Motif ID: AGCUGCC

Z-value: 1.067


Mature miRNA associated with seed AGCUGCC:

NamemiRBase Accession
hsa-miR-22 MIMAT0000077



Activity profile for motif AGCUGCC.

activity profile for motif AGCUGCC


Sorted Z-values histogram for motif AGCUGCC

Sorted Z-values for motif AGCUGCC



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCUGCC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_128577990 2.128 NM_001098629
NM_001098630
NM_001242452
IRF5


interferon regulatory factor 5


chr20_+_37434294 2.120 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr7_+_128578246 2.050 NM_032643
IRF5
interferon regulatory factor 5
chr18_-_74729049 2.008 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr11_+_119076974 1.806 NM_005188
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr22_-_30662787 1.657 NM_020530
OSM
oncostatin M
chr11_-_88796815 1.632 NM_000842
GRM5
glutamate receptor, metabotropic 5
chr9_-_19786886 1.592 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr14_+_71108373 1.559 NM_015351
TTC9
tetratricopeptide repeat domain 9
chr7_+_128580725 1.492 NM_001098627
IRF5
interferon regulatory factor 5
chr14_-_23288912 1.476 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr16_+_28996369 1.457 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr1_-_149889362 1.449 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr1_+_110693131 1.426 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr5_+_176784843 1.421 NM_006480
RGS14
regulator of G-protein signaling 14
chr2_+_70142152 1.391 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr14_-_67982020 1.370 NM_182526
TMEM229B
transmembrane protein 229B
chr2_-_73496595 1.339 NM_001080410
FBXO41
F-box protein 41
chr1_+_158149736 1.331 NM_001766
CD1D
CD1d molecule
chr1_-_162381805 1.298 NM_053282
SH2D1B
SH2 domain containing 1B
chr21_-_32931289 1.287 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr12_+_110437233 1.283 NM_033121
ANKRD13A
ankyrin repeat domain 13A
chr1_+_9711781 1.263 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr1_+_12227050 1.262 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr14_+_24780654 1.262 NM_001143919
LTB4R
leukotriene B4 receptor
chr10_-_99094427 1.250 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chrX_-_153095996 1.240 NM_032512
PDZD4
PDZ domain containing 4
chr11_-_75062650 1.235 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr1_-_25256767 1.234 NM_004350
RUNX3
runt-related transcription factor 3
chr16_+_28996146 1.227 NM_001014989
LAT
linker for activation of T cells
chr8_-_130951996 1.227 NM_016623
FAM49B
family with sequence similarity 49, member B
chr14_+_92788924 1.212 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr1_-_19282773 1.204 NM_001136265
IFFO2
intermediate filament family orphan 2
chr17_+_72462521 1.198 NM_007261
CD300A
CD300a molecule
chr1_-_25291474 1.187 NM_001031680
RUNX3
runt-related transcription factor 3
chr14_+_92790151 1.173 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr9_+_36136710 1.160 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr22_-_39268230 1.157 NM_014292
CBX6
chromobox homolog 6
chr12_+_6930689 1.145 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr14_+_92789536 1.144 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr10_-_3827418 1.139 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr5_-_175964223 1.126 NM_014901
RNF44
ring finger protein 44
chr1_-_175161832 1.116 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr14_-_78083109 1.107 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr14_+_24782312 1.074 NM_181657
LTB4R
leukotriene B4 receptor
chrX_-_142722869 1.060 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr14_-_23285011 1.039 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr15_+_58430394 1.035 NM_020980
AQP9
aquaporin 9
chr1_+_192778168 1.014 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr12_-_51785192 1.000 NM_007210
GALNT6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr12_+_52347163 0.999 NM_020327
ACVR1B
activin A receptor, type IB
chr8_-_95961543 0.983 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr12_+_49372235 0.974 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr2_+_226265601 0.957 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chrX_+_49832214 0.952 NM_000084
CLCN5
chloride channel 5
chr3_+_43328001 0.946 NM_001100594
NM_017719
SNRK

SNF related kinase

chr5_+_177540465 0.942 NM_015111
N4BP3
NEDD4 binding protein 3
chr1_-_43424834 0.936 NM_006516
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr17_+_74536114 0.924 NM_001077620
PRCD
progressive rod-cone degeneration
chrX_+_113818550 0.923 NM_000868
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C
chr1_-_212873306 0.911 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chrX_-_80065182 0.902 NM_153252
BRWD3
bromodomain and WD repeat domain containing 3
chr13_+_32313678 0.893 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr1_-_17766241 0.880 NM_018715
RCC2
regulator of chromosome condensation 2
chr7_-_11871735 0.878 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr10_-_7451198 0.872 NM_001018039
SFMBT2
Scm-like with four mbt domains 2
chrX_-_142722318 0.869 NM_001184750
SLITRK4
SLIT and NTRK-like family, member 4
chr12_+_120427476 0.865 NM_207311
CCDC64
coiled-coil domain containing 64
chr6_-_110501164 0.852 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr16_+_10971038 0.843 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr14_+_77228132 0.841 NM_014909
VASH1
vasohibin 1
chr17_+_29718641 0.828 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr7_+_2671582 0.826 NM_025250
TTYH3
tweety homolog 3 (Drosophila)
chr9_-_117568292 0.812 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chrX_+_12924738 0.804 NM_138636
TLR8
toll-like receptor 8
chr16_-_755718 0.785 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr5_-_149492934 0.779 NM_005211
CSF1R
colony stimulating factor 1 receptor
chr7_+_73703704 0.775 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr18_-_74844762 0.748 NM_001025100
NM_001025101
MBP

myelin basic protein

chr11_+_121322848 0.744 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr3_-_135914654 0.744 NM_018133
MSL2
male-specific lethal 2 homolog (Drosophila)
chr1_+_107682628 0.735 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr20_+_18488167 0.733 NM_006363
NM_032985
NM_032986
NM_001172746
SEC23B



Sec23 homolog B (S. cerevisiae)



chr8_+_103563847 0.732 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr4_-_87281374 0.710 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr1_-_35324645 0.709 NM_001164824
C1orf212
chromosome 1 open reading frame 212
chr1_-_8939150 0.700 NM_001428
ENO1
enolase 1, (alpha)
chr1_-_183604885 0.700 NM_005717
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr9_-_117554809 0.699 NM_001204344
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr3_-_135913276 0.698 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr17_-_76778306 0.698 NM_004762
NM_017456
CYTH1

cytohesin 1

chr1_-_8931634 0.696 NM_001201483
ENO1
enolase 1, (alpha)
chr1_-_17765052 0.690 NM_001136204
RCC2
regulator of chromosome condensation 2
chr9_+_125133228 0.685 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr4_+_106067754 0.683 NM_001127208
TET2
tet methylcytosine dioxygenase 2
chr20_+_18488548 0.682 NM_001172745
SEC23B
Sec23 homolog B (S. cerevisiae)
chr5_-_159739482 0.681 NM_024565
CCNJL
cyclin J-like
chr15_+_64791618 0.658 NM_015042
ZNF609
zinc finger protein 609
chrX_-_54070606 0.656 NM_001184897
NM_015107
PHF8

PHD finger protein 8

chr21_+_33245304 0.654 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr1_+_209757044 0.653 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr4_-_78740508 0.651 NM_144571
CNOT6L
CCR4-NOT transcription complex, subunit 6-like
chr1_+_166808721 0.649 NM_017542
POGK
pogo transposable element with KRAB domain
chr4_+_2061238 0.646 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr2_+_115919512 0.644 NM_001178034
NM_001004360
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr1_-_115259433 0.640 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr8_+_1449531 0.639 NM_004745
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr16_+_30935895 0.632 NM_001099784
FBXL19
F-box and leucine-rich repeat protein 19
chr17_-_7590731 0.631 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr12_+_27933162 0.631 NM_020782
KLHDC5
kelch domain containing 5
chr22_+_40573879 0.630 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr17_-_7578810 0.627 NM_001126115
NM_001126116
NM_001126117
TP53


tumor protein p53


chr12_-_92539614 0.627 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr9_+_115513050 0.621 NM_001012994
SNX30
sorting nexin family member 30
chr20_+_13976014 0.614 NM_080676
MACROD2
MACRO domain containing 2
chr6_+_96463844 0.614 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr14_-_88793250 0.603 NM_021161
KCNK10
potassium channel, subfamily K, member 10
chrX_-_142723921 0.595 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr14_-_74226890 0.594 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr14_-_88789531 0.592 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr1_-_17445865 0.590 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr5_+_141016516 0.583 NM_001130029
NM_173828
RELL2

RELT-like 2

chr8_-_101965601 0.578 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr16_+_50321822 0.578 NM_001114
ADCY7
adenylate cyclase 7
chr16_+_30675777 0.577 NM_001105079
FBRS
fibrosin
chr5_+_139739786 0.574 NM_031467
SLC4A9
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr10_-_7453412 0.572 NM_001029880
SFMBT2
Scm-like with four mbt domains 2
chr1_-_40157067 0.569 NM_016257
HPCAL4
hippocalcin like 4
chr20_-_31071187 0.563 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr5_+_176730812 0.561 NM_013237
PRELID1
PRELI domain containing 1
chr3_-_49823972 0.561 NM_001006115
NM_153273
IP6K1

inositol hexakisphosphate kinase 1

chrX_-_54071568 0.559 NM_001184896
PHF8
PHD finger protein 8
chr15_+_74833517 0.559 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr1_+_26438267 0.554 NM_001243533
NM_152835
PDIK1L

PDLIM1 interacting kinase 1 like

chr12_+_53574506 0.553 NM_001004304
ZNF740
zinc finger protein 740
chr1_-_35325335 0.550 NM_001164825
NM_138428
C1orf212

chromosome 1 open reading frame 212

chr12_-_53893195 0.540 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr1_-_40367539 0.534 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr22_+_40440664 0.532 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chrX_+_49687212 0.532 NM_001127898
NM_001127899
CLCN5

chloride channel 5

chr10_+_119301955 0.528 NM_001165924
NM_004098
EMX2

empty spiracles homeobox 2

chr1_-_204380903 0.527 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr3_+_185000714 0.525 NM_001242314
NM_001242317
MAP3K13

mitogen-activated protein kinase kinase kinase 13

chr1_+_110091185 0.523 NM_006496
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr14_-_88737160 0.521 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr2_-_127864505 0.520 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr16_+_24266873 0.519 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr19_+_47104490 0.517 NM_005184
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr7_-_71802207 0.516 NM_001017440
CALN1
calneuron 1
chr12_+_103351451 0.515 NM_004316
ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr12_+_52345437 0.515 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr3_-_52312655 0.513 NM_025222
WDR82
WD repeat domain 82
chr17_+_54911452 0.506 NM_003647
DGKE
diacylglycerol kinase, epsilon 64kDa
chr4_-_153273683 0.496 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chrX_+_108780235 0.495 NM_001242618
NXT2
nuclear transport factor 2-like export factor 2
chr11_+_35965530 0.495 NM_174902
LDLRAD3
low density lipoprotein receptor class A domain containing 3
chr3_-_49823626 0.491 NM_001242829
IP6K1
inositol hexakisphosphate kinase 1
chr1_+_154377668 0.488 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr6_+_41040687 0.487 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chr6_-_62995852 0.487 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr11_-_88781039 0.480 NM_001143831
GRM5
glutamate receptor, metabotropic 5
chr7_-_143059144 0.474 NM_014690
FAM131B
family with sequence similarity 131, member B
chr11_+_118978087 0.472 NM_014807
C2CD2L
C2CD2-like
chr20_+_11898536 0.470 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr19_+_49468557 0.467 NM_000146
FTL
ferritin, light polypeptide
chr12_+_53774422 0.467 NM_003109
SP1
Sp1 transcription factor
chrX_+_108780058 0.466 NM_001242617
NXT2
nuclear transport factor 2-like export factor 2
chr12_+_53773924 0.464 NM_001251825
NM_138473
SP1

Sp1 transcription factor

chr11_+_1411089 0.462 NM_003957
BRSK2
BR serine/threonine kinase 2
chr2_+_135676387 0.454 NM_001241
NM_058241
CCNT2

cyclin T2

chr19_+_14142261 0.451 NM_004843
IL27RA
interleukin 27 receptor, alpha
chr3_-_50649110 0.446 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr11_+_64949279 0.445 NM_005186
CAPN1
calpain 1, (mu/I) large subunit
chr1_+_2160133 0.443 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr7_-_143059696 0.443 NM_001031690
FAM131B
family with sequence similarity 131, member B
chr21_-_45660699 0.440 NM_015259
ICOSLG
inducible T-cell co-stimulator ligand
chr12_-_118406027 0.439 NM_173598
KSR2
kinase suppressor of ras 2
chr9_-_134612924 0.438 NM_005312
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr3_+_38179968 0.437 NM_001172566
NM_001172567
NM_001172568
NM_001172569
NM_002468
MYD88




myeloid differentiation primary response gene (88)




chr14_+_70078309 0.435 NM_014734
KIAA0247
KIAA0247
chr7_+_149535508 0.430 NM_001099220
ZNF862
zinc finger protein 862
chr7_-_35734762 0.427 NM_022373
HERPUD2
HERPUD family member 2
chr17_-_36831156 0.426 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chrX_+_123094377 0.421 NM_001042749
STAG2
stromal antigen 2
chr17_-_40075238 0.419 NM_001096
NM_198830
ACLY

ATP citrate lyase

chr3_-_197463713 0.418 NM_014687
KIAA0226
KIAA0226
chr7_+_39989955 0.417 NM_003718
NM_031267
CDK13

cyclin-dependent kinase 13

chr8_+_41435666 0.411 NM_178819
AGPAT6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
chr10_+_89623091 0.408 NM_000314
PTEN
phosphatase and tensin homolog
chr16_+_28303622 0.408 NM_001024401
SBK1
SH3-binding domain kinase 1
chr1_-_27481400 0.408 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chrX_+_108779009 0.407 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chrX_+_72223351 0.406 NM_001042506
PABPC1L2B
poly(A) binding protein, cytoplasmic 1-like 2B
chr2_+_115822246 0.403 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chrX_-_108868250 0.401 NM_012282
KCNE1L
KCNE1-like
chr2_-_162931051 0.398 NM_001935
DPP4
dipeptidyl-peptidase 4
chr17_-_4890664 0.397 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr2_+_24807345 0.395 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr9_+_126118447 0.394 NM_173689
CRB2
crumbs homolog 2 (Drosophila)
chr1_+_171454636 0.393 NM_015172
PRRC2C
proline-rich coiled-coil 2C

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
31.30 1.96e-03 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.55 2.41e-04 GO:0071944 cell periphery
2.46 9.13e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
187.66 2.66e-03 GO:0008273 calcium, potassium:sodium antiporter activity
134.05 5.56e-03 GO:0022821 potassium ion antiporter activity
93.84 1.19e-02 GO:0015368 calcium:cation antiporter activity