Motif ID: EGR1..3.p2

Z-value: 1.587


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EGR1hg19_v1_chr5_+_137801166_137801177-0.459.2e-03Click!
EGR2hg19_v1_chr10_-_64578926_64578926-0.077.2e-01Click!
EGR3hg19_v1_chr8_-_22549901_225499010.038.8e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_589849 4.021 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr20_-_62130390 3.312 NM_001958
 EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr4_-_6202251 3.244 NM_001099433
NM_144720
 JAKMIP1

janus kinase and microtubule interacting protein 1

chr11_+_124609775 2.839 NM_001126181
NM_006176
 NRGN

neurogranin (protein kinase C substrate, RC3)

chr7_-_44365019 2.769 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
 CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr11_+_124609841 2.200 NRGN
neurogranin (protein kinase C substrate, RC3)
chr3_-_183979074 2.168 NM_033259
 CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr5_+_7396030 2.141 NM_020546
 ADCY2
adenylate cyclase 2 (brain)
chr16_-_28074776 2.123 NM_001109763
 GSG1L
GSG1-like
chr10_+_134000335 2.039 NM_006426
 DPYSL4
dihydropyrimidinase-like 4
chr19_+_55795533 1.979 NM_032430
 BRSK1
BR serine/threonine kinase 1
chr17_-_79008372 1.843 FLJ90757
uncharacterized LOC440465
chr15_-_27018108 1.840 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chrX_+_16964730 1.789 NM_001080975
NM_004726
 REPS2

RALBP1 associated Eps domain containing 2

chr16_+_84002099 1.774 NM_019065
 NECAB2
N-terminal EF-hand calcium binding protein 2
chr14_+_29236882 1.770 FOXG1
forkhead box G1
chr16_+_56225301 1.737 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr19_-_42498320 1.706 NM_152296
 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chrX_-_152939256 1.701 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr19_+_55795766 1.661 BRSK1
BR serine/threonine kinase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
19.72 1.86e-03 GO:0007269 neurotransmitter secretion
14.12 9.60e-03 GO:0001505 regulation of neurotransmitter levels
12.19 1.96e-02 GO:0006836 neurotransmitter transport
11.73 2.35e-02 GO:0003001 generation of a signal involved in cell-cell signaling
11.73 2.35e-02 GO:0023061 signal release
6.86 1.70e-04 GO:0007268 synaptic transmission
6.67 6.54e-05 GO:0019226 transmission of nerve impulse
6.67 6.54e-05 GO:0035637 multicellular organismal signaling
4.36 5.48e-03 GO:0007267 cell-cell signaling
3.86 1.79e-02 GO:0048699 generation of neurons
3.64 3.16e-02 GO:0022008 neurogenesis
3.56 1.94e-02 GO:0007154 cell communication
3.39 1.04e-03 GO:0007399 nervous system development
2.74 3.27e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
124.18 9.76e-03 GO:0042583 chromaffin granule
124.18 9.76e-03 GO:0042584 chromaffin granule membrane
27.61 9.82e-05 GO:0030672 synaptic vesicle membrane
17.14 1.32e-04 GO:0008021 synaptic vesicle
14.62 2.33e-03 GO:0030665 clathrin coated vesicle membrane
10.81 9.94e-03 GO:0030662 coated vesicle membrane
9.27 4.56e-03 GO:0030136 clathrin-coated vesicle
7.58 1.39e-02 GO:0030135 coated vesicle
6.75 7.74e-03 GO:0030659 cytoplasmic vesicle membrane
6.53 9.60e-03 GO:0012506 vesicle membrane
6.05 1.54e-02 GO:0044456 synapse part
5.78 2.35e-03 GO:0045202 synapse
5.60 2.46e-02 GO:0044433 cytoplasmic vesicle part
4.83 1.44e-03 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
12.52 1.30e-04 GO:0005516 calmodulin binding