Motif ID: CRX.p2

Z-value: 1.598


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CRXhg19_v1_chr19_+_48325098_48325212-0.134.9e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_207277577 7.072 NM_000715
 C4BPA
complement component 4 binding protein, alpha
chr4_-_155533800 5.505 FGG
fibrinogen gamma chain
chr4_-_155533757 5.133 FGG
fibrinogen gamma chain
chr1_+_168545710 4.947 NM_002995
 XCL1
chemokine (C motif) ligand 1
chr9_-_104198045 4.249 NM_000035
 ALDOB
aldolase B, fructose-bisphosphate
chr12_+_8608521 4.206 NM_001007033
 CLEC6A
C-type lectin domain family 6, member A
chr4_+_187187342 4.180 F11
coagulation factor XI
chr1_-_168513201 4.004 NM_003175
 XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr1_-_47655723 3.945 NM_005764
 PDZK1IP1
PDZK1 interacting protein 1
chr4_-_155533882 3.923 NM_000509
NM_021870
 FGG

fibrinogen gamma chain

chr4_+_74281884 3.897 ALB
albumin
chr1_-_47655603 3.858 PDZK1IP1
PDZK1 interacting protein 1
chr1_+_31883020 3.856 NM_001199037
 SERINC2
serine incorporator 2
chr3_+_149192367 3.798 NM_004617
 TM4SF4
transmembrane 4 L six family member 4
chr4_+_74269971 3.686 NM_000477
 ALB
albumin
chr2_+_234590583 3.683 NM_019077
 UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr4_+_74286846 3.596 ALB
albumin
chrX_-_131573638 3.500 NM_018388
NM_133486
 MBNL3

muscleblind-like 3 (Drosophila)

chr9_-_100700422 3.468 NM_197978
 HEMGN
hemogen
chr2_-_88427535 3.459 NM_001443
 FABP1
fatty acid binding protein 1, liver

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 44 entries
Enrichment   P-value GO Accession GO Term
63.33 7.65e-03 GO:0051552 flavone metabolic process
42.22 1.44e-03 GO:0045672 positive regulation of osteoclast differentiation
20.30 3.69e-03 GO:0031343 positive regulation of cell killing
17.03 9.18e-03 GO:0006958 complement activation, classical pathway
17.03 9.18e-03 GO:0031341 regulation of cell killing
15.08 1.70e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
13.89 2.57e-02 GO:0002705 positive regulation of leukocyte mediated immunity
13.89 2.57e-02 GO:0002708 positive regulation of lymphocyte mediated immunity
13.85 9.47e-05 GO:0072376 protein activation cascade
13.44 7.57e-04 GO:0016064 immunoglobulin mediated immune response
13.20 8.58e-04 GO:0019724 B cell mediated immunity
12.57 4.23e-02 GO:0006956 complement activation
10.71 3.60e-03 GO:0002449 lymphocyte mediated immunity
9.99 5.78e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
9.73 6.91e-03 GO:0002250 adaptive immune response
9.24 9.73e-03 GO:0006959 humoral immune response
8.50 1.69e-02 GO:0002443 leukocyte mediated immunity
8.04 2.44e-02 GO:0010466 negative regulation of peptidase activity
6.63 7.16e-07 GO:0050778 positive regulation of immune response
6.36 3.69e-03 GO:0050863 regulation of T cell activation

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
6.12 6.90e-03 GO:0009897 external side of plasma membrane
3.41 1.82e-05 GO:0005615 extracellular space
2.73 5.68e-04 GO:0044421 extracellular region part
2.38 4.38e-06 GO:0005576 extracellular region
1.82 4.00e-02 GO:0044459 plasma membrane part
1.60 6.68e-03 GO:0071944 cell periphery
1.58 4.09e-04 GO:0031224 intrinsic to membrane
1.57 1.74e-02 GO:0005886 plasma membrane
1.52 2.79e-04 GO:0044425 membrane part
1.52 3.64e-03 GO:0016021 integral to membrane
1.39 2.82e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
105.55 1.84e-02 GO:0003973 (S)-2-hydroxy-acid oxidase activity
105.55 1.84e-02 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
31.67 1.96e-02 GO:0050997 quaternary ammonium group binding
18.85 1.20e-03 GO:0015020 glucuronosyltransferase activity
13.20 7.34e-03 GO:0003823 antigen binding
12.00 1.18e-02 GO:0043498 cell surface binding
9.43 3.78e-02 GO:0033293 monocarboxylic acid binding
5.87 1.68e-03 GO:0005126 cytokine receptor binding
5.56 2.69e-03 GO:0005529 sugar binding
5.45 3.23e-03 GO:0005125 cytokine activity
4.63 7.59e-05 GO:0030246 carbohydrate binding
3.30 3.42e-02 GO:0008289 lipid binding
2.44 1.87e-02 GO:0005102 receptor binding
2.01 3.11e-02 GO:0004872 receptor activity