Motif ID: AIRE.p2

Z-value: 1.396


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
AIREhg19_v1_chr21_+_45705720_457057690.271.4e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_14785626 9.636 NM_032571
 EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr1_+_84630575 8.771 NM_001242860
NM_001242861
 PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr4_-_74847669 7.765 NM_002619
 PF4
platelet factor 4
chr7_-_38313232 7.519 NM_001003799
NM_001003806
 TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr3_+_46395224 6.045 NM_001123041
NM_001123396
 CCR2

chemokine (C-C motif) receptor 2

chr19_-_39826676 5.939 NM_004877
 GMFG
glia maturation factor, gamma
chr19_-_8642337 5.735 MYO1F
myosin IF
chr15_+_58430394 5.502 NM_020980
 AQP9
aquaporin 9
chr7_-_115608366 4.719 NM_001244583
 TFEC
transcription factor EC
chr13_-_99910548 4.567 NM_001098200
NM_005292
 GPR18

G protein-coupled receptor 18

chr19_+_52266640 4.001 NM_001462
 FPR2
formyl peptide receptor 2
chr1_-_169680677 3.930 NM_000655
 SELL
selectin L
chr3_-_194119994 3.830 NM_004488
 GP5
glycoprotein V (platelet)
chr3_-_150920946 3.703 NM_013308
 GPR171
G protein-coupled receptor 171
chr4_-_84035888 3.602 PLAC8
placenta-specific 8
chr4_+_15704752 3.574 BST1
bone marrow stromal cell antigen 1
chr17_-_72709010 3.553 NM_139018
 CD300LF
CD300 molecule-like family member f
chr12_-_53600999 3.548 NM_000889
 ITGB7
integrin, beta 7
chr14_-_106725232 3.273 ZCWPW2
IGHV3-23
IGKV3-20
IGK@
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
immunoglobulin kappa locus
chr1_+_160709038 3.072 NM_021181
 SLAMF7
SLAM family member 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
Enrichment   P-value GO Accession GO Term
45.77 1.93e-02 GO:0042119 neutrophil activation
17.72 4.56e-02 GO:0002690 positive regulation of leukocyte chemotaxis
15.97 9.17e-03 GO:0030595 leukocyte chemotaxis
13.21 2.35e-02 GO:0048520 positive regulation of behavior
12.72 2.83e-02 GO:0006968 cellular defense response
12.49 3.09e-02 GO:0060326 cell chemotaxis
9.52 5.61e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
9.16 7.25e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
8.87 3.77e-02 GO:0050851 antigen receptor-mediated signaling pathway
6.72 4.48e-05 GO:0006954 inflammatory response
6.57 5.94e-04 GO:0045321 leukocyte activation
6.14 3.12e-02 GO:0050867 positive regulation of cell activation
6.09 4.22e-04 GO:0050778 positive regulation of immune response
5.98 1.29e-02 GO:0051249 regulation of lymphocyte activation
5.80 5.75e-03 GO:0050865 regulation of cell activation
5.43 2.77e-02 GO:0002694 regulation of leukocyte activation
5.34 3.18e-05 GO:0050776 regulation of immune response
5.23 1.41e-08 GO:0002682 regulation of immune system process
5.06 1.74e-04 GO:0002684 positive regulation of immune system process
5.05 1.08e-08 GO:0006955 immune response

Gene overrepresentation in compartment category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
68.65 3.56e-02 GO:0005639 integral to nuclear inner membrane
68.65 3.56e-02 GO:0031229 intrinsic to nuclear inner membrane

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
68.65 4.49e-02 GO:0048020 CCR chemokine receptor binding
13.74 2.87e-02 GO:0003823 antigen binding
13.47 4.86e-03 GO:0042379 chemokine receptor binding
11.95 4.95e-02 GO:0008009 chemokine activity
5.35 4.99e-02 GO:0005126 cytokine receptor binding
4.15 1.04e-02 GO:0030246 carbohydrate binding
2.44 9.80e-04 GO:0004872 receptor activity
2.21 2.14e-03 GO:0004871 signal transducer activity
2.21 2.14e-03 GO:0060089 molecular transducer activity