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• Activity deltas table
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Motif ID: CUX2.p2

Z-value: 1.579

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr3_+_52811601	11.488	NM_002215	ITIH1	inter-alpha-trypsin inhibitor heavy chain 1
chr1_+_57320442	11.203	NM_000562	C8A	complement component 8, alpha polypeptide
chr1_-_159684274	10.959	NM_000567	CRP	C-reactive protein, pentraxin-related
chr4_-_72649734	9.635	NM_000583	GC	group-specific component (vitamin D binding protein)
chr7_-_100239136	9.549	NM_003227	TFR2	transferrin receptor 2
chr19_-_58864820	8.349	NM_130786	A1BG	alpha-1-B glycoprotein
chr1_-_157811491	8.290	NM_005894	CD5L	CD5 molecule-like
chr1_+_198608216	8.288		PTPRC	protein tyrosine phosphatase, receptor type, C
chr1_+_198608244	7.571		PTPRC	protein tyrosine phosphatase, receptor type, C
chr1_+_198608136	7.353	NM_002838 NM_080921 NM_080923	PTPRC	protein tyrosine phosphatase, receptor type, C
chr2_-_89165652	6.681
chrX_+_123480131	5.864	NM_001114937 NM_002351	SH2D1A	SH2 domain containing 1A
chr3_-_170744458	5.573		SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2
chr13_-_46756291	5.287		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr7_-_36764000	5.183	NM_001177506 NM_001177507 NM_001637	AOAH	acyloxyacyl hydrolase (neutrophil)
chr14_+_88490893	4.873		LOC283587	uncharacterized LOC283587
chr17_-_64225496	4.546	NM_000042	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr13_-_46756295	4.287		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_206730456	4.016	NM_182665	RASSF5	Ras association (RalGDS/AF-6) domain family member 5
chr3_-_170744529	3.911		SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2
chr7_+_80231503	3.751	NM_001001547	CD36	CD36 molecule (thrombospondin receptor)
chr8_-_17752847	3.685	NM_147203 NM_201553 NM_004467 NM_201552	FGL1	fibrinogen-like 1
chr7_-_104909442	2.512	NM_182691	SRPK2	SRSF protein kinase 2
chr22_-_26961333	2.469	NM_001008566	TPST2	tyrosylprotein sulfotransferase 2
chr2_-_192016293	2.445	NM_001243835	STAT4	signal transducer and activator of transcription 4
chr2_+_169926084	2.375		DHRS9	dehydrogenase/reductase (SDR family) member 9
chr1_+_117297056	2.368	NM_001767	CD2	CD2 molecule
chr1_-_51887740	2.216	NM_001159969	EPS15	epidermal growth factor receptor pathway substrate 15
chr20_-_34241830	2.203	NM_003915	CPNE1	copine I
chr8_+_18248754	2.203	NM_000015	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr16_+_12058963	2.100	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr3_-_112693711	2.023	NM_138806 NM_138939 NM_138940 NM_170780	CD200R1	CD200 receptor 1
chr18_-_70532933	1.916	NM_138999	NETO1	neuropilin (NRP) and tolloid (TLL)-like 1
chr9_-_130497551	1.779		TOR2A	torsin family 2, member A
chr6_+_131571298	1.779	NM_004842 NM_138633	AKAP7	A kinase (PRKA) anchor protein 7
chr9_-_130497617	1.757	NM_001085347 NM_001134430 NM_001134431 NM_001252018 NM_001252021 NM_001252023 NM_130459	TOR2A	torsin family 2, member A
chr13_-_46756326	1.634	NM_002298	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_10562744	1.607	NM_001199805	KLRC4-KLRK1	KLRC4-KLRK1 readthrough
chr4_+_71091787	1.577	NM_152997	C4orf7	chromosome 4 open reading frame 7
chr2_+_202004997	1.430	NM_001202515	CFLAR	CASP8 and FADD-like apoptosis regulator
chr12_+_6554032	1.425	NM_001242	CD27	CD27 molecule
chr6_+_32709162	1.414	NM_020056	HLA-DQA1 HLA-DQA2	major histocompatibility complex, class II, DQ alpha 1 major histocompatibility complex, class II, DQ alpha 2
chr11_+_22689653	1.348	NM_177553	GAS2	growth arrest-specific 2
chr4_+_187187117	1.297	NM_000128	F11	coagulation factor XI
chr12_+_21168629	1.233	NM_001009562	SLCO1B7	solute carrier organic anion transporter family, member 1B7 (non-functional)
chr3_-_170744767	1.200	NM_000340	SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2
chr11_+_60145954	1.185	NM_021201 NM_206938 NM_206939 NM_206940	MS4A7	membrane-spanning 4-domains, subfamily A, member 7
chr7_+_99425635	1.184	NM_022820 NM_057095 NM_057096	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43
chr12_+_111471827	1.164	NM_015267	CUX2	cut-like homeobox 2
chr5_-_156390206	1.148	NM_001146726 NM_138379	TIMD4	T-cell immunoglobulin and mucin domain containing 4
chr5_+_57787260	1.136	NM_152687	GAPT	GRB2-binding adaptor protein, transmembrane
chr2_+_219125737	1.082	NM_001077191 NM_001077194 NM_170699	GPBAR1	G protein-coupled bile acid receptor 1
chr11_+_60146022	1.059		MS4A7	membrane-spanning 4-domains, subfamily A, member 7
chr8_-_86290333	1.055	NM_001128829 NM_001128830 NM_001128831 NM_001738	CA1	carbonic anhydrase I
chr3_+_119500866	0.996		NR1I2	nuclear receptor subfamily 1, group I, member 2
chr1_+_111413820	0.980	NM_001040033	CD53	CD53 molecule
chr14_-_107199126	0.930		IGHG3	immunoglobulin heavy constant gamma 3 (G3m marker)
chr12_-_81763127	0.902	NM_001220479 NM_001220480	PPFIA2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr6_-_154677868	0.879	NM_001130700 NM_015553	IPCEF1	interaction protein for cytohesin exchange factors 1
chr17_-_79876027	0.808		SIRT7	sirtuin 7
chr6_-_32160637	0.806		GPSM3	G-protein signaling modulator 3
chr22_-_37098620	0.766	NM_006078	CACNG2	calcium channel, voltage-dependent, gamma subunit 2
chr13_+_53035227	0.743		CKAP2	cytoskeleton associated protein 2
chr13_+_31309644	0.743	NM_001629	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr7_+_80275634	0.709	NM_001127443 NM_001127444	CD36	CD36 molecule (thrombospondin receptor)
chr17_-_79875995	0.688		SIRT7	sirtuin 7
chr1_-_146068244	0.670	NM_001101663	NBPF11 NBPF24	neuroblastoma breakpoint family, member 11 neuroblastoma breakpoint family, member 24
chr5_-_94224601	0.662		MCTP1	multiple C2 domains, transmembrane 1
chr12_-_54653369	0.661	NM_001127321	CBX5	chromobox homolog 5
chr3_+_134514044	0.636	NM_004441	EPHB1	EPH receptor B1
chr1_-_147610080	0.606	NM_001101663	NBPF11 NBPF24	neuroblastoma breakpoint family, member 11 neuroblastoma breakpoint family, member 24
chr4_+_166131170	0.586	NM_001161521 NM_001161522	KLHL2	kelch-like 2, Mayven (Drosophila)
chr11_+_57365026	0.581	NM_000062	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_63428752	0.573	NM_144642	SYNPR	synaptoporin
chr5_-_147162056	0.559		JAKMIP2	janus kinase and microtubule interacting protein 2
chr1_-_45477016	0.552	NM_024602	HECTD3	HECT domain containing 3
chr5_+_36606456	0.551	NM_001166696 NM_004172	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_119500930	0.546		NR1I2	nuclear receptor subfamily 1, group I, member 2
chr3_+_35721115	0.542	NM_001025068 NM_001025069	ARPP21	cAMP-regulated phosphoprotein, 21kDa
chr1_+_50571963	0.524	NM_001144775	ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_-_92777657	0.518	NM_152703	SAMD9L	sterile alpha motif domain containing 9-like
chr17_-_79876024	0.507		SIRT7	sirtuin 7
chr17_+_67498391	0.492		MAP2K6	mitogen-activated protein kinase kinase 6
chr14_+_21457964	0.481	NM_001029991 NM_022734	METTL17	methyltransferase like 17
chr20_-_22566092	0.480	NM_153675	FOXA2	forkhead box A2
chr5_-_140895407	0.466		DIAPH1	diaphanous homolog 1 (Drosophila)
chr3_-_93692898	0.441	NM_000313	PROS1	protein S (alpha)
chr2_-_172291227	0.440	NM_024770	METTL8	methyltransferase like 8
chr8_-_120651019	0.436	NM_001040092 NM_001130863 NM_006209	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr2_-_61245363	0.428	NM_144709	PUS10	pseudouridylate synthase 10
chr5_-_41261539	0.420	NM_001115131	C6	complement component 6
chr3_-_186262114	0.419	NM_017541	CRYGS	crystallin, gamma S
chr16_-_75150617	0.411		LDHD	lactate dehydrogenase D
chr11_+_33350076	0.398		HIPK3	homeodomain interacting protein kinase 3
chr5_+_36606667	0.390		SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_150413597	0.362	NM_001199577 NM_130759	GIMAP1-GIMAP5 GIMAP1	GIMAP1-GIMAP5 readthrough GTPase, IMAP family member 1
chr12_-_11422640	0.357	NM_006249	PRB3	proline-rich protein BstNI subfamily 3
chr17_+_7461591	0.350	NM_001198622 NM_001198623 NM_001198624 NM_003808 NM_172087 NM_172088	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13
chr8_-_133459508	0.309	NM_001204824	KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3
chr3_+_100238063	0.306		TMEM45A	transmembrane protein 45A
chr12_-_54653317	0.299	NM_001127322	CBX5	chromobox homolog 5
chr5_+_40841296	0.296	NM_032587	CARD6	caspase recruitment domain family, member 6
chr6_-_24719286	0.289	NM_030939	C6orf62	chromosome 6 open reading frame 62
chr22_+_25591072	0.284		KIAA1671	KIAA1671
chr11_-_58611979	0.282	NM_145016	GLYATL2	glycine-N-acyltransferase-like 2
chr10_+_95517565	0.274	NM_005097	LGI1	leucine-rich, glioma inactivated 1
chr2_-_20512016	0.272		PUM2	pumilio homolog 2 (Drosophila)
chr5_+_60933635	0.262	NM_173667	C5orf64	chromosome 5 open reading frame 64
chrX_-_118726852	0.239	NM_001173488	NKRF	NFKB repressing factor
chr15_+_80364902	0.234	NM_001242915 NM_001242916	ZFAND6	zinc finger, AN1-type domain 6
chr11_+_62037629	0.227	NM_002411	SCGB2A2	secretoglobin, family 2A, member 2
chr17_-_67311773	0.224	NM_018672	ABCA5	ATP-binding cassette, sub-family A (ABC1), member 5
chr7_-_112727799	0.224		GPR85	G protein-coupled receptor 85
chr3_-_25683825	0.224		TOP2B	topoisomerase (DNA) II beta 180kDa
chr10_-_116392099	0.221		ABLIM1	actin binding LIM protein 1
chr12_+_52056547	0.211	NM_001177984	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit
chr6_-_27799304	0.205	NM_003541	HIST1H4A HIST1H4F HIST1H4K HIST1H4J	histone cluster 1, H4a histone cluster 1, H4f histone cluster 1, H4k histone cluster 1, H4j
chr8_+_11188494	0.204	NM_054028	SLC35G5	solute carrier family 35, member G5
chr8_-_18541441	0.199		PSD3	pleckstrin and Sec7 domain containing 3
chr1_-_120484230	0.197		NOTCH2	notch 2
chr7_+_114066554	0.188	NM_001172767 NM_148899	FOXP2	forkhead box P2
chr12_+_14538232	0.177		ATF7IP	activating transcription factor 7 interacting protein
chr7_+_116395440	0.167
chr13_-_41556360	0.165	NM_001145353	ELF1	E74-like factor 1 (ets domain transcription factor)
chr13_-_41556188	0.165		ELF1	E74-like factor 1 (ets domain transcription factor)
chr9_+_74729510	0.157	NM_001242507	GDA	guanine deaminase
chr19_-_45033547	0.148	NM_001102597 NM_001102598 NM_001102599 NM_001102600	CEACAM20	carcinoembryonic antigen-related cell adhesion molecule 20
chr1_+_145883867	0.146	NM_001097616	GPR89C	G protein-coupled receptor 89C
chrX_-_106362050	0.145	NM_001171080 NM_018301	RBM41	RNA binding motif protein 41
chr2_-_161349874	0.143		RBMS1	RNA binding motif, single stranded interacting protein 1
chr21_+_30400229	0.139		USP16	ubiquitin specific peptidase 16
chr7_+_116451073	0.135		CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2
chr18_-_64271215	0.133	NM_021153	CDH19	cadherin 19, type 2
chr7_-_112727832	0.128	NM_001146265 NM_018970	GPR85	G protein-coupled receptor 85
chr11_+_5775922	0.127	NM_001005175	OR52N4	olfactory receptor, family 52, subfamily N, member 4
chr12_-_7818467	0.123	NM_001644	APOBEC1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr15_-_59981433	0.115		BNIP2	BCL2/adenovirus E1B 19kDa interacting protein 2
chr15_-_73051650	0.115
chr19_-_9811451	0.111	NM_001199814	ZNF812	zinc finger protein 812
chr6_+_72926144	0.091	NM_001168409	RIMS1	regulating synaptic membrane exocytosis 1
chr17_-_38956146	0.051	NM_181535	KRT28	keratin 28
chr14_-_74892804	0.051	NM_001105579	SYNDIG1L	synapse differentiation inducing 1-like
chr10_+_124151818	0.046	NM_021622	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr16_+_30064410	0.040	NM_000034	ALDOA	aldolase A, fructose-bisphosphate
chr14_+_67831484	0.035		EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_-_77749335	0.024	NM_001134745 NM_024993	LRRTM4	leucine rich repeat transmembrane neuronal 4
chr7_-_121944485	0.021	NM_001024613 NM_001160264	FEZF1	FEZ family zinc finger 1
chr1_+_145663156	0.010		RNF115	ring finger protein 115
chr3_+_159557649	0.005	NM_001197109	SCHIP1	schwannomin interacting protein 1
chr1_-_186430216	0.003	NM_002597	PDC	phosducin
chr3_+_85775631	0.003	NM_153184	CADM2	cell adhesion molecule 2
chr11_+_89984369	0.001
chr11_+_92085261	0.001	NM_001008781	FAT3	FAT tumor suppressor homolog 3 (Drosophila)

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
9.34	8.32e-05	GO:0002684	positive regulation of immune system process
6.72	3.44e-04	GO:0002682	regulation of immune system process
8.22	1.07e-03	GO:0050776	regulation of immune response
27.71	3.25e-03	GO:0072376	protein activation cascade
3.54	3.66e-03	GO:0048583	regulation of response to stimulus
14.89	5.08e-03	GO:0002252	immune effector process
4.19	8.62e-03	GO:0002376	immune system process
211.11	8.64e-03	GO:0031639	plasminogen activation
5.24	9.47e-03	GO:0048584	positive regulation of response to stimulus
9.37	9.62e-03	GO:0050778	positive regulation of immune response
5.17	1.05e-02	GO:0006952	defense response
12.02	1.42e-02	GO:0002696	positive regulation of leukocyte activation
11.82	1.54e-02	GO:0050867	positive regulation of cell activation
10.22	3.06e-02	GO:0051249	regulation of lymphocyte activation
9.94	3.50e-02	GO:0002253	activation of immune response
9.28	4.81e-02	GO:0002694	regulation of leukocyte activation

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
3.12	3.37e-03	GO:0005576	extracellular region
60.34	2.87e-02	GO:0042613	MHC class II protein complex

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
38.40	1.52e-04	GO:0043498	cell surface binding
3.50	1.62e-03	GO:0004872	receptor activity
168.90	2.52e-03	GO:0051637	Gram-positive bacterial cell surface binding
3.09	3.03e-03	GO:0004871	signal transducer activity
3.09	3.03e-03	GO:0060089	molecular transducer activity
105.57	7.02e-03	GO:0032395	MHC class II receptor activity
52.80	2.97e-02	GO:0051635	bacterial cell surface binding
49.69	3.37e-02	GO:0043499	eukaryotic cell surface binding
42.24	4.68e-02	GO:0030169	low-density lipoprotein particle binding