Motif ID: CEBPA,B_DDIT3.p2

Z-value: 1.872


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v1_chr12_-_57914287_57914302-0.327.0e-02Click!
CEBPBhg19_v1_chr20_+_48807460_488078010.163.7e-01Click!
CEBPAhg19_v1_chr19_-_33793429_337934370.144.4e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_22019167 7.931 NM_001172357
NM_001172410
NM_003018
 SFTPC


surfactant protein C


chr19_-_51920841 7.482 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
 SIGLEC10






sialic acid binding Ig-like lectin 10






chr17_-_34524054 6.877 NM_001001437
NM_021006
 CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr9_+_117085302 6.868 NM_000607
 ORM1
orosomucoid 1
chr9_+_117092068 6.792 NM_000608
 ORM2
orosomucoid 2
chr5_-_140013285 6.636 NM_001040021
NM_001174104
NM_001174105
 CD14


CD14 molecule


chr5_-_140012730 6.563 CD14
CD14 molecule
chr4_-_38806410 6.446 NM_003263
 TLR1
toll-like receptor 1
chr20_+_54987167 6.371 NM_001164116
NM_001164114
NM_001164115
NM_020356
 CASS4



Cas scaffolding protein family member 4



chr6_+_12717036 6.237 NM_001242648
NM_030948
 PHACTR1

phosphatase and actin regulator 1

chr20_+_57766074 6.086 NM_178457
 ZNF831
zinc finger protein 831
chr19_+_41430123 5.976 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr3_+_186330859 5.971 AHSG
alpha-2-HS-glycoprotein
chr19_+_45452427 5.901 APOC2
apolipoprotein C-II
chr2_-_113594325 5.702 NM_000576
 IL1B
interleukin 1, beta
chr3_+_186330844 5.657 NM_001622
 AHSG
alpha-2-HS-glycoprotein
chr17_-_64225496 5.387 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr9_+_80911990 5.356 NM_021154
NM_058179
 PSAT1

phosphoserine aminotransferase 1

chr20_+_24929904 5.177 CST7
cystatin F (leukocystatin)
chr6_+_131894343 5.148 NM_000045
NM_001244438
 ARG1

arginase, liver


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 55 entries
Enrichment   P-value GO Accession GO Term
85.01 2.33e-03 GO:0031639 plasminogen activation
50.38 6.12e-04 GO:0031638 zymogen activation
48.58 2.00e-02 GO:0010758 regulation of macrophage chemotaxis
42.51 3.17e-02 GO:0002827 positive regulation of T-helper 1 type immune response
42.51 3.17e-02 GO:0051006 positive regulation of lipoprotein lipase activity
37.79 2.36e-03 GO:0002825 regulation of T-helper 1 type immune response
30.23 6.37e-03 GO:0010574 regulation of vascular endothelial growth factor production
28.34 3.10e-06 GO:0030195 negative regulation of blood coagulation
27.36 4.06e-06 GO:0050819 negative regulation of coagulation
26.67 1.09e-02 GO:0007597 blood coagulation, intrinsic pathway
22.67 2.18e-02 GO:0072378 blood coagulation, fibrin clot formation
20.35 3.72e-05 GO:0030193 regulation of blood coagulation
18.90 6.38e-05 GO:0050818 regulation of coagulation
16.53 1.67e-04 GO:0061041 regulation of wound healing
16.20 1.13e-02 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
15.75 1.30e-02 GO:0002821 positive regulation of adaptive immune response
14.87 5.08e-05 GO:0072376 protein activation cascade
12.15 8.22e-03 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.94 9.12e-03 GO:0002819 regulation of adaptive immune response
9.92 5.69e-03 GO:0006959 humoral immune response

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
37.79 3.19e-04 GO:0042627 chylomicron
22.67 2.95e-03 GO:0034361 very-low-density lipoprotein particle
22.67 2.95e-03 GO:0034385 triglyceride-rich lipoprotein particle
12.96 2.88e-02 GO:0032994 protein-lipid complex
12.96 2.88e-02 GO:0034358 plasma lipoprotein particle
4.72 3.61e-11 GO:0005615 extracellular space
3.75 6.27e-09 GO:0044421 extracellular region part
2.86 5.67e-10 GO:0005576 extracellular region
1.54 3.74e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
113.34 1.15e-04 GO:0060230 lipoprotein lipase activator activity
56.67 2.27e-03 GO:0060229 lipase activator activity
22.67 3.06e-07 GO:0003823 antigen binding
14.17 4.35e-03 GO:0004869 cysteine-type endopeptidase inhibitor activity
11.12 1.44e-02 GO:0042379 chemokine receptor binding
6.22 7.66e-03 GO:0004866 endopeptidase inhibitor activity
5.97 1.02e-02 GO:0061135 endopeptidase regulator activity
5.89 1.12e-02 GO:0030414 peptidase inhibitor activity
5.55 6.22e-03 GO:0061134 peptidase regulator activity
5.04 3.31e-02 GO:0005126 cytokine receptor binding
5.01 8.75e-04 GO:0004857 enzyme inhibitor activity
4.04 3.50e-03 GO:0030246 carbohydrate binding
2.80 1.82e-03 GO:0030234 enzyme regulator activity
1.94 2.04e-02 GO:0004871 signal transducer activity
1.94 2.04e-02 GO:0060089 molecular transducer activity