Motif ID: AUGGCUU

Z-value: 2.150


Mature miRNA associated with seed AUGGCUU:

NamemiRBase Accession
hsa-miR-135a MIMAT0000428
hsa-miR-135b MIMAT0000758



Activity profile for motif AUGGCUU.

activity profile for motif AUGGCUU


Sorted Z-values histogram for motif AUGGCUU

Sorted Z-values for motif AUGGCUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AUGGCUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_175223519 13.298 NM_006650
 CPLX2
complexin 2
chr5_+_175298492 11.954 NM_001008220
 CPLX2
complexin 2
chr8_+_24771268 11.679 NM_005382
 NEFM
neurofilament, medium polypeptide
chr8_+_24772454 11.451 NM_001105541
 NEFM
neurofilament, medium polypeptide
chr9_-_19786886 9.998 NM_001193288
NM_020344
 SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr8_-_27115897 8.797 NM_030795
 STMN4
stathmin-like 4
chr6_+_24126349 8.471 NM_080723
 NRSN1
neurensin 1
chr5_-_160975124 8.176 NM_000813
NM_021911
 GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2

chr19_-_17799005 7.852 NM_001080421
 UNC13A
unc-13 homolog A (C. elegans)
chrX_+_12156584 7.640 NM_014728
 FRMPD4
FERM and PDZ domain containing 4
chr5_-_45696219 7.458 NM_021072
 HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr1_-_202679415 7.446 NM_177402
 SYT2
synaptotagmin II
chrX_+_152801579 7.410 NM_001001344
NM_021949
 ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr2_+_131674223 7.215 NM_015320
NM_032995
 ARHGEF4

Rho guanine nucleotide exchange factor (GEF) 4

chr1_+_181452685 7.122 NM_000721
NM_001205293
NM_001205294
 CACNA1E


calcium channel, voltage-dependent, R type, alpha 1E subunit


chr9_-_93405066 6.666 NM_017594
 DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr2_+_166150340 6.594 NM_021007
 SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr1_+_209757044 6.579 NM_020439
 CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr17_-_78450247 6.547 NM_002522
 NPTX1
neuronal pentraxin I
chr10_-_1779669 6.424 NM_018702
 ADARB2
adenosine deaminase, RNA-specific, B2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
Enrichment   P-value GO Accession GO Term
10.38 1.54e-02 GO:0007269 neurotransmitter secretion
9.62 2.61e-04 GO:0006836 neurotransmitter transport
8.67 1.05e-02 GO:0001505 regulation of neurotransmitter levels
7.20 3.51e-02 GO:0003001 generation of a signal involved in cell-cell signaling
7.20 3.51e-02 GO:0023061 signal release
6.87 1.44e-02 GO:0006814 sodium ion transport
6.83 1.89e-11 GO:0007268 synaptic transmission
6.46 7.23e-03 GO:0006813 potassium ion transport
6.33 3.31e-11 GO:0019226 transmission of nerve impulse
6.33 3.31e-11 GO:0035637 multicellular organismal signaling
4.65 3.12e-03 GO:0015672 monovalent inorganic cation transport
4.45 1.65e-08 GO:0007267 cell-cell signaling
3.48 2.28e-06 GO:0007154 cell communication
3.43 4.01e-02 GO:0030001 metal ion transport
3.40 5.03e-05 GO:0006811 ion transport
2.64 2.19e-04 GO:0007399 nervous system development
2.38 1.39e-02 GO:0050877 neurological system process
2.19 1.63e-02 GO:0003008 system process
2.18 1.68e-08 GO:0023052 signaling
2.18 4.35e-06 GO:0051234 establishment of localization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
Enrichment   P-value GO Accession GO Term
81.72 4.50e-04 GO:0042583 chromaffin granule
81.72 4.50e-04 GO:0042584 chromaffin granule membrane
17.67 1.49e-04 GO:0042734 presynaptic membrane
12.11 8.28e-03 GO:0030672 synaptic vesicle membrane
10.09 2.01e-02 GO:0034707 chloride channel complex
10.04 9.20e-04 GO:0033267 axon part
9.09 2.59e-14 GO:0044456 synapse part
8.43 2.36e-17 GO:0045202 synapse
8.28 1.30e-02 GO:0014069 postsynaptic density
8.10 1.77e-05 GO:0045211 postsynaptic membrane
8.08 6.99e-05 GO:0034703 cation channel complex
7.86 1.23e-07 GO:0034702 ion channel complex
7.52 2.22e-02 GO:0008076 voltage-gated potassium channel complex
7.52 2.22e-02 GO:0034705 potassium channel complex
6.20 7.80e-04 GO:0030424 axon
5.98 7.45e-09 GO:0043005 neuron projection
5.19 2.65e-10 GO:0030054 cell junction
4.76 1.70e-05 GO:0044463 cell projection part
3.34 1.67e-05 GO:0042995 cell projection
2.84 7.19e-11 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
Enrichment   P-value GO Accession GO Term
16.15 1.85e-02 GO:0019905 syntaxin binding
14.06 3.23e-02 GO:0005272 sodium channel activity
13.62 3.66e-02 GO:0000149 SNARE binding
7.68 1.36e-04 GO:0022843 voltage-gated cation channel activity
6.16 4.58e-07 GO:0022836 gated channel activity
6.11 2.82e-02 GO:0015276 ligand-gated ion channel activity
6.11 2.82e-02 GO:0022834 ligand-gated channel activity
6.06 2.96e-02 GO:0005267 potassium channel activity
5.83 1.63e-03 GO:0005244 voltage-gated ion channel activity
5.83 1.63e-03 GO:0022832 voltage-gated channel activity
5.73 5.88e-08 GO:0005216 ion channel activity
5.64 7.73e-08 GO:0022838 substrate-specific channel activity
5.49 2.02e-02 GO:0005085 guanyl-nucleotide exchange factor activity
5.47 1.32e-07 GO:0015267 channel activity
5.45 1.38e-07 GO:0022803 passive transmembrane transporter activity
5.37 1.80e-04 GO:0005261 cation channel activity
4.21 1.20e-02 GO:0005083 small GTPase regulator activity
3.86 1.14e-06 GO:0015075 ion transmembrane transporter activity
3.46 1.62e-03 GO:0008324 cation transmembrane transporter activity
3.44 1.63e-06 GO:0022857 transmembrane transporter activity