Motif ID: EN1,2.p2

Z-value: 1.846


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EN1hg19_v1_chr2_-_119605758_1196057580.077.2e-01Click!
EN2hg19_v1_chr7_+_155250705_155250823-0.029.3e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_74281884 4.418 ALB
albumin
chr11_+_60223281 4.388 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr4_+_71200670 4.344 NM_033122
 CABS1
calcium-binding protein, spermatid-specific 1
chr16_-_20364029 4.181 NM_001008389
NM_003361
 UMOD

uromodulin

chr7_+_141695678 3.794 NM_004668
 MGAM
maltase-glucoamylase (alpha-glucosidase)
chr4_+_78432905 3.782 NM_006419
 CXCL13
chemokine (C-X-C motif) ligand 13
chr17_+_45810609 3.677 NM_013351
 TBX21
T-box 21
chr7_+_117864711 3.589 NM_019644
 ANKRD7
ankyrin repeat domain 7
chr4_+_155484131 3.563 NM_001184741
NM_005141
 FGB

fibrinogen beta chain

chr4_+_156824846 3.548 NM_005651
 TDO2
tryptophan 2,3-dioxygenase
chr4_+_71091787 3.213 NM_152997
 C4orf7
chromosome 4 open reading frame 7
chr7_+_50348255 3.176 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr4_-_48136245 3.135 NM_003328
 TXK
TXK tyrosine kinase
chr12_+_100041527 3.124 NM_153364
 FAM71C
family with sequence similarity 71, member C
chr12_+_10460416 3.064 NM_002262
NM_007334
 KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr12_+_18891040 3.056 NM_033328
 CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr12_-_7281374 2.900 NM_031491
 RBP5
retinol binding protein 5, cellular
chr2_+_88047603 2.883 NM_002665
NM_001032392
 PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr2_-_87248942 2.852 NM_002665
NM_001032392
 PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr12_-_102591547 2.770 NM_002674
 PMCH
pro-melanin-concentrating hormone

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
34.05 4.91e-02 GO:0051917 regulation of fibrinolysis
19.46 2.97e-02 GO:0030195 negative regulation of blood coagulation
18.79 3.43e-02 GO:0050819 negative regulation of coagulation
16.62 7.10e-03 GO:0050871 positive regulation of B cell activation
13.40 3.27e-03 GO:0072376 protein activation cascade
12.17 3.32e-02 GO:0002706 regulation of lymphocyte mediated immunity
12.17 3.32e-02 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.95 3.62e-02 GO:0002819 regulation of adaptive immune response
11.36 4.64e-02 GO:0050864 regulation of B cell activation
10.90 1.09e-02 GO:0002699 positive regulation of immune effector process
6.97 3.46e-03 GO:0002696 positive regulation of leukocyte activation
6.86 3.97e-03 GO:0050867 positive regulation of cell activation
6.65 1.64e-02 GO:0051251 positive regulation of lymphocyte activation
6.15 3.41e-04 GO:0006954 inflammatory response
6.04 4.15e-04 GO:0050778 positive regulation of immune response
5.38 2.72e-02 GO:0002694 regulation of leukocyte activation
5.35 2.74e-05 GO:0002684 positive regulation of immune system process
5.18 3.67e-02 GO:0050865 regulation of cell activation
5.01 1.07e-08 GO:0006955 immune response
4.64 1.12e-03 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
13.10 3.41e-03 GO:0031983 vesicle lumen
11.60 3.44e-02 GO:0031093 platelet alpha granule lumen
11.36 3.73e-02 GO:0034774 secretory granule lumen
10.90 4.36e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
8.89 6.80e-05 GO:0009897 external side of plasma membrane
4.11 6.67e-03 GO:0009986 cell surface
3.48 1.63e-04 GO:0005615 extracellular space
2.68 6.46e-03 GO:0044421 extracellular region part
2.36 1.29e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
15.48 2.21e-03 GO:0043498 cell surface binding
14.81 2.76e-03 GO:0008009 chemokine activity
13.36 4.59e-03 GO:0042379 chemokine receptor binding