Motif ID: AAUGCCC

Z-value: 0.749


Mature miRNA associated with seed AAUGCCC:

NamemiRBase Accession
hsa-miR-365 MIMAT0000710



Activity profile for motif AAUGCCC.

activity profile for motif AAUGCCC


Sorted Z-values histogram for motif AAUGCCC

Sorted Z-values for motif AAUGCCC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAUGCCC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_34642587 1.783 NM_001206615
NM_012153
EHF

ets homologous factor

chr11_+_34654010 1.640 NM_001206616
EHF
ets homologous factor
chr2_+_155555092 1.217 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr14_-_36989333 1.147 NM_001079668
NKX2-1
NK2 homeobox 1
chr1_+_2985730 1.079 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr14_-_36988902 1.036 NM_003317
NKX2-1
NK2 homeobox 1
chr1_-_153588789 0.901 NM_020672
S100A14
S100 calcium binding protein A14
chr10_+_102505337 0.828 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr11_+_2466171 0.819 NM_000218
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr19_-_49576120 0.735 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chrX_-_83442906 0.722 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr16_-_51185150 0.721 NM_002968
SALL1
sal-like 1 (Drosophila)
chr14_-_61190458 0.716 NM_017420
SIX4
SIX homeobox 4
chr6_-_46138584 0.687 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr4_-_101439071 0.660 NM_001159694
NM_016242
EMCN

endomucin

chr6_+_17393610 0.658 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr16_-_51184507 0.647 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr10_+_52834233 0.640 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr2_-_158732341 0.600 NM_001111067
ACVR1
activin A receptor, type I
chr10_+_52750904 0.590 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr6_-_134498973 0.588 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr10_-_62332666 0.585 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr13_-_46425756 0.581 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr11_-_27742224 0.564 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr10_-_61900659 0.521 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_27721975 0.506 NM_001143813
NM_001143814
NM_001709
BDNF


brain-derived neurotrophic factor


chr5_-_142077508 0.504 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr12_-_70093064 0.496 NM_032735
BEST3
bestrophin 3
chr5_-_141993691 0.493 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr12_-_70083055 0.492 NM_152439
BEST3
bestrophin 3
chr9_-_116102533 0.492 NM_001012361
NM_145241
WDR31

WD repeat domain 31

chrX_-_3631654 0.489 NM_005044
PRKX
protein kinase, X-linked
chr12_+_50366619 0.480 NM_001652
AQP6
aquaporin 6, kidney specific
chr10_-_62493282 0.468 NM_001204403
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_183731279 0.463 NM_001463
FRZB
frizzled-related protein
chr12_+_26205490 0.461 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr10_-_98273444 0.461 NM_012465
TLL2
tolloid-like 2
chr3_-_55521330 0.460 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr11_-_34379526 0.460 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr12_+_26126687 0.454 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr6_-_134496006 0.429 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr11_+_64073040 0.428 NM_004451
ESRRA
estrogen-related receptor alpha
chr2_-_56151273 0.413 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr11_-_27722599 0.394 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr12_-_118406027 0.389 NM_173598
KSR2
kinase suppressor of ras 2
chr16_+_19422056 0.389 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr20_+_9198036 0.386 NM_182797
PLCB4
phospholipase C, beta 4
chr10_+_75670861 0.386 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr20_-_3149070 0.383 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr12_-_67072881 0.370 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr11_-_27721179 0.370 NM_170734
BDNF
brain-derived neurotrophic factor
chr3_+_189349215 0.367 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr5_-_90679115 0.366 NM_020801
ARRDC3
arrestin domain containing 3
chr5_+_133861685 0.365 NM_015288
PHF15
PHD finger protein 15
chr4_+_91048683 0.364 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr5_-_58571916 0.363 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_+_9049660 0.358 NM_001172646
PLCB4
phospholipase C, beta 4
chr8_+_35092963 0.349 NM_080872
UNC5D
unc-5 homolog D (C. elegans)
chr4_-_149363498 0.342 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr16_-_122573 0.337 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr3_+_189507448 0.337 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr1_+_145524989 0.334 NM_003637
ITGA10
integrin, alpha 10
chr8_+_120220554 0.334 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr5_-_142000899 0.331 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr15_+_99192696 0.330 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr6_-_139613114 0.330 NM_153235
TXLNB
taxilin beta
chr9_-_100395961 0.328 NM_139246
TSTD2
thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
chr6_-_134639195 0.324 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr21_+_38071990 0.318 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr5_-_142065991 0.316 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr4_+_148402068 0.315 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr2_-_158731622 0.313 NM_001105
ACVR1
activin A receptor, type I
chrX_+_109246338 0.312 NM_032227
TMEM164
transmembrane protein 164
chrX_+_69664704 0.312 NM_021120
DLG3
discs, large homolog 3 (Drosophila)
chr5_-_59189620 0.305 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_142065586 0.299 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr5_-_64777703 0.299 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr5_-_59064437 0.293 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_+_9288446 0.290 NM_000933
PLCB4
phospholipase C, beta 4
chr3_-_48632592 0.286 NM_000094
COL7A1
collagen, type VII, alpha 1
chr5_-_58882274 0.285 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_+_181410 0.285 NM_001202464
ZMYND11
zinc finger, MYND-type containing 11
chrX_+_109245851 0.284 NM_017698
TMEM164
transmembrane protein 164
chr19_+_18111923 0.281 NM_001025604
ARRDC2
arrestin domain containing 2
chr6_-_134497069 0.279 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_31479120 0.278 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr11_-_27723061 0.278 NM_170733
BDNF
brain-derived neurotrophic factor
chr3_+_23986735 0.272 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr11_+_72983246 0.271 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr6_+_16129285 0.268 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr1_-_117753476 0.266 NM_001253850
NM_024626
VTCN1

V-set domain containing T cell activation inhibitor 1

chr11_-_27741192 0.265 NM_001143807
BDNF
brain-derived neurotrophic factor
chr14_-_61115906 0.263 NM_005982
SIX1
SIX homeobox 1
chr5_-_58334936 0.261 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr3_-_15839674 0.260 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr4_-_11430502 0.258 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr2_-_183903225 0.258 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr8_+_120885899 0.258 NM_022783
DEPTOR
DEP domain containing MTOR-interacting protein
chr10_+_104474297 0.255 NM_178858
SFXN2
sideroflexin 2
chr15_+_96873845 0.254 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr18_+_32397925 0.252 NM_001198943
DTNA
dystrobrevin, alpha
chr8_+_28351694 0.249 NM_017412
NM_145866
FZD3

frizzled family receptor 3

chrX_+_69672110 0.249 NM_020730
DLG3
discs, large homolog 3 (Drosophila)
chr4_-_40517913 0.247 NM_019027
RBM47
RNA binding motif protein 47
chr17_-_48072566 0.246 NM_005220
DLX3
distal-less homeobox 3
chrX_+_69674914 0.246 NM_001166278
DLG3
discs, large homolog 3 (Drosophila)
chr3_+_23987514 0.245 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr10_-_62149487 0.245 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_56494930 0.244 NM_017763
RNF43
ring finger protein 43
chr5_-_58652671 0.240 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_+_4535030 0.236 NM_001099952
NM_001168272
NM_002222
ITPR1


inositol 1,4,5-trisphosphate receptor, type 1


chr15_+_96875793 0.235 NM_001145156
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr16_+_19467771 0.234 NM_024780
TMC5
transmembrane channel-like 5
chr1_+_203274646 0.233 NM_006763
BTG2
BTG family, member 2
chr3_-_9291251 0.231 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr3_+_14989076 0.231 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr3_-_11685395 0.229 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr5_+_122181159 0.229 NM_014035
SNX24
sorting nexin 24
chr3_+_119421865 0.229 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr19_+_33166312 0.223 NM_207391
RGS9BP
regulator of G protein signaling 9 binding protein
chr5_-_58295758 0.222 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_56414688 0.221 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr19_+_18118921 0.221 NM_015683
ARRDC2
arrestin domain containing 2
chr8_-_57123858 0.219 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr18_+_32398225 0.218 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr12_+_26111951 0.218 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr11_-_27681195 0.212 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr1_-_26197743 0.207 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr5_-_59783885 0.206 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr18_+_32335939 0.206 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr3_-_15798057 0.205 NM_001195099
ANKRD28
ankyrin repeat domain 28
chr16_-_66730466 0.203 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr5_-_41510627 0.202 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr11_-_18655962 0.197 NM_194285
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr4_+_88928797 0.196 NM_000297
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr4_+_41992492 0.195 NM_006345
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr3_+_14444083 0.193 NM_001134367
NM_001134368
NM_003043
SLC6A6


solute carrier family 6 (neurotransmitter transporter, taurine), member 6


chr9_+_116638544 0.193 NM_133374
ZNF618
zinc finger protein 618
chr2_-_153573858 0.192 NM_017892
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr11_-_27722446 0.191 NM_001143812
BDNF
brain-derived neurotrophic factor
chr12_+_56137063 0.191 NM_005811
GDF11
growth differentiation factor 11
chr12_+_74931550 0.190 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr16_+_67063035 0.189 NM_001755
NM_022845
CBFB

core-binding factor, beta subunit

chr7_+_101460881 0.189 NM_181552
CUX1
cut-like homeobox 1
chr11_-_16497917 0.188 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr16_+_53088791 0.188 NM_025134
CHD9
chromodomain helicase DNA binding protein 9
chr20_+_45523247 0.185 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr1_+_157963062 0.184 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr3_+_2933898 0.182 NM_001206956
NM_175613
CNTN4

contactin 4

chr5_-_39074494 0.182 NM_152756
RICTOR
RPTOR independent companion of MTOR, complex 2
chr18_+_32173281 0.180 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr3_+_113616317 0.180 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr3_-_113465101 0.179 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr13_+_30002776 0.178 NM_015233
MTUS2
microtubule associated tumor suppressor candidate 2
chr3_-_11623829 0.177 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr3_-_11761946 0.176 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr9_-_14398981 0.175 NM_001190738
NFIB
nuclear factor I/B
chr3_-_15900928 0.175 NM_015199
ANKRD28
ankyrin repeat domain 28
chr1_+_236958539 0.173 NM_000254
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr12_-_49182718 0.173 NM_020983
ADCY6
adenylate cyclase 6
chr12_+_2162388 0.172 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr7_-_150675236 0.170 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr1_-_100715388 0.170 NM_001918
DBT
dihydrolipoamide branched chain transacylase E2
chr10_-_101190201 0.169 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr6_+_46620631 0.169 NM_001204051
NM_001204052
NM_004277
SLC25A27


solute carrier family 25, member 27


chr20_+_33292117 0.168 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr3_+_113557679 0.168 NM_017577
GRAMD1C
GRAM domain containing 1C
chr20_-_3388219 0.166 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr4_-_74124456 0.165 NM_032217
NM_198889
ANKRD17

ankyrin repeat domain 17

chr10_+_180404 0.165 NM_006624
NM_001202465
NM_001202466
NM_212479
ZMYND11



zinc finger, MYND-type containing 11



chr3_-_125094003 0.162 NM_021964
ZNF148
zinc finger protein 148
chr18_+_7567313 0.162 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr10_-_7829906 0.160 NM_012311
KIN
KIN, antigenic determinant of recA protein homolog (mouse)
chr22_-_41842853 0.160 NM_016272
TOB2
transducer of ERBB2, 2
chr4_-_40631846 0.159 NM_001098634
RBM47
RNA binding motif protein 47
chr3_+_171757413 0.159 NM_022763
FNDC3B
fibronectin type III domain containing 3B
chr1_-_155904186 0.157 NM_014949
KIAA0907
KIAA0907
chr2_+_46524448 0.155 NM_001430
EPAS1
endothelial PAS domain protein 1
chr10_-_103815868 0.154 NM_024541
C10orf76
chromosome 10 open reading frame 76
chr7_-_27205148 0.152 NM_152739
HOXA9
homeobox A9
chr16_-_67840464 0.151 NM_020850
RANBP10
RAN binding protein 10
chr11_+_111895537 0.148 NM_001931
DLAT
dihydrolipoamide S-acetyltransferase
chr12_-_49177876 0.147 NM_015270
ADCY6
adenylate cyclase 6
chr17_-_17399494 0.146 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr17_-_44270144 0.146 NM_001193466
KIAA1267
KIAA1267
chr12_+_64238511 0.146 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr2_+_85980600 0.146 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr11_+_63655986 0.142 NM_017490
MARK2
MAP/microtubule affinity-regulating kinase 2
chr8_+_21946636 0.142 NM_022749
FAM160B2
family with sequence similarity 160, member B2
chr15_+_96876568 0.137 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_+_43138919 0.136 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr3_-_47823386 0.133 NM_003074
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr6_+_36644236 0.129 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr3_+_2280512 0.128 NM_001206955
CNTN4
contactin 4
chr11_-_16430425 0.124 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr14_+_55518313 0.124 NM_144578
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr10_-_103874661 0.122 NM_003893
LDB1
LIM domain binding 1
chr13_+_29598746 0.119 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr1_-_28415071 0.118 NM_001990
EYA3
eyes absent homolog 3 (Drosophila)
chr1_-_91487769 0.118 NM_032186
NM_201269
ZNF644

zinc finger protein 644


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
198.87 2.32e-03 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
118.71 6.58e-03 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
116.66 6.81e-03 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
18.23 1.42e-02 GO:0045893 positive regulation of transcription, DNA-dependent
17.00 1.75e-02 GO:0051254 positive regulation of RNA metabolic process
16.84 1.80e-02 GO:0010628 positive regulation of gene expression
15.28 2.41e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
15.01 2.54e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
58.94 2.69e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
14.57 2.78e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
13.60 3.42e-02 GO:0031328 positive regulation of cellular biosynthetic process
13.38 3.60e-02 GO:0009891 positive regulation of biosynthetic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
15.96 1.96e-03 GO:0043565 sequence-specific DNA binding
22.13 1.77e-02 GO:0016563 transcription activator activity