Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.849


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZHX2hg19_v1_chr8_+_123963649_123963750-0.772.7e-07Click!
ADNPhg19_v1_chr20_-_49547451_49547996-0.459.9e-03Click!
SIX2hg19_v1_chr2_-_45236521_45236580-0.441.2e-02Click!
IRX4hg19_v1_chr5_-_1882764_1882879-0.441.2e-02Click!
IRX5hg19_v1_chr16_+_54965110_54965110-0.309.0e-02Click!
ZHX3hg19_v1_chr20_-_39946119_39946312-0.261.5e-01Click!
ZHX1hg19_v1_chr8_-_124286566_124286817-0.163.8e-01Click!
SIX5hg19_v1_chr19_-_46272496_46272496-0.115.3e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_72649734 16.115 NM_000583
GC
group-specific component (vitamin D binding protein)
chr4_+_74269971 11.549 NM_000477
ALB
albumin
chr16_+_20462858 11.285 NM_001010845
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr17_-_64225496 11.155 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr16_-_20587625 11.125 NM_001105069
NM_182617
ACSM2B

acyl-CoA synthetase medium-chain family member 2B

chr1_-_159684274 10.956 NM_000567
CRP
C-reactive protein, pentraxin-related
chr2_+_234580504 9.354 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr12_+_20963637 9.330 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr20_-_7921068 8.931 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr2_+_234826042 8.073 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr8_-_17752847 7.543 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr17_+_27369917 7.075 NM_016518
PIPOX
pipecolic acid oxidase
chr3_+_151591428 6.800 NM_033050
SUCNR1
succinate receptor 1
chr6_-_25874439 6.774 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr3_-_194072004 6.735 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr17_+_27370155 6.588 PIPOX
pipecolic acid oxidase
chr9_-_104198045 6.085 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr14_+_39703119 5.733 NM_054024
MIA2
melanoma inhibitory activity 2
chr2_-_10942642 5.625 PDIA6
protein disulfide isomerase family A, member 6
chr20_+_5987897 5.567 NM_001127458
CRLS1
cardiolipin synthase 1
chr3_+_108855560 5.561 FLJ22763
uncharacterized LOC401081
chr15_-_99057610 5.374 NM_182562
FAM169B
family with sequence similarity 169, member B
chr2_+_158851690 5.310 NM_001135098
UPP2
uridine phosphorylase 2
chr4_+_155484131 5.218 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr2_-_21228189 5.200 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_-_65409445 5.033 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_207277577 4.978 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr17_+_41052813 4.963 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr2_+_234545099 4.826 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr2_-_133429069 4.712 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr1_-_57431620 4.644 NM_000066
C8B
complement component 8, beta polypeptide
chr16_+_82068830 4.641 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_155533850 4.619 FGG
fibrinogen gamma chain
chr3_+_186383770 4.601 NM_000412
HRG
histidine-rich glycoprotein
chr16_+_82068910 4.575 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_87248942 4.543 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr11_-_118900078 4.491 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr14_-_57960432 4.416 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr4_+_74270832 4.347 ALB
albumin
chr16_+_82068958 4.339 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr10_+_5005685 4.245 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_-_21807120 4.192


chr4_+_78432905 4.044 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr2_+_234637772 4.038 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr15_+_58724174 4.031 NM_000236
LIPC
lipase, hepatic
chr19_+_45116921 3.890 NM_001205280
IGSF23
immunoglobulin superfamily, member 23
chr9_-_14086901 3.845 NFIB
nuclear factor I/B
chr10_+_5136613 3.805 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_-_35118223 3.791 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr2_+_88047603 3.754 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr3_-_120401401 3.738 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr8_-_17743062 3.705 FGL1
fibrinogen-like 1
chr1_+_199996729 3.663 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr10_+_96698409 3.656 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr6_+_64356430 3.601 NM_015153
PHF3
PHD finger protein 3
chr4_+_187187117 3.551 NM_000128
F11
coagulation factor XI
chr12_+_21284127 3.500 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr4_-_70725792 3.494 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr5_-_41213513 3.493 NM_000065
C6
complement component 6
chr2_+_87144737 3.463 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr17_-_46651809 3.459 NM_002146
HOXB3
homeobox B3
chr10_+_5005601 3.449 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_+_39408541 3.424 KLB
klotho beta
chr10_+_5136589 3.390 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_-_46622274 3.383 NM_002145
HOXB2
homeobox B2
chr10_+_5136556 3.363 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_-_100140330 3.339 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr2_+_211458078 3.331 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr2_+_234627423 3.318 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr1_+_167298280 3.303 NM_001198783
POU2F1
POU class 2 homeobox 1
chr4_+_187187342 3.271 F11
coagulation factor XI
chrX_-_105282714 3.242 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr1_+_159557615 3.220 NM_001639
APCS
amyloid P component, serum
chr2_+_171571800 3.207 NM_001003845
SP5
Sp5 transcription factor
chr11_+_58710721 3.203 NM_001220496
NM_080661
GLYATL1

glycine-N-acyltransferase-like 1

chr11_-_16497917 3.185 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr12_+_50869531 3.052 LARP4
La ribonucleoprotein domain family, member 4
chr12_-_103311380 3.047 NM_000277
PAH
phenylalanine hydroxylase
chr17_-_34344933 3.035 NM_005064
NM_145898
CCL23

chemokine (C-C motif) ligand 23

chr7_+_114055048 3.001 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr17_+_4692226 2.950 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr7_-_15601574 2.949 NM_001004320
AGMO
alkylglycerol monooxygenase
chr4_+_169013687 2.934 NM_007193
ANXA10
annexin A10
chr3_-_120400957 2.917 HGD
homogentisate 1,2-dioxygenase
chr19_-_48389514 2.891 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr10_-_82049178 2.879 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chrX_-_106146546 2.822 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr4_+_74347461 2.821 NM_001133
AFM
afamin
chr15_+_48498497 2.817 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr2_+_158958381 2.807 NM_173355
UPP2
uridine phosphorylase 2
chr1_-_114414245 2.787 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_167298382 2.785 POU2F1
POU class 2 homeobox 1
chr4_-_69536314 2.742 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr11_+_60146022 2.727 MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr4_+_22694547 2.724 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr7_-_27205075 2.705 HOXA9
homeobox A9
chr7_-_27205148 2.690 NM_152739
HOXA9
homeobox A9
chr2_+_234526290 2.681 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr3_+_186358148 2.680 NM_014375
FETUB
fetuin B
chr2_+_234959345 2.676 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr1_-_216596737 2.660 NM_007123
NM_206933
USH2A

Usher syndrome 2A (autosomal recessive, mild)

chr7_-_50628744 2.646 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr21_-_37948866 2.624 NM_001146077
CLDN14
claudin 14
chr13_-_103719195 2.613 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr19_-_33360641 2.590 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr6_+_161123224 2.561 NM_000301
NM_001168338
PLG

plasminogen

chr4_-_69817478 2.556 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr11_-_58499368 2.533 NM_005838
NM_201648
GLYAT

glycine-N-acyltransferase

chr3_-_141747434 2.495 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr11_-_18258315 2.466 SAA4
serum amyloid A4, constitutive
chr8_+_9953061 2.464 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chr2_-_216245573 2.463 FN1
fibronectin 1
chr18_+_29171729 2.463 NM_000371
TTR
transthyretin
chr10_-_5045967 2.430 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr18_+_28956739 2.426 NM_001134453
NM_177986
DSG4

desmoglein 4

chr1_+_54359859 2.426 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr4_-_47983430 2.417 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr7_-_27205123 2.409 HOXA9
homeobox A9
chr10_-_129691202 2.395 NM_152311
CLRN3
clarin 3
chrX_-_131573638 2.381 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr7_-_87342569 2.366 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_+_201979689 2.358 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr18_+_33234532 2.356 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr4_-_70518964 2.355 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr21_-_37914897 2.353 NM_001146078
CLDN14
claudin 14
chr18_+_21572736 2.351 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr3_-_58200397 2.339 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr3_+_52813936 2.329 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr19_+_45409003 2.319 NM_000041
APOE
apolipoprotein E
chr11_+_60145954 2.318 NM_021201
NM_206938
NM_206939
NM_206940
MS4A7



membrane-spanning 4-domains, subfamily A, member 7



chr7_-_26232148 2.232 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_171571936 2.222


chr19_-_36304200 2.210 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_39408472 2.204 NM_175737
KLB
klotho beta
chr1_+_168250277 2.201 NM_005149
TBX19
T-box 19
chr6_-_66417069 2.197 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr3_+_149192367 2.196 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr16_+_8806825 2.192 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr6_+_25754926 2.186 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr10_+_115312777 2.174 NM_004132
HABP2
hyaluronan binding protein 2
chr19_+_39899749 2.150


chr7_-_27183225 2.150 NM_019102
HOXA5
homeobox A5
chr3_+_46919235 2.140 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr12_-_96390002 2.140 NM_002108
HAL
histidine ammonia-lyase
chr20_+_238376 2.110 NM_207469
DEFB132
defensin, beta 132
chr3_+_149192479 2.104 TM4SF4
transmembrane 4 L six family member 4
chr1_+_63063186 2.098 NM_014495
ANGPTL3
angiopoietin-like 3
chr6_+_21593963 2.089 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr1_+_201979747 2.083 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chrX_+_106161589 2.082 NM_001171095
CLDN2
claudin 2
chr1_-_20306093 2.071 NM_001161729
PLA2G2A
phospholipase A2, group IIA (platelets, synovial fluid)
chr1_+_153747767 2.066 NM_024330
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr6_+_50786438 2.055 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr3_-_170744767 2.045 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_-_93257950 2.045 NM_005665
EVI5
ecotropic viral integration site 5
chr17_-_46671322 2.042 HOXB5
homeobox B5
chr2_-_21252786 2.036 APOB
apolipoprotein B (including Ag(x) antigen)
chr9_-_215892 2.026 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr1_+_241695433 2.019 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr17_-_46682333 2.006 NM_018952
HOXB6
homeobox B6
chr2_+_234590583 2.003 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr2_-_88285308 2.000 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr12_-_105322056 1.998 NM_032148
SLC41A2
solute carrier family 41, member 2
chr11_+_114166534 1.993 NM_006169
NNMT
nicotinamide N-methyltransferase
chr9_-_123812535 1.981 NM_001735
C5
complement component 5
chr11_+_114167197 1.980 NNMT
nicotinamide N-methyltransferase
chr7_-_44580857 1.977 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr5_+_76248679 1.967 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr17_-_39092714 1.954 KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_57320442 1.931 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_-_184241926 1.918 NM_001111319
CLDN22
claudin 22
chr10_+_5005453 1.913 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr6_+_136172802 1.899 NM_018945
PDE7B
phosphodiesterase 7B
chr1_-_197036350 1.894 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr2_+_234601511 1.889 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr10_+_77542518 1.886 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr17_+_7533452 1.883 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr5_-_41261539 1.879 NM_001115131
C6
complement component 6
chr7_-_104909442 1.868 NM_182691
SRPK2
SRSF protein kinase 2
chr16_+_20775311 1.864 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr15_-_56209305 1.862 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr12_-_102874158 1.845 IGF1
insulin-like growth factor 1 (somatomedin C)
chr3_-_123339178 1.837 MYLK
myosin light chain kinase
chr7_-_92855780 1.822 NM_001039372
HEPACAM2
HEPACAM family member 2
chr17_-_38956146 1.809 NM_181535
KRT28
keratin 28
chr10_+_102123420 1.802


chr6_-_49712055 1.795 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr5_-_135290521 1.774 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr1_+_61869699 1.771 NFIA
nuclear factor I/A
chr14_+_68168602 1.750 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr11_+_87032428 1.749 TMEM135
transmembrane protein 135
chr10_-_91405320 1.747 NM_148977
PANK1
pantothenate kinase 1
chr2_+_211342405 1.734 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr16_-_48266181 1.732 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr19_-_48389571 1.725 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_-_24469571 1.723 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr3_+_119500866 1.712 NR1I2
nuclear receptor subfamily 1, group I, member 2
chrX_+_70765479 1.706 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr14_+_74035762 1.705 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr20_-_22565050 1.702 NM_021784
FOXA2
forkhead box A2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
10.69 7.90e-16 GO:0006805 xenobiotic metabolic process
10.69 7.90e-16 GO:0071466 cellular response to xenobiotic stimulus
10.61 9.56e-16 GO:0009410 response to xenobiotic stimulus
4.34 2.77e-15 GO:0006082 organic acid metabolic process
4.17 1.60e-13 GO:0019752 carboxylic acid metabolic process
4.17 1.60e-13 GO:0043436 oxoacid metabolic process
7.27 2.29e-13 GO:0008202 steroid metabolic process
4.08 3.72e-13 GO:0042180 cellular ketone metabolic process
3.44 4.42e-12 GO:0006629 lipid metabolic process
2.49 3.16e-10 GO:0044281 small molecule metabolic process
5.42 4.37e-10 GO:0032787 monocarboxylic acid metabolic process
2.15 1.54e-07 GO:0065008 regulation of biological quality
2.07 6.42e-07 GO:0042221 response to chemical stimulus
37.91 2.94e-06 GO:0009812 flavonoid metabolic process
2.69 1.38e-05 GO:0070887 cellular response to chemical stimulus
31.02 1.57e-05 GO:0009698 phenylpropanoid metabolic process
1.41 2.35e-05 GO:0008152 metabolic process
3.04 2.87e-05 GO:0044255 cellular lipid metabolic process
5.97 4.30e-05 GO:0042445 hormone metabolic process
5.17 4.45e-05 GO:0010817 regulation of hormone levels
1.43 3.04e-04 GO:0050896 response to stimulus
28.43 4.97e-04 GO:0034374 low-density lipoprotein particle remodeling
45.49 6.05e-04 GO:0051552 flavone metabolic process
4.79 7.73e-04 GO:0006725 cellular aromatic compound metabolic process
2.45 1.19e-03 GO:0009611 response to wounding
8.39 1.43e-03 GO:0072376 protein activation cascade
7.20 1.55e-03 GO:0048706 embryonic skeletal system development
1.39 2.41e-03 GO:0044237 cellular metabolic process
9.29 2.60e-03 GO:0042632 cholesterol homeostasis
9.29 2.60e-03 GO:0055092 sterol homeostasis
7.76 2.83e-03 GO:0055088 lipid homeostasis
10.76 4.12e-03 GO:0008206 bile acid metabolic process
3.42 4.36e-03 GO:0006520 cellular amino acid metabolic process
4.12 5.15e-03 GO:0006631 fatty acid metabolic process
3.12 5.67e-03 GO:0044106 cellular amine metabolic process
10.21 5.97e-03 GO:0030193 regulation of blood coagulation
2.99 6.70e-03 GO:0006066 alcohol metabolic process
17.77 7.91e-03 GO:0015721 bile acid and bile salt transport
2.65 8.33e-03 GO:0048878 chemical homeostasis
6.83 8.36e-03 GO:0034754 cellular hormone metabolic process
2.86 8.48e-03 GO:0009308 amine metabolic process
7.85 9.63e-03 GO:0048704 embryonic skeletal system morphogenesis
9.48 1.00e-02 GO:0050818 regulation of coagulation
3.18 1.25e-02 GO:0043009 chordate embryonic development
3.14 1.47e-02 GO:0009792 embryo development ending in birth or egg hatching
11.01 1.86e-02 GO:0006958 complement activation, classical pathway
1.34 2.17e-02 GO:0044238 primary metabolic process
7.00 2.28e-02 GO:0019748 secondary metabolic process
2.75 2.44e-02 GO:0001775 cell activation
8.30 2.50e-02 GO:0061041 regulation of wound healing
3.28 2.50e-02 GO:0001501 skeletal system development
42.65 2.79e-02 GO:0015712 hexose phosphate transport
42.65 2.79e-02 GO:0015760 glucose-6-phosphate transport
2.22 3.60e-02 GO:0042592 homeostatic process
4.60 3.69e-02 GO:0019216 regulation of lipid metabolic process
9.75 3.87e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
3.65 4.22e-02 GO:0032101 regulation of response to external stimulus
12.93 4.37e-02 GO:0034367 macromolecular complex remodeling
12.93 4.37e-02 GO:0034368 protein-lipid complex remodeling
12.93 4.37e-02 GO:0034369 plasma lipoprotein particle remodeling

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.21 3.45e-09 GO:0005615 extracellular space
2.18 1.09e-08 GO:0005576 extracellular region
2.65 3.28e-07 GO:0044421 extracellular region part
4.23 4.98e-05 GO:0042598 vesicular fraction
32.49 5.47e-04 GO:0005577 fibrinogen complex
32.49 5.47e-04 GO:0005579 membrane attack complex
8.75 5.50e-04 GO:0031983 vesicle lumen
3.89 6.90e-04 GO:0005792 microsome
2.09 2.29e-03 GO:0000267 cell fraction
8.47 2.88e-03 GO:0031093 platelet alpha granule lumen
8.30 3.32e-03 GO:0034774 secretory granule lumen
7.96 4.37e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.23 5.84e-03 GO:0005624 membrane fraction
6.99 1.04e-02 GO:0031091 platelet alpha granule
2.16 1.05e-02 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
24.37 5.00e-12 GO:0015020 glucuronosyltransferase activity
7.71 7.75e-08 GO:0008194 UDP-glycosyltransferase activity
5.29 1.94e-05 GO:0016758 transferase activity, transferring hexosyl groups
9.31 1.36e-04 GO:0042562 hormone binding
3.43 1.64e-04 GO:0030246 carbohydrate binding
3.14 4.18e-04 GO:0008289 lipid binding
3.96 4.72e-04 GO:0016757 transferase activity, transferring glycosyl groups
5.64 1.25e-03 GO:0008201 heparin binding
4.65 1.45e-03 GO:0001871 pattern binding
4.65 1.45e-03 GO:0030247 polysaccharide binding
8.13 1.74e-03 GO:0033293 monocarboxylic acid binding
5.40 1.92e-03 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
9.05 3.26e-03 GO:0043498 cell surface binding
4.64 3.44e-03 GO:0005539 glycosaminoglycan binding
4.58 3.95e-03 GO:0031406 carboxylic acid binding
5.47 4.50e-03 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
7.00 5.39e-03 GO:0005496 steroid binding
42.65 6.59e-03 GO:0047023 androsterone dehydrogenase activity
42.65 6.59e-03 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
42.65 6.59e-03 GO:0047961 glycine N-acyltransferase activity
20.68 8.68e-03 GO:0001972 retinoic acid binding
2.08 1.24e-02 GO:0001071 nucleic acid binding transcription factor activity
2.08 1.24e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
11.85 1.62e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
2.30 3.04e-02 GO:0046983 protein dimerization activity
10.16 3.54e-02 GO:0016229 steroid dehydrogenase activity
2.59 4.83e-02 GO:0042803 protein homodimerization activity