Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 4.464


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ELK1hg19_v1_chrX_-_47509864_475099910.173.5e-01Click!
GABPAhg19_v1_chr21_+_27107731_271078010.154.3e-01Click!
GABPB1hg19_v1_chr15_-_50647385_50647400-0.115.4e-01Click!
ELK4hg19_v1_chr1_-_205601999_2056019990.077.2e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_46722316 6.321 NM_024741
 ZNF408
zinc finger protein 408
chrY_+_2709630 5.848 RPS4Y1
ribosomal protein S4, Y-linked 1
chr11_+_46722564 5.795 NM_001184751
 ZNF408
zinc finger protein 408
chr16_-_29757264 5.743 NM_175900
 C16orf54
chromosome 16 open reading frame 54
chr20_+_60962120 5.740 NM_001024
 RPS21
ribosomal protein S21
chr7_+_50348255 5.719 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr5_-_140998480 5.171 DIAPH1
diaphanous homolog 1 (Drosophila)
chr5_-_140998563 4.913 DIAPH1
diaphanous homolog 1 (Drosophila)
chr14_-_24658010 4.892 NM_024658
 IPO4
importin 4
chrY_+_2709596 4.781 NM_001008
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr20_+_49575347 4.750 NM_014484
 MOCS3
molybdenum cofactor synthesis 3
chr9_-_134151905 4.647 NM_033387
 FAM78A
family with sequence similarity 78, member A
chr14_-_24657986 4.556 IPO4
importin 4
chr17_-_17184589 4.513 NM_003653
 COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr12_-_498256 4.498 KDM5A
lysine (K)-specific demethylase 5A
chr2_-_75062214 4.473


chr3_-_72897576 4.467 NM_018130
 SHQ1
SHQ1 homolog (S. cerevisiae)
chr5_-_140998560 4.415 DIAPH1
diaphanous homolog 1 (Drosophila)
chr12_-_498428 4.326 NM_001042603
 KDM5A
lysine (K)-specific demethylase 5A
chr5_-_140998567 4.308 NM_001079812
NM_005219
 DIAPH1

diaphanous homolog 1 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
Enrichment   P-value GO Accession GO Term
10.64 1.44e-02 GO:0042100 B cell proliferation
3.52 1.66e-03 GO:0042254 ribosome biogenesis
3.35 6.01e-06 GO:0071843 cellular component biogenesis at cellular level
3.30 2.70e-05 GO:0022613 ribonucleoprotein complex biogenesis
3.04 7.92e-04 GO:0034470 ncRNA processing
3.04 2.79e-02 GO:0010565 regulation of cellular ketone metabolic process
2.89 4.60e-06 GO:0006412 translation
2.75 2.54e-04 GO:0034660 ncRNA metabolic process
2.46 6.33e-05 GO:0016032 viral reproduction
2.45 2.16e-02 GO:0016567 protein ubiquitination
2.38 2.63e-02 GO:0010608 posttranscriptional regulation of gene expression
2.27 2.70e-06 GO:0006396 RNA processing
2.26 2.16e-02 GO:0070647 protein modification by small protein conjugation or removal
2.24 4.77e-02 GO:0006511 ubiquitin-dependent protein catabolic process
2.20 2.71e-04 GO:0044265 cellular macromolecule catabolic process
2.13 1.56e-04 GO:0009057 macromolecule catabolic process
2.05 4.97e-03 GO:0016071 mRNA metabolic process
1.99 2.84e-03 GO:0051726 regulation of cell cycle
1.94 4.90e-02 GO:0006974 response to DNA damage stimulus
1.93 1.83e-12 GO:0010467 gene expression

Gene overrepresentation in compartment category:

Showing 1 to 20 of 37 entries
Enrichment   P-value GO Accession GO Term
4.05 1.03e-02 GO:0000502 proteasome complex
4.01 5.51e-03 GO:0005643 nuclear pore
3.59 9.79e-03 GO:0046930 pore complex
2.91 9.15e-03 GO:0000151 ubiquitin ligase complex
2.72 3.64e-02 GO:0031965 nuclear membrane
2.46 4.44e-02 GO:0005840 ribosome
2.44 5.65e-03 GO:0005635 nuclear envelope
2.23 3.42e-05 GO:0005730 nucleolus
2.18 6.91e-05 GO:0030529 ribonucleoprotein complex
1.92 3.88e-16 GO:0044428 nuclear part
1.87 6.31e-12 GO:0031981 nuclear lumen
1.85 1.26e-03 GO:0044451 nucleoplasm part
1.75 1.90e-11 GO:0070013 intracellular organelle lumen
1.75 6.56e-06 GO:0005654 nucleoplasm
1.75 1.29e-02 GO:0031967 organelle envelope
1.73 5.60e-11 GO:0043233 organelle lumen
1.72 5.94e-11 GO:0031974 membrane-enclosed lumen
1.72 2.08e-02 GO:0031975 envelope
1.56 4.73e-03 GO:0005739 mitochondrion
1.55 2.46e-05 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
5.32 7.27e-04 GO:0003743 translation initiation factor activity
5.25 3.21e-07 GO:0008135 translation factor activity, nucleic acid binding
1.83 5.81e-04 GO:0003723 RNA binding
1.71 2.45e-02 GO:0019899 enzyme binding
1.31 1.62e-02 GO:0003676 nucleic acid binding
1.28 1.96e-08 GO:0005515 protein binding
1.22 2.01e-02 GO:0003824 catalytic activity
1.12 2.20e-04 GO:0005488 binding