Motif ID: E2F1..5.p2

Z-value: 2.750


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F2hg19_v1_chr1_-_23857284_238574670.691.0e-05Click!
E2F5hg19_v1_chr8_+_86099909_860999090.664.5e-05Click!
E2F1hg19_v1_chr20_-_32274154_322742410.646.8e-05Click!
E2F4hg19_v1_chr16_+_67226070_672260970.551.1e-03Click!
E2F3hg19_v1_chr6_+_20404033_204040330.354.8e-02Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_4909447 10.047 NM_001048201
 UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr10_+_96305521 6.758 NM_018063
 HELLS
helicase, lymphoid-specific
chr1_-_23857284 6.570 E2F2
E2F transcription factor 2
chr1_-_36235422 5.938 NM_001190481
NM_022111
 CLSPN

claspin

chr1_-_23857711 5.811 NM_004091
 E2F2
E2F transcription factor 2
chr2_-_27485774 4.373 NM_003459
 SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr6_+_135502445 4.336 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
 MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135502521 4.218 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr12_-_12849120 4.087 NM_006143
 GPR19
G protein-coupled receptor 19
chr20_-_32274070 4.070 E2F1
E2F transcription factor 1
chr20_-_32274154 3.926 NM_005225
 E2F1
E2F transcription factor 1
chr19_+_36545757 3.420 NM_001083961
NM_173636
 WDR62

WD repeat domain 62

chr10_-_131762374 3.158 EBF3
early B-cell factor 3
chr17_-_56565700 3.122 NM_001080439
 HSF5
heat shock transcription factor family member 5
chr8_-_24814028 3.107 NM_006158
 NEFL
neurofilament, light polypeptide
chr20_-_35724330 3.011 RBL1
retinoblastoma-like 1 (p107)
chr2_+_27498288 3.005 NM_173650
 DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr9_+_841689 2.979 NM_021951
 DMRT1
doublesex and mab-3 related transcription factor 1
chr16_+_11439279 2.967 NM_152308
 RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr3_+_10068097 2.844 NM_001018115
NM_033084
 FANCD2

Fanconi anemia, complementation group D2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 98 entries
Enrichment   P-value GO Accession GO Term
39.48 3.28e-10 GO:0006270 DNA-dependent DNA replication initiation
38.60 8.62e-09 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
37.92 1.27e-12 GO:0006271 DNA strand elongation involved in DNA replication
35.39 3.17e-12 GO:0022616 DNA strand elongation
35.10 2.50e-03 GO:0000076 DNA replication checkpoint
35.10 2.50e-03 GO:0032297 negative regulation of DNA-dependent DNA replication initiation
33.78 5.38e-07 GO:2000104 negative regulation of DNA-dependent DNA replication
32.17 3.71e-03 GO:0071897 DNA biosynthetic process
30.16 3.18e-04 GO:0006297 nucleotide-excision repair, DNA gap filling
29.37 1.66e-06 GO:0090329 regulation of DNA-dependent DNA replication
27.58 7.39e-03 GO:0030174 regulation of DNA-dependent DNA replication initiation
25.40 8.25e-04 GO:0032201 telomere maintenance via semi-conservative replication
24.82 6.41e-18 GO:0006261 DNA-dependent DNA replication
24.13 1.09e-03 GO:0000722 telomere maintenance via recombination
22.27 1.53e-04 GO:0006312 mitotic recombination
20.32 2.75e-02 GO:0050000 chromosome localization
20.32 2.75e-02 GO:0051303 establishment of chromosome localization
19.31 3.41e-02 GO:0006298 mismatch repair
19.31 3.41e-02 GO:0031572 G2/M transition DNA damage checkpoint
17.78 7.51e-05 GO:0008156 negative regulation of DNA replication

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
Enrichment   P-value GO Accession GO Term
48.25 9.20e-05 GO:0042555 MCM complex
22.98 2.41e-04 GO:0000795 synaptonemal complex
20.68 4.54e-02 GO:0001673 male germ cell nucleus
15.65 2.39e-04 GO:0005657 replication fork
14.04 1.04e-05 GO:0000794 condensed nuclear chromosome
8.62 3.39e-02 GO:0016605 PML body
8.05 4.69e-02 GO:0000786 nucleosome
7.64 2.36e-05 GO:0000793 condensed chromosome
7.36 6.02e-08 GO:0000228 nuclear chromosome
7.12 6.85e-03 GO:0032993 protein-DNA complex
6.82 2.26e-05 GO:0044454 nuclear chromosome part
5.72 5.33e-11 GO:0044427 chromosomal part
5.71 2.28e-13 GO:0005694 chromosome
4.20 1.66e-02 GO:0000785 chromatin
3.31 2.34e-10 GO:0005654 nucleoplasm
3.08 1.04e-12 GO:0031981 nuclear lumen
2.74 1.16e-02 GO:0015630 microtubule cytoskeleton
2.71 6.48e-11 GO:0044428 nuclear part
2.57 2.58e-02 GO:0044451 nucleoplasm part
2.51 3.84e-09 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
24.13 3.51e-02 GO:0000217 DNA secondary structure binding
11.86 2.86e-04 GO:0003697 single-stranded DNA binding
10.73 5.69e-04 GO:0008094 DNA-dependent ATPase activity
5.74 5.12e-04 GO:0043566 structure-specific DNA binding
2.93 3.82e-15 GO:0003677 DNA binding
2.31 8.18e-12 GO:0003676 nucleic acid binding
2.30 3.98e-04 GO:0005524 ATP binding
2.27 5.57e-04 GO:0032559 adenyl ribonucleotide binding
2.26 6.29e-04 GO:0030554 adenyl nucleotide binding
1.88 2.69e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.85 3.67e-02 GO:0032553 ribonucleotide binding
1.85 3.67e-02 GO:0032555 purine ribonucleotide binding
1.84 4.08e-02 GO:0017076 purine nucleotide binding
1.79 1.79e-02 GO:0000166 nucleotide binding
1.22 1.96e-04 GO:0005488 binding