ISMARA results: Stat4_Stat3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Stat4_Stat3_Stat5b

Z-value: 1.24

Motif logo

Transcription factors associated with Stat4_Stat3_Stat5b

Gene Symbol	Gene ID	Gene Info
Stat3 NCBI RGD Ensembl	ENSRNOG00000019742	signal transducer and activator of transcription 3
Stat5b NCBI RGD Ensembl	ENSRNOG00000019075	signal transducer and activator of transcription 5B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Stat3	rn6_v1_chr10_-_88842233_88842233	0.41	3.1e-14	Click!
Stat5b	rn6_v1_chr10_-_88754829_88754829	0.19	6.7e-04	Click!

Activity profile of Stat4_Stat3_Stat5b motif

Sorted Z-values of Stat4_Stat3_Stat5b motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_6970342 Show fit	111.11	ENSRNOT00000061294 ENSRNOT00000048344	Itih4 NCBI RGD Ensembl Show fit	inter-alpha-trypsin inhibitor heavy chain family, member 4
chr19_-_57333433 Show fit	70.23	ENSRNOT00000024917	Agt NCBI RGD Ensembl Show fit	angiotensinogen
chr2_+_181987217 Show fit	46.40	ENSRNOT00000034521	Fgg NCBI RGD Ensembl Show fit	fibrinogen gamma chain
chr10_+_65767930 Show fit	44.52	ENSRNOT00000039954	Vtn NCBI RGD Ensembl Show fit	vitronectin
chr7_+_1206648 Show fit	41.16	ENSRNOT00000073689	Pros1 NCBI RGD Ensembl Show fit	protein S (alpha)
chr6_-_127656603 Show fit	39.94	ENSRNOT00000015516	Serpina11 NCBI RGD Ensembl Show fit	serpin family A member 11
chr2_+_182006242 Show fit	39.45	ENSRNOT00000064091	Fga NCBI RGD Ensembl Show fit	fibrinogen alpha chain
chrX_+_143097525 Show fit	39.00	ENSRNOT00000004559	F9 NCBI RGD Ensembl Show fit	coagulation factor IX
chrX_-_143453612 Show fit	33.63	ENSRNOT00000051319	Atp11c NCBI RGD Ensembl Show fit	ATPase phospholipid transporting 11C
chr4_-_17594598 Show fit	32.61	ENSRNOT00000008936	Sema3e NCBI RGD Ensembl Show fit	semaphorin 3E
chr8_+_22035256 Show fit	31.84	ENSRNOT00000028066	Icam1 NCBI RGD Ensembl Show fit	intercellular adhesion molecule 1
chr2_+_104744461 Show fit	29.74	ENSRNOT00000016083 ENSRNOT00000082627	Cp NCBI RGD Ensembl Show fit	ceruloplasmin
chr1_-_170431073 Show fit	29.72	ENSRNOT00000024710	Hpx NCBI RGD Ensembl Show fit	hemopexin
chr7_-_102298522 Show fit	29.17	ENSRNOT00000006273	A1bg NCBI RGD Ensembl Show fit	alpha-1-B glycoprotein
chr4_+_70776046 Show fit	28.85	ENSRNOT00000040403	Prss1 NCBI RGD Ensembl Show fit	protease, serine 1
chr15_-_34392066 Show fit	27.73	ENSRNOT00000027315	Tgm1 NCBI RGD Ensembl Show fit	transglutaminase 1
chr8_+_21890319 Show fit	25.44	ENSRNOT00000027949	LOC500956 NCBI RGD Ensembl Show fit	hypothetical protein LOC500956
chr5_+_165415136 Show fit	24.91	ENSRNOT00000016317 ENSRNOT00000079407	Masp2 NCBI RGD Ensembl Show fit	mannan-binding lectin serine peptidase 2
chr19_+_15294248 Show fit	22.69	ENSRNOT00000024622	Ces1f NCBI RGD Ensembl Show fit	carboxylesterase 1F
chr1_-_176079125 Show fit	21.59	ENSRNOT00000047044	RGD1566189 NCBI RGD Ensembl Show fit	similar to ferritin light chain
chr10_+_34277993 Show fit	21.51	ENSRNOT00000055872 ENSRNOT00000003343	Ifi47 NCBI RGD Ensembl Show fit	interferon gamma inducible protein 47
chr7_-_70355619 Show fit	21.21	ENSRNOT00000031272	Tspan31 NCBI RGD Ensembl Show fit	tetraspanin 31
chr2_-_182035032 Show fit	20.53	ENSRNOT00000009813	Fgb NCBI RGD Ensembl Show fit	fibrinogen beta chain
chr1_-_89369960 Show fit	20.20	ENSRNOT00000028545	Hamp NCBI RGD Ensembl Show fit	hepcidin antimicrobial peptide
chr1_-_80617057 Show fit	19.93	ENSRNOT00000080453	Apoe NCBI RGD Ensembl Show fit	apolipoprotein E
chr1_-_78180216 Show fit	19.65	ENSRNOT00000071576	C5ar2 NCBI RGD Ensembl Show fit	complement component 5a receptor 2
chr11_+_84396033 Show fit	19.41	ENSRNOT00000002316	Abcc5 NCBI RGD Ensembl Show fit	ATP binding cassette subfamily C member 5
chr3_-_72171078 Show fit	19.37	ENSRNOT00000009817	Serping1 NCBI RGD Ensembl Show fit	serpin family G member 1
chr4_+_163162211 Show fit	19.03	ENSRNOT00000082537	Clec1b NCBI RGD Ensembl Show fit	C-type lectin domain family 1, member B
chr11_+_68105369 Show fit	18.80	ENSRNOT00000046888	Parp14 NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 14
chr11_+_74057361 Show fit	17.97	ENSRNOT00000048746	Cpn2 NCBI RGD Ensembl Show fit	carboxypeptidase N subunit 2
chr15_-_35417273 Show fit	17.81	ENSRNOT00000083961 ENSRNOT00000041430	Gzmb NCBI RGD Ensembl Show fit	granzyme B
chr10_+_90085559 Show fit	16.77	ENSRNOT00000028332	Nags NCBI RGD Ensembl Show fit	N-acetylglutamate synthase
chr15_-_36472327 Show fit	16.09	ENSRNOT00000032601 ENSRNOT00000059660	LOC102553861 NCBI RGD Ensembl Show fit	granzyme-like protein 1-like
chr1_+_154131926 Show fit	16.09	ENSRNOT00000035257	LOC102549852 NCBI RGD Ensembl Show fit	ferritin light chain 1-like
chr14_-_80973456 Show fit	15.96	ENSRNOT00000013257	Hgfac NCBI RGD Ensembl Show fit	HGF activator
chr7_-_94563001 Show fit	15.74	ENSRNOT00000051139 ENSRNOT00000005561	Enpp2 NCBI RGD Ensembl Show fit	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr17_+_57075218 Show fit	15.34	ENSRNOT00000089536	Crem NCBI RGD Ensembl Show fit	cAMP responsive element modulator
chr4_+_61850348 Show fit	15.26	ENSRNOT00000013423	Akr1b7 NCBI RGD Ensembl Show fit	aldo-keto reductase family 1, member B7
chr6_-_127508452 Show fit	15.13	ENSRNOT00000073709	LOC100909524 NCBI RGD Ensembl Show fit	protein Z-dependent protease inhibitor-like
chr2_+_235264219 Show fit	14.69	ENSRNOT00000086245	Cfi NCBI RGD Ensembl Show fit	complement factor I
chr1_+_84044551 Show fit	14.65	ENSRNOT00000028290	Coq8b NCBI RGD Ensembl Show fit	coenzyme Q8B
chrX_+_9436707 Show fit	14.65	ENSRNOT00000004187	Cask NCBI RGD Ensembl Show fit	calcium/calmodulin dependent serine protein kinase
chr7_+_54980120 Show fit	14.39	ENSRNOT00000005690 ENSRNOT00000005773	Kcnc2 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily C member 2
chr20_-_35449280 Show fit	14.13	ENSRNOT00000057422	Man1a1 NCBI RGD Ensembl Show fit	mannosidase, alpha, class 1A, member 1
chr20_-_29029905 Show fit	14.07	ENSRNOT00000075682	Oit3 NCBI RGD Ensembl Show fit	oncoprotein induced transcript 3
chr20_-_4542073 Show fit	13.97	ENSRNOT00000000477	Cfb NCBI RGD Ensembl Show fit	complement factor B
chr7_-_76294663 Show fit	13.49	ENSRNOT00000064513	Ncald NCBI RGD Ensembl Show fit	neurocalcin delta
chr1_-_80594136 Show fit	13.41	ENSRNOT00000024800	Apoc2 NCBI RGD Ensembl Show fit	apolipoprotein C2
chr9_-_19880346 Show fit	13.28	ENSRNOT00000014051	Cyp39a1 NCBI RGD Ensembl Show fit	cytochrome P450, family 39, subfamily a, polypeptide 1
chr8_+_116857684 Show fit	13.12	ENSRNOT00000026711	Mst1 NCBI RGD Ensembl Show fit	macrophage stimulating 1
chr1_-_98493978 Show fit	13.00	ENSRNOT00000023942	Nkg7 NCBI RGD Ensembl Show fit	natural killer cell granule protein 7
chr13_+_47739526 Show fit	12.95	ENSRNOT00000006246	Il10 NCBI RGD Ensembl Show fit	interleukin 10
chr18_-_29562153 Show fit	12.29	ENSRNOT00000023977	Cd14 NCBI RGD Ensembl Show fit	CD14 molecule
chr19_+_37282018 Show fit	12.23	ENSRNOT00000021723	Tmem208 NCBI RGD Ensembl Show fit	transmembrane protein 208
chr4_+_100166863 Show fit	11.82	ENSRNOT00000014505	Sftpb NCBI RGD Ensembl Show fit	surfactant protein B
chr9_-_27452902 Show fit	11.52	ENSRNOT00000018325	Gsta1 NCBI RGD Ensembl Show fit	glutathione S-transferase alpha 1
chr1_+_170383682 Show fit	11.49	ENSRNOT00000024224	Smpd1 NCBI RGD Ensembl Show fit	sphingomyelin phosphodiesterase 1
chr10_+_39109522 Show fit	11.48	ENSRNOT00000010968	Irf1 NCBI RGD Ensembl Show fit	interferon regulatory factor 1
chr5_-_134871775 Show fit	11.45	ENSRNOT00000015667	LOC100911581 NCBI RGD Ensembl Show fit	fatty-acid amide hydrolase 1-like
chr5_-_134348995 Show fit	11.35	ENSRNOT00000015961	Faah NCBI RGD Ensembl Show fit	fatty acid amide hydrolase
chr7_-_116161708 Show fit	11.32	ENSRNOT00000068707	Cyp11b2 NCBI RGD Ensembl Show fit	cytochrome P450, family 11, subfamily b, polypeptide 2
chr13_+_89386023 Show fit	11.07	ENSRNOT00000086223	Fcgr3a NCBI RGD Ensembl Show fit	Fc fragment of IgG receptor IIIa
chr13_-_47397890 Show fit	11.06	ENSRNOT00000005505	C4bpb NCBI RGD Ensembl Show fit	complement component 4 binding protein, beta
chr11_-_11585765 Show fit	11.01	ENSRNOT00000066439	Robo2 NCBI RGD Ensembl Show fit	roundabout guidance receptor 2
chr3_-_107760550 Show fit	10.82	ENSRNOT00000077091 ENSRNOT00000051638	Meis2 NCBI RGD Ensembl Show fit	Meis homeobox 2
chr16_+_74886719 Show fit	10.71	ENSRNOT00000089265	Atp7b NCBI RGD Ensembl Show fit	ATPase copper transporting beta
chr13_+_51022681 Show fit	10.66	ENSRNOT00000078599	Chi3l1 NCBI RGD Ensembl Show fit	chitinase 3 like 1
chr9_+_10952374 Show fit	10.57	ENSRNOT00000074993	Lrg1 NCBI RGD Ensembl Show fit	leucine-rich alpha-2-glycoprotein 1
chr4_-_78458179 Show fit	10.45	ENSRNOT00000078473 ENSRNOT00000011327	Tmem176b NCBI RGD Ensembl Show fit	transmembrane protein 176B
chrX_+_15049462 Show fit	10.20	ENSRNOT00000007015	Ebp NCBI RGD Ensembl Show fit	emopamil binding protein (sterol isomerase)
chr4_+_78458625 Show fit	10.09	ENSRNOT00000049891	Tmem176a NCBI RGD Ensembl Show fit	transmembrane protein 176A
chr19_+_54314865 Show fit	10.09	ENSRNOT00000024069	Irf8 NCBI RGD Ensembl Show fit	interferon regulatory factor 8
chr9_-_85243001 Show fit	9.54	ENSRNOT00000020219	Scg2 NCBI RGD Ensembl Show fit	secretogranin II
chr1_-_225283326 Show fit	9.48	ENSRNOT00000027342	Scgb1a1 NCBI RGD Ensembl Show fit	secretoglobin family 1A member 1
chr6_-_61405195 Show fit	9.35	ENSRNOT00000008655	Lrrn3 NCBI RGD Ensembl Show fit	leucine rich repeat neuronal 3
chr6_-_1583417 Show fit	9.35	ENSRNOT00000084528	Prkd3 NCBI RGD Ensembl Show fit	protein kinase D3
chr8_+_127735258 Show fit	9.33	ENSRNOT00000015888	Vill NCBI RGD Ensembl Show fit	villin-like
chr2_+_30685840 Show fit	9.28	ENSRNOT00000031385	Ccdc125 NCBI RGD Ensembl Show fit	coiled-coil domain containing 125
chr17_+_31441630 Show fit	9.17	ENSRNOT00000083705 ENSRNOT00000023582	Tubb2b NCBI RGD Ensembl Show fit	tubulin, beta 2B class IIb
chr6_+_64808238 Show fit	9.08	ENSRNOT00000093195	Nrcam NCBI RGD Ensembl Show fit	neuronal cell adhesion molecule
chr3_+_119015412 Show fit	9.08	ENSRNOT00000013605	Slc27a2 NCBI RGD Ensembl Show fit	solute carrier family 27 member 2
chr10_+_45893018 Show fit	8.93	ENSRNOT00000004280 ENSRNOT00000086710	Nlrp3 NCBI RGD Ensembl Show fit	NLR family, pyrin domain containing 3
chr4_+_70689737 Show fit	8.86	ENSRNOT00000018852	Prss2 NCBI RGD Ensembl Show fit	protease, serine, 2
chr8_-_23148396 Show fit	8.86	ENSRNOT00000075237	Acp5 NCBI RGD Ensembl Show fit	acid phosphatase 5, tartrate resistant
chr4_-_29092753 Show fit	8.80	ENSRNOT00000014810	Bet1 NCBI RGD Ensembl Show fit	Bet1 golgi vesicular membrane trafficking protein
chr1_-_82279145 Show fit	8.75	ENSRNOT00000057433	Cxcl17 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 17
chr11_-_82938357 Show fit	8.74	ENSRNOT00000035945	Map3k13 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase kinase kinase 13
chr8_-_52937972 Show fit	8.66	ENSRNOT00000007789	Nnmt NCBI RGD Ensembl Show fit	nicotinamide N-methyltransferase
chr11_+_50781127 Show fit	8.59	ENSRNOT00000002738	Alcam NCBI RGD Ensembl Show fit	activated leukocyte cell adhesion molecule
chr7_+_11724962 Show fit	8.57	ENSRNOT00000026551	Lsm7 NCBI RGD Ensembl Show fit	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr4_+_57855416 Show fit	8.56	ENSRNOT00000029608	Cpa2 NCBI RGD Ensembl Show fit	carboxypeptidase A2
chr10_-_90999506 Show fit	8.54	ENSRNOT00000034401	Gfap NCBI RGD Ensembl Show fit	glial fibrillary acidic protein
chr20_+_3979035 Show fit	8.40	ENSRNOT00000000529	Tap1 NCBI RGD Ensembl Show fit	transporter 1, ATP binding cassette subfamily B member
chr4_-_89695928 Show fit	8.37	ENSRNOT00000039316	Gprin3 NCBI RGD Ensembl Show fit	GPRIN family member 3
chr18_-_41389510 Show fit	8.28	ENSRNOT00000005476 ENSRNOT00000005446	Sema6a NCBI RGD Ensembl Show fit	semaphorin 6A
chr7_+_143707237 Show fit	8.04	ENSRNOT00000074212	Tns2 NCBI RGD Ensembl Show fit	tensin 2
chr2_-_89310946 Show fit	8.02	ENSRNOT00000015195	Ralyl NCBI RGD Ensembl Show fit	RALY RNA binding protein-like
chr20_+_4363508 Show fit	7.97	ENSRNOT00000077205	Ager NCBI RGD Ensembl Show fit	advanced glycosylation end product-specific receptor
chr7_-_50638798 Show fit	7.80	ENSRNOT00000048880	Syt1 NCBI RGD Ensembl Show fit	synaptotagmin 1
chr10_-_70744315 Show fit	7.79	ENSRNOT00000014865	Ccl5 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 5
chr18_+_30017918 Show fit	7.73	ENSRNOT00000079794	Pcdha4 NCBI RGD Ensembl Show fit	protocadherin alpha 4
chrX_-_70461553 Show fit	7.66	ENSRNOT00000076110 ENSRNOT00000003872 ENSRNOT00000076812	Pdzd11 NCBI RGD Ensembl Show fit	PDZ domain containing 11
chr1_-_8751198 Show fit	7.62	ENSRNOT00000030511	Adgrg6 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor G6
chr18_-_55992885 Show fit	7.55	ENSRNOT00000025881	Ndst1 NCBI RGD Ensembl Show fit	N-deacetylase and N-sulfotransferase 1
chr16_-_19942343 Show fit	7.53	ENSRNOT00000087162 ENSRNOT00000091906	Bst2 NCBI RGD Ensembl Show fit	bone marrow stromal cell antigen 2
chr17_-_10818835 Show fit	7.49	ENSRNOT00000091046	Cplx2 NCBI RGD Ensembl Show fit	complexin 2
chr4_+_173732248 Show fit	7.47	ENSRNOT00000041499	Pik3c2g NCBI RGD Ensembl Show fit	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr1_-_167093560 Show fit	7.37	ENSRNOT00000027301	Il18bp NCBI RGD Ensembl Show fit	interleukin 18 binding protein
chr13_-_26811904 Show fit	7.30	ENSRNOT00000090097	Kdsr NCBI RGD Ensembl Show fit	3-ketodihydrosphingosine reductase
chr3_-_52998650 Show fit	7.11	ENSRNOT00000009988	RGD1560831 NCBI RGD Ensembl Show fit	similar to 40S ribosomal protein S3
chr2_-_258997138 Show fit	7.05	ENSRNOT00000045020 ENSRNOT00000042256	Adgrl2 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor L2
chr7_-_3074359 Show fit	7.04	ENSRNOT00000019738	Ikzf4 NCBI RGD Ensembl Show fit	IKAROS family zinc finger 4
chr8_-_128026841 Show fit	7.00	ENSRNOT00000018341	Myd88 NCBI RGD Ensembl Show fit	myeloid differentiation primary response 88
chr2_+_263212051 Show fit	6.93	ENSRNOT00000089396	Negr1 NCBI RGD Ensembl Show fit	neuronal growth regulator 1
chr3_-_36660758 Show fit	6.89	ENSRNOT00000006111	Rnd3 NCBI RGD Ensembl Show fit	Rho family GTPase 3
chr1_+_276659542 Show fit	6.89	ENSRNOT00000019681	Tcf7l2 NCBI RGD Ensembl Show fit	transcription factor 7 like 2
chr3_-_83048289 Show fit	6.87	ENSRNOT00000047571 ENSRNOT00000012806	Hsd17b12 NCBI RGD Ensembl Show fit	hydroxysteroid (17-beta) dehydrogenase 12
chr10_-_34221928 Show fit	6.85	ENSRNOT00000045545	Irgm NCBI RGD Ensembl Show fit	immunity-related GTPase M
chr9_+_82632230 Show fit	6.82	ENSRNOT00000085165	Gmppa NCBI RGD Ensembl Show fit	GDP-mannose pyrophosphorylase A
chr18_-_35780519 Show fit	6.78	ENSRNOT00000079667	Mcc NCBI RGD Ensembl Show fit	mutated in colorectal cancers
chr20_+_4363152 Show fit	6.56	ENSRNOT00000000508 ENSRNOT00000084841 ENSRNOT00000072848 ENSRNOT00000077561	Ager NCBI RGD Ensembl Show fit	advanced glycosylation end product-specific receptor
chr10_-_110274768 Show fit	6.46	ENSRNOT00000054931	Sectm1a NCBI RGD Ensembl Show fit	secreted and transmembrane 1A
chr4_+_100465170 Show fit	6.45	ENSRNOT00000019571	Retsat NCBI RGD Ensembl Show fit	retinol saturase
chr13_+_89253617 Show fit	6.45	ENSRNOT00000044575	LOC100362384 NCBI RGD Ensembl Show fit	ferritin light chain 1-like
chr1_+_203160323 Show fit	6.45	ENSRNOT00000027919	AABR07005844.1 NCBI RGD Ensembl Show fit
chr5_-_147784311 Show fit	6.36	ENSRNOT00000074172	Fam167b NCBI RGD Ensembl Show fit	family with sequence similarity 167, member B
chr10_+_14240219 Show fit	6.35	ENSRNOT00000020233	Igfals NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein, acid labile subunit
chr20_-_3793985 Show fit	6.31	ENSRNOT00000049540 ENSRNOT00000086293	RT1-CE16 NCBI RGD Ensembl Show fit	RT1 class I, locus CE16
chr4_-_15505362 Show fit	6.30	ENSRNOT00000009763	Hgf NCBI RGD Ensembl Show fit	hepatocyte growth factor
chr9_+_9704346 Show fit	6.21	ENSRNOT00000075403	Gpr108 NCBI RGD Ensembl Show fit	G protein-coupled receptor 108
chr3_+_100768637 Show fit	6.18	ENSRNOT00000083542	Bdnf NCBI RGD Ensembl Show fit	brain-derived neurotrophic factor
chr2_-_113616766 Show fit	6.17	ENSRNOT00000016858 ENSRNOT00000074723	Tmem212 NCBI RGD Ensembl Show fit	transmembrane protein 212
chr8_+_64531594 Show fit	6.08	ENSRNOT00000036798	Gramd2 NCBI RGD Ensembl Show fit	GRAM domain containing 2
chr7_+_116889572 Show fit	5.94	ENSRNOT00000075917	Gsdmd NCBI RGD Ensembl Show fit	gasdermin D
chr19_-_15431274 Show fit	5.85	ENSRNOT00000022285 ENSRNOT00000048470	Slc6a2 NCBI RGD Ensembl Show fit	solute carrier family 6 member 2
chr12_+_41155497 Show fit	5.84	ENSRNOT00000041741	Oas1g NCBI RGD Ensembl Show fit	2'-5' oligoadenylate synthetase 1G
chr13_-_73460912 Show fit	5.83	ENSRNOT00000005052 ENSRNOT00000068044	Qsox1 NCBI RGD Ensembl Show fit	quiescin sulfhydryl oxidase 1
chr2_+_189609800 Show fit	5.82	ENSRNOT00000089016	Slc39a1 NCBI RGD Ensembl Show fit	solute carrier family 39 member 1
chr1_+_105284753 Show fit	5.80	ENSRNOT00000041950	Slc6a5 NCBI RGD Ensembl Show fit	solute carrier family 6 member 5
chr13_+_92103123 Show fit	5.77	ENSRNOT00000004643	Olr1584 NCBI RGD Ensembl Show fit	olfactory receptor 1584
chr7_-_134722215 Show fit	5.75	ENSRNOT00000036750	Prickle1 NCBI RGD Ensembl Show fit	prickle planar cell polarity protein 1
chr4_+_147037179 Show fit	5.74	ENSRNOT00000011292	Syn2 NCBI RGD Ensembl Show fit	synapsin II
chr4_+_163174487 Show fit	5.64	ENSRNOT00000088108	Clec9a NCBI RGD Ensembl Show fit	C-type lectin domain family 9, member A
chr20_-_3978845 Show fit	5.62	ENSRNOT00000000532	Psmb9 NCBI RGD Ensembl Show fit	proteasome subunit beta 9
chrX_+_28072826 Show fit	5.57	ENSRNOT00000039796	Frmpd4 NCBI RGD Ensembl Show fit	FERM and PDZ domain containing 4
chr7_-_140437467 Show fit	5.56	ENSRNOT00000087181	Fkbp11 NCBI RGD Ensembl Show fit	FK506 binding protein 11
chr17_-_76410294 Show fit	5.55	ENSRNOT00000023892	Nudt5 NCBI RGD Ensembl Show fit	nudix hydrolase 5
chr4_+_167754525 Show fit	5.55	ENSRNOT00000007889	Etv6 NCBI RGD Ensembl Show fit	ets variant 6
chr4_+_71621729 Show fit	5.53	ENSRNOT00000022275	Gstk1 NCBI RGD Ensembl Show fit	glutathione S-transferase kappa 1
chr2_+_187697523 Show fit	5.52	ENSRNOT00000026153	Glmp NCBI RGD Ensembl Show fit	glycosylated lysosomal membrane protein
chr1_+_72784966 Show fit	5.51	ENSRNOT00000090065 ENSRNOT00000041527	Tmem86b NCBI RGD Ensembl Show fit	transmembrane protein 86B
chr16_-_71125316 Show fit	5.43	ENSRNOT00000020900	Plpp5 NCBI RGD Ensembl Show fit	phospholipid phosphatase 5
chr14_+_81488008 Show fit	5.42	ENSRNOT00000018477	Tnip2 NCBI RGD Ensembl Show fit	TNFAIP3 interacting protein 2
chr2_-_167607919 Show fit	5.40	ENSRNOT00000089083	AABR07011733.1 NCBI RGD Ensembl Show fit
chr9_+_82632384 Show fit	5.36	ENSRNOT00000027064	Gmppa NCBI RGD Ensembl Show fit	GDP-mannose pyrophosphorylase A
chrX_-_105417323 Show fit	5.33	ENSRNOT00000015494	Gla NCBI RGD Ensembl Show fit	galactosidase, alpha
chr7_-_130350570 Show fit	5.31	ENSRNOT00000055805	Odf3b NCBI RGD Ensembl Show fit	outer dense fiber of sperm tails 3B
chr19_+_14508616 Show fit	5.30	ENSRNOT00000019192	Hmox1 NCBI RGD Ensembl Show fit	heme oxygenase 1
chr12_+_49419582 Show fit	5.28	ENSRNOT00000082998	RGD1306556 NCBI RGD Ensembl Show fit	similar to hypothetical protein A530094D01
chr2_+_201172312 Show fit	5.24	ENSRNOT00000026458	Wars2 NCBI RGD Ensembl Show fit	tryptophanyl tRNA synthetase 2 (mitochondrial)
chr16_+_23317953 Show fit	5.20	ENSRNOT00000075287	AABR07024972.1 NCBI RGD Ensembl Show fit
chr5_-_147846095 Show fit	5.18	ENSRNOT00000072165	Txlna NCBI RGD Ensembl Show fit	taxilin alpha
chr6_-_55001464 Show fit	5.15	ENSRNOT00000006618	Ahr NCBI RGD Ensembl Show fit	aryl hydrocarbon receptor
chr2_-_179704629 Show fit	5.15	ENSRNOT00000083361 ENSRNOT00000077941	Gria2 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr3_-_134696654 Show fit	5.14	ENSRNOT00000006454	Flrt3 NCBI RGD Ensembl Show fit	fibronectin leucine rich transmembrane protein 3
chr17_+_9596957 Show fit	5.12	ENSRNOT00000017349	Fam193b NCBI RGD Ensembl Show fit	family with sequence similarity 193, member B
chr12_-_36555694 Show fit	5.11	ENSRNOT00000001292	Aacs NCBI RGD Ensembl Show fit	acetoacetyl-CoA synthetase
chr14_-_14390699 Show fit	5.05	ENSRNOT00000046639	Anxa3 NCBI RGD Ensembl Show fit	annexin A3
chr7_-_50278842 Show fit	5.00	ENSRNOT00000088950	Syt1 NCBI RGD Ensembl Show fit	synaptotagmin 1
chr1_-_275876329 Show fit	4.99	ENSRNOT00000047903	Gpam NCBI RGD Ensembl Show fit	glycerol-3-phosphate acyltransferase, mitochondrial
chr10_-_106976040 Show fit	4.93	ENSRNOT00000003940	Socs3 NCBI RGD Ensembl Show fit	suppressor of cytokine signaling 3
chr8_-_62248013 Show fit	4.89	ENSRNOT00000080012 ENSRNOT00000089602	Scamp5 NCBI RGD Ensembl Show fit	secretory carrier membrane protein 5
chr13_-_55173692 Show fit	4.89	ENSRNOT00000064785 ENSRNOT00000029878 ENSRNOT00000029865 ENSRNOT00000060292 ENSRNOT00000000814	Ptprc NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, C
chr13_+_88265331 Show fit	4.86	ENSRNOT00000031190	Ccdc190 NCBI RGD Ensembl Show fit	coiled-coil domain containing 190
chr6_+_73553210 Show fit	4.74	ENSRNOT00000006562	Akap6 NCBI RGD Ensembl Show fit	A-kinase anchoring protein 6
chrX_+_43626480 Show fit	4.72	ENSRNOT00000068078	Sat1 NCBI RGD Ensembl Show fit	spermidine/spermine N1-acetyl transferase 1
chrX_-_15620841 Show fit	4.71	ENSRNOT00000085397	Praf2 NCBI RGD Ensembl Show fit	PRA1 domain family, member 2
chr5_+_151436464 Show fit	4.70	ENSRNOT00000012463	Map3k6 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase kinase kinase 6
chrX_+_111122552 Show fit	4.66	ENSRNOT00000083566 ENSRNOT00000085078 ENSRNOT00000090928	Cldn2 NCBI RGD Ensembl Show fit	claudin 2
chr1_+_87790104 Show fit	4.65	ENSRNOT00000074580	LOC103690114 NCBI RGD Ensembl Show fit	zinc finger protein 383-like
chr6_-_1454480 Show fit	4.64	ENSRNOT00000072810	Eif2ak2 NCBI RGD Ensembl Show fit	eukaryotic translation initiation factor 2-alpha kinase 2
chrX_-_74968405 Show fit	4.63	ENSRNOT00000035653	RGD1561931 NCBI RGD Ensembl Show fit	similar to KIAA2022 protein
chr10_+_65805860 Show fit	4.54	ENSRNOT00000011795	Ift20 NCBI RGD Ensembl Show fit	intraflagellar transport 20
chr5_+_74766636 Show fit	4.48	ENSRNOT00000030913	Rn50_5_0791.1 NCBI RGD Ensembl Show fit
chr2_+_53109684 Show fit	4.45	ENSRNOT00000086590	Selenop NCBI RGD Ensembl Show fit	selenoprotein P
chr11_-_64421248 Show fit	4.43	ENSRNOT00000066997	Igsf11 NCBI RGD Ensembl Show fit	immunoglobulin superfamily, member 11
chr4_+_100277391 Show fit	4.40	ENSRNOT00000086820 ENSRNOT00000084281 ENSRNOT00000017927	Ggcx NCBI RGD Ensembl Show fit	gamma-glutamyl carboxylase
chr1_+_15799853 Show fit	4.35	ENSRNOT00000078589	Bclaf1 NCBI RGD Ensembl Show fit	BCL2-associated transcription factor 1
chr5_-_155258392 Show fit	4.34	ENSRNOT00000017065	C1qc NCBI RGD Ensembl Show fit	complement C1q C chain
chr12_+_21678580 Show fit	4.31	ENSRNOT00000039797	LOC100910669 NCBI RGD Ensembl Show fit	paired immunoglobulin-like type 2 receptor alpha-like
chr10_-_65805693 Show fit	4.30	ENSRNOT00000012245	Tnfaip1 NCBI RGD Ensembl Show fit	TNF alpha induced protein 1
chr7_+_16404755 Show fit	4.29	ENSRNOT00000044977	LOC108349290 NCBI RGD Ensembl Show fit	olfactory receptor 6C70-like
chr20_+_3156170 Show fit	4.25	ENSRNOT00000082880	RT1-S2 NCBI RGD Ensembl Show fit	RT1 class Ib, locus S2
chr12_+_42343123 Show fit	4.25	ENSRNOT00000043279	Oas1i NCBI RGD Ensembl Show fit	2 ' -5 ' oligoadenylate synthetase 1I
chr2_-_61414038 Show fit	4.24	ENSRNOT00000051910 ENSRNOT00000088202	Tars NCBI RGD Ensembl Show fit	threonyl-tRNA synthetase
chr18_+_35489274 Show fit	4.15	ENSRNOT00000073952 ENSRNOT00000076060	Dcp2 NCBI RGD Ensembl Show fit	decapping mRNA 2
chr7_-_117151694 Show fit	4.13	ENSRNOT00000051294	Nrbp2 NCBI RGD Ensembl Show fit	nuclear receptor binding protein 2
chr14_+_84465515 Show fit	4.13	ENSRNOT00000035591	Osm NCBI RGD Ensembl Show fit	oncostatin M
chr7_-_117151256 Show fit	4.13	ENSRNOT00000078846	Nrbp2 NCBI RGD Ensembl Show fit	nuclear receptor binding protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat4_Stat3_Stat5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
23.4	70.2	GO:0003051	ovarian follicle rupture(GO:0001543) angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) angiotensin-mediated drinking behavior(GO:0003051) regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) positive regulation of gap junction assembly(GO:1903598)
12.0	60.0	GO:0043152	induction of bacterial agglutination(GO:0043152)
7.4	29.7	GO:0060335	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
6.6	19.9	GO:1903002	regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
6.6	19.7	GO:0071623	negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
6.4	31.8	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
5.9	29.7	GO:0015679	plasma membrane copper ion transport(GO:0015679)
5.9	17.8	GO:0060545	positive regulation of necroptotic process(GO:0060545)
5.4	10.7	GO:0060003	copper ion export(GO:0060003)
5.3	106.9	GO:0042730	fibrinolysis(GO:0042730)
5.2	15.7	GO:1903165	response to polycyclic arene(GO:1903165)
5.1	20.5	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
5.1	15.3	GO:1905204	negative regulation of connective tissue replacement(GO:1905204)
5.1	20.2	GO:1903413	negative regulation of iron ion transmembrane transport(GO:0034760) cellular response to bile acid(GO:1903413)
4.9	44.5	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
4.5	13.4	GO:0060697	positive regulation of phospholipid catabolic process(GO:0060697)
4.3	13.0	GO:0060300	regulation of cytokine activity(GO:0060300) negative regulation of sensory perception of pain(GO:1904057)
3.9	7.8	GO:0071307	cellular response to vitamin K(GO:0071307)
3.8	11.5	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
3.7	33.6	GO:0002329	pre-B cell differentiation(GO:0002329)
3.7	11.1	GO:0045959	negative regulation of complement activation, classical pathway(GO:0045959)
3.5	115.9	GO:0030212	hyaluronan metabolic process(GO:0030212)
3.4	16.8	GO:0006526	arginine biosynthetic process(GO:0006526)
3.2	9.5	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
3.0	9.1	GO:0097089	methyl-branched fatty acid metabolic process(GO:0097089)
2.9	11.5	GO:0023021	termination of signal transduction(GO:0023021)
2.8	8.4	GO:0046968	cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
2.4	14.4	GO:0021759	globus pallidus development(GO:0021759)
2.4	9.5	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
2.4	11.8	GO:0050828	regulation of liquid surface tension(GO:0050828)
2.3	7.0	GO:2000338	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
2.3	6.9	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909)
2.2	8.9	GO:0050713	negative regulation of interleukin-1 beta secretion(GO:0050713) positive regulation of T-helper 17 type immune response(GO:2000318)
2.2	13.1	GO:0060763	mammary duct terminal end bud growth(GO:0060763)
2.0	27.8	GO:0010838	positive regulation of keratinocyte proliferation(GO:0010838)
1.9	9.7	GO:0061364	negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
1.9	24.9	GO:0001867	complement activation, lectin pathway(GO:0001867)
1.9	3.8	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
1.9	7.6	GO:0072719	cellular response to cisplatin(GO:0072719)
1.9	11.3	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
1.9	9.3	GO:0089700	protein kinase D signaling(GO:0089700)
1.9	5.6	GO:0019303	D-ribose catabolic process(GO:0019303)
1.7	5.2	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
1.7	3.5	GO:0001788	antibody-dependent cellular cytotoxicity(GO:0001788)
1.6	4.9	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
1.5	8.9	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
1.5	10.2	GO:0006477	protein sulfation(GO:0006477)
1.4	8.5	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
1.4	4.2	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
1.4	5.6	GO:1901423	response to benzene(GO:1901423)
1.4	14.0	GO:0006957	complement activation, alternative pathway(GO:0006957)
1.4	5.5	GO:0007296	vitellogenesis(GO:0007296)
1.4	12.3	GO:0071220	response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) positive regulation of interleukin-8 secretion(GO:2000484)
1.3	5.4	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
1.3	5.2	GO:0040009	regulation of growth rate(GO:0040009)
1.3	7.7	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
1.2	13.3	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.2	3.6	GO:0002462	tolerance induction to nonself antigen(GO:0002462)
1.2	19.0	GO:0006958	complement activation, classical pathway(GO:0006958)
1.2	4.7	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.2	4.7	GO:0032919	spermine acetylation(GO:0032919)
1.2	14.1	GO:0010579	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
1.2	3.5	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
1.2	39.3	GO:0001953	negative regulation of cell-matrix adhesion(GO:0001953)
1.1	9.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
1.1	3.4	GO:0000915	assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
1.1	4.4	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.1	23.9	GO:0030574	collagen catabolic process(GO:0030574)
1.1	5.3	GO:0046477	glycosylceramide catabolic process(GO:0046477)
1.1	2.1	GO:0070560	protein secretion by platelet(GO:0070560)
1.0	4.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
1.0	13.1	GO:0048245	eosinophil chemotaxis(GO:0048245)
1.0	3.0	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
1.0	4.9	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
1.0	10.7	GO:0072606	interleukin-8 secretion(GO:0072606)
1.0	25.2	GO:0034340	response to type I interferon(GO:0034340)
1.0	11.5	GO:0042178	xenobiotic catabolic process(GO:0042178)
1.0	3.8	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.9	3.8	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.9	4.6	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.9	12.8	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.9	4.5	GO:0015780	nucleotide-sugar transport(GO:0015780)
0.9	1.8	GO:0097018	renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532)
0.9	30.5	GO:0035458	cellular response to interferon-beta(GO:0035458)
0.9	11.1	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.9	5.1	GO:0034201	response to oleic acid(GO:0034201)
0.8	5.9	GO:0070269	pyroptosis(GO:0070269)
0.8	8.5	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.8	5.7	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.8	13.0	GO:0001887	selenium compound metabolic process(GO:0001887)
0.8	1.6	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.8	1.6	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.8	10.9	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.8	6.2	GO:0061193	taste bud development(GO:0061193)
0.8	6.9	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.8	1.5	GO:0048691	positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.7	1.5	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.7	3.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.7	5.2	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.7	8.1	GO:0060012	synaptic transmission, glycinergic(GO:0060012)
0.7	2.8	GO:0014028	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) notochord formation(GO:0014028)
0.7	5.6	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.7	1.4	GO:0018312	peptidyl-serine ADP-ribosylation(GO:0018312)
0.7	2.0	GO:0006431	methionyl-tRNA aminoacylation(GO:0006431)
0.7	5.4	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.7	10.8	GO:0006744	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.7	14.1	GO:0006491	N-glycan processing(GO:0006491)
0.7	0.7	GO:0046103	inosine biosynthetic process(GO:0046103)
0.6	1.9	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.6	5.1	GO:0003344	pericardium morphogenesis(GO:0003344)
0.6	3.2	GO:0007207	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.6	1.3	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.6	3.8	GO:0048539	bone marrow development(GO:0048539)
0.6	7.5	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.6	1.8	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.6	1.8	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.6	1.8	GO:0032197	transposition, RNA-mediated(GO:0032197)
0.6	4.1	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.6	1.8	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.6	2.3	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.6	2.2	GO:0090289	regulation of osteoclast proliferation(GO:0090289) positive regulation of osteoclast proliferation(GO:0090290)
0.6	5.0	GO:0070235	CDP-diacylglycerol biosynthetic process(GO:0016024) regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.6	2.2	GO:0003284	septum primum development(GO:0003284)
0.6	2.8	GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.5	0.5	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.5	2.2	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.5	13.7	GO:0030220	platelet formation(GO:0030220)
0.5	2.2	GO:0006172	ADP biosynthetic process(GO:0006172)
0.5	2.1	GO:0000393	spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.5	2.1	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.5	4.7	GO:0034134	toll-like receptor 2 signaling pathway(GO:0034134)
0.5	1.6	GO:0038091	VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.5	2.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.5	7.6	GO:0044130	negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.5	2.0	GO:0050812	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.5	1.9	GO:0034486	vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
0.5	10.6	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.5	5.5	GO:0046485	ether lipid metabolic process(GO:0046485)
0.4	5.9	GO:0051934	dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934)
0.4	4.5	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.4	8.9	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.4	1.2	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.4	3.6	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.4	15.3	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
0.4	2.7	GO:0090232	positive regulation of spindle checkpoint(GO:0090232) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.4	2.7	GO:0019348	dolichol metabolic process(GO:0019348)
0.4	8.7	GO:0010575	positive regulation of vascular endothelial growth factor production(GO:0010575)
0.4	4.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4	1.5	GO:0071409	cellular response to cycloheximide(GO:0071409)
0.4	0.7	GO:1990859	response to endothelin(GO:1990839) cellular response to endothelin(GO:1990859)
0.4	38.5	GO:0031638	zymogen activation(GO:0031638)
0.4	1.1	GO:0033385	geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.4	1.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.3	3.4	GO:0009650	UV protection(GO:0009650)
0.3	1.7	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.3	1.7	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.3	3.1	GO:0070863	positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.3	9.3	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.3	8.0	GO:0014850	response to muscle activity(GO:0014850)
0.3	5.2	GO:0060992	response to fungicide(GO:0060992)
0.3	3.8	GO:0043312	neutrophil degranulation(GO:0043312)
0.3	2.3	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.3	2.6	GO:0007258	JUN phosphorylation(GO:0007258)
0.3	7.8	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.3	1.2	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.3	2.3	GO:0035855	megakaryocyte development(GO:0035855)
0.3	1.4	GO:0090131	mesenchyme migration(GO:0090131)
0.3	1.7	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.3	1.4	GO:0052055	modulation by symbiont of host molecular function(GO:0052055)
0.3	3.5	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.3	0.8	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.3	10.2	GO:0006695	cholesterol biosynthetic process(GO:0006695)
0.3	3.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3	1.5	GO:0034475	U4 snRNA 3'-end processing(GO:0034475) DNA deamination(GO:0045006) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.2	1.5	GO:0016081	synaptic vesicle docking(GO:0016081)
0.2	3.0	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2	16.1	GO:0000186	activation of MAPKK activity(GO:0000186)
0.2	14.1	GO:0008542	visual learning(GO:0008542)
0.2	2.0	GO:0051182	coenzyme transport(GO:0051182)
0.2	5.7	GO:0095500	acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2	0.9	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2	1.6	GO:0014831	intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831)
0.2	0.7	GO:0070200	establishment of protein localization to telomere(GO:0070200)
0.2	0.5	GO:0006824	cobalt ion transport(GO:0006824)
0.2	1.3	GO:0021764	amygdala development(GO:0021764)
0.2	1.9	GO:0000055	ribosomal large subunit export from nucleus(GO:0000055)
0.2	49.9	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.2	0.8	GO:0002386	immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.2	17.0	GO:0009062	fatty acid catabolic process(GO:0009062)
0.2	1.9	GO:2001054	negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2	0.8	GO:2000393	negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2	1.7	GO:0032836	glomerular basement membrane development(GO:0032836)
0.2	4.9	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.2	6.5	GO:0042572	retinol metabolic process(GO:0042572)
0.2	1.5	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.2	12.0	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.2	0.9	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2	4.9	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.2	0.7	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.2	1.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.2	5.7	GO:0006749	glutathione metabolic process(GO:0006749)
0.2	0.7	GO:0016198	axon choice point recognition(GO:0016198)
0.2	0.2	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280)
0.2	2.6	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.2	2.0	GO:0007097	nuclear migration(GO:0007097)
0.2	1.5	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.2	2.9	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.2	1.3	GO:0009235	cobalamin metabolic process(GO:0009235)
0.2	6.1	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.2	0.6	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.2	3.0	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.2	1.2	GO:1904116	CDP-choline pathway(GO:0006657) response to vasopressin(GO:1904116)
0.1	0.4	GO:0070127	tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1	3.4	GO:1903861	positive regulation of dendrite extension(GO:1903861)
0.1	1.5	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.1	3.8	GO:0030488	tRNA methylation(GO:0030488)
0.1	3.8	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1	0.8	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1	0.8	GO:0015791	polyol transport(GO:0015791)
0.1	0.5	GO:0071025	RNA surveillance(GO:0071025)
0.1	4.4	GO:0042088	T-helper 1 type immune response(GO:0042088)
0.1	1.7	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.1	5.7	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.1	5.6	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.1	0.4	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	4.9	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.1	0.7	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.1	0.7	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1	4.3	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.1	4.7	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.1	0.7	GO:0015808	L-alanine transport(GO:0015808)
0.1	2.3	GO:0010591	regulation of lamellipodium assembly(GO:0010591)
0.1	3.1	GO:1904659	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1	1.9	GO:0043030	regulation of macrophage activation(GO:0043030)
0.1	1.7	GO:0080182	histone H3-K4 trimethylation(GO:0080182)
0.1	2.3	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.1	0.8	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.1	5.0	GO:0019882	antigen processing and presentation(GO:0019882)
0.1	2.4	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.1	2.9	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1	0.5	GO:0015074	DNA integration(GO:0015074)
0.1	1.7	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.1	0.7	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1	1.6	GO:0001964	startle response(GO:0001964)
0.1	1.1	GO:0046519	sphingoid metabolic process(GO:0046519)
0.1	4.0	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	5.1	GO:0003073	regulation of systemic arterial blood pressure(GO:0003073)
0.1	1.8	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.1	1.7	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.1	9.3	GO:0051607	defense response to virus(GO:0051607)
0.1	0.8	GO:0007183	SMAD protein complex assembly(GO:0007183)
0.1	8.7	GO:0001764	neuron migration(GO:0001764)
0.1	0.6	GO:0007000	nucleolus organization(GO:0007000)
0.1	0.7	GO:0044872	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1	0.7	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1	1.3	GO:0048266	behavioral response to pain(GO:0048266)
0.1	1.6	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1	0.5	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1	3.1	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1	0.6	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.1	1.9	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.1	1.9	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.1	4.9	GO:0045740	positive regulation of DNA replication(GO:0045740)
0.1	1.2	GO:0006270	DNA replication initiation(GO:0006270)
0.1	0.4	GO:0001865	NK T cell differentiation(GO:0001865)
0.1	2.5	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.1	1.6	GO:0030835	negative regulation of actin filament depolymerization(GO:0030835)
0.0	6.4	GO:0016485	protein processing(GO:0016485)
0.0	1.2	GO:0031297	replication fork processing(GO:0031297)
0.0	1.1	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.0	0.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	1.7	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0	0.2	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.1	GO:1905216	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	1.0	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.3	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.4	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	2.5	GO:0006165	nucleoside diphosphate phosphorylation(GO:0006165)
0.0	0.5	GO:0035196	dsRNA fragmentation(GO:0031050) production of miRNAs involved in gene silencing by miRNA(GO:0035196) production of small RNA involved in gene silencing by RNA(GO:0070918)
0.0	0.7	GO:0031935	regulation of chromatin silencing(GO:0031935)
0.0	2.7	GO:0010921	regulation of phosphatase activity(GO:0010921)
0.0	0.4	GO:0006880	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0	0.8	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.7	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.0	0.9	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.7	GO:0070527	platelet aggregation(GO:0070527)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	3.1	GO:0000375	RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0	1.0	GO:0008033	tRNA processing(GO:0008033)
0.0	0.3	GO:0048147	negative regulation of fibroblast proliferation(GO:0048147)
0.0	0.3	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0	1.3	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0	0.8	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0	0.8	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	0.8	GO:0007492	endoderm development(GO:0007492)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
13.3	106.4	GO:0005577	fibrinogen complex(GO:0005577)
7.4	44.5	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
5.6	33.3	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
3.0	368.8	GO:0072562	blood microparticle(GO:0072562)
2.5	12.3	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
2.3	6.9	GO:1990907	beta-catenin-TCF complex(GO:1990907)
2.2	17.8	GO:0044194	cytolytic granule(GO:0044194)
2.1	8.5	GO:0098574	cytoplasmic side of lysosomal membrane(GO:0098574)
2.1	12.8	GO:0042584	chromaffin granule membrane(GO:0042584)
2.1	14.9	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
2.0	20.2	GO:0045179	apical cortex(GO:0045179)
1.7	8.6	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
1.6	4.7	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
1.2	7.5	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
1.2	23.3	GO:0042599	lamellar body(GO:0042599)
1.2	8.4	GO:0042825	TAP complex(GO:0042825)
1.1	14.6	GO:0005652	nuclear lamina(GO:0005652)
1.1	6.3	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
1.0	42.3	GO:0001772	immunological synapse(GO:0001772)
1.0	5.2	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.9	5.6	GO:1990111	spermatoproteasome complex(GO:1990111)
0.8	2.3	GO:0098982	glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
0.7	3.0	GO:0035339	SPOTS complex(GO:0035339)
0.7	11.1	GO:0044215	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.7	8.7	GO:0008385	IkappaB kinase complex(GO:0008385)
0.7	18.0	GO:0005640	nuclear outer membrane(GO:0005640)
0.7	2.1	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006)
0.7	8.4	GO:0032279	asymmetric synapse(GO:0032279)
0.7	23.9	GO:0030673	axolemma(GO:0030673)
0.7	9.5	GO:0031045	dense core granule(GO:0031045)
0.7	5.4	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.6	3.9	GO:0005796	Golgi lumen(GO:0005796)
0.6	9.6	GO:0042612	MHC class I protein complex(GO:0042612)
0.6	15.6	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.6	1.8	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.6	1.7	GO:0044308	axonal spine(GO:0044308)
0.5	3.7	GO:0031528	microvillus membrane(GO:0031528)
0.5	1.6	GO:0060187	cell pole(GO:0060187)
0.5	10.9	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.5	9.1	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.4	6.7	GO:0030061	mitochondrial crista(GO:0030061)
0.4	2.1	GO:0016035	zeta DNA polymerase complex(GO:0016035)
0.4	8.8	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.3	2.3	GO:0035748	myelin sheath abaxonal region(GO:0035748)
0.3	7.5	GO:0005771	multivesicular body(GO:0005771)
0.3	1.5	GO:0048179	activin receptor complex(GO:0048179)
0.3	1.8	GO:0097433	dense body(GO:0097433)
0.3	0.9	GO:1990879	CST complex(GO:1990879)
0.3	1.7	GO:0089701	U2AF(GO:0089701)
0.3	9.3	GO:0030131	clathrin adaptor complex(GO:0030131)
0.3	11.6	GO:0031201	SNARE complex(GO:0031201)
0.3	3.5	GO:0000124	SAGA complex(GO:0000124)
0.2	27.7	GO:0005913	cell-cell adherens junction(GO:0005913)
0.2	4.0	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.2	3.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	0.7	GO:0032584	growth cone membrane(GO:0032584)
0.2	4.5	GO:0044292	dendrite terminus(GO:0044292)
0.2	12.4	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.2	3.8	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2	14.3	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2	1.5	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.2	0.8	GO:1990745	EARP complex(GO:1990745)
0.2	5.1	GO:0044295	axonal growth cone(GO:0044295)
0.2	24.9	GO:0055037	recycling endosome(GO:0055037)
0.2	1.5	GO:0097512	cardiac myofibril(GO:0097512)
0.2	251.0	GO:0005615	extracellular space(GO:0005615)
0.2	0.7	GO:0070876	SOSS complex(GO:0070876)
0.2	1.6	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2	0.7	GO:0070436	Grb2-EGFR complex(GO:0070436)
0.2	0.5	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.2	0.7	GO:1990769	proximal neuron projection(GO:1990769)
0.1	0.7	GO:0070695	FHF complex(GO:0070695)
0.1	1.7	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1	1.5	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	1.6	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1	6.9	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.1	9.7	GO:0031225	anchored component of membrane(GO:0031225)
0.1	1.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.1	0.5	GO:1990630	IRE1-RACK1-PP2A complex(GO:1990630)
0.1	0.8	GO:0016589	NURF complex(GO:0016589)
0.1	0.7	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.1	1.2	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.1	7.2	GO:0035097	histone methyltransferase complex(GO:0035097)
0.1	2.1	GO:0019013	viral nucleocapsid(GO:0019013)
0.1	2.3	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.1	58.2	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	1.0	GO:0071004	U2-type prespliceosome(GO:0071004)
0.1	5.6	GO:0032587	ruffle membrane(GO:0032587)
0.1	0.7	GO:0043202	lysosomal lumen(GO:0043202)
0.1	2.7	GO:0034707	chloride channel complex(GO:0034707)
0.1	1.8	GO:0060077	inhibitory synapse(GO:0060077)
0.1	21.4	GO:0005925	focal adhesion(GO:0005925)
0.1	2.5	GO:0016235	aggresome(GO:0016235)
0.1	0.5	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1	0.3	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.1	2.2	GO:0005912	adherens junction(GO:0005912)
0.1	2.0	GO:0031526	brush border membrane(GO:0031526)
0.1	57.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	0.3	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.1	6.2	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	0.6	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	8.5	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	0.7	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.3	GO:0070847	core mediator complex(GO:0070847)
0.0	3.8	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.9	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.7	GO:0030660	Golgi-associated vesicle membrane(GO:0030660)
0.0	1.6	GO:0043197	dendritic spine(GO:0043197)
0.0	0.2	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.0	0.4	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.8	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	3.2	GO:0005681	spliceosomal complex(GO:0005681)
0.0	0.8	GO:0015030	Cajal body(GO:0015030)
0.0	0.7	GO:0045171	intercellular bridge(GO:0045171)
0.0	5.2	GO:0000790	nuclear chromatin(GO:0000790)
0.0	2.0	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0	3.2	GO:0005667	transcription factor complex(GO:0005667)
0.0	0.1	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.0	70.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
6.6	19.9	GO:0046911	metal chelating activity(GO:0046911)
6.6	19.7	GO:0001847	opsonin receptor activity(GO:0001847)
5.2	15.7	GO:0004528	phosphodiesterase I activity(GO:0004528)
5.0	29.7	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
4.5	13.4	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
4.4	13.3	GO:0008396	oxysterol 7-alpha-hydroxylase activity(GO:0008396)
4.2	16.8	GO:0034618	arginine binding(GO:0034618)
4.0	111.1	GO:0005540	hyaluronic acid binding(GO:0005540)
3.8	11.3	GO:0004040	amidase activity(GO:0004040)
3.8	11.3	GO:0047783	steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
3.4	10.2	GO:0004769	steroid delta-isomerase activity(GO:0004769)
3.3	29.7	GO:0015232	heme transporter activity(GO:0015232)
3.1	40.9	GO:0030215	semaphorin receptor binding(GO:0030215)
3.1	12.4	GO:0070568	guanylyltransferase activity(GO:0070568)
2.9	14.6	GO:0019770	IgG receptor activity(GO:0019770)
2.9	14.5	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
2.9	14.5	GO:0050785	advanced glycation end-product receptor activity(GO:0050785)
2.9	8.7	GO:0098603	selenol Se-methyltransferase activity(GO:0098603)
2.8	8.4	GO:0046980	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
2.8	27.7	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
2.6	44.8	GO:0001848	complement binding(GO:0001848)
2.6	12.8	GO:0030348	syntaxin-3 binding(GO:0030348)
2.5	12.3	GO:0070891	lipoteichoic acid binding(GO:0070891)
2.3	7.0	GO:0070976	TIR domain binding(GO:0070976)
2.3	6.9	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
2.2	44.7	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
2.2	15.2	GO:0048019	receptor antagonist activity(GO:0048019)
2.1	10.7	GO:0004008	copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
1.9	5.8	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
1.9	5.8	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
1.9	5.6	GO:0044715	8-oxo-dGDP phosphatase activity(GO:0044715)
1.8	10.7	GO:0004568	chitinase activity(GO:0004568)
1.8	5.3	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
1.7	5.2	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
1.7	5.2	GO:0004874	aryl hydrocarbon receptor activity(GO:0004874)
1.7	3.4	GO:0031871	proteinase activated receptor binding(GO:0031871)
1.6	11.5	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
1.6	4.7	GO:0019809	spermidine binding(GO:0019809)
1.5	33.6	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
1.5	5.9	GO:0005333	norepinephrine transmembrane transporter activity(GO:0005333)
1.4	4.2	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
1.4	10.9	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
1.3	5.4	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
1.3	14.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
1.3	15.3	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.3	7.5	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.0	14.6	GO:0042043	neurexin family protein binding(GO:0042043)
1.0	5.2	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
1.0	4.1	GO:0002046	opsin binding(GO:0002046)
1.0	9.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
1.0	3.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
1.0	3.0	GO:0046979	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
1.0	5.9	GO:1901612	cardiolipin binding(GO:1901612)
0.9	21.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.9	5.5	GO:0016803	ether hydrolase activity(GO:0016803)
0.9	9.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.9	2.7	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.9	4.5	GO:0008430	selenium binding(GO:0008430)
0.9	1.8	GO:0033691	sialic acid binding(GO:0033691)
0.9	11.4	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.9	9.7	GO:0008046	axon guidance receptor activity(GO:0008046)
0.9	2.6	GO:0008476	protein-tyrosine sulfotransferase activity(GO:0008476)
0.8	5.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.8	4.6	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.8	6.2	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.8	2.3	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.8	3.8	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.8	2.3	GO:0022852	glycine-gated chloride ion channel activity(GO:0022852)
0.8	4.5	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.7	167.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.7	17.0	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.7	7.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.7	2.0	GO:0004825	methionine-tRNA ligase activity(GO:0004825)
0.7	5.3	GO:0016936	galactoside binding(GO:0016936)
0.7	3.9	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.6	3.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.6	1.9	GO:0017098	UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.6	2.5	GO:0004127	cytidylate kinase activity(GO:0004127)
0.6	7.5	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.6	14.4	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.6	3.6	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.6	5.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.5	2.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.5	4.9	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.5	58.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	9.3	GO:0004697	protein kinase C activity(GO:0004697)
0.5	11.4	GO:0042056	chemoattractant activity(GO:0042056)
0.5	1.6	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.5	13.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.5	4.1	GO:0030274	LIM domain binding(GO:0030274)
0.5	9.2	GO:0008199	ferric iron binding(GO:0008199)
0.5	2.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.5	64.9	GO:0030674	protein binding, bridging(GO:0030674)
0.5	0.5	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.4	4.9	GO:0045499	chemorepellent activity(GO:0045499)
0.4	2.7	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.4	1.3	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.4	3.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.4	5.7	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.4	2.7	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4	1.9	GO:0003680	AT DNA binding(GO:0003680)
0.4	5.6	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.4	7.6	GO:0043236	laminin binding(GO:0043236)
0.4	1.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.4	1.4	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.3	4.2	GO:0050072	m7G(5')pppN diphosphatase activity(GO:0050072)
0.3	2.1	GO:0004985	opioid receptor activity(GO:0004985)
0.3	3.6	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3	1.6	GO:0016427	tRNA (cytosine) methyltransferase activity(GO:0016427)
0.3	1.6	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.3	5.6	GO:0070628	proteasome binding(GO:0070628)
0.3	2.8	GO:0043495	protein anchor(GO:0043495)
0.3	20.2	GO:0005507	copper ion binding(GO:0005507)
0.3	2.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.3	14.0	GO:0019905	syntaxin binding(GO:0019905)
0.3	2.3	GO:0050815	phosphoserine binding(GO:0050815)
0.3	2.6	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.3	1.2	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.3	3.8	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637)
0.3	2.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.3	28.3	GO:0005178	integrin binding(GO:0005178)
0.3	2.6	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3	5.9	GO:0004601	peroxidase activity(GO:0004601)
0.3	6.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.3	1.5	GO:0016361	activin receptor activity, type I(GO:0016361)
0.3	1.5	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.2	0.7	GO:0005302	L-tyrosine transmembrane transporter activity(GO:0005302)
0.2	2.7	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2	0.7	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.2	2.0	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.2	1.2	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2	4.3	GO:0042288	MHC class I protein binding(GO:0042288)
0.2	0.7	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.2	7.0	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	13.5	GO:0030276	clathrin binding(GO:0030276)
0.2	1.1	GO:0050733	RS domain binding(GO:0050733)
0.2	4.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.2	1.1	GO:0004337	dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.2	1.7	GO:0051525	NFAT protein binding(GO:0051525)
0.2	2.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2	1.5	GO:0003896	DNA primase activity(GO:0003896)
0.2	1.7	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.2	3.1	GO:0005351	sugar:proton symporter activity(GO:0005351)
0.2	10.6	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.2	2.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2	2.3	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2	1.7	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.2	4.9	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.2	0.5	GO:0031728	CCR3 chemokine receptor binding(GO:0031728)
0.2	3.4	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.2	9.0	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2	0.7	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.2	0.7	GO:0055077	gap junction hemi-channel activity(GO:0055077) gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2	5.3	GO:0001784	phosphotyrosine binding(GO:0001784)
0.2	1.7	GO:0015386	potassium:proton antiporter activity(GO:0015386)
0.2	14.0	GO:0001046	core promoter sequence-specific DNA binding(GO:0001046)
0.1	1.5	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	2.3	GO:0005523	tropomyosin binding(GO:0005523)
0.1	0.7	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	1.8	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.1	0.7	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	8.1	GO:0003724	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1	2.2	GO:0008175	tRNA methyltransferase activity(GO:0008175)
0.1	18.7	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
0.1	5.6	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1	38.3	GO:0003924	GTPase activity(GO:0003924)
0.1	1.6	GO:0043047	single-stranded telomeric DNA binding(GO:0043047)
0.1	10.1	GO:0003725	double-stranded RNA binding(GO:0003725)
0.1	0.2	GO:0004046	aminoacylase activity(GO:0004046)
0.1	0.6	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.1	0.5	GO:0030911	TPR domain binding(GO:0030911)
0.1	1.5	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1	1.7	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.1	15.2	GO:0042626	ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1	5.6	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1	1.6	GO:0051378	serotonin binding(GO:0051378)
0.1	1.6	GO:0003688	DNA replication origin binding(GO:0003688)
0.1	2.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1	4.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.1	4.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.1	3.0	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	5.0	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1	9.8	GO:0070851	growth factor receptor binding(GO:0070851)
0.1	21.9	GO:0030246	carbohydrate binding(GO:0030246)
0.1	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.1	2.9	GO:0000049	tRNA binding(GO:0000049)
0.1	1.6	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.5	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.1	0.4	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.1	1.9	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1	0.4	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.1	2.0	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.1	1.8	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	0.6	GO:0001054	RNA polymerase I activity(GO:0001054)
0.1	0.7	GO:0004000	adenosine deaminase activity(GO:0004000)
0.1	2.4	GO:0004532	exoribonuclease activity(GO:0004532)
0.1	0.5	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	1.3	GO:0004890	GABA-A receptor activity(GO:0004890)
0.1	1.4	GO:0008483	transaminase activity(GO:0008483)
0.1	2.0	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	1.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	21.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0	2.6	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	2.3	GO:0030551	cyclic nucleotide binding(GO:0030551)
0.0	0.7	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.8	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	5.8	GO:0008022	protein C-terminus binding(GO:0008022)
0.0	1.5	GO:0008083	growth factor activity(GO:0008083)
0.0	3.2	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0	14.9	GO:0005509	calcium ion binding(GO:0005509)
0.0	1.1	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.9	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0	0.5	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.4	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	2.6	GO:0020037	heme binding(GO:0020037)
0.0	26.3	GO:0003723	RNA binding(GO:0003723)
0.0	0.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.5	GO:0008094	DNA-dependent ATPase activity(GO:0008094)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.3	134.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
2.4	36.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
2.4	70.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
1.3	295.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	19.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.8	29.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.8	14.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.8	17.8	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.8	0.8	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.7	112.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7	11.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.6	29.6	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.6	4.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.6	23.9	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.5	11.5	PID TRAIL PATHWAY	TRAIL signaling pathway
0.5	29.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.5	20.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.5	16.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.5	34.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.5	7.5	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4	11.5	PID IFNG PATHWAY	IFN-gamma pathway
0.4	10.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.4	5.0	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.3	3.4	ST GA12 PATHWAY	G alpha 12 Pathway
0.3	1.9	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	5.3	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.3	10.2	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.3	4.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	13.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	1.9	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2	7.8	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.2	1.6	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	5.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	3.5	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.2	6.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	1.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	1.5	PID ALK2 PATHWAY	ALK2 signaling events
0.1	1.5	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	4.2	PID ATR PATHWAY	ATR signaling pathway
0.1	1.7	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	2.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	2.0	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	2.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	3.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	1.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	1.3	PID RAS PATHWAY	Regulation of Ras family activation
0.0	1.2	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	8.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	1.4	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	3.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	2.3	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.4	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.4	PID BARD1 PATHWAY	BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.2	147.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
7.2	43.4	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
3.1	39.7	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
2.7	29.3	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
2.3	40.9	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
2.0	33.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.9	22.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.4	37.7	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.4	12.3	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
1.3	13.8	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
1.2	18.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.2	34.6	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
1.1	19.4	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
1.1	19.4	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
1.1	11.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
1.1	63.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.9	44.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.9	7.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.8	13.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.8	8.9	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.7	11.6	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.6	11.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.6	22.8	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.5	65.6	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.5	9.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.5	16.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.4	6.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	6.9	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.4	6.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4	11.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.4	14.1	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.4	7.5	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.4	11.5	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.3	5.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3	6.5	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.3	5.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.3	3.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3	6.6	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.3	5.5	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.3	3.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3	3.9	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.3	20.1	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	14.4	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.3	7.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.3	8.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	4.7	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	2.4	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.2	1.9	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2	2.6	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.2	2.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.2	9.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	1.9	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.2	5.9	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.2	9.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	3.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.2	5.0	REACTOME ION CHANNEL TRANSPORT	Genes involved in Ion channel transport
0.2	8.7	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.2	5.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.2	4.9	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	2.0	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	1.6	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1	5.7	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.1	1.9	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.1	1.6	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.1	1.5	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	5.5	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	1.9	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	1.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	5.2	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.1	3.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	2.8	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	1.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	1.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	1.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.0	REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0	2.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	1.5	REACTOME RNA POL III TRANSCRIPTION	Genes involved in RNA Polymerase III Transcription
0.0	0.7	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.7	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.7	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	2.0	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.0	0.8	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.8	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0	0.7	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.7	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	0.8	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.5	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	1.6	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0	1.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.2	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis

Results for Stat4_Stat3_Stat5b

Z-value: 1.24

Motif logo

Transcription factors associated with Stat4_Stat3_Stat5b

Activity-expression correlation:

Activity profile of Stat4_Stat3_Stat5b motif

Sorted Z-values of Stat4_Stat3_Stat5b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat4_Stat3_Stat5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: