Motif ID: CREB1.p2

Z-value: 2.282


Transcription factors associated with CREB1.p2:

Gene SymbolEntrez IDGene Name
CREB1 1385 cAMP responsive element binding protein 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CREB1hg19_v1_chr2_+_208394756_2083948060.222.4e-01Click!


Activity profile for motif CREB1.p2.

activity profile for motif CREB1.p2


Sorted Z-values histogram for motif CREB1.p2

Sorted Z-values for motif CREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_66754276 5.102 PDE7A
phosphodiesterase 7A
chr4_+_75310852 5.083 NM_001657
AREG
amphiregulin
chr6_+_15249034 4.755 JARID2
jumonji, AT rich interactive domain 2
chr19_-_46088074 3.799 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr3_+_50654558 3.624 NM_001243925
NM_004635
MAPKAPK3

mitogen-activated protein kinase-activated protein kinase 3

chr19_-_47617008 3.585 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr19_-_46088084 3.565 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr6_+_117586720 3.527 NM_153453
NM_182645
VGLL2

vestigial like 2 (Drosophila)

chr3_+_50654589 3.362 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr16_-_88772732 3.312 NM_001171815
RNF166
ring finger protein 166
chr6_+_35227234 3.300 ZNF76
zinc finger protein 76
chr16_-_3930713 3.282 CREBBP
CREB binding protein
chr6_+_35227300 3.199 ZNF76
zinc finger protein 76
chr12_+_98987389 3.101 NM_002635
NM_005888
NM_213611
SLC25A3


solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3


chr6_+_35227478 3.050 NM_003427
ZNF76
zinc finger protein 76
chr3_+_50654868 3.012 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr1_+_26496382 2.985 NM_015871
ZNF593
zinc finger protein 593
chr17_-_8151353 2.965 CTC1
CTS telomere maintenance complex component 1
chr1_+_12040475 2.944 MFN2
mitofusin 2
chr19_-_46088021 2.903 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr13_-_45915277 2.877 NM_003295
TPT1
tumor protein, translationally-controlled 1
chr16_-_88772807 2.852 NM_178841
RNF166
ring finger protein 166
chr6_-_15248886 2.850


chr11_-_119252267 2.850 USP2
ubiquitin specific peptidase 2
chr16_-_3930685 2.844 CREBBP
CREB binding protein
chr7_-_158622184 2.828 ESYT2
extended synaptotagmin-like protein 2
chr16_-_68057098 2.782 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr9_+_134165075 2.764 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr13_-_45915308 2.736 TPT1
tumor protein, translationally-controlled 1
chr16_-_68057120 2.716 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chrY_-_297689 2.655 NM_013239
PPP2R3B
protein phosphatase 2, regulatory subunit B'', beta
chr16_-_85045086 2.626 ZDHHC7
zinc finger, DHHC-type containing 7
chr17_+_685606 2.597 RNMTL1
RNA methyltransferase like 1
chr8_-_17104266 2.589 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr2_+_30454396 2.583 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr13_-_45915203 2.581 TPT1
tumor protein, translationally-controlled 1
chr12_+_98987500 2.570 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chrY_+_2803409 2.555 NM_001145275
NM_003411
ZFY

zinc finger protein, Y-linked

chr12_+_98987470 2.542 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr8_-_17104103 2.539 CNOT7
CCR4-NOT transcription complex, subunit 7
chr1_-_200638996 2.527 DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr9_-_125027080 2.524 NM_033117
RBM18
RNA binding motif protein 18
chr16_+_19078916 2.484 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr19_-_49496564 2.456 GYS1
glycogen synthase 1 (muscle)
chr19_-_49496369 2.441 GYS1
glycogen synthase 1 (muscle)
chr17_-_8151373 2.425 NM_025099
CTC1
CTS telomere maintenance complex component 1
chr1_-_200639091 2.418 NM_001031725
DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr7_-_158622202 2.381 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr12_+_98987674 2.371 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr1_-_119683210 2.366 NM_015836
NM_201263
WARS2

tryptophanyl tRNA synthetase 2, mitochondrial

chr17_+_685512 2.365 NM_018146
RNMTL1
RNA methyltransferase like 1
chr1_+_119683006 2.282


chr1_+_12040504 2.276 MFN2
mitofusin 2
chr1_+_36690038 2.265 THRAP3
thyroid hormone receptor associated protein 3
chr19_-_49496520 2.247 GYS1
glycogen synthase 1 (muscle)
chr19_+_36103616 2.244 NM_015302
HAUS5
HAUS augmin-like complex, subunit 5
chr1_+_110009220 2.223 SYPL2
synaptophysin-like 2
chr7_+_44646180 2.187 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr8_-_144623579 2.185 ZC3H3
zinc finger CCCH-type containing 3
chr16_+_19078958 2.185 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr7_+_44646168 2.168 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr12_+_98987463 2.139 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr7_+_44646197 2.125 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr12_+_132629014 2.124 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr9_+_125027152 2.099 MRRF
mitochondrial ribosome recycling factor
chr7_+_44646120 2.098 NM_001003941
NM_001165036
NM_002541
OGDH


oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)


chr5_-_172198160 2.093 NM_004417
DUSP1
dual specificity phosphatase 1
chr7_+_44646189 2.084 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr3_+_170075521 2.083 SKIL
SKI-like oncogene
chr14_+_68086633 2.056 ARG2
arginase, type II
chr9_-_125027017 2.056 RBM18
RNA binding motif protein 18
chr8_-_66753968 2.041 NM_001242318
PDE7A
phosphodiesterase 7A
chr4_+_152330326 2.034 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr19_+_16435734 2.029 KLF2
Kruppel-like factor 2 (lung)
chr11_-_77184549 2.029 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr15_+_72766665 2.012 NM_005744
ARIH1
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
chr11_+_809985 1.997 RPLP2
ribosomal protein, large, P2
chr16_+_68298326 1.996 NM_001076785
NM_003983
SLC7A6

solute carrier family 7 (amino acid transporter light chain, y+L system), member 6

chr11_-_3818971 1.982 NM_005387
NM_016320
NM_139131
NM_139132
NUP98



nucleoporin 98kDa



chr12_+_122516555 1.970 NM_014938
MLXIP
MLX interacting protein
chr11_+_66610882 1.964 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein protease (S. cerevisiae)

chr16_+_19079220 1.944 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr1_+_203274646 1.938 NM_006763
BTG2
BTG family, member 2
chr1_+_150980895 1.934 NM_021222
PRUNE
prune homolog (Drosophila)
chr12_+_54378929 1.931 NM_017409
HOXC10
homeobox C10
chr4_+_8442496 1.925 NM_152544
METTL19
methyltransferase like 19
chr19_-_49496566 1.906 NM_001161587
NM_002103
GYS1

glycogen synthase 1 (muscle)

chrY_+_15016775 1.905 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr14_+_105190533 1.895 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr1_-_229643996 1.877 NUP133
nucleoporin 133kDa
chr21_+_38739193 1.877 DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr19_-_55668956 1.874 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr14_-_102975996 1.873 ANKRD9
ankyrin repeat domain 9
chr10_-_99094427 1.867 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr20_+_44420606 1.863 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr15_-_55700456 1.842 NM_004748
NM_001204450
NM_001204451
NM_020739
CCPG1



cell cycle progression 1



chrY_+_15016698 1.830 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr17_-_36981552 1.829 NM_017748
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr7_-_107204336 1.814 COG5
component of oligomeric golgi complex 5
chr3_+_16306666 1.798 NM_138381
OXNAD1
oxidoreductase NAD-binding domain containing 1
chr16_-_3767449 1.793 NM_016292
TRAP1
TNF receptor-associated protein 1
chr14_-_50053068 1.790 NM_001030001
NM_001032
RPS29

ribosomal protein S29

chr19_+_13263890 1.785 IER2
immediate early response 2
chr3_+_170075494 1.758 SKIL
SKI-like oncogene
chr8_-_144623611 1.755 NM_015117
ZC3H3
zinc finger CCCH-type containing 3
chr2_+_28615668 1.749 FOSL2
FOS-like antigen 2
chr7_+_44646220 1.734 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr16_-_4588738 1.729 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr12_+_56660724 1.704 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr9_-_140082983 1.699 ANAPC2
anaphase promoting complex subunit 2
chr3_+_170075449 1.689 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr2_+_75061234 1.689 HK2
hexokinase 2
chr5_+_139927182 1.687 NM_003732
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr4_+_113558119 1.685 NM_016648
LARP7
La ribonucleoprotein domain family, member 7
chr12_+_122516676 1.683 MLXIP
MLX interacting protein
chr19_+_54058493 1.683 NM_001079907
ZNF331
zinc finger protein 331
chr15_+_31619043 1.676 NM_015995
KLF13
Kruppel-like factor 13
chr15_+_72766689 1.660 ARIH1
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
chr9_-_140083010 1.652 ANAPC2
anaphase promoting complex subunit 2
chr5_+_148206155 1.651 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr7_+_1200097 1.647


chr12_-_58165877 1.634 NM_005371
NM_023033
METTL1

methyltransferase like 1

chr20_+_44420610 1.631 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr8_+_128806720 1.629 PVT1
Pvt1 oncogene (non-protein coding)
chr1_-_150980840 1.629 NM_001163258
NM_018379
FAM63A

family with sequence similarity 63, member A

chr2_-_240964807 1.622 NM_004544
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr2_-_27531113 1.614 NM_003353
UCN
urocortin
chr1_-_52344010 1.600 NRD1
nardilysin (N-arginine dibasic convertase)
chr10_+_134210691 1.595 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr3_-_52312655 1.591 NM_025222
WDR82
WD repeat domain 82
chr15_-_40401041 1.589 NM_001003940
BMF
Bcl2 modifying factor
chr10_-_99094264 1.582 FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr11_+_28129797 1.577 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr11_+_68228182 1.577 NM_001164160
NM_001164161
NM_001164162
NM_001164163
NM_001164164
NM_018312
PPP6R3





protein phosphatase 6, regulatory subunit 3





chr10_+_99079017 1.576 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr1_+_12040237 1.574 NM_001127660
NM_014874
MFN2

mitofusin 2

chr5_-_16617085 1.570 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr12_+_132629009 1.544


chr16_-_2014826 1.539 NM_002952
RPS2
ribosomal protein S2
chr16_+_2022081 1.539 TBL3
transducin (beta)-like 3
chr17_-_2240677 1.536 NM_018128
TSR1
TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
chr21_+_45079375 1.535 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr11_-_1785104 1.533 CTSD
cathepsin D
chr16_+_2802683 1.517 SRRM2
serine/arginine repetitive matrix 2
chr19_+_35491225 1.516 NM_001136199
NM_020895
GRAMD1A

GRAM domain containing 1A

chr17_-_685385 1.507 NM_016080
GLOD4
glyoxalase domain containing 4
chr3_-_71803923 1.504 NM_173359
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr22_+_41487787 1.503 EP300
E1A binding protein p300
chr7_+_120590816 1.499 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr22_-_47134044 1.497 CERK
ceramide kinase
chr6_-_18122850 1.493 NM_198586
NHLRC1
NHL repeat containing 1
chr3_+_50654600 1.491 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr2_+_61108702 1.486 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr7_-_19748602 1.485 NM_001002926
TWISTNB
TWIST neighbor
chr1_-_52344306 1.479 NRD1
nardilysin (N-arginine dibasic convertase)
chr17_+_57642885 1.478 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr1_+_222791151 1.478 NM_198551
MIA3
melanoma inhibitory activity family, member 3
chrX_-_46618471 1.477 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr6_+_64281910 1.471 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_238536183 1.468 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr11_-_1785087 1.461 CTSD
cathepsin D
chr3_+_128598520 1.457 ACAD9
acyl-CoA dehydrogenase family, member 9
chr15_+_40861531 1.455 NM_152260
RPUSD2
RNA pseudouridylate synthase domain containing 2
chr3_+_44771097 1.452 NM_145044
ZNF501
zinc finger protein 501
chr11_+_117857062 1.451 NM_001558
IL10RA
interleukin 10 receptor, alpha
chr3_+_133293256 1.444 NM_001134423
CDV3
CDV3 homolog (mouse)
chr2_+_109271484 1.438 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr1_+_52082755 1.433 OSBPL9
oxysterol binding protein-like 9
chr6_-_26285726 1.430 NM_003543
HIST1H4H
histone cluster 1, H4h
chr19_+_42901297 1.428


chr4_-_8430185 1.422 ACOX3
acyl-CoA oxidase 3, pristanoyl
chr11_+_117049387 1.416 SIDT2
SID1 transmembrane family, member 2
chr8_+_17104384 1.410 NM_001145152
NM_152415
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr15_+_40861527 1.405 RPUSD2
RNA pseudouridylate synthase domain containing 2
chr3_+_38207247 1.403 OXSR1
oxidative-stress responsive 1
chr17_-_36981405 1.399 CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr3_+_38206968 1.398 NM_005109
OXSR1
oxidative-stress responsive 1
chr15_+_40861509 1.393 RPUSD2
RNA pseudouridylate synthase domain containing 2
chr2_-_54198055 1.392


chr1_-_229644077 1.390 NM_018230
NUP133
nucleoporin 133kDa
chr3_-_49066813 1.385 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chrY_+_2803111 1.384 NM_001145276
ZFY
zinc finger protein, Y-linked
chr16_+_88772884 1.380 NM_001012759
NM_001012762
CTU2

cytosolic thiouridylase subunit 2 homolog (S. pombe)

chr17_-_20946088 1.376 NM_015276
USP22
ubiquitin specific peptidase 22
chr11_-_64889581 1.373 NM_001997
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr18_+_11851388 1.371 NM_020412
CHMP1B
charged multivesicular body protein 1B
chr14_+_105267378 1.365 ZBTB42
zinc finger and BTB domain containing 42
chr17_-_76836852 1.364 NM_025090
USP36
ubiquitin specific peptidase 36
chrX_+_24167728 1.363 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr3_-_49066760 1.360 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr7_+_56019552 1.354 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr12_-_76478347 1.353 NAP1L1
nucleosome assembly protein 1-like 1
chr16_-_86588680 1.351 NM_001159380
NM_001159377
NM_001159378
NM_001159379
NM_022764
MTHFSD




methenyltetrahydrofolate synthetase domain containing




chrX_-_135055834 1.349 MMGT1
membrane magnesium transporter 1
chr20_+_44420575 1.348 NM_052951
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr2_+_28615771 1.346 NM_005253
FOSL2
FOS-like antigen 2
chr7_-_129592711 1.343 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr12_-_121790141 1.340 ANAPC5
anaphase promoting complex subunit 5
chr9_-_77643156 1.330 C9orf41
chromosome 9 open reading frame 41
chr13_-_113344050 1.329 LOC440149
uncharacterized LOC440149

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.35 1.85e-05 GO:0043231 intracellular membrane-bounded organelle
1.35 2.02e-05 GO:0043227 membrane-bounded organelle
2.39 4.63e-05 GO:0005739 mitochondrion
1.24 7.35e-05 GO:0044424 intracellular part
1.98 8.06e-05 GO:0070013 intracellular organelle lumen
1.94 1.52e-04 GO:0043233 organelle lumen
1.22 1.80e-04 GO:0005622 intracellular
1.91 2.53e-04 GO:0031974 membrane-enclosed lumen
1.48 4.12e-04 GO:0044446 intracellular organelle part
1.28 5.03e-04 GO:0043229 intracellular organelle
1.27 5.75e-04 GO:0043226 organelle
1.46 8.31e-04 GO:0044422 organelle part
1.87 1.64e-03 GO:0044428 nuclear part
2.76 1.83e-03 GO:0044429 mitochondrial part
1.93 2.87e-03 GO:0031981 nuclear lumen
2.62 3.98e-03 GO:0031967 organelle envelope
2.58 5.25e-03 GO:0031975 envelope
1.40 1.13e-02 GO:0005634 nucleus
2.77 3.92e-02 GO:0005740 mitochondrial envelope

Nothing significant found in function category.