Motif ID: ALX1.p2

Z-value: 1.362


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ALX1hg19_v1_chr12_+_85673884_85674035-0.028.9e-01Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_107288199 6.009 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_+_63263814 4.192 NM_001130003
SYNPR
synaptoporin
chr7_-_107880492 3.888 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr9_-_28719302 3.861 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chrX_-_13835313 3.736 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr16_-_11375094 3.703 NM_002761
PRM1
protamine 1
chr1_+_155853546 3.377 SYT11
synaptotagmin XI
chr1_+_151739130 3.359 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr6_-_41254392 3.193 NM_001242589
NM_001242590
NM_018643
TREM1


triggering receptor expressed on myeloid cells 1


chr9_+_111624545 3.083 NM_006687
ACTL7A
actin-like 7A
chrX_-_21776158 3.059 NM_014332
SMPX
small muscle protein, X-linked
chr1_-_35370983 3.048 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr6_-_49989647 2.977 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr5_+_57787260 2.959 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr14_-_101036130 2.850 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr20_+_44350987 2.837 NM_178455
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr13_-_20805371 2.673 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr16_+_30034654 2.671 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr8_-_110986923 2.615 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr15_+_38227456 2.601 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr1_-_76397975 2.589 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr18_-_51880942 2.519 NM_139171
STARD6
StAR-related lipid transfer (START) domain containing 6
chr9_-_27297106 2.472 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr1_+_222910557 2.460 NM_207468
FAM177B
family with sequence similarity 177, member B
chr19_+_54466289 2.381 NM_031895
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr4_-_159956332 2.348 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr12_+_20848288 2.330 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr4_-_38858407 2.317 NM_006068
TLR6
toll-like receptor 6
chr8_-_15095791 2.260 NM_139167
SGCZ
sarcoglycan, zeta
chrX_+_78003205 2.040 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr6_+_26251826 2.007 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr13_+_51915167 1.971 NM_001101320
SERPINE3
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr3_+_107096187 1.964 NM_032600
CCDC54
coiled-coil domain containing 54
chr2_-_77749335 1.960 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr19_-_23869939 1.942 NM_138330
ZNF675
zinc finger protein 675
chr13_-_99959649 1.915 NM_004951
GPR183
G protein-coupled receptor 183
chr1_+_182419255 1.909 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr3_+_111717585 1.891 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr4_-_164534656 1.884 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr18_+_29769986 1.875 NM_005925
MEP1B
meprin A, beta
chr4_-_159093523 1.864 FAM198B
family with sequence similarity 198, member B
chrX_+_102965836 1.863 NM_182541
TMEM31
transmembrane protein 31
chr12_+_9980076 1.832 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chrX_+_91089658 1.827 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr22_-_23922376 1.812 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr19_+_7562444 1.811 NM_198534
C19orf45
chromosome 19 open reading frame 45
chr10_-_128209996 1.810 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr12_+_101988746 1.799 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr19_+_56347943 1.794 NM_134444
NLRP4
NLR family, pyrin domain containing 4
chr4_-_74864296 1.780 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr7_+_74188308 1.759 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr3_-_167371288 1.700 NM_178824
WDR49
WD repeat domain 49
chr19_-_23941571 1.686 NM_138286
ZNF681
zinc finger protein 681
chr16_+_31271327 1.671 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr17_+_19976828 1.659 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr5_-_149466110 1.659 CSF1R
colony stimulating factor 1 receptor
chr1_-_198906536 1.646 LOC100131234
familial acute myelogenous leukemia related factor
chr2_+_166095911 1.638 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr11_+_60163486 1.622 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr19_-_23433161 1.620 ZNF724P
zinc finger protein 724, pseudogene
chr1_+_192127591 1.618 NM_130782
RGS18
regulator of G-protein signaling 18
chr3_+_68040733 1.612 NM_001252216
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr20_+_32250089 1.595 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr20_+_58296264 1.565 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr6_-_133084585 1.540 NM_078488
VNN2
vanin 2
chr19_-_51872256 1.500 NM_152353
CLDND2
claudin domain containing 2
chr14_+_21236585 1.494 NM_022360
EDDM3B
epididymal protein 3B
chr9_-_117444368 1.491 NM_001199233
LOC100505478
uncharacterized LOC100505478
chr18_+_22040592 1.486 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr4_-_46125929 1.477 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr14_+_62462540 1.474 NM_031914
SYT16
synaptotagmin XVI
chr19_+_39786964 1.472 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr2_-_228244005 1.456 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr18_-_3845295 1.453 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr11_-_77122877 1.425 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr17_-_29641068 1.425 EVI2B
ecotropic viral integration site 2B
chr7_+_63667580 1.417 NM_001159524
ZNF735
zinc finger protein 735
chr22_-_17302555 1.414 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr6_-_110501164 1.413 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr12_+_48722762 1.397 NM_181788
H1FNT
H1 histone family, member N, testis-specific
chr7_-_108142934 1.380 PNPLA8
patatin-like phospholipase domain containing 8
chr5_-_39270708 1.378 NM_001243093
FYB
FYN binding protein
chr8_-_33457491 1.377 DUSP26
dual specificity phosphatase 26 (putative)
chr18_+_28898051 1.374 NM_001942
DSG1
desmoglein 1
chrX_+_91090459 1.371 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr3_+_98250742 1.370 NM_005290
GPR15
G protein-coupled receptor 15
chr16_+_31271311 1.363 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr10_+_124320180 1.362 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr14_+_101295409 1.350 MEG3
maternally expressed 3 (non-protein coding)
chr20_+_34556528 1.345 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr14_+_20403766 1.337 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr9_+_35042222 1.332 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr4_+_68424444 1.303 NM_012108
STAP1
signal transducing adaptor family member 1
chr7_-_115608366 1.298 NM_001244583
TFEC
transcription factor EC
chr4_+_158141735 1.271 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr16_+_31271277 1.264 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr9_-_74675498 1.260 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr1_+_92632608 1.253 NM_015237
KIAA1107
KIAA1107
chr17_-_29641087 1.250 EVI2B
ecotropic viral integration site 2B
chr2_-_233877901 1.202 NGEF
neuronal guanine nucleotide exchange factor
chr17_-_29641094 1.192 NM_006495
EVI2B
ecotropic viral integration site 2B
chr16_-_72206348 1.188 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr12_+_9142136 1.187 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr19_+_7733971 1.182 NM_001193374
NM_020415
RETN

resistin

chr1_+_115572414 1.172 NM_000549
TSHB
thyroid stimulating hormone, beta
chr3_-_36781351 1.166 NM_033403
DCLK3
doublecortin-like kinase 3
chr10_-_69425356 1.164 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chrX_-_138790328 1.148 NM_001099855
NM_001171876
MCF2

MCF.2 cell line derived transforming sequence

chr5_+_147795459 1.146 FBXO38
F-box protein 38
chr1_+_51567899 1.145 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr4_+_74719012 1.141 NM_002620
PF4V1
platelet factor 4 variant 1
chr8_-_18541441 1.131 PSD3
pleckstrin and Sec7 domain containing 3
chr7_-_115670811 1.128 TFEC
transcription factor EC
chr5_-_147162251 1.125 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr1_+_74701070 1.125 NM_015978
TNNI3K
TNNI3 interacting kinase
chr2_-_233877920 1.123 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chrY_+_4924128 1.121 NM_032972
NM_032973
PCDH11X
PCDH11Y

protocadherin 11 X-linked
protocadherin 11 Y-linked

chr5_+_161275897 1.118 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_-_46911223 1.117 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr11_-_85425790 1.116 NM_032379
SYTL2
synaptotagmin-like 2
chr22_+_21821458 1.116 NM_001207052
TMEM191C
transmembrane protein 191C
chr3_+_63428752 1.102 NM_144642
SYNPR
synaptoporin
chr19_-_53794874 1.099 NM_033341
BIRC8
baculoviral IAP repeat containing 8
chr19_+_48758931 1.098 LOC100505812
uncharacterized LOC100505812
chr11_+_59807747 1.097 NM_173801
PLAC1L
placenta-specific 1-like
chr1_+_117544371 1.086 NM_004258
CD101
CD101 molecule
chr6_-_128239741 1.084 NM_001164687
THEMIS
thymocyte selection associated
chr9_+_90497740 1.084 NM_178828
C9orf79
chromosome 9 open reading frame 79
chr14_+_94385239 1.083 NM_001207071
NM_138344
FAM181A

family with sequence similarity 181, member A

chr18_+_32335939 1.083 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr13_+_108922205 1.075 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chrX_-_151619669 1.064 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr16_+_85061303 1.051 NM_014732
KIAA0513
KIAA0513
chr18_-_70211722 1.043 NM_182511
CBLN2
cerebellin 2 precursor
chr3_-_112013073 1.042 NM_183061
SLC9A10
solute carrier family 9, member 10
chr7_-_115670774 1.033 TFEC
transcription factor EC
chr11_-_64703334 1.029 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr4_-_185139018 1.027 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr8_-_125183703 1.025 C8orf78
chromosome 8 open reading frame 78
chr16_+_22103861 1.015 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr6_-_154651214 1.012 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr18_-_70532933 1.008 NM_138999
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr14_-_21029089 1.007 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr2_+_204571379 1.007 CD28
CD28 molecule
chr2_+_226265601 1.002 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr22_+_25202135 1.000 NM_001039948
NM_001098497
NM_001098498
NM_133454
SGSM1



small G protein signaling modulator 1



chrX_-_75004979 1.000 NM_138703
MAGEE2
melanoma antigen family E, 2
chr2_+_204571197 0.994 NM_001243077
NM_001243078
NM_006139
CD28


CD28 molecule


chr13_+_108921976 0.994 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr5_-_147162264 0.985 JAKMIP2
janus kinase and microtubule interacting protein 2
chr8_-_33457435 0.982 NM_024025
DUSP26
dual specificity phosphatase 26 (putative)
chrX_+_140982451 0.982 NM_177456
MAGEC3
melanoma antigen family C, 3
chr9_-_21368005 0.979 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr17_-_39183453 0.975 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr10_+_91152321 0.969 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr2_+_207406815 0.962 ADAM23
ADAM metallopeptidase domain 23
chr9_-_21217303 0.960 NM_002173
IFNA16
interferon, alpha 16
chr4_-_176923572 0.951 NM_005277
NM_201592
GPM6A

glycoprotein M6A

chr19_+_21264952 0.943 NM_182515
ZNF714
zinc finger protein 714
chr7_+_139208673 0.942 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr3_+_44692500 0.937 ZNF35
zinc finger protein 35
chr4_-_21699317 0.935 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr1_-_157522151 0.933 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr17_-_16557157 0.928 NM_020787
ZNF624
zinc finger protein 624
chr5_-_149465989 0.922 CSF1R
colony stimulating factor 1 receptor
chr3_-_39321479 0.920 NM_001337
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr2_-_200213802 0.919 SATB2
SATB homeobox 2
chr3_+_35683848 0.917 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_-_73520448 0.913 NM_001965
EGR4
early growth response 4
chr3_+_57094468 0.913 NM_181727
SPATA12
spermatogenesis associated 12
chr2_+_115822246 0.912 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr3_-_151058439 0.909 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chrX_+_36254050 0.897 NM_001098843
CXorf30
chromosome X open reading frame 30
chr17_-_36997641 0.879 NM_001080465
C17orf98
chromosome 17 open reading frame 98
chr21_+_42733916 0.877 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr17_+_66031814 0.876 NM_002266
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr12_+_15699544 0.867 PTPRO
protein tyrosine phosphatase, receptor type, O
chr5_-_22853730 0.867 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr4_-_159094163 0.861 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr12_-_11463353 0.859 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr6_+_31683084 0.858 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr7_+_37723378 0.857


chr1_-_67266930 0.853 NM_005478
INSL5
insulin-like 5
chr10_+_29577989 0.846 NM_032517
LYZL1
lysozyme-like 1
chr20_+_15177503 0.845 NM_001033087
MACROD2
MACRO domain containing 2
chr12_-_11548485 0.844 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr2_+_28718937 0.840 NM_001170585
NM_153021
PLB1

phospholipase B1

chr7_+_129906702 0.827 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr6_-_31648140 0.814 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr3_-_87325611 0.814 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr1_+_244515936 0.812 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr7_-_86595203 0.807 NM_152748
KIAA1324L
KIAA1324-like
chr3_+_121774208 0.805 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr1_-_67594219 0.804 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr12_-_62586547 0.802 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr20_+_43803539 0.798 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr3_+_122334461 0.797 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr18_-_14132426 0.796 NM_145287
ZNF519
zinc finger protein 519
chr17_-_1029059 0.795 ABR
active BCR-related gene
chr22_+_20377668 0.794 NM_001242313
TMEM191B
transmembrane protein 191B

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.64 5.82e-05 GO:0044425 membrane part
2.38 5.98e-05 GO:0044459 plasma membrane part
1.84 2.05e-04 GO:0005886 plasma membrane
1.68 2.15e-04 GO:0031224 intrinsic to membrane
1.69 2.57e-04 GO:0016021 integral to membrane
1.82 3.21e-04 GO:0071944 cell periphery
1.49 4.51e-04 GO:0016020 membrane
7.49 1.23e-03 GO:0045211 postsynaptic membrane
3.67 1.48e-03 GO:0030054 cell junction
4.29 2.50e-03 GO:0045202 synapse
4.81 4.69e-03 GO:0044456 synapse part
12.31 3.18e-02 GO:0030666 endocytic vesicle membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.07 2.64e-03 GO:XXXXXXX unannotated