Motif ID: ATF4.p2

Z-value: 1.251


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF4hg19_v1_chr22_+_39916563_39916625-0.291.0e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_139456240 4.139 NM_016217
HECA
headcase homolog (Drosophila)
chr11_+_117857062 3.794 NM_001558
IL10RA
interleukin 10 receptor, alpha
chr11_-_77184549 2.410 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr1_+_26496382 2.410 NM_015871
ZNF593
zinc finger protein 593
chr6_-_91006580 2.387 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr14_+_68086633 2.336 ARG2
arginase, type II
chr5_+_112849352 2.214 NM_022828
YTHDC2
YTH domain containing 2
chr6_-_91006460 2.164 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr14_-_50329567 2.148 RN7SL2
RNA, 7SL, cytoplasmic 2
chr14_-_50053068 2.111 NM_001030001
NM_001032
RPS29

ribosomal protein S29

chr17_-_8151353 2.062 CTC1
CTS telomere maintenance complex component 1
chr7_-_105925329 2.035 NAMPT
nicotinamide phosphoribosyltransferase
chr11_+_117857123 1.941 IL10RA
interleukin 10 receptor, alpha
chr19_+_13263890 1.874 IER2
immediate early response 2
chr16_-_88772732 1.859 NM_001171815
RNF166
ring finger protein 166
chr19_+_18284578 1.858 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr19_+_16187306 1.853 TPM4
tropomyosin 4
chr19_+_18284631 1.826 IFI30
interferon, gamma-inducible protein 30
chr18_+_72163582 1.810 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr6_-_53213699 1.806 ELOVL5
ELOVL fatty acid elongase 5
chr17_-_8151373 1.715 NM_025099
CTC1
CTS telomere maintenance complex component 1
chr11_+_73087396 1.686 NM_152222
RELT
RELT tumor necrosis factor receptor
chr15_+_31619043 1.672 NM_015995
KLF13
Kruppel-like factor 13
chr18_+_72163335 1.669 NM_018235
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chrX_-_135055834 1.627 MMGT1
membrane magnesium transporter 1
chr12_-_123380682 1.619 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr7_-_105925410 1.509 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr19_+_16187315 1.475 TPM4
tropomyosin 4
chr11_+_809918 1.473 NM_001004
RPLP2
ribosomal protein, large, P2
chr12_-_123380608 1.472


chrX_+_152240726 1.457 NM_001170944
NM_001242319
NM_032882
PNMA6C
PNMA6D
PNMA6A
paraneoplastic antigen like 6C
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr19_-_42721802 1.453 NM_133328
DEDD2
death effector domain containing 2
chr8_-_66754276 1.439 PDE7A
phosphodiesterase 7A
chr1_+_154377847 1.436 IL6R
interleukin 6 receptor
chr12_-_132628841 1.431 NM_175066
DDX51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr3_+_16306666 1.431 NM_138381
OXNAD1
oxidoreductase NAD-binding domain containing 1
chr7_+_44646197 1.344 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_+_44646189 1.341 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_+_65540821 1.323 NM_001024943
NM_001024944
NM_001024946
ASL


argininosuccinate lyase


chr16_-_68057098 1.319 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr7_+_44646180 1.310 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr5_-_172198160 1.308 NM_004417
DUSP1
dual specificity phosphatase 1
chr6_-_42713837 1.305 NM_003192
TBCC
tubulin folding cofactor C
chr12_-_6862131 1.299 MLF2
myeloid leukemia factor 2
chr11_+_117049387 1.297 SIDT2
SID1 transmembrane family, member 2
chr16_-_68057120 1.289 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr6_+_64281910 1.286 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_129592711 1.275 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr6_-_42713822 1.264 TBCC
tubulin folding cofactor C
chr19_+_16187266 1.264 TPM4
tropomyosin 4
chr7_+_44646168 1.262 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr10_+_99079017 1.254 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr1_+_110527432 1.242 AHCYL1
adenosylhomocysteinase-like 1
chr1_-_17445865 1.236 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr2_+_219745243 1.234 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr11_+_809985 1.228 RPLP2
ribosomal protein, large, P2
chr5_+_138211084 1.222 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr1_+_110527418 1.216 AHCYL1
adenosylhomocysteinase-like 1
chr7_-_129592794 1.215 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr1_+_110527756 1.208 AHCYL1
adenosylhomocysteinase-like 1
chr7_+_44646220 1.208 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_-_45026204 1.206 SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr20_+_57766074 1.199 NM_178457
ZNF831
zinc finger protein 831
chr6_-_53213586 1.175 ELOVL5
ELOVL fatty acid elongase 5
chr1_+_110527327 1.166 NM_001242673
NM_006621
AHCYL1

adenosylhomocysteinase-like 1

chr7_+_100273776 1.159 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr6_+_89791510 1.151 PNRC1
proline-rich nuclear receptor coactivator 1
chr12_-_123380628 1.148 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr3_-_16306283 1.146 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr11_-_14993790 1.139 NM_001033952
NM_001033953
NM_001741
CALCA


calcitonin-related polypeptide alpha


chr1_+_162760491 1.135 NM_016371
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr4_+_170541690 1.128 CLCN3
chloride channel 3
chr19_-_47617008 1.124 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr20_+_44420610 1.124 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr6_+_64282429 1.119 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr10_+_99496847 1.113 NM_001002262
NM_001174119
NM_001174120
NM_001174121
NM_001174122
NM_144588
ZFYVE27





zinc finger, FYVE domain containing 27





chr6_+_47445440 1.112 NM_012120
CD2AP
CD2-associated protein
chr4_+_170541728 1.091 CLCN3
chloride channel 3
chr1_-_32110464 1.087 PEF1
penta-EF-hand domain containing 1
chr19_+_50979788 1.086 C19orf63
chromosome 19 open reading frame 63
chr7_+_127228405 1.084 NM_001662
ARF5
ADP-ribosylation factor 5
chr18_-_77711603 1.078 PQLC1
PQ loop repeat containing 1
chr16_-_88772807 1.076 NM_178841
RNF166
ring finger protein 166
chr19_-_46088074 1.074 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr1_+_52082755 1.064 OSBPL9
oxysterol binding protein-like 9
chr22_+_32340435 1.061 NM_003405
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr7_+_151722826 1.054 GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr20_+_48807365 1.047 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_+_70671375 1.041 SRSF11
serine/arginine-rich splicing factor 11
chr3_-_156877882 1.027 CCNL1
cyclin L1
chr22_+_18121540 1.027 BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr18_-_77711652 1.025 NM_001146343
NM_001146345
NM_025078
PQLC1


PQ loop repeat containing 1


chr12_+_66583029 1.019 IRAK3
interleukin-1 receptor-associated kinase 3
chr10_+_99496891 1.013 ZFYVE27
zinc finger, FYVE domain containing 27
chr6_+_64282449 1.006 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_+_65540937 0.998 ASL
argininosuccinate lyase
chr19_+_17666457 0.987 GLT25D1
glycosyltransferase 25 domain containing 1
chr2_-_240964717 0.984 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr20_+_19915716 0.983 RIN2
Ras and Rab interactor 2
chr10_+_99496897 0.980 ZFYVE27
zinc finger, FYVE domain containing 27
chr5_-_16509106 0.978 NM_019000
FAM134B
family with sequence similarity 134, member B
chr19_+_50979772 0.974 C19orf63
chromosome 19 open reading frame 63
chr19_+_17666381 0.967 GLT25D1
glycosyltransferase 25 domain containing 1
chr22_-_47134044 0.964 CERK
ceramide kinase
chr17_-_40540576 0.951 STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr3_+_128598471 0.950 ACAD9
acyl-CoA dehydrogenase family, member 9
chr3_+_44380003 0.946 C3orf23
chromosome 3 open reading frame 23
chr15_+_81293286 0.945 NM_022566
MESDC1
mesoderm development candidate 1
chr12_-_103311053 0.943 PAH
phenylalanine hydroxylase
chr20_+_44420575 0.940 NM_052951
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr20_+_361675 0.939 TRIB3
tribbles homolog 3 (Drosophila)
chr3_+_128598459 0.933 ACAD9
acyl-CoA dehydrogenase family, member 9
chr17_-_20946088 0.927 NM_015276
USP22
ubiquitin specific peptidase 22
chr2_+_74781846 0.922 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr2_+_70142152 0.920 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr20_+_44420606 0.918 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr6_+_43211221 0.918 NM_032538
TTBK1
tau tubulin kinase 1
chr7_+_151722774 0.917 NM_022087
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr11_+_95523608 0.905 NM_001243776
NM_001243777
NM_014679
CEP57


centrosomal protein 57kDa


chr11_-_6633400 0.898 TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr15_-_41047421 0.895 FAM82A2
family with sequence similarity 82, member A2
chr1_-_150552005 0.887 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr1_+_110527701 0.882 AHCYL1
adenosylhomocysteinase-like 1
chr22_+_21271619 0.881 NM_005207
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr1_+_109289353 0.878


chr3_-_71632741 0.877 NM_001244808
NM_001012505
NM_001244810
NM_032682
FOXP1



forkhead box P1



chr20_+_48807460 0.869 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr22_+_21271721 0.867 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr14_+_68086655 0.863 ARG2
arginase, type II
chr19_+_18668652 0.861 KXD1
KxDL motif containing 1
chr3_+_128598497 0.861 ACAD9
acyl-CoA dehydrogenase family, member 9
chr12_+_66583004 0.860 IRAK3
interleukin-1 receptor-associated kinase 3
chr8_+_126442557 0.860 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr10_+_99496938 0.859 ZFYVE27
zinc finger, FYVE domain containing 27
chr9_-_70490145 0.850 CBWD5
COBW domain containing 5
chr3_+_44379923 0.845 NM_001029839
NM_173826
C3orf23

chromosome 3 open reading frame 23

chr20_-_17949384 0.844 NM_152227
SNX5
sorting nexin 5
chr13_-_52378230 0.841 NM_001031719
NM_024705
DHRS12

dehydrogenase/reductase (SDR family) member 12

chr3_+_141087298 0.841 ZBTB38
zinc finger and BTB domain containing 38
chr8_+_42128851 0.840 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr3_+_128598440 0.837 ACAD9
acyl-CoA dehydrogenase family, member 9
chr6_-_32812409 0.836 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr11_-_64889581 0.836 NM_001997
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr19_+_1067536 0.836 HMHA1
histocompatibility (minor) HA-1
chr12_-_64616032 0.835 NM_152440
C12orf66
chromosome 12 open reading frame 66
chr4_-_8430185 0.833 ACOX3
acyl-CoA oxidase 3, pristanoyl
chr8_-_17104266 0.829 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr7_+_120590816 0.827 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr1_-_228290929 0.825 NM_024319
C1orf35
chromosome 1 open reading frame 35
chr14_+_55493837 0.824 NM_080867
NM_199421
SOCS4

suppressor of cytokine signaling 4

chr10_-_23003443 0.820 NM_005028
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr5_-_95297597 0.819 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr11_+_60869929 0.818 NM_014207
CD5
CD5 molecule
chr9_+_132251323 0.816 LOC100506190
uncharacterized LOC100506190
chr15_-_41047448 0.815 NM_018145
FAM82A2
family with sequence similarity 82, member A2
chr11_-_67188614 0.814 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr7_+_17338182 0.813 NM_001621
AHR
aryl hydrocarbon receptor
chr3_+_44379590 0.813 NM_001029840
C3orf23
chromosome 3 open reading frame 23
chr19_+_42388445 0.809 NM_199002
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr3_+_38206968 0.806 NM_005109
OXSR1
oxidative-stress responsive 1
chr2_-_202645653 0.800 ALS2
amyotrophic lateral sclerosis 2 (juvenile)
chr2_-_240964807 0.798 NM_004544
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr9_-_178913 0.795 NM_001145355
NM_001145356
NM_018491
CBWD1


COBW domain containing 1


chr22_+_22550159 0.794 IGLV6-57
immunoglobulin lambda variable 6-57
chr12_+_69004708 0.789 RAP1B
RAP1B, member of RAS oncogene family
chr12_+_50135953 0.788 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr1_+_154377668 0.787 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr1_-_70671263 0.786 NM_017768
LRRC40
leucine rich repeat containing 40
chr17_-_56084656 0.784 NM_001078166
NM_006924
SRSF1

serine/arginine-rich splicing factor 1

chr10_+_64893003 0.782 NM_030759
NRBF2
nuclear receptor binding factor 2
chr19_+_50979656 0.781 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr9_-_74979829 0.781 NM_001102420
NM_001102421
NM_006007
ZFAND5


zinc finger, AN1-type domain 5


chr11_+_62649160 0.778 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr17_-_76778306 0.775 NM_004762
NM_017456
CYTH1

cytohesin 1

chr22_+_18121446 0.775 NM_015367
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr16_+_475605 0.771 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr19_+_45504686 0.769 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr19_+_1941157 0.769 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr15_-_23034365 0.769 NIPA2
non imprinted in Prader-Willi/Angelman syndrome 2
chr3_-_33759743 0.768 CLASP2
cytoplasmic linker associated protein 2
chr7_-_994008 0.768 ADAP1
ArfGAP with dual PH domains 1
chr6_-_137540435 0.767 IFNGR1
interferon gamma receptor 1
chr19_+_18284619 0.764 IFI30
interferon, gamma-inducible protein 30
chr7_+_151722842 0.762 GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr20_+_30697512 0.762 TM9SF4
transmembrane 9 superfamily protein member 4
chr11_+_117049838 0.761 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr11_+_73087670 0.760 NM_032871
RELT
RELT tumor necrosis factor receptor
chr2_+_96068423 0.760 NM_016044
FAHD2A
fumarylacetoacetate hydrolase domain containing 2A
chr17_-_4890920 0.757 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr8_+_42128834 0.757 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr10_+_119000583 0.756 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr20_-_33865905 0.756 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr2_+_61108702 0.753 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr3_-_33759684 0.753 NM_015097
CLASP2
cytoplasmic linker associated protein 2
chr14_-_92588065 0.749 NM_004545
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr5_-_32174355 0.749 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr16_+_11762235 0.748 NM_003498
SNN
stannin
chrX_-_152245957 0.748 NM_001242319
NM_032882
PNMA6D
PNMA6A
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr12_+_66582914 0.746 NM_001142523
NM_007199
IRAK3

interleukin-1 receptor-associated kinase 3

chr20_+_44637539 0.745 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
40.87 1.87e-02 GO:0043603 cellular amide metabolic process

Nothing significant found in compartment category.

Nothing significant found in function category.