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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Vdr

Z-value: 0.84

Motif logo

Transcription factors associated with Vdr

Gene Symbol Gene ID Gene Info
ENSRNOG00000054420 vitamin D (1,25- dihydroxyvitamin D3) receptor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Vdrrn6_v1_chr7_-_139394166_139394166-0.276.6e-07Click!

Activity profile of Vdr motif

Sorted Z-values of Vdr motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_248723397 33.55 ENSRNOT00000072188
mannose-binding protein C-like
chr16_-_7007287 28.58 ENSRNOT00000041216
inter-alpha trypsin inhibitor, heavy chain 3
chr16_-_7007051 28.19 ENSRNOT00000023984
inter-alpha trypsin inhibitor, heavy chain 3
chr10_+_64952119 24.25 ENSRNOT00000012154
pipecolic acid and sarcosine oxidase
chr6_+_128050250 24.05 ENSRNOT00000077517
ENSRNOT00000013961
Ab1-233
chr12_-_11733099 22.26 ENSRNOT00000051244
ENSRNOT00000087257
cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1
chr7_-_123621102 21.08 ENSRNOT00000046024
cytochrome P450, family 2, subfamily d, polypeptide 5
chr2_-_23256158 18.87 ENSRNOT00000015336
betaine-homocysteine S-methyltransferase
chr10_+_65767930 18.84 ENSRNOT00000039954
vitronectin
chr1_+_83711251 18.30 ENSRNOT00000028237
ENSRNOT00000092008
cytochrome P450, family 2, subfamily a, polypeptide 1
chr1_+_83744238 17.95 ENSRNOT00000028249
cytochrome P450, family 2, subfamily a, polypeptide 1
chr1_-_162385575 17.79 ENSRNOT00000016540
thyroid hormone responsive
chr13_-_80738634 17.15 ENSRNOT00000081551
flavin containing monooxygenase 1
chr16_+_10267482 17.13 ENSRNOT00000085255
growth differentiation factor 2
chrX_+_71272042 17.02 ENSRNOT00000076034
ENSRNOT00000076816
gap junction protein, beta 1
chr11_+_74057361 16.27 ENSRNOT00000048746
carboxypeptidase N subunit 2
chr9_+_16530074 15.52 ENSRNOT00000091565
pre T-cell antigen receptor alpha
chr20_+_40769586 14.09 ENSRNOT00000001079
fatty acid binding protein 7
chr20_+_3156170 13.23 ENSRNOT00000082880
RT1 class Ib, locus S2
chr3_-_101465995 12.72 ENSRNOT00000080175
gamma-butyrobetaine hydroxylase 1
chr2_-_220535751 12.64 ENSRNOT00000089082
palmdelphin
chr10_-_29450644 12.61 ENSRNOT00000087937
adrenoceptor alpha 1B
chr18_-_15637715 11.75 ENSRNOT00000022270
desmoglein 2
chr7_-_117187367 11.75 ENSRNOT00000014191
similar to dystonin isoform 1
chr8_-_116422366 11.64 ENSRNOT00000023623
solute carrier family 38, member 3
chr1_+_264741911 11.48 ENSRNOT00000019956
semaphorin 4G
chr15_+_30525754 11.36 ENSRNOT00000086842

chr4_+_69457472 11.21 ENSRNOT00000067597
T cell receptor beta, variable 19
chr13_+_99335020 10.83 ENSRNOT00000029787

chr15_-_60512704 10.48 ENSRNOT00000049056
tumor necrosis factor superfamily member 11
chr7_-_70452675 10.48 ENSRNOT00000090498

chr5_+_126670825 10.35 ENSRNOT00000012201
cytochrome b5 reductase-like
chr15_+_32817343 9.56 ENSRNOT00000073853

chr1_-_102826965 9.53 ENSRNOT00000078692
serum amyloid A4
chr15_+_31462806 9.29 ENSRNOT00000072946

chr4_-_177196180 8.90 ENSRNOT00000018999
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr11_+_87058616 8.52 ENSRNOT00000002576
ENSRNOT00000082855
proline dehydrogenase 1
chr6_-_75551625 8.49 ENSRNOT00000005825
serine palmitoyltransferase, small subunit A
chr8_+_22856539 8.18 ENSRNOT00000015381
angiopoietin-like 8
chr19_-_10620671 7.96 ENSRNOT00000021842
C-C motif chemokine ligand 17
chr15_+_31533675 7.95 ENSRNOT00000084141

chr15_+_29096865 7.83 ENSRNOT00000077709

chr2_+_207108552 7.23 ENSRNOT00000027234
solute carrier family 16 member 1
chr1_-_53038229 7.18 ENSRNOT00000017282
mitochondrial pyruvate carrier 1
chr10_-_87067456 7.16 ENSRNOT00000014163
C-C motif chemokine receptor 7
chr6_-_138093643 6.99 ENSRNOT00000045874
immunoglobulin heavy chain 6
chr1_+_197659187 6.90 ENSRNOT00000082228
serine/threonine-protein kinase SBK1
chr1_-_189238776 6.75 ENSRNOT00000020817
protein disulfide isomerase-like, testis expressed
chr9_-_98551410 6.73 ENSRNOT00000066346
ENSRNOT00000086678
hes family bHLH transcription factor 6
chr13_+_91481461 6.55 ENSRNOT00000012103
olfactory receptor 1576
chr8_-_33661049 6.49 ENSRNOT00000068037
Fli-1 proto-oncogene, ETS transcription factor
chr16_-_54513349 6.44 ENSRNOT00000014809
ENSRNOT00000015127
solute carrier family 7 member 2
chr16_+_26859397 6.11 ENSRNOT00000044171
methylsterol monooxygenase 1
chr15_-_29810811 5.85 ENSRNOT00000060386

chr8_+_48718329 5.71 ENSRNOT00000089763
solute carrier family 37 member 4
chr13_+_89586283 5.58 ENSRNOT00000079355
ENSRNOT00000049873
nuclear receptor subfamily 1, group I, member 3
chr1_+_164706276 5.55 ENSRNOT00000024311
olfactory receptor 36
chr5_-_79317110 5.51 ENSRNOT00000082513
ENSRNOT00000002309
whirlin
chr10_+_11724032 5.42 ENSRNOT00000008966
TNF receptor-associated protein 1
chr16_+_81153489 5.40 ENSRNOT00000024999
G protein-coupled receptor kinase 1
chr5_-_169200109 5.22 ENSRNOT00000012745
zinc finger and BTB domain containing 48
chr2_+_185524774 5.14 ENSRNOT00000089338
LPS responsive beige-like anchor protein
chr17_+_43661222 5.05 ENSRNOT00000022881
ENSRNOT00000022809
ENSRNOT00000022810
hemochromatosis
chr16_+_6609668 4.74 ENSRNOT00000021862
transketolase
chr7_-_3010350 4.72 ENSRNOT00000006796
erb-b2 receptor tyrosine kinase 3
chr10_-_90410569 4.65 ENSRNOT00000036112
integrin subunit alpha 2b
chr20_-_11359090 4.64 ENSRNOT00000001610
DNA methyltransferase 3 like
chr11_+_88122271 4.47 ENSRNOT00000002540
stromal cell-derived factor 2-like 1
chr8_+_43348973 4.32 ENSRNOT00000007862
olfactory receptor 1308
chr6_+_7961413 4.22 ENSRNOT00000007638
ENSRNOT00000061871
ATP binding cassette subfamily G member 8
chr12_+_10255416 4.17 ENSRNOT00000092720
G protein-coupled receptor 12
chrX_-_124162058 4.05 ENSRNOT00000071436
similar to B-cell translocation gene 1
chr11_-_87240833 4.04 ENSRNOT00000052200
testis-specific serine kinase 1B
chr3_-_172537877 4.04 ENSRNOT00000072069
cathepsin Z
chr9_-_93404883 4.03 ENSRNOT00000025024
neuromedin U receptor 1
chr16_+_72086878 3.94 ENSRNOT00000023756
ENSRNOT00000078085
ADAM metallopeptidase domain 3A
chrX_-_4957529 3.90 ENSRNOT00000000173
dual specificity phosphatase 21
chr4_-_38240848 3.80 ENSRNOT00000007567
NADH:ubiquinone oxidoreductase subunit A4
chr6_-_33088582 3.78 ENSRNOT00000083144
tudor domain containing 15
chr10_+_43817947 3.73 ENSRNOT00000032816
LY6/PLAUR domain containing 8
chr1_+_189514553 3.72 ENSRNOT00000020039
acyl-CoA synthetase medium-chain family member 3
chr16_+_50111306 3.59 ENSRNOT00000019302
cytochrome P450, family 4, subfamily v, polypeptide 3
chr9_-_101107535 3.58 ENSRNOT00000080892
ENSRNOT00000071424
coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial-like
chrX_-_75291938 3.53 ENSRNOT00000003739
ENSRNOT00000083655
ATP binding cassette subfamily B member 7
chr13_+_77940454 3.50 ENSRNOT00000003460
mitochondrial ribosomal protein S14
chr1_+_53531947 3.45 ENSRNOT00000077340
t-complex protein 10b
chr1_-_226732736 3.44 ENSRNOT00000072343
pepsin F-like
chr1_-_216942782 3.42 ENSRNOT00000049057
similar to MAS-related G-protein coupled receptor, member G
chr12_-_17186679 3.41 ENSRNOT00000001730
UNC homeobox
chr5_-_157268903 3.37 ENSRNOT00000022716
phospholipase A2, group V
chr9_-_92435363 3.30 ENSRNOT00000093735
ENSRNOT00000022822
ENSRNOT00000093245
thyroid hormone receptor interactor 12
chr8_-_13680870 3.28 ENSRNOT00000081616
hephaestin-like 1
chr19_-_36239712 3.26 ENSRNOT00000071962

chrX_+_42951237 3.24 ENSRNOT00000060113
similar to vitellogenin-like 1 precursor
chr7_+_2458833 3.09 ENSRNOT00000085092
nascent polypeptide-associated complex alpha subunit
chr14_-_44524252 3.09 ENSRNOT00000003779
lipoic acid synthetase
chrX_-_15467875 3.07 ENSRNOT00000011207
Pim-2 proto-oncogene, serine/threonine kinase
chr10_+_34564009 3.05 ENSRNOT00000041536
olfactory receptor 1388
chr6_-_99274269 3.00 ENSRNOT00000058675
testis expressed 21
chr17_-_44595323 2.99 ENSRNOT00000086767
POM121 transmembrane nucleoporin-like 2
chrX_-_102510007 2.94 ENSRNOT00000082854

chr5_+_159484370 2.88 ENSRNOT00000010593
succinate dehydrogenase complex iron sulfur subunit B
chr5_-_24631679 2.88 ENSRNOT00000010846
ENSRNOT00000067129
epithelial splicing regulatory protein 1
chr7_+_141953794 2.84 ENSRNOT00000041938
transmembrane protease, serine 12
chr10_-_70516421 2.83 ENSRNOT00000013233
peroxisomal biogenesis factor 12
chr6_-_8066868 2.82 ENSRNOT00000008200
leucine-rich pentatricopeptide repeat containing
chr9_+_17782395 2.79 ENSRNOT00000064497
uncharacterized LOC108352018
chr11_-_43099412 2.77 ENSRNOT00000002281
gamma-aminobutyric acid type A receptor rho3 subunit
chr3_+_175982777 2.73 ENSRNOT00000082073
neurotensin receptor 1
chr2_+_60180215 2.73 ENSRNOT00000084624
prolactin receptor
chr9_-_10054359 2.71 ENSRNOT00000072001
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr4_-_71870273 2.67 ENSRNOT00000077384
olfactory receptor 801
chr1_+_87045796 2.65 ENSRNOT00000027620
galectin 7
chrX_+_124894466 2.64 ENSRNOT00000080894
MCTS1, re-initiation and release factor
chr19_-_46167950 2.63 ENSRNOT00000071024

chr7_-_113937941 2.63 ENSRNOT00000012408
potassium two pore domain channel subfamily K member 9
chr4_+_162937774 2.58 ENSRNOT00000083188
C-type lectin domain family 2, member G
chr5_-_155252003 2.55 ENSRNOT00000017060
complement C1q B chain
chr4_+_148589144 2.51 ENSRNOT00000044870
olfactory receptor 827
chrX_+_124894706 2.50 ENSRNOT00000066677
MCTS1, re-initiation and release factor
chr1_+_217151166 2.44 ENSRNOT00000071484
SH3 and multiple ankyrin repeat domains 2
chr1_-_141533908 2.44 ENSRNOT00000020117
mesoderm posterior bHLH transcription factor 1
chr4_+_149970567 2.42 ENSRNOT00000091765
heterogeneous nuclear ribonucleoprotein F
chr5_-_157518511 2.40 ENSRNOT00000070865
ENSRNOT00000078028
5-hydroxytryptamine receptor 6
chr6_-_138250089 2.39 ENSRNOT00000048378
immunoglobulin heavy constant mu
chr12_+_44931494 2.38 ENSRNOT00000001498
replication factor C subunit 5
chr2_-_208420163 2.37 ENSRNOT00000021920
ATP synthase subunit b, mitochondrial-like
chr3_+_73089269 2.34 ENSRNOT00000084321
olfactory receptor 453
chr1_-_168160811 2.34 ENSRNOT00000020981
olfactory receptor 70
chr17_+_39542096 2.33 ENSRNOT00000090652
Prolactin family 2, subfamily b, member 1
chr10_+_34553284 2.28 ENSRNOT00000049989
olfactory receptor 1387
chr18_+_16590408 2.27 ENSRNOT00000093715
molybdenum cofactor sulfurase
chr5_-_158313426 2.23 ENSRNOT00000025488
paired box 7
chr2_-_211322719 2.22 ENSRNOT00000027493
similar to KIAA1324 protein
chr10_-_88611105 2.22 ENSRNOT00000024718
DEXH-box helicase 58
chr3_+_164665532 2.15 ENSRNOT00000014309
protein tyrosine phosphatase, non-receptor type 1
chrX_+_26294066 2.13 ENSRNOT00000037862
holocytochrome c synthase
chr4_+_72332490 2.13 ENSRNOT00000088294
olfactory receptor 6B1
chr7_-_130170609 2.11 ENSRNOT00000088030
DENN domain containing 6B
chr4_+_149970237 2.10 ENSRNOT00000019529
heterogeneous nuclear ribonucleoprotein F
chr10_+_34756094 2.10 ENSRNOT00000050554
olfactory receptor 1399
chr19_-_53625665 2.07 ENSRNOT00000079651
ENSRNOT00000068764
F-box protein 31
chr1_+_163398891 2.07 ENSRNOT00000020513
guanylate cyclase 2E
chr3_+_148635775 2.07 ENSRNOT00000067261
transmembrane 9 superfamily member 4
chr3_+_21292026 2.05 ENSRNOT00000036382
olfactory receptor 429
chr3_-_8981362 2.04 ENSRNOT00000086717
carnitine O-acetyltransferase
chr15_-_34566719 2.03 ENSRNOT00000064643
short chain dehydrogenase/reductase family 39U, member 1
chr1_+_170887363 2.01 ENSRNOT00000036261
olfactory receptor 215
chr10_+_14722756 2.00 ENSRNOT00000025220
tryptase beta 2
chr9_+_17163354 1.96 ENSRNOT00000026049
DNA polymerase eta
chr3_-_74503106 1.95 ENSRNOT00000057508
olfactory receptor 529
chr20_-_11546046 1.95 ENSRNOT00000068374
hypothetical protein LOC690386
chr1_+_167374182 1.94 ENSRNOT00000092882
stromal interaction molecule 1
chr3_-_5330466 1.94 ENSRNOT00000081193

chr1_+_167169442 1.94 ENSRNOT00000048172
short transient receptor potential channel 2-like
chr6_-_127552151 1.93 ENSRNOT00000035035
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16
chr1_-_167911961 1.93 ENSRNOT00000025097
olfactory receptor 59
chr1_-_173180745 1.93 ENSRNOT00000043904
olfactory receptor 203
chr20_-_12351813 1.91 ENSRNOT00000065236
solute carrier family 19 member 1
chr7_+_35125424 1.91 ENSRNOT00000085978
ENSRNOT00000010117
NADH:ubiquinone oxidoreductase subunit A12
chr3_-_114235933 1.89 ENSRNOT00000023939
dual oxidase 2
chr1_+_99762253 1.86 ENSRNOT00000065876
kallikrein related-peptidase 6
chr9_-_61974898 1.86 ENSRNOT00000091519
boule homolog, RNA binding protein
chr17_+_44794130 1.84 ENSRNOT00000077571
histone cluster 1, H2ac
chr8_-_48564722 1.84 ENSRNOT00000067902
Cbl proto-oncogene
chr3_+_43255567 1.83 ENSRNOT00000044419
glycerol-3-phosphate dehydrogenase 2
chr6_+_99817431 1.83 ENSRNOT00000009621
churchill domain containing 1
chr10_+_68232094 1.83 ENSRNOT00000009172
sperm acrosome associated 3
chr10_+_49368314 1.81 ENSRNOT00000004392
CMT1A duplicated region transcript 4
chr9_-_64573660 1.80 ENSRNOT00000021299
protein boule-like
chr19_-_11057254 1.80 ENSRNOT00000025559
homocysteine inducible ER protein with ubiquitin like domain 1
chr11_-_60546997 1.78 ENSRNOT00000083124
ENSRNOT00000050092
B and T lymphocyte associated
chr5_-_134638150 1.78 ENSRNOT00000013480
testis expressed 38
chr1_-_169334093 1.78 ENSRNOT00000032587
ubiquilin 3
chr17_+_4063432 1.72 ENSRNOT00000073585
cathepsin Q-like 2
chr9_+_99763768 1.71 ENSRNOT00000049910
olfactory receptor 1351
chr1_-_71342633 1.70 ENSRNOT00000071400
zinc finger and SCAN domain containing 5B
chr7_-_144886926 1.68 ENSRNOT00000051929

chr11_-_60547201 1.67 ENSRNOT00000093151
B and T lymphocyte associated
chr3_-_74670392 1.67 ENSRNOT00000048376
olfactory receptor 540
chr1_-_212679602 1.66 ENSRNOT00000029171
olfactory receptor 288
chr8_+_61901128 1.66 ENSRNOT00000033209
similar to taste receptor protein 1
chr12_+_23473270 1.65 ENSRNOT00000001935
SH2B adaptor protein 2
chr9_-_64573076 1.63 ENSRNOT00000084658
protein boule-like
chr10_-_14092289 1.62 ENSRNOT00000019624
NADH:ubiquinone oxidoreductase subunit B10
chr3_+_19441604 1.61 ENSRNOT00000090581

chr13_-_89518939 1.61 ENSRNOT00000004228
succinate dehydrogenase complex subunit C
chr2_+_200076054 1.61 ENSRNOT00000025327
SEC22 homolog B, vesicle trafficking protein
chr3_-_78942535 1.55 ENSRNOT00000008924
olfactory receptor 731
chr17_-_42777186 1.54 ENSRNOT00000023086
Prolactin family 3, subfamily b, member 1
chr3_-_123206828 1.47 ENSRNOT00000030192
DDRGK domain containing 1
chr2_-_199529864 1.46 ENSRNOT00000023742
olfactory receptor 390
chr3_-_172566010 1.44 ENSRNOT00000071913
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr1_+_220746387 1.42 ENSRNOT00000027753
eukaryotic translation initiation factor 1A domain containing
chr7_+_130227456 1.41 ENSRNOT00000078423
ENSRNOT00000011070
protein phosphatase 6, regulatory subunit 2
chr3_+_52588288 1.40 ENSRNOT00000081962

chr16_-_74662194 1.39 ENSRNOT00000034670
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr13_+_91768256 1.38 ENSRNOT00000071206
similar to olfactory receptor 1403
chr3_-_75185017 1.37 ENSRNOT00000046809
olfactory receptor 546
chr19_-_41541986 1.37 ENSRNOT00000059172
transducin-like enhancer protein 2-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Vdr

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 18.9 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
6.1 24.3 GO:0006554 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
5.2 36.2 GO:0009804 coumarin metabolic process(GO:0009804)
4.2 12.6 GO:0045819 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) positive regulation of glycogen catabolic process(GO:0045819)
3.9 11.6 GO:0089709 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
3.1 9.2 GO:0089718 amino acid import across plasma membrane(GO:0089718)
2.8 8.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
2.6 10.5 GO:2001206 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) TNFSF11-mediated signaling pathway(GO:0071847) positive regulation of osteoclast development(GO:2001206)
2.4 33.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
2.4 7.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
2.1 12.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
1.9 5.6 GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901227)
1.9 22.3 GO:0070989 oxidative demethylation(GO:0070989)
1.8 5.4 GO:1901856 negative regulation of cellular respiration(GO:1901856)
1.8 5.4 GO:0008594 photoreceptor cell morphogenesis(GO:0008594) post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
1.8 7.2 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.7 56.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
1.7 17.2 GO:0070995 NADPH oxidation(GO:0070995)
1.7 18.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.7 5.0 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
1.7 11.8 GO:0003164 His-Purkinje system development(GO:0003164)
1.3 5.1 GO:0002188 translation reinitiation(GO:0002188)
1.2 2.4 GO:0060921 sinoatrial node cell differentiation(GO:0060921)
1.2 21.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
1.1 17.0 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
1.1 3.4 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
1.1 15.5 GO:0070244 negative regulation of thymocyte apoptotic process(GO:0070244)
1.0 3.1 GO:0009106 lipoate metabolic process(GO:0009106)
1.0 2.0 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
1.0 1.0 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.9 4.7 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.8 3.3 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.8 5.7 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.8 4.6 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.8 6.9 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.7 14.1 GO:0060134 prepulse inhibition(GO:0060134)
0.7 1.5 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.7 4.2 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.7 4.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.7 17.8 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.6 1.3 GO:0002930 trabecular meshwork development(GO:0002930)
0.6 1.9 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
0.6 1.9 GO:0042335 cuticle development(GO:0042335)
0.6 2.4 GO:0014055 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056)
0.6 2.8 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.6 2.2 GO:1900245 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.5 2.1 GO:1903898 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.5 7.5 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
0.5 6.8 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.5 1.9 GO:0051958 methotrexate transport(GO:0051958)
0.5 0.9 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.4 1.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.4 3.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 8.9 GO:0097503 sialylation(GO:0097503)
0.4 9.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 5.5 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.4 1.2 GO:0051012 microtubule sliding(GO:0051012)
0.4 3.5 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.4 1.8 GO:0019563 glycerol catabolic process(GO:0019563)
0.4 21.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.4 1.8 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.3 2.7 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 4.7 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.3 1.7 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.3 2.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.3 8.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.3 4.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.3 6.5 GO:0035855 megakaryocyte development(GO:0035855)
0.3 2.2 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.3 0.8 GO:1901726 negative regulation of histone deacetylase activity(GO:1901726)
0.3 1.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.3 2.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3 1.3 GO:0006566 threonine metabolic process(GO:0006566) short-chain fatty acid biosynthetic process(GO:0051790)
0.2 0.7 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.2 2.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.2 1.0 GO:0060155 platelet dense granule organization(GO:0060155)
0.2 1.9 GO:0000012 single strand break repair(GO:0000012)
0.2 2.3 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.2 3.2 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.2 2.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.2 2.4 GO:0098880 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.2 9.5 GO:0006953 acute-phase response(GO:0006953)
0.2 0.7 GO:0060468 prevention of polyspermy(GO:0060468)
0.2 2.1 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.2 1.8 GO:0090649 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.2 2.8 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.2 1.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 4.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.2 5.8 GO:0035036 sperm-egg recognition(GO:0035036)
0.2 0.9 GO:0032466 negative regulation of cytokinesis(GO:0032466)
0.1 2.8 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 3.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.2 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.1 0.5 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0002397 MHC class I protein complex assembly(GO:0002397)
0.1 3.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.2 GO:0007000 nucleolus organization(GO:0007000)
0.1 1.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 13.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 4.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 2.9 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 4.0 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 0.6 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.1 1.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.6 GO:0015074 DNA integration(GO:0015074)
0.1 1.0 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.1 12.9 GO:0008360 regulation of cell shape(GO:0008360)
0.1 3.7 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 4.7 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.9 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.1 3.1 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 2.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 1.2 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 2.1 GO:0017004 cytochrome complex assembly(GO:0017004)
0.1 5.2 GO:0010833 telomere maintenance via telomere lengthening(GO:0010833)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 1.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.9 GO:0018410 C-terminal protein amino acid modification(GO:0018410) regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 3.6 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 0.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.2 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.1 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 2.1 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 2.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.4 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 1.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.6 GO:0002675 positive regulation of acute inflammatory response(GO:0002675)
0.0 4.5 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.5 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 5.4 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 33.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.6 GO:0006308 DNA catabolic process(GO:0006308)
0.0 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.8 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.0 GO:0009156 ribonucleoside monophosphate biosynthetic process(GO:0009156)
0.0 0.6 GO:0043278 response to morphine(GO:0043278)
0.0 0.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.8 GO:0007595 lactation(GO:0007595)
0.0 0.1 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.0 0.0 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.4 GO:0001825 blastocyst formation(GO:0001825)
0.0 0.2 GO:0019236 response to pheromone(GO:0019236)
0.0 0.6 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 18.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.7 7.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.4 4.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
1.1 4.5 GO:0045273 respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281)
1.1 8.5 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.9 2.8 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.9 5.5 GO:0002142 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.8 5.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.8 17.0 GO:0005922 connexon complex(GO:0005922)
0.6 1.8 GO:1990037 Lewy body core(GO:1990037)
0.5 11.8 GO:0030057 desmosome(GO:0030057)
0.5 2.7 GO:0032280 symmetric synapse(GO:0032280)
0.4 4.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.4 2.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.4 1.2 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.4 1.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 27.6 GO:0005581 collagen trimer(GO:0005581)
0.3 2.8 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.3 1.0 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.3 9.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.3 0.9 GO:0097444 spine apparatus(GO:0097444)
0.3 1.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.3 3.0 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.3 2.1 GO:0097443 sorting endosome(GO:0097443)
0.2 1.2 GO:1990716 axonemal central apparatus(GO:1990716)
0.2 4.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 7.2 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 20.7 GO:0072562 blood microparticle(GO:0072562)
0.2 31.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 1.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 2.4 GO:0005883 neurofilament(GO:0005883)
0.2 0.9 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.2 4.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 1.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 1.8 GO:0016600 flotillin complex(GO:0016600)
0.1 7.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.4 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 7.4 GO:0014704 intercalated disc(GO:0014704)
0.1 1.0 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 4.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 5.4 GO:0005811 lipid particle(GO:0005811)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 74.9 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1 0.7 GO:0005771 multivesicular body(GO:0005771)
0.1 2.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.2 GO:1990597 climbing fiber(GO:0044301) parallel fiber(GO:1990032) AIP1-IRE1 complex(GO:1990597)
0.1 10.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 4.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 11.0 GO:0043197 dendritic spine(GO:0043197)
0.1 5.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 3.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 4.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 7.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.9 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 2.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.8 GO:0000786 nucleosome(GO:0000786)
0.0 6.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 26.9 GO:0005615 extracellular space(GO:0005615)
0.0 2.1 GO:0055037 recycling endosome(GO:0055037)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 5.2 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.2 GO:0001533 cornified envelope(GO:0001533)
0.0 24.8 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 24.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
4.2 12.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
3.9 11.6 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
2.8 8.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
2.4 18.9 GO:0008172 S-methyltransferase activity(GO:0008172)
2.1 58.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
1.7 8.5 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
1.4 7.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.4 17.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.4 6.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.2 17.0 GO:0005243 gap junction channel activity(GO:0005243)
1.1 4.5 GO:0000104 succinate dehydrogenase activity(GO:0000104)
1.1 6.4 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.9 4.7 GO:0038132 neuregulin binding(GO:0038132)
0.9 4.7 GO:0070051 fibrinogen binding(GO:0070051)
0.9 2.7 GO:0004925 prolactin receptor activity(GO:0004925)
0.9 4.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.8 6.8 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.8 5.7 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.8 4.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.8 18.8 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.8 21.1 GO:0070330 aromatase activity(GO:0070330)
0.7 5.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.7 7.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.7 2.7 GO:0016492 G-protein coupled neurotensin receptor activity(GO:0016492)
0.7 5.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.6 1.8 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.6 7.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.6 2.3 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
0.5 3.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.5 5.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.5 1.9 GO:0015350 methotrexate transporter activity(GO:0015350)
0.5 5.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.5 54.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 3.7 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.4 1.3 GO:0070905 serine binding(GO:0070905)
0.4 8.9 GO:0008373 sialyltransferase activity(GO:0008373)
0.4 3.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 3.0 GO:0008494 translation activator activity(GO:0008494)
0.3 17.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.3 12.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.3 3.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.3 8.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.3 14.1 GO:0005504 fatty acid binding(GO:0005504)
0.3 8.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 8.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 2.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 1.0 GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding(GO:1990269)
0.2 3.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 10.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 0.7 GO:0032190 acrosin binding(GO:0032190)
0.2 2.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 3.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 4.2 GO:0017127 cholesterol transporter activity(GO:0017127)
0.2 1.9 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 5.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 1.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.0 GO:0032027 myosin light chain binding(GO:0032027)
0.2 4.2 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 1.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.2 2.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 3.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.4 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.2 0.7 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 3.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.8 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.9 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 3.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.9 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.1 3.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 2.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 4.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 14.2 GO:0005179 hormone activity(GO:0005179)
0.1 4.0 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.7 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 6.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 2.9 GO:0035326 enhancer binding(GO:0035326)
0.1 1.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 4.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.2 GO:0008199 ferric iron binding(GO:0008199)
0.1 2.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.4 GO:0046977 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.1 2.1 GO:0030332 cyclin binding(GO:0030332)
0.1 0.7 GO:0042923 neuropeptide binding(GO:0042923)
0.1 2.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 5.4 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 1.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 7.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.8 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 27.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 4.6 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 3.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 6.6 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0005507 copper ion binding(GO:0005507)
0.0 2.2 GO:0050662 coenzyme binding(GO:0050662)
0.0 1.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 18.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4 12.9 PID ALK1 PATHWAY ALK1 signaling events
0.3 65.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 17.4 PID NOTCH PATHWAY Notch signaling pathway
0.2 4.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 12.6 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.2 10.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 6.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 3.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 2.1 PID IGF1 PATHWAY IGF1 pathway
0.1 8.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 2.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 1.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 5.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 1.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.4 PID ATR PATHWAY ATR signaling pathway
0.0 1.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 17.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.8 11.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.7 18.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 6.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.5 18.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.4 15.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 26.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 4.7 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 14.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 13.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.3 6.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 4.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 2.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 4.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 3.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 1.8 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 2.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 1.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.4 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 7.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.6 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 5.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 3.2 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 1.2 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 6.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 4.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 3.2 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 1.9 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.0 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)