Motif ID: EGR1..3.p2

Z-value: 1.587


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EGR1hg19_v1_chr5_+_137801166_137801177-0.459.2e-03Click!
EGR2hg19_v1_chr10_-_64578926_64578926-0.077.2e-01Click!
EGR3hg19_v1_chr8_-_22549901_225499010.038.8e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_589849 4.021 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr20_-_62130390 3.312 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr4_-_6202251 3.244 NM_001099433
NM_144720
JAKMIP1

janus kinase and microtubule interacting protein 1

chr11_+_124609775 2.839 NM_001126181
NM_006176
NRGN

neurogranin (protein kinase C substrate, RC3)

chr7_-_44365019 2.769 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr11_+_124609841 2.200 NRGN
neurogranin (protein kinase C substrate, RC3)
chr3_-_183979074 2.168 NM_033259
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr5_+_7396030 2.141 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr16_-_28074776 2.123 NM_001109763
GSG1L
GSG1-like
chr10_+_134000335 2.039 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr19_+_55795533 1.979 NM_032430
BRSK1
BR serine/threonine kinase 1
chr17_-_79008372 1.843 FLJ90757
uncharacterized LOC440465
chr15_-_27018108 1.840 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chrX_+_16964730 1.789 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr16_+_84002099 1.774 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr14_+_29236882 1.770 FOXG1
forkhead box G1
chr16_+_56225301 1.737 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr19_-_42498320 1.706 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chrX_-_152939256 1.701 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr19_+_55795766 1.661 BRSK1
BR serine/threonine kinase 1
chr7_+_55955129 1.649 ZNF713
zinc finger protein 713
chr15_-_27018160 1.590 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr19_-_55691468 1.578 NM_003180
SYT5
synaptotagmin V
chr7_-_51384458 1.561 NM_015198
COBL
cordon-bleu homolog (mouse)
chr3_+_50712671 1.547 NM_004947
DOCK3
dedicator of cytokinesis 3
chr10_+_135043776 1.537 NM_003577
UTF1
undifferentiated embryonic cell transcription factor 1
chr12_+_79258794 1.532 SYT1
synaptotagmin I
chr11_+_107461807 1.526 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr7_-_51384331 1.504 COBL
cordon-bleu homolog (mouse)
chr6_-_110500803 1.498 WASF1
WAS protein family, member 1
chr11_-_134281725 1.488 NM_018644
NM_054025
B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr10_-_98592186 1.436


chr22_+_19701968 1.434 NM_002688
SEPT5
septin 5
chr9_-_23821477 1.431 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr12_-_120806893 1.430 NM_002442
MSI1
musashi homolog 1 (Drosophila)
chr1_+_237205701 1.424 NM_001035
RYR2
ryanodine receptor 2 (cardiac)
chr1_+_77747602 1.400 NM_174858
AK5
adenylate kinase 5
chr17_-_1083008 1.393 NM_021962
ABR
active BCR-related gene
chr9_-_86432546 1.386 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr19_+_51815095 1.378 NM_001101372
IGLON5
IgLON family member 5
chr17_+_79008945 1.363 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr2_+_27498288 1.360 NM_173650
DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr8_-_144241918 1.353 NM_001130478
LY6H
lymphocyte antigen 6 complex, locus H
chr10_-_75255718 1.352 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr2_-_99552677 1.351 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr12_+_79258517 1.348 SYT1
synaptotagmin I
chr17_+_29815018 1.340 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr11_+_369723 1.339 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr11_+_66059335 1.317 TMEM151A
transmembrane protein 151A
chr12_+_79258588 1.292 SYT1
synaptotagmin I
chr16_+_87636492 1.280 NM_020655
JPH3
junctophilin 3
chr17_+_79008958 1.279 BAIAP2
BAI1-associated protein 2
chr11_+_107461955 1.275 ELMOD1
ELMO/CED-12 domain containing 1
chr3_-_49907304 1.271 NM_024046
CAMKV
CaM kinase-like vesicle-associated
chr20_+_10199455 1.264 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr19_-_11591439 1.246 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr10_+_105253734 1.231 NM_004210
NEURL
neuralized homolog (Drosophila)
chr1_-_202612580 1.229 NM_001136504
SYT2
synaptotagmin II
chr1_-_99470177 1.216 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chr10_+_122216465 1.211 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr22_+_26565424 1.204 NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777
NM_021115
SEZ6L





seizure related 6 homolog (mouse)-like





chr11_+_66059364 1.200 NM_153266
TMEM151A
transmembrane protein 151A
chr3_-_171177851 1.199 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr14_+_29236171 1.198 NM_005249
FOXG1
forkhead box G1
chr16_+_25703346 1.190 NM_006040
HS3ST4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr17_+_30593194 1.188 NM_138328
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr19_-_42498221 1.188 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr22_+_50609159 1.174 NM_001160300
NM_052839
PANX2

pannexin 2

chr12_+_57943843 1.173 NM_004984
KIF5A
kinesin family member 5A
chr9_+_17578952 1.157 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr5_-_11903964 1.148 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr11_+_107462073 1.139 ELMOD1
ELMO/CED-12 domain containing 1
chr7_-_143059144 1.133 NM_014690
FAM131B
family with sequence similarity 131, member B
chrX_-_51239426 1.130 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr12_+_57943780 1.119 KIF5A
kinesin family member 5A
chr6_+_99282597 1.108 POU3F2
POU class 3 homeobox 2
chr6_-_143266283 1.107 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chrX_-_47479229 1.089 NM_006950
NM_133499
SYN1

synapsin I

chr10_-_75255647 1.086 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr8_-_144241678 1.075 LY6H
lymphocyte antigen 6 complex, locus H
chr7_+_49813228 1.046 NM_198570
VWC2
von Willebrand factor C domain containing 2
chr1_+_33352071 1.042 NM_002143
HPCA
hippocalcin
chr9_-_138798957 1.041 NM_015447
CAMSAP1
calmodulin regulated spectrin-associated protein 1
chr4_-_102267952 1.038 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr14_+_94640648 1.035 NM_020958
NM_058237
PPP4R4

protein phosphatase 4, regulatory subunit 4

chr14_-_65346554 1.032 SPTB
spectrin, beta, erythrocytic
chr22_+_26565454 1.029 SEZ6L
seizure related 6 homolog (mouse)-like
chr12_+_79258448 1.027 NM_005639
SYT1
synaptotagmin I
chr8_-_144241725 1.017 NM_001135655
LY6H
lymphocyte antigen 6 complex, locus H
chr13_+_88324777 1.007 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr22_+_39745757 1.007 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chrX_-_152938742 0.998 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr22_+_43808011 0.993 NM_001044370
MPPED1
metallophosphoesterase domain containing 1
chr16_+_56225250 0.992 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr12_+_57943806 0.991 KIF5A
kinesin family member 5A
chr11_-_575848 0.987 LOC143666
uncharacterized LOC143666
chr3_-_13921617 0.987 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr20_-_21494663 0.986 NM_002509
NKX2-2
NK2 homeobox 2
chr14_-_77737549 0.978 NM_021257
NGB
neuroglobin
chr16_-_755718 0.975 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr22_+_38035447 0.972


chr22_-_17602142 0.965 NM_031890
NM_001163079
CECR6

cat eye syndrome chromosome region, candidate 6

chrX_-_51239295 0.963 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr15_+_41786055 0.958 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr17_-_72889704 0.957 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr9_+_34958171 0.955 NM_015297
KIAA1045
KIAA1045
chr19_+_35634153 0.952 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chr1_+_116380404 0.946 NHLH2
nescient helix loop helix 2
chr17_-_36762105 0.942 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr12_+_130822590 0.940 PIWIL1
piwi-like 1 (Drosophila)
chr6_+_124125068 0.939 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr11_+_107799134 0.939 NM_017516
RAB39A
RAB39A, member RAS oncogene family
chr18_-_72124461 0.938 NM_001044369
FAM69C
family with sequence similarity 69, member C
chr11_+_120382420 0.937 GRIK4
glutamate receptor, ionotropic, kainate 4
chr11_-_77184549 0.933 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr7_-_150945731 0.932 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_+_70034029 0.928 LRRC7
leucine rich repeat containing 7
chr6_-_84418705 0.926 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr13_+_25946084 0.924 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr17_-_66287256 0.922 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr1_-_15850776 0.921 NM_001229
NM_032996
CASP9

caspase 9, apoptosis-related cysteine peptidase

chr2_+_149633173 0.920


chr4_-_105412466 0.919 NM_025212
CXXC4
CXXC finger protein 4
chr1_+_77747727 0.917 AK5
adenylate kinase 5
chr7_-_4998744 0.917 NM_001100600
NM_198403
MMD2

monocyte to macrophage differentiation-associated 2

chr6_+_99282579 0.901 NM_005604
POU3F2
POU class 3 homeobox 2
chrX_-_153095746 0.900 PDZD4
PDZ domain containing 4
chr12_+_51985016 0.899 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr17_-_74236272 0.895 NM_052916
RNF157
ring finger protein 157
chr3_+_10857867 0.895 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr13_+_26042965 0.886 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr7_-_100254048 0.886 NM_016188
ACTL6B
actin-like 6B
chr9_+_115513050 0.883 NM_001012994
SNX30
sorting nexin family member 30
chr20_+_44034632 0.880 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr3_-_186079776 0.871 NM_001080744
NM_001080745
NM_001346
DGKG


diacylglycerol kinase, gamma 90kDa


chr8_-_144241456 0.870 NM_002347
LY6H
lymphocyte antigen 6 complex, locus H
chr19_-_15090349 0.868 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr5_-_114632240 0.862 NM_001040440
CCDC112
coiled-coil domain containing 112
chr10_+_134973935 0.859 NM_152643
KNDC1
kinase non-catalytic C-lobe domain (KIND) containing 1
chr14_+_101193313 0.857 DLK1
delta-like 1 homolog (Drosophila)
chr2_-_233792825 0.857 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr18_-_35145603 0.855 CELF4
CUGBP, Elav-like family member 4
chr20_+_17207596 0.851 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr15_-_27018216 0.846 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_-_229478687 0.844 NM_145257
C1orf96
chromosome 1 open reading frame 96
chr22_+_42372763 0.844 NM_019106
NM_145733
SEPT3

septin 3

chr5_+_137774897 0.844 REEP2
receptor accessory protein 2
chr3_+_183948216 0.840 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr18_-_35145999 0.837 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr13_-_27334777 0.833 NM_005288
GPR12
G protein-coupled receptor 12
chr15_-_83316621 0.832 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chrX_+_117957733 0.830 NM_173798
ZCCHC12
zinc finger, CCHC domain containing 12
chr21_+_34444004 0.821 OLIG1
oligodendrocyte transcription factor 1
chr19_-_13617037 0.821 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr8_-_22014263 0.817 NM_139278
LGI3
leucine-rich repeat LGI family, member 3
chr9_+_140772228 0.816 NM_000718
NM_001243812
CACNA1B

calcium channel, voltage-dependent, N type, alpha 1B subunit

chr3_-_118753428 0.813 IGSF11
immunoglobulin superfamily, member 11
chr10_-_75255747 0.811 NM_001142353
NM_001142354
NM_021132
PPP3CB


protein phosphatase 3, catalytic subunit, beta isozyme


chr13_+_26042917 0.809 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chrX_+_101380659 0.808 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr2_-_102003859 0.807 CREG2
cellular repressor of E1A-stimulated genes 2
chr8_+_73449625 0.801 NM_004770
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chrX_+_49126299 0.798 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr7_-_150945701 0.798 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_-_40314510 0.795 LRRC4C
leucine rich repeat containing 4C
chr5_+_167956545 0.795


chr2_+_207308280 0.794 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr12_-_6809595 0.794 NM_001244015
C12orf53
chromosome 12 open reading frame 53
chr20_+_44035203 0.794 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr4_-_102268626 0.792 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr3_+_71803200 0.792 NM_018971
GPR27
G protein-coupled receptor 27
chr6_-_84419108 0.790 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr1_+_205012329 0.789 NM_005076
CNTN2
contactin 2 (axonal)
chr4_+_71570768 0.788 RUFY3
RUN and FYVE domain containing 3
chr1_-_223537400 0.783 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr9_-_15510209 0.782 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr19_-_821913 0.771 NM_024888
LPPR3
lipid phosphate phosphatase-related protein type 3
chr5_+_149569519 0.769 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr17_-_78450247 0.768 NM_002522
NPTX1
neuronal pentraxin I
chr19_+_18794391 0.767 NM_001098482
NM_015321
CRTC1

CREB regulated transcription coactivator 1

chr22_+_26565623 0.766 SEZ6L
seizure related 6 homolog (mouse)-like
chr17_+_65822206 0.765 BPTF
bromodomain PHD finger transcription factor
chr17_-_27916395 0.763 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr1_+_205012427 0.762 CNTN2
contactin 2 (axonal)
chr13_-_51417831 0.761 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr21_+_22370622 0.761 NM_004540
NCAM2
neural cell adhesion molecule 2
chr12_-_6809965 0.755 NM_001244014
NM_153685
C12orf53

chromosome 12 open reading frame 53

chrX_-_153095332 0.753 PDZD4
PDZ domain containing 4
chr1_-_51425829 0.752 FAF1
Fas (TNFRSF6) associated factor 1
chrX_-_47479095 0.752


chr22_+_51039178 0.752 MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr19_+_10400646 0.747 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr7_-_105029321 0.747 NM_182692
SRPK2
SRSF protein kinase 2
chr19_-_18654280 0.747 FKBP8
FK506 binding protein 8, 38kDa
chr9_-_139907614 0.745 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr7_+_73498106 0.743 NM_002314
LIMK1
LIM domain kinase 1
chr19_+_12949258 0.742 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr16_+_5008317 0.735 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr9_+_34958320 0.731 KIAA1045
KIAA1045
chr7_-_100253976 0.730



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.67 6.54e-05 GO:0019226 transmission of nerve impulse
6.67 6.54e-05 GO:0035637 multicellular organismal signaling
6.86 1.70e-04 GO:0007268 synaptic transmission
3.39 1.04e-03 GO:0007399 nervous system development
19.72 1.86e-03 GO:0007269 neurotransmitter secretion
4.36 5.48e-03 GO:0007267 cell-cell signaling
14.12 9.60e-03 GO:0001505 regulation of neurotransmitter levels
3.86 1.79e-02 GO:0048699 generation of neurons
3.56 1.94e-02 GO:0007154 cell communication
12.19 1.96e-02 GO:0006836 neurotransmitter transport
11.73 2.35e-02 GO:0003001 generation of a signal involved in cell-cell signaling
11.73 2.35e-02 GO:0023061 signal release
3.64 3.16e-02 GO:0022008 neurogenesis
2.74 3.27e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
27.61 9.82e-05 GO:0030672 synaptic vesicle membrane
17.14 1.32e-04 GO:0008021 synaptic vesicle
4.83 1.44e-03 GO:0030054 cell junction
14.62 2.33e-03 GO:0030665 clathrin coated vesicle membrane
5.78 2.35e-03 GO:0045202 synapse
9.27 4.56e-03 GO:0030136 clathrin-coated vesicle
6.75 7.74e-03 GO:0030659 cytoplasmic vesicle membrane
6.53 9.60e-03 GO:0012506 vesicle membrane
124.18 9.76e-03 GO:0042583 chromaffin granule
124.18 9.76e-03 GO:0042584 chromaffin granule membrane
10.81 9.94e-03 GO:0030662 coated vesicle membrane
7.58 1.39e-02 GO:0030135 coated vesicle
6.05 1.54e-02 GO:0044456 synapse part
5.60 2.46e-02 GO:0044433 cytoplasmic vesicle part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
12.52 1.30e-04 GO:0005516 calmodulin binding