Motif ID: ACUGGCC

Z-value: 0.719


Mature miRNA associated with seed ACUGGCC:

NamemiRBase Accession
hsa-miR-193a-3p MIMAT0000459
hsa-miR-193b MIMAT0002819



Activity profile for motif ACUGGCC.

activity profile for motif ACUGGCC


Sorted Z-values histogram for motif ACUGGCC

Sorted Z-values for motif ACUGGCC



Network of associatons between targets according to the STRING database.



First level regulatory network of ACUGGCC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_217560247 3.398 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr1_-_117210301 2.462 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr2_+_14772809 1.936 NM_145175
FAM84A
family with sequence similarity 84, member A
chr2_+_176957448 1.932 NM_000523
HOXD13
homeobox D13
chr14_-_80677839 1.704 NM_001007023
NM_001242502
NM_001242503
NM_013989
DIO2



deiodinase, iodothyronine, type II



chr6_-_166075520 1.690 NM_006661
NM_001130690
PDE10A

phosphodiesterase 10A

chr17_+_37896219 1.617 NM_001242443
GRB7
growth factor receptor-bound protein 7
chr4_+_55523906 1.616 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr17_+_37894558 1.543 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr1_+_218518675 1.479 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr11_+_69455837 1.476 NM_053056
CCND1
cyclin D1
chr17_+_37895023 1.420 NM_001242442
GRB7
growth factor receptor-bound protein 7
chr4_-_87374282 1.378 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr2_+_85980600 1.348 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr13_-_99404883 1.343 NM_005073
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr2_-_20424627 1.271 NM_002997
SDC1
syndecan 1
chr11_-_27494232 1.255 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr1_+_77333158 1.225 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr18_+_55862577 1.179 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr13_+_98795410 1.146 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr14_-_80697396 1.136 NM_000793
DIO2
deiodinase, iodothyronine, type II
chr2_+_204192915 1.134 NM_005759
ABI2
abl-interactor 2
chr2_-_213403280 1.103 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr18_+_55711388 1.092 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr15_+_84322809 1.080 NM_207517
ADAMTSL3
ADAMTS-like 3
chr12_+_50344523 1.039 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr7_-_14029641 1.008 NM_001163147
NM_004956
ETV1

ets variant 1

chr9_+_116638544 1.004 NM_133374
ZNF618
zinc finger protein 618
chr7_-_14030864 1.001 NM_001163149
ETV1
ets variant 1
chr2_-_20425166 0.988 NM_001006946
SDC1
syndecan 1
chr1_+_183605207 0.980 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr4_-_87028805 0.976 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr18_+_55888750 0.956 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_+_37894161 0.945 NM_005310
GRB7
growth factor receptor-bound protein 7
chr18_+_55816546 0.943 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr3_-_57199402 0.940 NM_017563
IL17RD
interleukin 17 receptor D
chr14_-_27066959 0.929 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr7_-_14031049 0.890 NM_001163148
ETV1
ets variant 1
chr10_-_108924287 0.830 NM_001013031
NM_001206569
NM_001206570
NM_001206571
NM_001206572
NM_052918
SORCS1





sortilin-related VPS10 domain containing receptor 1





chr18_+_55714457 0.827 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr13_+_93879011 0.812 NM_005708
GPC6
glypican 6
chr6_-_42110714 0.794 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr4_-_87281374 0.771 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr8_-_91094924 0.755 NM_004929
CALB1
calbindin 1, 28kDa
chr12_-_23737507 0.748 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr4_-_23891608 0.724 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr3_-_123603144 0.647 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr7_+_108210188 0.646 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr4_+_153864134 0.644 NM_033393
FHDC1
FH2 domain containing 1
chr5_-_141704575 0.643 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr2_-_218808705 0.605 NM_022648
TNS1
tensin 1
chr14_-_89020888 0.594 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr18_-_24445652 0.583 NM_001650
AQP4
aquaporin 4
chr8_-_93107881 0.568 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr12_-_50297575 0.567 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr8_-_93115453 0.560 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr18_-_24442534 0.540 NM_004028
AQP4
aquaporin 4
chr10_-_62332666 0.540 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_-_123339423 0.540 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr9_+_127539382 0.520 NM_182487
OLFML2A
olfactomedin-like 2A
chr20_-_14318200 0.520 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr16_-_75285383 0.520 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr3_-_184870727 0.519 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr8_-_93107442 0.509 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr11_+_120195837 0.497 NM_001198670
NM_001198671
NM_001198672
NM_001198673
NM_001198674
NM_001198675
NM_174926
TMEM136






transmembrane protein 136






chr4_+_126237566 0.486 NM_024582
FAT4
FAT tumor suppressor homolog 4 (Drosophila)
chr12_+_79439432 0.471 NM_001135806
SYT1
synaptotagmin I
chr16_-_75299713 0.438 NM_001170720
NM_001170714
NM_001170718
BCAR1


breast cancer anti-estrogen resistance 1


chr6_+_86159301 0.437 NM_001204813
NM_002526
NT5E

5'-nucleotidase, ecto (CD73)

chr12_+_54393876 0.437 NM_006897
HOXC9
homeobox C9
chr7_-_22396511 0.431 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_47074749 0.407 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr11_+_33563772 0.372 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr18_+_46065367 0.370 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr13_-_37494370 0.367 NM_001127217
NM_005905
SMAD9

SMAD family member 9

chr11_-_118023534 0.365 NM_001142348
NM_174934
SCN4B

sodium channel, voltage-gated, type IV, beta

chr7_+_140774031 0.363 NM_001195278
LOC100507421
transmembrane protein 178-like
chr5_-_159739482 0.363 NM_024565
CCNJL
cyclin J-like
chr10_-_62493282 0.357 NM_001204403
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrX_-_40594774 0.351 NM_004229
MED14
mediator complex subunit 14
chr11_+_120207617 0.346 NM_001198665
NM_015313
ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12

chr12_-_24715349 0.344 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr5_-_124080773 0.333 NM_020747
ZNF608
zinc finger protein 608
chr11_-_118016134 0.332 NM_001142349
SCN4B
sodium channel, voltage-gated, type IV, beta
chr21_+_27107257 0.325 NM_001197297
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr11_-_30607762 0.322 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr1_-_216896640 0.318 NM_001243515
NM_001243518
NM_001243519
NM_001438
ESRRG



estrogen-related receptor gamma



chr16_-_75300678 0.317 NM_001170716
BCAR1
breast cancer anti-estrogen resistance 1
chr9_-_35749209 0.315 NM_020944
GBA2
glucosidase, beta (bile acid) 2
chr21_+_33245304 0.300 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr12_-_24102563 0.294 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr10_-_100027943 0.281 NM_032211
LOXL4
lysyl oxidase-like 4
chr1_-_217311095 0.279 NM_001134285
ESRRG
estrogen-related receptor gamma
chr12_+_79258448 0.269 NM_005639
SYT1
synaptotagmin I
chr16_-_75282137 0.269 NM_001170719
BCAR1
breast cancer anti-estrogen resistance 1
chr14_-_54955714 0.266 NM_004124
GMFB
glia maturation factor, beta
chr1_+_210502188 0.262 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr18_+_67068134 0.261 NM_152721
DOK6
docking protein 6
chr16_-_75301950 0.258 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr9_-_37465384 0.258 NM_014872
ZBTB5
zinc finger and BTB domain containing 5
chr1_+_164528586 0.257 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr20_-_39928708 0.257 NM_015035
ZHX3
zinc fingers and homeoboxes 3
chr21_+_27107322 0.254 NM_002040
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr1_-_217262946 0.245 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr16_+_12995454 0.241 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr1_+_181452685 0.228 NM_000721
NM_001205293
NM_001205294
CACNA1E


calcium channel, voltage-dependent, R type, alpha 1E subunit


chr6_-_2635297 0.213 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr1_+_210502639 0.208 NM_001170580
HHAT
hedgehog acyltransferase
chr9_+_136243226 0.207 NM_153710
C9orf96
chromosome 9 open reading frame 96
chr3_-_183979074 0.205 NM_033259
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr11_-_95657255 0.205 NM_001243571
NM_016156
NM_201278
NM_201281
MTMR2



myotubularin related protein 2



chr12_+_54422193 0.196 NM_004503
HOXC6
homeobox C6
chr20_+_42086468 0.189 NM_006275
SRSF6
serine/arginine-rich splicing factor 6
chr10_-_61900659 0.188 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr12_+_79257772 0.187 NM_001135805
SYT1
synaptotagmin I
chr16_-_75272979 0.185 NM_001170721
BCAR1
breast cancer anti-estrogen resistance 1
chr3_-_129147331 0.177 NM_207307
C3orf25
chromosome 3 open reading frame 25
chr3_+_187871473 0.167 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_62149487 0.161 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_+_797390 0.161 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr22_+_23487512 0.156 NM_004914
RAB36
RAB36, member RAS oncogene family
chr12_-_56236614 0.150 NM_002429
MMP19
matrix metallopeptidase 19
chr1_+_210501595 0.148 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr16_-_4166185 0.146 NM_001116
ADCY9
adenylate cyclase 9
chr1_+_6845381 0.141 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr1_-_92371558 0.137 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr7_-_14025826 0.129 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr12_+_78225068 0.125 NM_014903
NAV3
neuron navigator 3
chr6_-_75994631 0.116 NM_001143958
NM_018247
TMEM30A

transmembrane protein 30A

chr3_+_187930720 0.100 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_48796919 0.096 NM_006107
NM_016424
LUC7L3

LUC7-like 3 (S. cerevisiae)

chr1_+_155290639 0.096 NM_001105203
NM_001105204
RUSC1

RUN and SH3 domain containing 1

chr8_-_93075190 0.093 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_131644368 0.092 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr15_+_74422589 0.091 NM_001130138
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr22_+_42470247 0.079 NM_001002034
FAM109B
family with sequence similarity 109, member B
chr9_-_99382073 0.075 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr4_-_87770267 0.075 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr8_-_93029864 0.075 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_+_67956136 0.072 NM_004232
SOCS6
suppressor of cytokine signaling 6
chr3_-_33481862 0.069 NM_001128160
NM_014517
UBP1

upstream binding protein 1 (LBP-1a)

chr20_-_4990913 0.068 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr20_+_43104513 0.056 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr1_+_245133628 0.054 NM_001143943
EFCAB2
EF-hand calcium binding domain 2
chr15_+_74421986 0.054 NM_001130137
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr15_+_74421698 0.054 NM_001130136
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr17_+_26698986 0.053 NM_015077
SARM1
sterile alpha and TIR motif containing 1
chr16_-_69166062 0.048 NM_001040146
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr15_+_74422742 0.045 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr17_-_40190043 0.045 NM_001242704
ZNF385C
zinc finger protein 385C
chr2_-_131850988 0.044 NM_001009993
FAM168B
family with sequence similarity 168, member B
chr16_-_69166492 0.044 NM_001039690
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr20_+_60718473 0.039 NM_198935
SS18L1
synovial sarcoma translocation gene on chromosome 18-like 1
chr9_-_99329092 0.036 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr7_+_100136784 0.029 NM_006076
AGFG2
ArfGAP with FG repeats 2
chr3_-_33481877 0.028 NM_001128161
UBP1
upstream binding protein 1 (LBP-1a)
chrX_-_152486073 0.026 NM_004988
MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chrX_-_151938194 0.024 NM_005362
MAGEA3
melanoma antigen family A, 3
chr2_+_242641310 0.022 NM_032329
ING5
inhibitor of growth family, member 5
chr12_+_50017340 0.021 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr6_-_38607923 0.021 NM_001099272
NM_052893
BTBD9

BTB (POZ) domain containing 9

chr1_+_155293727 0.019 NM_001105205
RUSC1
RUN and SH3 domain containing 1
chr7_+_155250705 0.013 NM_001427
EN2
engrailed homeobox 2
chr4_+_166128769 0.012 NM_007246
KLHL2
kelch-like 2, Mayven (Drosophila)
chr15_-_23086842 0.011 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chrX_+_151867244 0.010 NM_005363
NM_175868
MAGEA2
MAGEA6

melanoma antigen family A, 2
melanoma antigen family A, 6

chr15_+_64388082 0.008 NM_001242933
NM_003099
NM_148955
SNX1


sorting nexin 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
33.95 1.36e-03 GO:0046546 development of primary male sexual characteristics
31.67 1.80e-03 GO:0046661 male sex differentiation
13.63 6.71e-03 GO:0010035 response to inorganic substance
11.28 1.66e-02 GO:0003006 developmental process involved in reproduction
17.31 1.95e-02 GO:0045137 development of primary sexual characteristics
17.20 2.00e-02 GO:0010038 response to metal ion
35.22 2.17e-02 GO:0051592 response to calcium ion
15.94 2.69e-02 GO:0048608 reproductive structure development
32.02 2.89e-02 GO:0042476 odontogenesis
15.59 2.93e-02 GO:0048732 gland development
30.63 3.29e-02 GO:0008584 male gonad development
14.85 3.53e-02 GO:0007548 sex differentiation
5.63 3.73e-02 GO:0032879 regulation of localization
100.56 4.80e-02 GO:0048103 somatic stem cell division

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
28.19 5.02e-04 GO:0005057 receptor signaling protein activity
127.97 5.11e-03 GO:0004716 receptor signaling protein tyrosine kinase activity
87.99 1.11e-02 GO:0016248 channel inhibitor activity