Motif ID: CDX1,2,4.p2

Z-value: 1.859


Transcription factors associated with CDX1,2,4.p2:

Gene SymbolEntrez IDGene Name
CDX1 1044 caudal type homeobox 1
CDX2 1045 caudal type homeobox 2
CDX4 1046 caudal type homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CDX1hg19_v1_chr5_+_149546340_1495464370.383.2e-02Click!
CDX4hg19_v1_chrX_+_72667089_726670890.336.4e-02Click!
CDX2hg19_v1_chr13_-_28543423_285435040.173.7e-01Click!


Activity profile for motif CDX1,2,4.p2.

activity profile for motif CDX1,2,4.p2


Sorted Z-values histogram for motif CDX1,2,4.p2

Sorted Z-values for motif CDX1,2,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CDX1,2,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_122107559 7.087 NM_173855
MORN3
MORN repeat containing 3
chr1_-_67594219 5.333 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr7_+_151653463 5.143 NM_145292
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr8_+_24151579 5.081 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr10_+_32856650 4.736 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr3_+_107096187 4.138 NM_032600
CCDC54
coiled-coil domain containing 54
chr6_-_130544098 3.989 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr3_+_108541544 3.920 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr22_+_23054862 3.629 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr5_+_94727047 3.589 NM_152548
FAM81B
family with sequence similarity 81, member B
chr11_+_7110164 3.467 NM_014469
RBMXL2
RNA binding motif protein, X-linked-like 2
chr10_+_97759847 3.442 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr1_+_160709038 3.274 NM_021181
SLAMF7
SLAM family member 7
chr14_-_106452693 3.167 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_57094468 3.104 NM_181727
SPATA12
spermatogenesis associated 12
chr6_-_49834188 3.047 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr17_-_34195745 2.992 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr12_+_49297892 2.983 NM_033124
CCDC65
coiled-coil domain containing 65
chr9_-_139927291 2.877 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr18_-_51880942 2.828 NM_139171
STARD6
StAR-related lipid transfer (START) domain containing 6
chr11_+_73661363 2.825 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr12_-_102591547 2.782 NM_002674
PMCH
pro-melanin-concentrating hormone
chr1_-_167059524 2.778 NM_005814
GPA33
glycoprotein A33 (transmembrane)
chr4_-_159956332 2.732 NM_152543
C4orf45
chromosome 4 open reading frame 45
chrX_-_6453158 2.649 NM_016379
VCX2
VCX3A
variable charge, X-linked 2
variable charge, X-linked 3A
chr12_-_10562744 2.647 NM_001199805
KLRC4-KLRK1
KLRC4-KLRK1 readthrough
chr2_-_192016293 2.637 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr5_+_35856990 2.614 NM_002185
IL7R
interleukin 7 receptor
chr6_-_165723074 2.606 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr5_+_147648374 2.590 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr19_+_36203829 2.581 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr3_-_183273407 2.552 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr8_+_27631902 2.540 NM_001017420
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr11_+_122709205 2.511 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr16_+_27438578 2.499 NM_021798
IL21R
interleukin 21 receptor
chr3_-_101039403 2.448 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr4_-_76944585 2.440 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr4_-_177116713 2.371 NM_144644
SPATA4
spermatogenesis associated 4
chr19_-_50847957 2.369 NAPSB
napsin B aspartic peptidase pseudogene
chr2_-_224866616 2.368 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr12_-_10542616 2.365 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr14_-_47120940 2.336 NM_080746
RPL10L
ribosomal protein L10-like
chr14_+_88471467 2.333 NM_003608
GPR65
G protein-coupled receptor 65
chr12_-_10282680 2.329 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr2_+_79252825 2.284 NM_001008387
NM_198448
REG3G

regenerating islet-derived 3 gamma

chr13_-_39564857 2.282 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr20_+_138121 2.271 NM_139074
DEFB127
defensin, beta 127
chr19_-_10697907 2.258 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_-_157522151 2.243 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr15_+_94899163 2.235 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr1_+_84630575 2.230 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr3_-_150920946 2.201 NM_013308
GPR171
G protein-coupled receptor 171
chr13_-_99910548 2.187 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr12_+_107078476 2.184 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr13_-_99959649 2.107 NM_004951
GPR183
G protein-coupled receptor 183
chr19_-_35719578 2.103 NM_152481
FAM187B
family with sequence similarity 187, member B
chr10_+_101088794 2.093 NM_020348
CNNM1
cyclin M1
chr17_+_28268622 2.093 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr19_-_17932312 2.077 NM_005543
INSL3
insulin-like 3 (Leydig cell)
chr2_+_204801453 2.072 NM_012092
ICOS
inducible T-cell co-stimulator
chr1_+_32739711 2.066 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr3_+_121902529 2.059 NM_000388
CASR
calcium-sensing receptor
chr22_+_37678519 2.058 CYTH4
cytohesin 4
chr6_-_130536417 2.052 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr15_+_22382381 1.995 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr17_-_38721701 1.968 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_-_5537815 1.962 NM_145053
UBQLNL
ubiquilin-like
chr11_+_86085777 1.903 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr13_+_52436116 1.884 NM_031290
CCDC70
coiled-coil domain containing 70
chr11_+_63304272 1.883 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr22_+_37678565 1.868 CYTH4
cytohesin 4
chr12_+_10457044 1.866 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr15_+_59908908 1.861 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr2_-_32490688 1.857 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr19_-_46417952 1.838 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr5_+_49961732 1.828 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr6_-_50016363 1.825 NM_001037498
DEFB112
defensin, beta 112
chr9_-_104357202 1.824 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr19_+_14693895 1.814 NM_001204118
NM_207390
CLEC17A

C-type lectin domain family 17, member A

chr10_+_111765725 1.807 NM_019903
ADD3
adducin 3 (gamma)
chr2_-_219031646 1.801 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr16_-_11375094 1.800 NM_002761
PRM1
protamine 1
chr6_+_31683084 1.781 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr1_-_197115566 1.774 NM_001206846
NM_018136
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr17_-_34524054 1.771 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr4_-_38784588 1.769 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr10_+_35464514 1.753 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr6_+_144185572 1.751 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr20_+_56725982 1.747 NM_178456
C20orf85
chromosome 20 open reading frame 85
chr14_-_99737821 1.739 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr7_+_141695678 1.730 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr18_+_616671 1.707 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr5_-_114515733 1.694 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr20_+_123230 1.688 NM_030931
DEFB126
defensin, beta 126
chr2_+_204571379 1.685 CD28
CD28 molecule
chr16_+_11439279 1.677 NM_152308
RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chrX_+_135730335 1.673 NM_000074
CD40LG
CD40 ligand
chr11_-_104905849 1.670 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr17_+_61086897 1.657 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr5_-_146460991 1.656 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr1_+_43613593 1.654 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr12_+_54892567 1.649 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr17_+_9479943 1.644 NM_001080556
NM_145054
WDR16

WD repeat domain 16

chr9_-_100700422 1.640 NM_197978
HEMGN
hemogen
chr5_+_57787260 1.637 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr1_+_198608136 1.637 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr11_-_104916041 1.635 NM_001017534
NM_052889
CARD16

caspase recruitment domain family, member 16

chr7_-_38313232 1.628 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr18_-_3874688 1.627 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr19_-_54604070 1.619 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chrX_-_49965003 1.617 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr19_+_6464259 1.607 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr17_+_34087915 1.603 NM_145272
C17orf50
chromosome 17 open reading frame 50
chr4_-_39033981 1.600 NM_024943
TMEM156
transmembrane protein 156
chr2_+_204732509 1.596 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr8_+_66933790 1.595 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr7_+_6793739 1.595 NM_173565
NM_001099697
RSPH10B
RSPH10B2
radial spoke head 10 homolog B (Chlamydomonas)
radial spoke head 10 homolog B2 (Chlamydomonas)
chr10_-_50342052 1.592 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr17_-_5138049 1.584 NM_207103
SCIMP
SLP adaptor and CSK interacting membrane protein
chr1_-_24239758 1.583 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr12_-_53600999 1.583 NM_000889
ITGB7
integrin, beta 7
chr10_+_91498724 1.573 KIF20B
kinesin family member 20B
chr1_+_192544856 1.567 NM_002922
RGS1
regulator of G-protein signaling 1
chr22_-_17302555 1.565 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr19_-_14785626 1.556 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_+_90211704 1.551


chr1_+_40942878 1.549 ZNF642
zinc finger protein 642
chr1_-_190446701 1.547 NM_199051
FAM5C
family with sequence similarity 5, member C
chr15_-_55800431 1.544 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr10_-_98031154 1.538 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_+_18647325 1.520 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chrX_+_83116153 1.517 NM_021118
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr22_+_37678423 1.500 NM_013385
CYTH4
cytohesin 4
chr1_-_151826042 1.495 NM_182578
THEM5
thioesterase superfamily member 5
chr11_-_102496049 1.486 NM_004771
MMP20
matrix metallopeptidase 20
chr5_+_40909558 1.468 NM_000587
C7
complement component 7
chr12_-_10562142 1.460 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr19_-_54824343 1.457 NM_021250
NM_181879
NM_181985
NM_181986
LILRA5



leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5



chr12_-_95945226 1.452 NM_032147
USP44
ubiquitin specific peptidase 44
chr19_-_50666279 1.443 NM_152358
IZUMO2
IZUMO family member 2
chr12_-_45307710 1.439 NM_001145110
NELL2
NEL-like 2 (chicken)
chr2_+_204571197 1.430 NM_001243077
NM_001243078
NM_006139
CD28


CD28 molecule


chr19_-_53794874 1.429 NM_033341
BIRC8
baculoviral IAP repeat containing 8
chrX_+_22291029 1.423 NM_152577
ZNF645
zinc finger protein 645
chr16_+_67381252 1.423 NM_001161575
LRRC36
leucine rich repeat containing 36
chr11_+_6260321 1.420 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr1_+_198608216 1.418 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_36065052 1.404 NM_173695
CXorf59
chromosome X open reading frame 59
chr11_-_17191287 1.402 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr16_-_53405040 1.402 NM_001207030
LOC643802
u3 small nucleolar ribonucleoprotein protein MPP10-like
chr8_+_92261515 1.400 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr6_-_49712055 1.396 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chrX_-_62570968 1.395 NM_001012968
SPIN4
spindlin family, member 4
chr1_+_47137496 1.390 NM_001145474
ATPAF1-AS1
ATPAF1 antisense RNA 1 (non-protein coding)
chrX_+_23018077 1.383 NM_182699
DDX53
DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
chr1_+_34326075 1.382 NM_145205
HMGB4
high mobility group box 4
chr15_+_97326629 1.378 NM_173499
SPATA8
spermatogenesis associated 8
chr12_-_53601051 1.374 ITGB7
integrin, beta 7
chr19_-_55458864 1.368 NM_001127255
NM_139176
NM_206828
NLRP7


NLR family, pyrin domain containing 7


chr20_+_68312 1.366 NM_153325
DEFB125
defensin, beta 125
chr9_-_16727887 1.362 BNC2
basonuclin 2
chr1_-_108231122 1.361 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr4_+_78432905 1.356 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr8_-_124749573 1.355 NM_001003954
NM_004306
ANXA13

annexin A13

chrX_+_49216616 1.352 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr14_-_21029089 1.348 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chrX_-_44202834 1.344 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr7_-_104567089 1.342 LOC723809
uncharacterized LOC723809
chr9_-_88874518 1.336 NM_001010907
C9orf153
chromosome 9 open reading frame 153
chr1_+_117297056 1.336 NM_001767
CD2
CD2 molecule
chr4_+_41983712 1.334 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr19_-_48495339 1.331 NM_001128326
BSPH1
binder of sperm protein homolog 1
chr13_-_60325073 1.330


chr2_-_99917638 1.315 NM_174898
LYG1
lysozyme G-like 1
chr5_-_35938736 1.312 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr3_-_189838673 1.311 LEPREL1
leprecan-like 1
chr6_-_24383519 1.310 NM_001195610
DCDC2
doublecortin domain containing 2
chr7_+_73275488 1.308 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr10_-_85931723 1.303 LOC642934
uncharacterized LOC642934
chr12_-_10573041 1.301 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr20_-_17539480 1.300 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr18_-_61329113 1.296 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr4_-_185139018 1.286 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr7_-_141541220 1.286 NM_001008270
NM_001171951
PRSS37

protease, serine, 37

chr12_+_47610051 1.281 NM_138371
FAM113B
family with sequence similarity 113, member B
chr8_-_87755880 1.270 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr8_-_30706532 1.266 NM_031271
TEX15
testis expressed 15
chr7_-_84751246 1.266 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr13_+_78109808 1.264 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr16_+_27078218 1.260 NM_001145545
C16orf82
chromosome 16 open reading frame 82
chr19_-_23941571 1.253 NM_138286
ZNF681
zinc finger protein 681
chrX_+_49226137 1.248 NM_001472
NM_001098407
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr7_-_112726143 1.247 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr4_-_84035908 1.247 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr5_-_110062365 1.244 NM_001039763
TMEM232
transmembrane protein 232
chr10_+_15001437 1.244 NM_001080836
MEIG1
meiosis expressed gene 1 homolog (mouse)
chr15_+_94841429 1.240 NM_001159643
NM_018349
MCTP2

multiple C2 domains, transmembrane 2

chr2_+_219221578 1.239 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr15_-_80263460 1.235 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr13_+_108921976 1.235 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.22 5.27e-10 GO:0002376 immune system process
3.78 2.50e-08 GO:0006955 immune response
3.48 2.11e-07 GO:0006952 defense response
4.39 1.81e-06 GO:0002684 positive regulation of immune system process
3.46 6.29e-06 GO:0002682 regulation of immune system process
5.59 7.33e-06 GO:0050865 regulation of cell activation
6.31 1.09e-05 GO:0046649 lymphocyte activation
5.47 2.76e-05 GO:0002694 regulation of leukocyte activation
5.42 3.11e-05 GO:0045321 leukocyte activation
6.19 4.25e-05 GO:0002696 positive regulation of leukocyte activation
5.64 4.89e-05 GO:0051249 regulation of lymphocyte activation
6.09 5.26e-05 GO:0050867 positive regulation of cell activation
4.89 5.28e-05 GO:0050778 positive regulation of immune response
3.97 5.29e-05 GO:0050776 regulation of immune response
24.58 7.02e-05 GO:0050853 B cell receptor signaling pathway
8.16 7.14e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
6.17 1.34e-04 GO:0051251 positive regulation of lymphocyte activation
5.12 4.47e-04 GO:0002253 activation of immune response
7.71 4.72e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
6.39 8.54e-04 GO:0050870 positive regulation of T cell activation
5.63 1.08e-03 GO:0050863 regulation of T cell activation
3.37 1.48e-03 GO:0019953 sexual reproduction
5.34 1.87e-03 GO:0002764 immune response-regulating signaling pathway
10.09 3.91e-03 GO:0006968 cellular defense response
12.29 5.84e-03 GO:0030888 regulation of B cell proliferation
7.69 6.55e-03 GO:0009566 fertilization
5.01 9.10e-03 GO:0002757 immune response-activating signal transduction
8.79 9.97e-03 GO:0031294 lymphocyte costimulation
8.79 9.97e-03 GO:0031295 T cell costimulation
8.52 1.23e-02 GO:0007338 single fertilization
46.70 1.50e-02 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
6.70 1.82e-02 GO:0050851 antigen receptor-mediated signaling pathway
3.81 2.80e-02 GO:0006954 inflammatory response
6.23 3.08e-02 GO:0050670 regulation of lymphocyte proliferation
6.17 3.31e-02 GO:0032944 regulation of mononuclear cell proliferation
18.32 4.01e-02 GO:0030101 natural killer cell activation
5.99 4.08e-02 GO:0070663 regulation of leukocyte proliferation
11.80 4.25e-02 GO:0046651 lymphocyte proliferation
1.88 5.00e-02 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.08 2.13e-05 GO:0005576 extracellular region
6.21 1.99e-04 GO:0009897 external side of plasma membrane
2.99 3.25e-02 GO:0009986 cell surface

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
13.62 1.13e-04 GO:0003823 antigen binding
1.98 3.01e-03 GO:0004872 receptor activity
4.51 5.73e-03 GO:0005529 sugar binding
1.78 1.41e-02 GO:0004871 signal transducer activity
1.78 1.41e-02 GO:0060089 molecular transducer activity
2.99 4.40e-02 GO:0030246 carbohydrate binding