Motif ID: E2F1..5.p2

Z-value: 2.750


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F2hg19_v1_chr1_-_23857284_238574670.691.0e-05Click!
E2F5hg19_v1_chr8_+_86099909_860999090.664.5e-05Click!
E2F1hg19_v1_chr20_-_32274154_322742410.646.8e-05Click!
E2F4hg19_v1_chr16_+_67226070_672260970.551.1e-03Click!
E2F3hg19_v1_chr6_+_20404033_204040330.354.8e-02Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_4909447 10.047 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr10_+_96305521 6.758 NM_018063
HELLS
helicase, lymphoid-specific
chr1_-_23857284 6.570 E2F2
E2F transcription factor 2
chr1_-_36235422 5.938 NM_001190481
NM_022111
CLSPN

claspin

chr1_-_23857711 5.811 NM_004091
E2F2
E2F transcription factor 2
chr2_-_27485774 4.373 NM_003459
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr6_+_135502445 4.336 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135502521 4.218 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr12_-_12849120 4.087 NM_006143
GPR19
G protein-coupled receptor 19
chr20_-_32274070 4.070 E2F1
E2F transcription factor 1
chr20_-_32274154 3.926 NM_005225
E2F1
E2F transcription factor 1
chr19_+_36545757 3.420 NM_001083961
NM_173636
WDR62

WD repeat domain 62

chr10_-_131762374 3.158 EBF3
early B-cell factor 3
chr17_-_56565700 3.122 NM_001080439
HSF5
heat shock transcription factor family member 5
chr8_-_24814028 3.107 NM_006158
NEFL
neurofilament, light polypeptide
chr20_-_35724330 3.011 RBL1
retinoblastoma-like 1 (p107)
chr2_+_27498288 3.005 NM_173650
DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr9_+_841689 2.979 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr16_+_11439279 2.967 NM_152308
RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr3_+_10068097 2.844 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr2_-_136634002 2.830 NM_005915
MCM6
minichromosome maintenance complex component 6
chr22_+_42095502 2.815 NM_152513
MEI1
meiosis inhibitor 1
chr12_-_77459198 2.777 NM_203394
E2F7
E2F transcription factor 7
chr13_+_32889594 2.745 NM_000059
BRCA2
breast cancer 2, early onset
chr6_-_36807734 2.712 CPNE5
copine V
chr3_+_10068123 2.711 FANCD2
Fanconi anemia, complementation group D2
chr1_+_115397454 2.698 NM_003176
SYCP1
synaptonemal complex protein 1
chr8_-_67525426 2.695 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

uncharacterized LOC645895
chr2_-_136633934 2.689 MCM6
minichromosome maintenance complex component 6
chr1_+_53925482 2.660 DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr10_-_58121019 2.622 NM_001005413
NM_007057
NM_032997
ZWINT


ZW10 interactor


chr3_+_121554029 2.577 NM_018456
EAF2
ELL associated factor 2
chr9_-_23821842 2.545 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_+_53925071 2.534 NM_033067
DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr22_+_35796104 2.530 NM_006739
MCM5
minichromosome maintenance complex component 5
chr3_+_44803280 2.509 KIF15
kinesin family member 15
chr14_-_55658205 2.469 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr19_+_4910339 2.437 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr1_-_26232643 2.436 NM_203401
STMN1
stathmin 1
chr8_+_121457642 2.430 NM_022045
MTBP
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
chr3_+_10068139 2.424 FANCD2
Fanconi anemia, complementation group D2
chr3_-_48229800 2.417 NM_001789
NM_201567
CDC25A

cell division cycle 25 homolog A (S. pombe)

chr2_+_16080639 2.410 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr11_+_64067862 2.392 NM_001039496
C11orf20
chromosome 11 open reading frame 20
chr19_+_36545804 2.367 WDR62
WD repeat domain 62
chr7_+_50344255 2.366 NM_001220765
NM_001220766
NM_001220767
NM_001220768
NM_001220769
NM_001220770
NM_001220771
NM_001220772
NM_001220773
NM_001220774
NM_001220775
NM_001220776
NM_006060
IKZF1












IKAROS family zinc finger 1 (Ikaros)












chr10_+_62538088 2.353 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr12_-_45269340 2.336 NM_001145109
NELL2
NEL-like 2 (chicken)
chr20_-_35724401 2.333 NM_002895
NM_183404
RBL1

retinoblastoma-like 1 (p107)

chr6_+_27100784 2.327 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr2_+_238707387 2.314 NM_001080504
RBM44
RNA binding motif protein 44
chr16_+_11439311 2.314 RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr2_+_10262853 2.245 NM_001034
RRM2
ribonucleotide reductase M2
chr22_+_35796154 2.229 MCM5
minichromosome maintenance complex component 5
chr16_-_66835522 2.216 NM_001136505
CCDC79
coiled-coil domain containing 79
chr10_-_131762017 2.204 NM_001005463
EBF3
early B-cell factor 3
chr16_-_85722503 2.157 GINS2
GINS complex subunit 2 (Psf2 homolog)
chr5_+_121187649 2.129 NM_177478
FTMT
ferritin mitochondrial
chr12_-_45270071 2.110 NELL2
NEL-like 2 (chicken)
chr8_-_27695288 2.077 NM_018492
PBK
PDZ binding kinase
chr1_-_26233367 2.069 NM_203399
STMN1
stathmin 1
chr11_+_125495853 2.055 CHEK1
checkpoint kinase 1
chr10_-_58121011 2.053 ZWINT
ZW10 interactor
chr10_+_62538250 2.045 CDK1
cyclin-dependent kinase 1
chrX_-_103499559 2.044 NM_153448
ESX1
ESX homeobox 1
chr2_+_174219537 2.040 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chr19_-_49828434 2.039 NM_014037
SLC6A16
solute carrier family 6, member 16
chr1_-_47779651 2.035 NM_001048166
NM_003035
STIL

SCL/TAL1 interrupting locus

chr17_+_38024416 2.015 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr19_-_38397233 1.981 NM_031951
WDR87
WD repeat domain 87
chr9_-_23821808 1.968 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr19_-_19738973 1.966 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr19_-_13030074 1.958 NM_001105578
SYCE2
synaptonemal complex central element protein 2
chr13_-_48877796 1.938


chr7_-_105516923 1.931 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr19_+_36545848 1.926 WDR62
WD repeat domain 62
chr3_+_127317212 1.917 NM_004526
MCM2
minichromosome maintenance complex component 2
chr1_-_26232890 1.911 NM_001145454
NM_005563
STMN1

stathmin 1

chr12_-_45270157 1.903 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr16_+_87636492 1.891 NM_020655
JPH3
junctophilin 3
chr16_+_67679011 1.889 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr13_-_79177682 1.869 NM_006237
POU4F1
POU class 4 homeobox 1
chr3_+_127317274 1.864 MCM2
minichromosome maintenance complex component 2
chr6_+_27775898 1.862 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr17_+_42733744 1.840 NM_001145080
C17orf104
chromosome 17 open reading frame 104
chr22_+_35796294 1.826 MCM5
minichromosome maintenance complex component 5
chr17_+_38444134 1.816 NM_001254
CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr12_+_27933162 1.800 NM_020782
KLHDC5
kelch domain containing 5
chr15_+_40987326 1.798 NM_001164270
NM_002875
NM_133487
NM_001164269
RAD51



RAD51 homolog (S. cerevisiae)



chr15_+_32907690 1.795 NM_014783
NM_199357
ARHGAP11A

Rho GTPase activating protein 11A

chr1_+_212208918 1.788 NM_016448
DTL
denticleless homolog (Drosophila)
chr1_-_120612175 1.767 NOTCH2
notch 2
chr20_-_5100443 1.764 NM_182649
PCNA
proliferating cell nuclear antigen
chr16_+_67679058 1.744 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_-_7197866 1.743 NM_015982
YBX2
Y box binding protein 2
chr22_-_38966066 1.734 NM_007068
DMC1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
chr1_-_91487543 1.716 ZNF644
zinc finger protein 644
chr10_-_73848309 1.711 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr9_-_21994414 1.691 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr16_-_3030391 1.687 PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr13_+_34392254 1.686 RFC3
replication factor C (activator 1) 3, 38kDa
chr10_-_73848278 1.684 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr22_+_42394728 1.677 NM_152613
WBP2NL
WBP2 N-terminal like
chr1_+_212209129 1.674 DTL
denticleless homolog (Drosophila)
chr3_+_10028579 1.670 LOC442075
uncharacterized LOC442075
chr6_+_26045611 1.655 NM_003531
HIST1H3C
histone cluster 1, H3c
chr4_+_154265774 1.654 NM_001253861
NM_032117
MND1

meiotic nuclear divisions 1 homolog (S. cerevisiae)

chr17_-_7197811 1.639 YBX2
Y box binding protein 2
chr19_+_50094911 1.637 NM_020719
PRR12
proline rich 12
chr12_-_133263988 1.636 POLE
polymerase (DNA directed), epsilon
chr5_+_55033844 1.627 NM_001142549
NM_001166533
NM_024415
DDX4


DEAD (Asp-Glu-Ala-Asp) box polypeptide 4


chr3_-_138665981 1.623 NM_023067
FOXL2
forkhead box L2
chr19_-_38878663 1.603 NM_152657
GGN
gametogenetin
chr2_+_47168362 1.590 TTC7A
tetratricopeptide repeat domain 7A
chr2_+_10262694 1.574 NM_001165931
RRM2
ribonucleotide reductase M2
chr12_-_45269953 1.570 NELL2
NEL-like 2 (chicken)
chr16_-_3030473 1.569 NM_004203
NM_182687
PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

chr15_+_91260575 1.564 NM_000057
BLM
Bloom syndrome, RecQ helicase-like
chr3_+_127317271 1.554 MCM2
minichromosome maintenance complex component 2
chr1_-_91487586 1.550 ZNF644
zinc finger protein 644
chr2_-_24346143 1.540 NM_199346
PFN4
profilin family, member 4
chr3_-_148804122 1.535 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr9_-_123639462 1.533 PHF19
PHD finger protein 19
chrX_+_131157231 1.525 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr15_-_64673569 1.524 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr17_+_38444151 1.524 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr7_-_148581403 1.523 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr2_+_17935124 1.521 NM_182625
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr19_+_46144904 1.519 NM_001242348
LOC100287177
uncharacterized LOC100287177
chr1_+_23037329 1.512 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr3_+_51428720 1.504 RBM15B
RNA binding motif protein 15B
chr11_-_64851449 1.492 CDCA5
cell division cycle associated 5
chr3_-_48229328 1.488 CDC25A
cell division cycle 25 homolog A (S. pombe)
chr3_+_51428698 1.474 NM_013286
RBM15B
RNA binding motif protein 15B
chr3_+_44803208 1.474 NM_020242
KIF15
kinesin family member 15
chr6_+_27114860 1.468 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr6_-_27100528 1.464 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr5_+_93954352 1.462 NM_032290
ANKRD32
ankyrin repeat domain 32
chr1_+_36038970 1.458 NM_178548
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr9_-_104500861 1.456 NM_133445
GRIN3A
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
chr2_-_70995113 1.452 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr1_-_120612260 1.452 NOTCH2
notch 2
chr1_-_25256364 1.450 RUNX3
runt-related transcription factor 3
chr19_+_48867650 1.448 NM_012451
SYNGR4
synaptogyrin 4
chr2_+_17935379 1.442 NM_001130009
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr17_+_29158948 1.438 NM_024857
ATAD5
ATPase family, AAA domain containing 5
chr4_+_178231013 1.434 NEIL3
nei endonuclease VIII-like 3 (E. coli)
chr16_-_85722587 1.433 NM_016095
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr20_+_25388320 1.423 NM_021067
GINS1
GINS complex subunit 1 (Psf1 homolog)
chr1_-_120612301 1.418 NM_001200001
NM_024408
NOTCH2

notch 2

chr19_-_6502224 1.415 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr7_-_100026284 1.405 NM_017984
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr6_+_31707724 1.402 NM_002441
NM_025259
NM_172165
NM_172166
MSH5-C6orf26
MSH5



MSH5-C6orf26 readthrough (non-protein coding)
mutS homolog 5 (E. coli)



chr6_+_79787548 1.398 PHIP
pleckstrin homology domain interacting protein
chr4_-_130014405 1.396 NM_144643
SCLT1
sodium channel and clathrin linker 1
chr2_+_74781511 1.392 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr17_+_38444130 1.392 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr1_-_200992824 1.387 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr18_+_71983109 1.387 NM_001174123
C18orf63
chromosome 18 open reading frame 63
chr17_-_33288475 1.383 NM_001193529
NM_001193530
NM_006584
CCT6B


chaperonin containing TCP1, subunit 6B (zeta 2)


chr9_-_123639566 1.382 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr9_+_114287438 1.379 NM_001007169
NM_133464
ZNF483

zinc finger protein 483

chr7_-_148581297 1.378 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr8_+_24771276 1.372 NEFM
neurofilament, medium polypeptide
chr1_+_61542790 1.364


chr17_-_56769375 1.364 NM_001201457
NM_031272
NM_198393
TEX14


testis expressed 14


chr8_-_132052834 1.355 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr15_-_83952194 1.349 BNC1
basonuclin 1
chrX_+_131157635 1.342 NM_001042452
MST4
serine/threonine protein kinase MST4
chr6_-_27806116 1.331 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr13_+_34392205 1.330 NM_002915
NM_181558
RFC3

replication factor C (activator 1) 3, 38kDa

chr17_-_7197896 1.325 YBX2
Y box binding protein 2
chr20_+_25388328 1.318 GINS1
GINS complex subunit 1 (Psf1 homolog)
chrX_-_139587224 1.313 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr8_+_99439249 1.308 NM_020697
KCNS2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
chr19_-_14016908 1.299 NM_024323
C19orf57
chromosome 19 open reading frame 57
chr19_-_1863546 1.297 NM_031918
KLF16
Kruppel-like factor 16
chr1_-_182922002 1.295 SHCBP1L
SHC SH2-domain binding protein 1-like
chr15_+_92397027 1.285 SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr7_+_94285676 1.281 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chrX_+_105066531 1.272 NM_198465
NRK
Nik related kinase
chr7_+_94285620 1.270 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr7_-_148581377 1.265 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr15_+_40987387 1.260 RAD51
RAD51 homolog (S. cerevisiae)
chr5_+_133861685 1.259 NM_015288
PHF15
PHD finger protein 15
chr10_+_112327411 1.258 NM_005445
SMC3
structural maintenance of chromosomes 3
chr6_-_36164973 1.258


chr7_+_94285736 1.257 PEG10
paternally expressed 10
chr19_+_2096792 1.256 NM_001031735
NM_001039846
IZUMO4

IZUMO family member 4

chr5_+_68485367 1.256 NM_022909
CENPH
centromere protein H
chr1_+_2518071 1.254 NM_001195736
NM_001195737
NM_001195738
NM_001195740
NM_001195741
NM_152371
FAM213B





family with sequence similarity 213, member B





chr1_-_91487769 1.249 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr1_+_151043079 1.249 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr1_+_38158189 1.247 CDCA8
cell division cycle associated 8
chr20_-_44563573 1.244 FLJ40606
uncharacterized LOC643549
chr1_+_240255171 1.243 NM_020066
FMN2
formin 2
chr16_+_88870214 1.243 CDT1
chromatin licensing and DNA replication factor 1
chr8_+_48873533 1.240 MCM4
minichromosome maintenance complex component 4
chr1_-_228645517 1.227 NM_033445
HIST3H2A
histone cluster 3, H2a
chr3_+_10857867 1.225 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.29 7.49e-30 GO:0007049 cell cycle
7.78 2.35e-28 GO:0022403 cell cycle phase
6.87 4.94e-27 GO:0022402 cell cycle process
7.75 8.96e-24 GO:0006259 DNA metabolic process
14.34 3.66e-20 GO:0006260 DNA replication
6.79 4.77e-18 GO:0000278 mitotic cell cycle
9.79 5.91e-18 GO:0051325 interphase
24.82 6.41e-18 GO:0006261 DNA-dependent DNA replication
6.47 7.03e-18 GO:0051726 regulation of cell cycle
9.62 4.73e-17 GO:0051329 interphase of mitotic cell cycle
8.67 1.76e-16 GO:0010564 regulation of cell cycle process
13.89 9.13e-15 GO:0000082 G1/S transition of mitotic cell cycle
14.92 8.10e-13 GO:0051320 S phase
37.92 1.27e-12 GO:0006271 DNA strand elongation involved in DNA replication
9.94 1.44e-12 GO:0000075 cell cycle checkpoint
9.56 3.14e-12 GO:0071156 regulation of cell cycle arrest
35.39 3.17e-12 GO:0022616 DNA strand elongation
6.54 4.19e-12 GO:0000279 M phase
14.30 1.16e-11 GO:0000084 S phase of mitotic cell cycle
7.29 1.41e-11 GO:0006281 DNA repair
2.74 2.41e-10 GO:0090304 nucleic acid metabolic process
5.02 3.27e-10 GO:0051276 chromosome organization
39.48 3.28e-10 GO:0006270 DNA-dependent DNA replication initiation
5.33 1.57e-09 GO:0006974 response to DNA damage stimulus
12.40 4.07e-09 GO:0007126 meiosis
12.40 4.07e-09 GO:0051327 M phase of meiotic cell cycle
12.29 4.63e-09 GO:0051321 meiotic cell cycle
10.73 5.89e-09 GO:0006310 DNA recombination
38.60 8.62e-09 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
2.80 2.85e-07 GO:0006996 organelle organization
13.61 2.96e-07 GO:0000216 M/G1 transition of mitotic cell cycle
3.73 4.39e-07 GO:0033554 cellular response to stress
1.88 4.77e-07 GO:0044260 cellular macromolecule metabolic process
2.23 5.26e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
33.78 5.38e-07 GO:2000104 negative regulation of DNA-dependent DNA replication
29.37 1.66e-06 GO:0090329 regulation of DNA-dependent DNA replication
15.51 3.71e-06 GO:0007127 meiosis I
2.18 6.26e-06 GO:0071842 cellular component organization at cellular level
2.11 2.16e-05 GO:0071841 cellular component organization or biogenesis at cellular level
2.53 2.41e-05 GO:0034645 cellular macromolecule biosynthetic process
15.14 3.33e-05 GO:0051053 negative regulation of DNA metabolic process
2.50 3.33e-05 GO:0009059 macromolecule biosynthetic process
1.97 3.92e-05 GO:0034641 cellular nitrogen compound metabolic process
17.78 7.51e-05 GO:0008156 negative regulation of DNA replication
10.86 9.22e-05 GO:0006275 regulation of DNA replication
7.70 1.29e-04 GO:0051052 regulation of DNA metabolic process
1.91 1.30e-04 GO:0006807 nitrogen compound metabolic process
1.66 1.45e-04 GO:0043170 macromolecule metabolic process
22.27 1.53e-04 GO:0006312 mitotic recombination
8.55 1.80e-04 GO:0031570 DNA integrity checkpoint
30.16 3.18e-04 GO:0006297 nucleotide-excision repair, DNA gap filling
1.83 7.42e-04 GO:0016043 cellular component organization
25.40 8.25e-04 GO:0032201 telomere maintenance via semi-conservative replication
4.43 1.02e-03 GO:0051301 cell division
8.20 1.04e-03 GO:0065004 protein-DNA complex assembly
24.13 1.09e-03 GO:0000722 telomere maintenance via recombination
7.76 1.65e-03 GO:0071824 protein-DNA complex subunit organization
1.25 1.77e-03 GO:0009987 cellular process
1.77 2.14e-03 GO:0071840 cellular component organization or biogenesis
6.53 2.17e-03 GO:0071103 DNA conformation change
35.10 2.50e-03 GO:0000076 DNA replication checkpoint
35.10 2.50e-03 GO:0032297 negative regulation of DNA-dependent DNA replication initiation
4.60 3.54e-03 GO:0000280 nuclear division
4.60 3.54e-03 GO:0007067 mitosis
32.17 3.71e-03 GO:0071897 DNA biosynthetic process
9.94 4.46e-03 GO:0006289 nucleotide-excision repair
1.43 4.58e-03 GO:0050794 regulation of cellular process
4.47 4.85e-03 GO:0000087 M phase of mitotic cell cycle
4.45 5.04e-03 GO:0048285 organelle fission
12.07 6.79e-03 GO:0000723 telomere maintenance
27.58 7.39e-03 GO:0030174 regulation of DNA-dependent DNA replication initiation
11.82 7.67e-03 GO:0032200 telomere organization
7.50 7.93e-03 GO:0007059 chromosome segregation
1.74 7.98e-03 GO:0060255 regulation of macromolecule metabolic process
1.92 8.02e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.86 8.30e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39 9.35e-03 GO:0050789 regulation of biological process
15.57 1.09e-02 GO:0010833 telomere maintenance via telomere lengthening
1.36 1.52e-02 GO:0065007 biological regulation
1.87 1.55e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.80 1.81e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.82 1.88e-02 GO:0031326 regulation of cellular biosynthetic process
9.82 2.27e-02 GO:0000079 regulation of cyclin-dependent protein kinase activity
1.80 2.49e-02 GO:0009889 regulation of biosynthetic process
1.66 2.61e-02 GO:0031323 regulation of cellular metabolic process
3.38 2.63e-02 GO:0006325 chromatin organization
20.32 2.75e-02 GO:0050000 chromosome localization
20.32 2.75e-02 GO:0051303 establishment of chromosome localization
19.31 3.41e-02 GO:0006298 mismatch repair
19.31 3.41e-02 GO:0031572 G2/M transition DNA damage checkpoint
6.08 3.64e-02 GO:0006323 DNA packaging
1.65 3.64e-02 GO:0080090 regulation of primary metabolic process
11.77 4.43e-02 GO:0006283 transcription-coupled nucleotide-excision repair
4.20 4.48e-02 GO:0007346 regulation of mitotic cell cycle
6.97 4.61e-02 GO:0031497 chromatin assembly
1.88 4.67e-02 GO:0006355 regulation of transcription, DNA-dependent
2.72 4.75e-02 GO:0071844 cellular component assembly at cellular level
1.86 4.76e-02 GO:0051252 regulation of RNA metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.10 1.01e-18 GO:0005634 nucleus
5.71 2.28e-13 GO:0005694 chromosome
3.08 1.04e-12 GO:0031981 nuclear lumen
5.72 5.33e-11 GO:0044427 chromosomal part
2.71 6.48e-11 GO:0044428 nuclear part
3.31 2.34e-10 GO:0005654 nucleoplasm
2.51 3.84e-09 GO:0070013 intracellular organelle lumen
2.46 8.28e-09 GO:0043233 organelle lumen
2.42 1.54e-08 GO:0031974 membrane-enclosed lumen
7.36 6.02e-08 GO:0000228 nuclear chromosome
1.37 1.02e-06 GO:0043229 intracellular organelle
1.36 1.18e-06 GO:0043226 organelle
1.40 3.22e-06 GO:0043231 intracellular membrane-bounded organelle
1.40 3.48e-06 GO:0043227 membrane-bounded organelle
14.04 1.04e-05 GO:0000794 condensed nuclear chromosome
2.02 1.50e-05 GO:0043228 non-membrane-bounded organelle
2.02 1.50e-05 GO:0043232 intracellular non-membrane-bounded organelle
6.82 2.26e-05 GO:0044454 nuclear chromosome part
7.64 2.36e-05 GO:0000793 condensed chromosome
1.25 6.88e-05 GO:0044424 intracellular part
48.25 9.20e-05 GO:0042555 MCM complex
1.24 9.58e-05 GO:0005622 intracellular
15.65 2.39e-04 GO:0005657 replication fork
22.98 2.41e-04 GO:0000795 synaptonemal complex
1.45 6.56e-03 GO:0044446 intracellular organelle part
7.12 6.85e-03 GO:0032993 protein-DNA complex
1.43 1.12e-02 GO:0044422 organelle part
2.74 1.16e-02 GO:0015630 microtubule cytoskeleton
4.20 1.66e-02 GO:0000785 chromatin
2.57 2.58e-02 GO:0044451 nucleoplasm part
8.62 3.39e-02 GO:0016605 PML body
20.68 4.54e-02 GO:0001673 male germ cell nucleus
8.05 4.69e-02 GO:0000786 nucleosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.93 3.82e-15 GO:0003677 DNA binding
2.31 8.18e-12 GO:0003676 nucleic acid binding
1.22 1.96e-04 GO:0005488 binding
11.86 2.86e-04 GO:0003697 single-stranded DNA binding
2.30 3.98e-04 GO:0005524 ATP binding
5.74 5.12e-04 GO:0043566 structure-specific DNA binding
2.27 5.57e-04 GO:0032559 adenyl ribonucleotide binding
10.73 5.69e-04 GO:0008094 DNA-dependent ATPase activity
2.26 6.29e-04 GO:0030554 adenyl nucleotide binding
1.79 1.79e-02 GO:0000166 nucleotide binding
1.88 2.69e-02 GO:0035639 purine ribonucleoside triphosphate binding
24.13 3.51e-02 GO:0000217 DNA secondary structure binding
1.85 3.67e-02 GO:0032553 ribonucleotide binding
1.85 3.67e-02 GO:0032555 purine ribonucleotide binding
1.84 4.08e-02 GO:0017076 purine nucleotide binding