Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.849


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZHX2hg19_v1_chr8_+_123963649_123963750-0.772.7e-07Click!
ADNPhg19_v1_chr20_-_49547451_49547996-0.459.9e-03Click!
SIX2hg19_v1_chr2_-_45236521_45236580-0.441.2e-02Click!
IRX4hg19_v1_chr5_-_1882764_1882879-0.441.2e-02Click!
IRX5hg19_v1_chr16_+_54965110_54965110-0.309.0e-02Click!
ZHX3hg19_v1_chr20_-_39946119_39946312-0.261.5e-01Click!
ZHX1hg19_v1_chr8_-_124286566_124286817-0.163.8e-01Click!
SIX5hg19_v1_chr19_-_46272496_46272496-0.115.3e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_72649734 16.115 NM_000583
 GC
group-specific component (vitamin D binding protein)
chr4_+_74269971 11.549 NM_000477
 ALB
albumin
chr16_+_20462858 11.285 NM_001010845
 ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr17_-_64225496 11.155 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr16_-_20587625 11.125 NM_001105069
NM_182617
 ACSM2B

acyl-CoA synthetase medium-chain family member 2B

chr1_-_159684274 10.956 NM_000567
 CRP
C-reactive protein, pentraxin-related
chr2_+_234580504 9.354 NM_021027
 UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr12_+_20963637 9.330 NM_019844
 SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr20_-_7921068 8.931 NM_017545
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr2_+_234826042 8.073 NM_024080
 TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr8_-_17752847 7.543 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chr17_+_27369917 7.075 NM_016518
 PIPOX
pipecolic acid oxidase
chr3_+_151591428 6.800 NM_033050
 SUCNR1
succinate receptor 1
chr6_-_25874439 6.774 NM_001098486
NM_006632
 SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr3_-_194072004 6.735 NM_001080513
 CPN2
carboxypeptidase N, polypeptide 2
chr17_+_27370155 6.588 PIPOX
pipecolic acid oxidase
chr9_-_104198045 6.085 NM_000035
 ALDOB
aldolase B, fructose-bisphosphate
chr14_+_39703119 5.733 NM_054024
 MIA2
melanoma inhibitory activity 2
chr2_-_10942642 5.625 PDIA6
protein disulfide isomerase family A, member 6
chr20_+_5987897 5.567 NM_001127458
 CRLS1
cardiolipin synthase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 60 entries
Enrichment   P-value GO Accession GO Term
45.49 6.05e-04 GO:0051552 flavone metabolic process
42.65 2.79e-02 GO:0015712 hexose phosphate transport
42.65 2.79e-02 GO:0015760 glucose-6-phosphate transport
37.91 2.94e-06 GO:0009812 flavonoid metabolic process
31.02 1.57e-05 GO:0009698 phenylpropanoid metabolic process
28.43 4.97e-04 GO:0034374 low-density lipoprotein particle remodeling
17.77 7.91e-03 GO:0015721 bile acid and bile salt transport
12.93 4.37e-02 GO:0034367 macromolecular complex remodeling
12.93 4.37e-02 GO:0034368 protein-lipid complex remodeling
12.93 4.37e-02 GO:0034369 plasma lipoprotein particle remodeling
11.01 1.86e-02 GO:0006958 complement activation, classical pathway
10.76 4.12e-03 GO:0008206 bile acid metabolic process
10.69 7.90e-16 GO:0006805 xenobiotic metabolic process
10.69 7.90e-16 GO:0071466 cellular response to xenobiotic stimulus
10.61 9.56e-16 GO:0009410 response to xenobiotic stimulus
10.21 5.97e-03 GO:0030193 regulation of blood coagulation
9.75 3.87e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
9.48 1.00e-02 GO:0050818 regulation of coagulation
9.29 2.60e-03 GO:0042632 cholesterol homeostasis
9.29 2.60e-03 GO:0055092 sterol homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
32.49 5.47e-04 GO:0005577 fibrinogen complex
32.49 5.47e-04 GO:0005579 membrane attack complex
8.75 5.50e-04 GO:0031983 vesicle lumen
8.47 2.88e-03 GO:0031093 platelet alpha granule lumen
8.30 3.32e-03 GO:0034774 secretory granule lumen
7.96 4.37e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
6.99 1.04e-02 GO:0031091 platelet alpha granule
4.23 4.98e-05 GO:0042598 vesicular fraction
3.89 6.90e-04 GO:0005792 microsome
3.21 3.45e-09 GO:0005615 extracellular space
2.65 3.28e-07 GO:0044421 extracellular region part
2.23 5.84e-03 GO:0005624 membrane fraction
2.18 1.09e-08 GO:0005576 extracellular region
2.16 1.05e-02 GO:0005626 insoluble fraction
2.09 2.29e-03 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 20 of 27 entries
Enrichment   P-value GO Accession GO Term
42.65 6.59e-03 GO:0047023 androsterone dehydrogenase activity
42.65 6.59e-03 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
42.65 6.59e-03 GO:0047961 glycine N-acyltransferase activity
24.37 5.00e-12 GO:0015020 glucuronosyltransferase activity
20.68 8.68e-03 GO:0001972 retinoic acid binding
11.85 1.62e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
10.16 3.54e-02 GO:0016229 steroid dehydrogenase activity
9.31 1.36e-04 GO:0042562 hormone binding
9.05 3.26e-03 GO:0043498 cell surface binding
8.13 1.74e-03 GO:0033293 monocarboxylic acid binding
7.71 7.75e-08 GO:0008194 UDP-glycosyltransferase activity
7.00 5.39e-03 GO:0005496 steroid binding
5.64 1.25e-03 GO:0008201 heparin binding
5.47 4.50e-03 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
5.40 1.92e-03 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
5.29 1.94e-05 GO:0016758 transferase activity, transferring hexosyl groups
4.65 1.45e-03 GO:0001871 pattern binding
4.65 1.45e-03 GO:0030247 polysaccharide binding
4.64 3.44e-03 GO:0005539 glycosaminoglycan binding
4.58 3.95e-03 GO:0031406 carboxylic acid binding