1	1.5	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1	4.5	GO:0090090	negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1	5.6	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.1	2.9	GO:0032024	positive regulation of insulin secretion(GO:0032024)
0.1	1.0	GO:0048662	negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1	1.1	GO:0043171	peptide catabolic process(GO:0043171)
0.0	1.0	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	1.6	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0	0.5	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.0	0.3	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.1	GO:0046083	adenine metabolic process(GO:0046083)
0.0	0.5	GO:0032958	inositol phosphate biosynthetic process(GO:0032958)
0.0	3.2	GO:0007179	transforming growth factor beta receptor signaling pathway(GO:0007179)
0.0	1.1	GO:1904659	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0	0.3	GO:0015866	ADP transport(GO:0015866) ATP transport(GO:0015867)
0.0	0.3	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.0	1.0	GO:0097480	synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)
0.0	3.9	GO:0006836	neurotransmitter transport(GO:0006836)
0.0	0.1	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.0	0.7	GO:0048278	vesicle docking(GO:0048278)
0.0	0.9	GO:0016126	sterol biosynthetic process(GO:0016126)
0.0	0.4	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.0	GO:0033234	negative regulation of protein sumoylation(GO:0033234)
0.0	0.1	GO:0006311	meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
10.3	10.3	GO:0090534	calcium ion-transporting ATPase complex(GO:0090534)
7.0	62.8	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
6.7	20.0	GO:0014801	longitudinal sarcoplasmic reticulum(GO:0014801)
4.2	33.8	GO:0032584	growth cone membrane(GO:0032584)
4.1	24.3	GO:0032280	symmetric synapse(GO:0032280)
3.9	77.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
3.8	15.1	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
2.6	39.4	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
2.5	10.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
2.0	8.1	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
1.9	95.3	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.8	7.3	GO:1990761	growth cone lamellipodium(GO:1990761)
1.8	8.9	GO:1990769	proximal neuron projection(GO:1990769)
1.6	4.8	GO:1990730	VCP-NSFL1C complex(GO:1990730)
1.5	26.1	GO:0045277	respiratory chain complex IV(GO:0045277)
1.4	4.2	GO:1990032	parallel fiber(GO:1990032)
1.3	8.1	GO:0016012	sarcoglycan complex(GO:0016012)
1.3	19.9	GO:0031045	dense core granule(GO:0031045)
1.2	8.7	GO:0090543	Flemming body(GO:0090543)
1.2	8.4	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
1.2	4.7	GO:0044279	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.2	36.9	GO:0031430	M band(GO:0031430)
1.2	3.5	GO:0016935	glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
1.1	14.3	GO:0070852	cell body fiber(GO:0070852)
1.0	19.8	GO:0005916	fascia adherens(GO:0005916)
1.0	12.0	GO:0045275	respiratory chain complex III(GO:0045275)
0.9	10.4	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.9	10.0	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.9	4.4	GO:0097454	Schwann cell microvillus(GO:0097454)
0.9	2.6	GO:0045203	intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.8	31.0	GO:0060077	inhibitory synapse(GO:0060077)
0.7	4.3	GO:0033093	Weibel-Palade body(GO:0033093)
0.7	8.4	GO:0043083	synaptic cleft(GO:0043083)
0.7	23.0	GO:0032839	dendrite cytoplasm(GO:0032839)
0.7	10.9	GO:0044292	dendrite terminus(GO:0044292)
0.7	11.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.7	6.0	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.6	13.0	GO:0005922	connexon complex(GO:0005922)
0.6	4.5	GO:0030991	intraciliary transport particle A(GO:0030991)
0.6	10.1	GO:0005883	neurofilament(GO:0005883)
0.6	23.9	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.6	29.1	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.6	3.0	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.6	8.7	GO:0070469	respiratory chain(GO:0070469)
0.5	3.2	GO:0044308	axonal spine(GO:0044308)
0.5	55.8	GO:0016605	PML body(GO:0016605)
0.5	2.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.5	1.9	GO:0031021	interphase microtubule organizing center(GO:0031021)
0.4	5.3	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.4	12.0	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.4	19.4	GO:0014704	intercalated disc(GO:0014704)
0.4	4.7	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4	10.5	GO:0005865	striated muscle thin filament(GO:0005865)
0.4	1.2	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.4	14.7	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.4	3.9	GO:0042788	polysomal ribosome(GO:0042788)
0.4	30.3	GO:0042734	presynaptic membrane(GO:0042734)
0.4	31.5	GO:0031526	brush border membrane(GO:0031526)
0.4	6.0	GO:0071437	invadopodium(GO:0071437)
0.4	7.7	GO:0044295	axonal growth cone(GO:0044295)
0.4	5.0	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.4	4.6	GO:0044291	cell-cell contact zone(GO:0044291)
0.4	4.6	GO:0097539	ciliary transition fiber(GO:0097539)
0.3	2.7	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3	1.6	GO:0005915	zonula adherens(GO:0005915)
0.3	26.0	GO:0005901	caveola(GO:0005901)
0.3	18.7	GO:0016459	myosin complex(GO:0016459)
0.3	3.2	GO:0072546	ER membrane protein complex(GO:0072546)
0.3	4.6	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.3	1.1	GO:0043541	UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3	1.8	GO:0005826	actomyosin contractile ring(GO:0005826)
0.3	4.0	GO:0043198	dendritic shaft(GO:0043198)
0.2	14.4	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2	5.6	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2	5.7	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.2	3.0	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2	3.1	GO:0017119	Golgi transport complex(GO:0017119)
0.2	1.9	GO:0072687	meiotic spindle(GO:0072687)
0.2	17.9	GO:0030018	Z disc(GO:0030018)
0.2	3.9	GO:0033391	chromatoid body(GO:0033391)
0.2	3.7	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2	0.6	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2	19.2	GO:0031225	anchored component of membrane(GO:0031225)
0.2	4.5	GO:0030125	clathrin vesicle coat(GO:0030125)
0.2	3.7	GO:0034707	chloride channel complex(GO:0034707)
0.2	2.3	GO:0030673	axolemma(GO:0030673)
0.2	1.4	GO:0031209	SCAR complex(GO:0031209)
0.2	112.8	GO:0043025	neuronal cell body(GO:0043025)
0.2	1.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.2	51.8	GO:0015629	actin cytoskeleton(GO:0015629)
0.2	10.0	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.2	8.3	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.2	1.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	8.5	GO:0045171	intercellular bridge(GO:0045171)
0.2	1.7	GO:0031527	filopodium membrane(GO:0031527)
0.2	10.4	GO:0030427	site of polarized growth(GO:0030427)
0.2	14.8	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	20.1	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.1	7.0	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	41.2	GO:0016607	nuclear speck(GO:0016607)
0.1	1.7	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	1.8	GO:0070822	Sin3-type complex(GO:0070822)
0.1	13.3	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.1	6.2	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1	2.9	GO:0001533	cornified envelope(GO:0001533)
0.1	5.8	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.1	25.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	9.5	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	0.7	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032) autolysosome(GO:0044754)
0.1	2.0	GO:0034451	centriolar satellite(GO:0034451)
0.1	2.1	GO:0031594	neuromuscular junction(GO:0031594)
0.1	4.7	GO:0044297	cell body(GO:0044297)
0.1	6.6	GO:0098794	postsynapse(GO:0098794)
0.1	0.5	GO:0070820	tertiary granule(GO:0070820)
0.1	0.6	GO:0000124	SAGA complex(GO:0000124)
0.1	20.5	GO:0031966	mitochondrial membrane(GO:0031966)
0.1	0.8	GO:0035371	microtubule plus-end(GO:0035371)
0.1	63.6	GO:0005739	mitochondrion(GO:0005739)
0.1	3.7	GO:0005776	autophagosome(GO:0005776)
0.1	1.7	GO:0005771	multivesicular body(GO:0005771)
0.1	1.0	GO:0034709	methylosome(GO:0034709)
0.1	1.5	GO:0060170	ciliary membrane(GO:0060170)
0.1	4.2	GO:0036064	ciliary basal body(GO:0036064)
0.1	5.3	GO:0043296	apical junction complex(GO:0043296)
0.0	3.7	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	2.4	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	10.6	GO:0000139	Golgi membrane(GO:0000139)
0.0	0.4	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.4	GO:0031011	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0	3.1	GO:0005770	late endosome(GO:0005770)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.7	GO:0030425	dendrite(GO:0030425)
0.0	0.8	GO:0000795	synaptonemal complex(GO:0000795)
0.0	0.7	GO:0070382	exocytic vesicle(GO:0070382)
0.0	0.6	GO:0031519	PcG protein complex(GO:0031519)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.3	45.8	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
7.2	28.7	GO:0001642	group III metabotropic glutamate receptor activity(GO:0001642)
7.0	27.9	GO:0035727	lysophosphatidic acid binding(GO:0035727)
5.3	15.9	GO:0071885	N-terminal protein N-methyltransferase activity(GO:0071885)
5.1	20.4	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
4.2	4.2	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
4.1	24.3	GO:0001515	opioid peptide activity(GO:0001515)
3.8	15.1	GO:0019002	GMP binding(GO:0019002)
3.7	14.6	GO:0008940	nitrate reductase activity(GO:0008940)
3.6	97.7	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
3.5	10.5	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
3.4	10.1	GO:0008281	sulfonylurea receptor activity(GO:0008281)
3.2	9.5	GO:0003844	1,4-alpha-glucan branching enzyme activity(GO:0003844)
3.2	12.7	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
3.0	15.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
3.0	15.0	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
3.0	11.9	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
2.8	75.2	GO:0031402	sodium ion binding(GO:0031402)
2.7	13.3	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
2.6	7.9	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.6	23.3	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
2.6	5.2	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
2.4	7.3	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
2.3	7.0	GO:0031714	C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
2.2	8.8	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
2.0	26.4	GO:0030215	semaphorin receptor binding(GO:0030215)
1.8	26.8	GO:0005523	tropomyosin binding(GO:0005523)
1.7	10.4	GO:0098821	BMP receptor activity(GO:0098821)
1.7	8.7	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
1.7	5.2	GO:0001641	group II metabotropic glutamate receptor activity(GO:0001641)
1.7	6.7	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.7	5.0	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
1.7	11.6	GO:0042030	ATPase inhibitor activity(GO:0042030)
1.6	6.4	GO:0016300	tRNA (uracil) methyltransferase activity(GO:0016300)
1.6	11.0	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
1.5	7.6	GO:0031013	troponin I binding(GO:0031013)
1.5	12.0	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.5	30.9	GO:0002162	dystroglycan binding(GO:0002162)
1.5	5.9	GO:0004027	alcohol sulfotransferase activity(GO:0004027)
1.4	4.3	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
1.4	4.2	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
1.3	10.8	GO:0030368	interleukin-17 receptor activity(GO:0030368)
1.3	49.4	GO:0015301	anion:anion antiporter activity(GO:0015301)
1.3	7.9	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
1.3	5.1	GO:0019166	2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
1.2	19.5	GO:0005542	folic acid binding(GO:0005542)
1.2	4.7	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
1.2	11.8	GO:0003680	AT DNA binding(GO:0003680)
1.2	3.5	GO:0022852	glycine-gated chloride ion channel activity(GO:0022852)
1.1	5.7	GO:0030348	syntaxin-3 binding(GO:0030348)
1.1	33.2	GO:0043014	alpha-tubulin binding(GO:0043014)
1.1	3.4	GO:0008511	sodium:potassium:chloride symporter activity(GO:0008511)
1.1	5.6	GO:0005042	netrin receptor activity(GO:0005042)
1.1	4.4	GO:0004859	phospholipase inhibitor activity(GO:0004859)
1.1	10.9	GO:0031681	G-protein beta-subunit binding(GO:0031681)
1.1	12.0	GO:0019855	calcium channel inhibitor activity(GO:0019855)
1.0	8.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
1.0	8.1	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.0	16.8	GO:0005234	extracellular-glutamate-gated ion channel activity(GO:0005234)
0.9	4.7	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.9	6.4	GO:0061133	endopeptidase activator activity(GO:0061133)
0.9	20.0	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.9	8.8	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.9	6.2	GO:0001849	complement component C1q binding(GO:0001849)
0.9	26.1	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.9	4.3	GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.9	3.5	GO:0003973	(S)-2-hydroxy-acid oxidase activity(GO:0003973)
0.9	1.7	GO:0008517	folic acid transporter activity(GO:0008517)
0.8	4.2	GO:0030280	structural constituent of epidermis(GO:0030280)
0.8	2.5	GO:0050429	calcium-dependent phospholipase C activity(GO:0050429)
0.8	3.3	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.8	2.5	GO:0031766	galanin receptor binding(GO:0031763) type 2 galanin receptor binding(GO:0031765) type 3 galanin receptor binding(GO:0031766)
0.8	4.9	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.8	3.2	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.8	10.4	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.8	10.1	GO:0098919	structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.8	7.6	GO:0070700	co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700)
0.7	2.8	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.7	4.2	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.7	2.7	GO:0043532	angiostatin binding(GO:0043532)
0.7	3.4	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.7	30.6	GO:0030507	spectrin binding(GO:0030507)
0.6	4.5	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.6	16.7	GO:0019825	oxygen binding(GO:0019825)
0.6	1.9	GO:0030977	taurine binding(GO:0030977)
0.6	41.1	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.6	7.2	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.6	24.0	GO:0070330	aromatase activity(GO:0070330)
0.6	4.6	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.6	2.3	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.6	10.1	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5	0.5	GO:0050294	steroid sulfotransferase activity(GO:0050294)
0.5	3.8	GO:0004111	creatine kinase activity(GO:0004111)
0.5	5.4	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.5	3.2	GO:0017040	ceramidase activity(GO:0017040)
0.5	3.7	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.5	2.6	GO:0047493	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.5	2.6	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.5	4.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.5	24.7	GO:0070888	E-box binding(GO:0070888)
0.5	7.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.5	2.5	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.5	7.5	GO:0050811	GABA receptor binding(GO:0050811)
0.5	2.9	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.5	4.8	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.5	4.7	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.5	7.0	GO:0044548	S100 protein binding(GO:0044548)
0.4	3.1	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4	1.3	GO:0042284	sphingolipid delta-4 desaturase activity(GO:0042284)
0.4	5.1	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.4	5.9	GO:0033038	bitter taste receptor activity(GO:0033038)
0.4	2.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.4	11.1	GO:0048487	beta-tubulin binding(GO:0048487)
0.4	4.5	GO:0051378	serotonin binding(GO:0051378)
0.4	6.0	GO:0051787	misfolded protein binding(GO:0051787)
0.4	11.9	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.4	1.6	GO:0005534	galactose binding(GO:0005534)
0.4	12.7	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.4	2.7	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.4	5.7	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.4	38.1	GO:0016503	pheromone receptor activity(GO:0016503)
0.4	2.2	GO:0003840	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.4	2.9	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.4	26.4	GO:0015179	L-amino acid transmembrane transporter activity(GO:0015179)
0.3	9.8	GO:0070412	R-SMAD binding(GO:0070412)
0.3	2.7	GO:0043559	insulin binding(GO:0043559)
0.3	1.6	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.3	8.1	GO:0042056	chemoattractant activity(GO:0042056)
0.3	4.2	GO:0008097	5S rRNA binding(GO:0008097)
0.3	3.8	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.3	4.4	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3	3.4	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.3	1.9	GO:0045503	dynein light chain binding(GO:0045503)
0.3	0.9	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.3	2.5	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.3	4.0	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.3	7.3	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.3	2.1	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.3	6.8	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.3	16.8	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.3	6.7	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3	14.1	GO:0042805	actinin binding(GO:0042805)
0.3	4.1	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.3	4.9	GO:0043295	glutathione binding(GO:0043295)
0.3	5.9	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3	0.8	GO:0061665	SUMO ligase activity(GO:0061665)
0.3	1.6	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.3	25.7	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.3	24.8	GO:0017137	Rab GTPase binding(GO:0017137)
0.3	0.8	GO:0004084	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2	0.7	GO:0031531	thyrotropin-releasing hormone receptor binding(GO:0031531)
0.2	1.2	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.2	3.9	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2	4.8	GO:0034185	apolipoprotein binding(GO:0034185)
0.2	1.2	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.2	13.8	GO:0015078	hydrogen ion transmembrane transporter activity(GO:0015078)
0.2	2.8	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.2	2.1	GO:0019841	retinol binding(GO:0019841)
0.2	4.2	GO:0030695	GTPase regulator activity(GO:0030695)
0.2	4.8	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.2	0.9	GO:0070411	I-SMAD binding(GO:0070411)
0.2	1.1	GO:0090555	phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.2	0.9	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2	7.7	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.2	5.2	GO:0017147	Wnt-protein binding(GO:0017147)
0.2	1.2	GO:0000405	bubble DNA binding(GO:0000405)
0.2	2.5	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.2	3.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2	80.0	GO:0005549	odorant binding(GO:0005549)
0.2	2.8	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.2	0.7	GO:0071532	ankyrin repeat binding(GO:0071532)
0.2	7.5	GO:0005504	fatty acid binding(GO:0005504)
0.2	3.1	GO:0043274	phospholipase binding(GO:0043274)
0.2	15.0	GO:0005178	integrin binding(GO:0005178)
0.2	4.8	GO:0005109	frizzled binding(GO:0005109)
0.2	1.7	GO:0070300	phosphatidic acid binding(GO:0070300)
0.2	1.3	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.2	7.0	GO:0016831	carboxy-lyase activity(GO:0016831)
0.2	3.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.2	42.3	GO:0005096	GTPase activator activity(GO:0005096)
0.2	14.6	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.2	13.5	GO:0005262	calcium channel activity(GO:0005262)
0.2	3.5	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1	0.7	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1	0.9	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1	14.9	GO:0030165	PDZ domain binding(GO:0030165)
0.1	5.0	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	1.0	GO:0045340	mercury ion binding(GO:0045340)
0.1	4.0	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	0.4	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	2.0	GO:0019215	intermediate filament binding(GO:0019215)
0.1	120.4	GO:0004984	olfactory receptor activity(GO:0004984)
0.1	2.4	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.1	3.3	GO:0070064	proline-rich region binding(GO:0070064)
0.1	4.5	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1	0.5	GO:0000829	inositol heptakisphosphate kinase activity(GO:0000829)
0.1	0.7	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.1	2.4	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.1	72.3	GO:0005509	calcium ion binding(GO:0005509)
0.1	3.3	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	1.7	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.1	6.7	GO:0008146	sulfotransferase activity(GO:0008146)
0.1	5.4	GO:0004812	aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1	3.7	GO:0016790	thiolester hydrolase activity(GO:0016790)
0.1	2.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	1.5	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.1	1.4	GO:0008199	ferric iron binding(GO:0008199)
0.1	2.7	GO:0019894	kinesin binding(GO:0019894)
0.1	1.5	GO:0001540	beta-amyloid binding(GO:0001540)
0.1	1.8	GO:0004407	histone deacetylase activity(GO:0004407)
0.1	0.2	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.1	1.4	GO:0008483	transaminase activity(GO:0008483)
0.1	2.6	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1	4.0	GO:0051117	ATPase binding(GO:0051117)
0.1	1.1	GO:0005351	sugar:proton symporter activity(GO:0005351)
0.1	3.0	GO:0043621	protein self-association(GO:0043621)
0.1	1.1	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.1	0.2	GO:0048185	activin binding(GO:0048185)
0.1	1.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	3.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.9	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	4.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	1.0	GO:0030332	cyclin binding(GO:0030332)
0.0	4.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	1.7	GO:0008013	beta-catenin binding(GO:0008013)
0.0	0.1	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.0	0.3	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	1.1	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
0.0	0.6	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	1.0	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0	0.2	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	4.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	25.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.7	33.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.6	4.0	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.5	6.6	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.5	37.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.5	13.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4	9.3	PID ALK1 PATHWAY	ALK1 signaling events
0.4	27.2	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.4	3.8	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.4	4.8	PID ALK2 PATHWAY	ALK2 signaling events
0.4	21.0	PID LKB1 PATHWAY	LKB1 signaling events
0.4	5.7	ST G ALPHA I PATHWAY	G alpha i Pathway
0.4	4.7	ST ADRENERGIC	Adrenergic Pathway
0.3	5.6	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.3	14.4	PID FGF PATHWAY	FGF signaling pathway
0.3	48.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	16.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.3	5.8	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.3	13.8	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.3	14.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.3	13.6	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.3	4.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.3	5.7	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	7.0	PID EPHA FWDPATHWAY	EPHA forward signaling
0.2	8.8	PID BMP PATHWAY	BMP receptor signaling
0.2	9.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	3.9	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	6.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	4.7	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	8.6	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.2	6.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	6.5	PID CDC42 PATHWAY	CDC42 signaling events
0.2	6.0	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.2	1.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	5.9	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	5.6	PID AURORA B PATHWAY	Aurora B signaling
0.1	27.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	2.7	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	0.8	PID IFNG PATHWAY	IFN-gamma pathway
0.1	8.5	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	3.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	3.1	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	6.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	2.0	PID RAS PATHWAY	Regulation of Ras family activation
0.1	0.7	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	6.1	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	1.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	3.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	0.7	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	1.0	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	11.3	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0	2.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.9	PID P73PATHWAY	p73 transcription factor network
0.0	0.3	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.3	PID RHOA REG PATHWAY	Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.3	45.8	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
2.6	23.6	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
2.1	33.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
1.5	33.9	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.3	34.7	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
1.1	11.8	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
1.0	12.8	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.9	12.9	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.9	12.9	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.8	22.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.8	12.8	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.5	7.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.5	11.3	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.5	9.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.4	27.1	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.4	11.7	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.4	23.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.4	8.0	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.4	8.7	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.4	3.5	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4	9.9	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.3	4.9	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.3	10.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	20.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.3	11.8	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.3	8.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.3	5.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3	7.5	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.3	7.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.3	15.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.3	5.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	4.7	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.2	3.4	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.2	7.5	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.2	9.2	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.2	4.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	6.6	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	4.9	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.2	6.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	1.2	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.2	3.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.2	9.3	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	4.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.2	15.8	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.2	27.0	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.2	3.9	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	1.8	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	2.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	7.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.1	5.7	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	1.2	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1	1.5	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	14.1	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	5.4	REACTOME TRNA AMINOACYLATION	Genes involved in tRNA Aminoacylation
0.1	1.6	REACTOME METABOLISM OF CARBOHYDRATES	Genes involved in Metabolism of carbohydrates
0.1	1.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	1.4	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	3.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	1.3	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1	2.3	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.1	1.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	1.4	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	5.0	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.1	0.7	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1	1.1	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	0.8	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.8	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.2	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0	0.5	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.8	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	1.1	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0	2.0	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	1.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.5	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.7	REACTOME SPHINGOLIPID METABOLISM	Genes involved in Sphingolipid metabolism
0.0	0.4	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.3	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation

Results for Nkx6-1_Evx1_Hesx1

Z-value: 1.04

Motif logo

Transcription factors associated with Nkx6-1_Evx1_Hesx1

Activity-expression correlation:

Activity profile of Nkx6-1_Evx1_Hesx1 motif

Sorted Z-values of Nkx6-1_Evx1_Hesx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-1_Evx1_Hesx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: