Motif ID: CRX.p2

Z-value: 1.598


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CRXhg19_v1_chr19_+_48325098_48325212-0.134.9e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_207277577 7.072 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr4_-_155533800 5.505 FGG
fibrinogen gamma chain
chr4_-_155533757 5.133 FGG
fibrinogen gamma chain
chr1_+_168545710 4.947 NM_002995
XCL1
chemokine (C motif) ligand 1
chr9_-_104198045 4.249 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr12_+_8608521 4.206 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr4_+_187187342 4.180 F11
coagulation factor XI
chr1_-_168513201 4.004 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr1_-_47655723 3.945 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr4_-_155533882 3.923 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr4_+_74281884 3.897 ALB
albumin
chr1_-_47655603 3.858 PDZK1IP1
PDZK1 interacting protein 1
chr1_+_31883020 3.856 NM_001199037
SERINC2
serine incorporator 2
chr3_+_149192367 3.798 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr4_+_74269971 3.686 NM_000477
ALB
albumin
chr2_+_234590583 3.683 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr4_+_74286846 3.596 ALB
albumin
chrX_-_131573638 3.500 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr9_-_100700422 3.468 NM_197978
HEMGN
hemogen
chr2_-_88427535 3.459 NM_001443
FABP1
fatty acid binding protein 1, liver
chr12_+_10124007 3.396 NM_138337
NM_201623
CLEC12A

CLEC12B
C-type lectin domain family 12, member A

C-type lectin domain family 12, member B
chr1_+_160765927 3.377 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr6_-_133078894 3.314 NM_001242350
NM_004665
VNN2

vanin 2

chr4_-_155533850 3.292 FGG
fibrinogen gamma chain
chr5_-_35991343 3.283 NM_152404
UGT3A1
UDP glycosyltransferase 3 family, polypeptide A1
chr11_-_116663106 3.095 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr2_-_73869493 2.939 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chrX_+_135730335 2.883 NM_000074
CD40LG
CD40 ligand
chr3_+_122044010 2.847 NM_005213
CSTA
cystatin A (stefin A)
chr3_-_194072004 2.800 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr2_-_75796847 2.789 NM_032181
FAM176A
family with sequence similarity 176, member A
chr4_-_184243578 2.783 NM_001185149
CLDN24
claudin 24
chr20_-_7921068 2.761 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_+_119911395 2.727 NM_001005783
NM_016527
HAO2

hydroxyacid oxidase 2 (long chain)

chr10_-_82049178 2.679 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr16_-_48266181 2.577 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr2_+_234580504 2.547 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr17_+_41052813 2.503 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr12_+_6881669 2.428 NM_002286
LAG3
lymphocyte-activation gene 3
chr17_-_39092714 2.346 KRT23
keratin 23 (histone deacetylase inducible)
chr14_+_88471467 2.330 NM_003608
GPR65
G protein-coupled receptor 65
chr7_+_37779995 2.317 NM_181791
GPR141
G protein-coupled receptor 141
chr2_-_73928466 2.312 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr12_+_57828457 2.269 NM_005538
INHBC
inhibin, beta C
chrX_+_123480131 2.235 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr21_+_39628869 2.232 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_66417069 2.226 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr15_+_58430394 2.219 NM_020980
AQP9
aquaporin 9
chr2_+_234545099 2.211 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr22_-_37975937 2.189 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr12_+_8666135 2.188 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr16_-_20338808 2.177 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr8_+_86376130 2.161 NM_000067
CA2
carbonic anhydrase II
chr11_+_58695101 2.143 NM_001220494
GLYATL1
glycine-N-acyltransferase-like 1
chr6_+_10585978 2.110 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr7_-_115670828 2.098 NM_001018058
NM_012252
TFEC

transcription factor EC

chr7_-_99277518 2.074 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr12_-_10562142 2.072 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr5_+_70944968 2.025 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr12_-_89746244 2.011 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chrX_-_70331297 1.994 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr3_-_109056388 1.994 NM_018189
DPPA4
developmental pluripotency associated 4
chr6_-_25832268 1.988 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr12_-_89745753 1.941 DUSP6
dual specificity phosphatase 6
chr4_+_25658085 1.925 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr21_-_43187265 1.911 RIPK4
receptor-interacting serine-threonine kinase 4
chr21_+_39628663 1.894 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_57320442 1.889 NM_000562
C8A
complement component 8, alpha polypeptide
chr11_+_118175294 1.859 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr19_-_6670598 1.833 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr13_-_99910548 1.826 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr12_-_10151689 1.817 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr8_-_80993009 1.790 NM_001025252
TPD52
tumor protein D52
chr16_-_68033355 1.785 NM_022355
DPEP2
dipeptidase 2
chr12_-_89746238 1.783 DUSP6
dual specificity phosphatase 6
chr20_+_5987897 1.780 NM_001127458
CRLS1
cardiolipin synthase 1
chr7_+_29519485 1.780 NM_001039936
CHN2
chimerin (chimaerin) 2
chr3_-_109056333 1.776 DPPA4
developmental pluripotency associated 4
chr4_-_69536314 1.756 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr7_-_115670774 1.753 TFEC
transcription factor EC
chr11_+_63057371 1.733 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr2_+_113885137 1.729 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr16_+_30483959 1.726 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr1_-_161601752 1.723 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr11_-_118084073 1.723 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr17_-_34207308 1.721 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr20_+_43803539 1.707 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr19_-_4302381 1.701 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr1_-_7913094 1.683 NM_006786
UTS2
urotensin 2
chr20_+_42984338 1.658 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr2_+_113875469 1.641 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr2_-_89513056 1.626 IGKC
immunoglobulin kappa constant
chr2_+_113885145 1.623 IL1RN
interleukin 1 receptor antagonist
chr4_+_187187117 1.611 NM_000128
F11
coagulation factor XI
chr1_-_159684274 1.602 NM_000567
CRP
C-reactive protein, pentraxin-related
chr2_-_158300517 1.596 NM_004288
CYTIP
cytohesin 1 interacting protein
chr7_-_115670811 1.593 TFEC
transcription factor EC
chr8_+_32579350 1.591 NM_001159996
NRG1
neuregulin 1
chr8_-_134087255 1.580 SLA
Src-like-adaptor
chr1_+_16068916 1.571 NM_001013641
TMEM82
transmembrane protein 82
chr3_-_47098906 1.531 SETD2
SET domain containing 2
chr3_-_170744767 1.528 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_-_157670280 1.520 NM_052939
FCRL3
Fc receptor-like 3
chr2_+_102608305 1.517 NM_004633
IL1R2
interleukin 1 receptor, type II
chr19_-_43032525 1.514 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr17_-_39274587 1.501 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr6_+_31554475 1.501 NM_205837
LST1
leukocyte specific transcript 1
chr19_+_51645556 1.491 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chr2_+_211342405 1.481 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_-_160617042 1.470 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr8_-_17752847 1.467 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr16_+_30484108 1.464


chr2_-_89619820 1.461 IGKC
immunoglobulin kappa constant
chrX_-_129519420 1.425 NM_178471
GPR119
G protein-coupled receptor 119
chr4_-_72669757 1.413 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr11_+_118215058 1.411 NM_000073
CD3G
CD3g molecule, gamma (CD3-TCR complex)
chr16_+_56899118 1.407 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr16_+_30484049 1.401 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr1_-_169555624 1.399 F5
coagulation factor V (proaccelerin, labile factor)
chrX_-_24690740 1.389 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chrX_+_119738542 1.364 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr19_-_5838740 1.359 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr18_+_33234532 1.349 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr7_-_38313232 1.334 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr22_+_24999113 1.332 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr9_-_86584079 1.332 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_+_149192479 1.329 TM4SF4
transmembrane 4 L six family member 4
chr1_+_156119734 1.328 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_+_26400503 1.328 NM_001199837
SNX10
sorting nexin 10
chr11_-_118900078 1.328 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr6_-_149806116 1.319 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr10_+_7745354 1.304 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_-_152146373 1.303 NM_004688
NMI
N-myc (and STAT) interactor
chr2_+_211421322 1.302 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr18_+_21693316 1.299 TTC39C
tetratricopeptide repeat domain 39C
chr1_-_110155672 1.296 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr7_-_18067445 1.289 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr3_-_120401401 1.281 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr6_-_134496833 1.274 SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_24877453 1.272 NM_015864
FAM65B
family with sequence similarity 65, member B
chr17_-_46035109 1.269 NM_024320
PRR15L
proline rich 15-like
chr12_-_53012332 1.264 NM_175068
KRT73
keratin 73
chrX_-_124097601 1.263 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr1_-_100231348 1.259 NM_001013660
FRRS1
ferric-chelate reductase 1
chr1_-_169555710 1.257 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr2_-_89292396 1.237 IGKC
immunoglobulin kappa constant
chr14_+_88490893 1.233 LOC283587
uncharacterized LOC283587
chr11_-_128712340 1.230 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr12_-_57873628 1.216 NM_032496
ARHGAP9
Rho GTPase activating protein 9
chr12_-_89745997 1.207 DUSP6
dual specificity phosphatase 6
chr3_+_39371196 1.202 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr6_-_30899926 1.188 NM_205854
SFTA2
surfactant associated 2
chr3_+_128779609 1.183 NM_000174
GP9
glycoprotein IX (platelet)
chr2_+_3627725 1.174 RPS7
ribosomal protein S7
chr21_-_31588242 1.174 NM_199328
CLDN8
claudin 8
chr1_+_32739711 1.172 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr6_+_31553955 1.155 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr6_-_31560497 1.152 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr2_+_90211704 1.147


chr17_+_34538464 1.146 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr12_-_15091441 1.140 NM_152321
ERP27
endoplasmic reticulum protein 27
chr17_-_64225496 1.136 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr5_-_159739482 1.125 NM_024565
CCNJL
cyclin J-like
chrX_+_106161589 1.125 NM_001171095
CLDN2
claudin 2
chr4_-_84035888 1.118 PLAC8
placenta-specific 8
chr1_-_173886464 1.114 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr22_+_22764094 1.112


chr10_-_91405320 1.112 NM_148977
PANK1
pantothenate kinase 1
chr11_-_59950498 1.112 NM_022349
NM_152851
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr18_-_24722757 1.110 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr6_+_32407618 1.107 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr6_+_31543340 1.104 NM_000594
TNF
tumor necrosis factor
chr12_-_68553322 1.097 NM_000619
IFNG
interferon, gamma
chr4_-_71532341 1.094 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_+_36283243 1.089 NM_001136536
DTHD1
death domain containing 1
chr17_-_26697293 1.083 VTN
vitronectin
chr3_+_52811601 1.078 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr1_-_27998700 1.074 IFI6
interferon, alpha-inducible protein 6
chr1_+_117297056 1.051 NM_001767
CD2
CD2 molecule
chr8_+_76452202 1.048 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr16_-_71610948 1.046 NM_000353
TAT
tyrosine aminotransferase
chr1_+_117544371 1.044 NM_004258
CD101
CD101 molecule
chr9_-_104145800 1.044 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr17_-_26697224 1.043 VTN
vitronectin
chr14_-_61748510 1.037 NM_001017970
TMEM30B
transmembrane protein 30B
chr21_+_45905447 1.031


chr17_-_47286742 1.029 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chrX_-_106146546 1.028 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr22_+_23040394 1.023 IGL@
immunoglobulin lambda locus
chr11_+_117947785 1.019 TMPRSS4
transmembrane protease, serine 4
chr9_+_4839763 1.019 RCL1
RNA terminal phosphate cyclase-like 1
chr14_-_94789641 1.017 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr14_-_61747956 1.010 TMEM30B
transmembrane protein 30B
chr1_+_207262583 1.004 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr2_+_228678556 0.993 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr12_+_50869531 0.991 LARP4
La ribonucleoprotein domain family, member 4
chr14_+_71996041 0.991 NM_015556
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr10_-_74714479 0.981 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr10_-_86001197 0.980 NM_015613
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr2_-_88285308 0.977 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.81 2.04e-10 GO:0006955 immune response
3.70 4.37e-10 GO:0002376 immune system process
6.63 7.16e-07 GO:0050778 positive regulation of immune response
5.18 1.59e-06 GO:0002684 positive regulation of immune system process
5.13 1.88e-06 GO:0050776 regulation of immune response
3.85 2.48e-05 GO:0002682 regulation of immune system process
13.85 9.47e-05 GO:0072376 protein activation cascade
13.44 7.57e-04 GO:0016064 immunoglobulin mediated immune response
13.20 8.58e-04 GO:0019724 B cell mediated immunity
3.19 1.28e-03 GO:0048584 positive regulation of response to stimulus
3.95 1.34e-03 GO:0001775 cell activation
42.22 1.44e-03 GO:0045672 positive regulation of osteoclast differentiation
5.51 1.78e-03 GO:0045321 leukocyte activation
2.99 2.21e-03 GO:0009611 response to wounding
2.04 3.02e-03 GO:0006950 response to stress
10.71 3.60e-03 GO:0002449 lymphocyte mediated immunity
20.30 3.69e-03 GO:0031343 positive regulation of cell killing
6.36 3.69e-03 GO:0050863 regulation of T cell activation
5.61 4.05e-03 GO:0051249 regulation of lymphocyte activation
9.99 5.78e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
3.01 5.82e-03 GO:0006952 defense response
9.73 6.91e-03 GO:0002250 adaptive immune response
63.33 7.65e-03 GO:0051552 flavone metabolic process
4.35 8.93e-03 GO:0051240 positive regulation of multicellular organismal process
17.03 9.18e-03 GO:0006958 complement activation, classical pathway
17.03 9.18e-03 GO:0031341 regulation of cell killing
5.71 9.65e-03 GO:0046649 lymphocyte activation
9.24 9.73e-03 GO:0006959 humoral immune response
1.50 9.87e-03 GO:0050896 response to stimulus
5.10 1.02e-02 GO:0002694 regulation of leukocyte activation
3.36 1.16e-02 GO:0042060 wound healing
4.90 1.46e-02 GO:0050865 regulation of cell activation
3.42 1.67e-02 GO:0051336 regulation of hydrolase activity
8.50 1.69e-02 GO:0002443 leukocyte mediated immunity
15.08 1.70e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
8.04 2.44e-02 GO:0010466 negative regulation of peptidase activity
13.89 2.57e-02 GO:0002705 positive regulation of leukocyte mediated immunity
13.89 2.57e-02 GO:0002708 positive regulation of lymphocyte mediated immunity
4.96 3.26e-02 GO:0002253 activation of immune response
2.97 3.37e-02 GO:0006082 organic acid metabolic process
5.40 4.18e-02 GO:0002696 positive regulation of leukocyte activation
12.57 4.23e-02 GO:0006956 complement activation
5.31 4.77e-02 GO:0050867 positive regulation of cell activation
5.28 4.98e-02 GO:0052547 regulation of peptidase activity

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.38 4.38e-06 GO:0005576 extracellular region
3.41 1.82e-05 GO:0005615 extracellular space
1.52 2.79e-04 GO:0044425 membrane part
1.58 4.09e-04 GO:0031224 intrinsic to membrane
2.73 5.68e-04 GO:0044421 extracellular region part
1.39 2.82e-03 GO:0016020 membrane
1.52 3.64e-03 GO:0016021 integral to membrane
1.60 6.68e-03 GO:0071944 cell periphery
6.12 6.90e-03 GO:0009897 external side of plasma membrane
1.57 1.74e-02 GO:0005886 plasma membrane
1.82 4.00e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.63 7.59e-05 GO:0030246 carbohydrate binding
18.85 1.20e-03 GO:0015020 glucuronosyltransferase activity
5.87 1.68e-03 GO:0005126 cytokine receptor binding
5.56 2.69e-03 GO:0005529 sugar binding
5.45 3.23e-03 GO:0005125 cytokine activity
13.20 7.34e-03 GO:0003823 antigen binding
12.00 1.18e-02 GO:0043498 cell surface binding
105.55 1.84e-02 GO:0003973 (S)-2-hydroxy-acid oxidase activity
105.55 1.84e-02 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
2.44 1.87e-02 GO:0005102 receptor binding
31.67 1.96e-02 GO:0050997 quaternary ammonium group binding
2.01 3.11e-02 GO:0004872 receptor activity
3.30 3.42e-02 GO:0008289 lipid binding
9.43 3.78e-02 GO:0033293 monocarboxylic acid binding