Motif ID: EN1,2.p2

Z-value: 1.846


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EN1hg19_v1_chr2_-_119605758_1196057580.077.2e-01Click!
EN2hg19_v1_chr7_+_155250705_155250823-0.029.3e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74281884 4.418 ALB
albumin
chr11_+_60223281 4.388 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr4_+_71200670 4.344 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr16_-_20364029 4.181 NM_001008389
NM_003361
UMOD

uromodulin

chr7_+_141695678 3.794 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr4_+_78432905 3.782 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr17_+_45810609 3.677 NM_013351
TBX21
T-box 21
chr7_+_117864711 3.589 NM_019644
ANKRD7
ankyrin repeat domain 7
chr4_+_155484131 3.563 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr4_+_156824846 3.548 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr4_+_71091787 3.213 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr7_+_50348255 3.176 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr4_-_48136245 3.135 NM_003328
TXK
TXK tyrosine kinase
chr12_+_100041527 3.124 NM_153364
FAM71C
family with sequence similarity 71, member C
chr12_+_10460416 3.064 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr12_+_18891040 3.056 NM_033328
CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr12_-_7281374 2.900 NM_031491
RBP5
retinol binding protein 5, cellular
chr2_+_88047603 2.883 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr2_-_87248942 2.852 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr12_-_102591547 2.770 NM_002674
PMCH
pro-melanin-concentrating hormone
chr4_-_39033981 2.604 NM_024943
TMEM156
transmembrane protein 156
chr14_+_88471467 2.604 NM_003608
GPR65
G protein-coupled receptor 65
chr1_-_159684274 2.576 NM_000567
CRP
C-reactive protein, pentraxin-related
chr3_+_108541544 2.409 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr10_-_98031154 2.355 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_96991934 2.333 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-trisphosphate receptor interacting protein-like 1

chr2_+_231860838 2.272 NM_139073
SPATA3
spermatogenesis associated 3
chr4_+_40198526 2.212 NM_004310
RHOH
ras homolog gene family, member H
chr22_+_40297085 2.205 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr20_-_23967431 2.197 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr9_+_139872014 2.195 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr9_+_139871954 2.193 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr17_-_64225496 2.178 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_+_160765927 2.176 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr12_+_86268072 2.166 NM_006183
NTS
neurotensin
chr9_-_34729463 2.144 NM_001141917
FAM205A
family with sequence similarity 205, member A
chr4_+_74269971 2.124 NM_000477
ALB
albumin
chr7_-_115670828 2.105 NM_001018058
NM_012252
TFEC

transcription factor EC

chr12_-_9760481 2.057 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr15_+_97326629 2.050 NM_173499
SPATA8
spermatogenesis associated 8
chr7_-_115670774 1.980 TFEC
transcription factor EC
chr3_-_183273407 1.952 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chrX_+_142113703 1.949 NM_001009613
SPANXN4
SPANX family, member N4
chr2_+_103035148 1.943 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_161676761 1.919 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr7_+_128578246 1.874 NM_032643
IRF5
interferon regulatory factor 5
chrX_+_106171328 1.835 CLDN2
claudin 2
chr6_+_42123143 1.828 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chrX_+_128913897 1.783 SASH3
SAM and SH3 domain containing 3
chr19_-_7764283 1.772 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr11_+_103907307 1.772 NM_001001711
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr12_+_10163225 1.750 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr4_-_76928601 1.703 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr6_-_52668599 1.693 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr3_+_48264836 1.675 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr15_-_80263460 1.664 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr3_-_46505077 1.660 NM_001199149
LTF
lactotransferrin
chr17_+_72732958 1.655 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr6_-_159466019 1.620 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr5_+_55062712 1.605 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chrX_+_65235279 1.603


chr15_-_90349819 1.594 ANPEP
alanyl (membrane) aminopeptidase
chr5_+_79615789 1.571 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr20_+_62367945 1.568 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr15_-_50558161 1.542 NM_002112
HDC
histidine decarboxylase
chr19_+_42381189 1.532 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr15_+_58430394 1.525 NM_020980
AQP9
aquaporin 9
chrX_+_128913881 1.489 NM_018990
SASH3
SAM and SH3 domain containing 3
chr6_-_116866772 1.489 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr11_+_18433845 1.486 NM_002301
NM_017448
LDHC

lactate dehydrogenase C

chr5_+_131993864 1.481 NM_002188
IL13
interleukin 13
chr17_-_34417386 1.476 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr22_+_40297183 1.476 GRAP2
GRB2-related adaptor protein 2
chr2_-_158300517 1.460 NM_004288
CYTIP
cytohesin 1 interacting protein
chr10_-_72362513 1.451 NM_001083116
NM_005041
PRF1

perforin 1 (pore forming protein)

chr14_+_76837689 1.435 NM_004452
ESRRB
estrogen-related receptor beta
chr16_-_20416032 1.426 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr15_-_66857704 1.421 NM_207338
LCTL
lactase-like
chr3_+_186714335 1.414


chr9_-_34691135 1.409 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr3_+_140770742 1.406 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr20_+_238376 1.397 NM_207469
DEFB132
defensin, beta 132
chr3_-_120401401 1.355 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr11_+_124134699 1.352 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr16_-_28518131 1.349 NM_145659
IL27
interleukin 27
chr12_-_49999259 1.348 NM_032130
FAM186B
family with sequence similarity 186, member B
chr2_+_182850550 1.343 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_+_56732658 1.340 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr19_-_42348507 1.339 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr3_+_186435097 1.339 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chrX_-_104465349 1.332 NM_031274
TEX13A
testis expressed 13A
chr1_+_6105980 1.331 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr17_-_38956146 1.328 NM_181535
KRT28
keratin 28
chr5_+_57787260 1.302 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr6_+_31674639 1.287 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr6_+_31583766 1.287 NM_032955
AIF1
allograft inflammatory factor 1
chr11_-_62752370 1.277 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr2_-_192015706 1.272 STAT4
signal transducer and activator of transcription 4
chr1_+_212208918 1.267 NM_016448
DTL
denticleless homolog (Drosophila)
chr2_+_135596185 1.260 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr6_-_25726754 1.256 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr5_-_66492574 1.253 NM_005582
CD180
CD180 molecule
chr1_+_192605267 1.250 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr12_+_6554032 1.246 NM_001242
CD27
CD27 molecule
chr1_-_157789832 1.232 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr1_+_57320442 1.230 NM_000562
C8A
complement component 8, alpha polypeptide
chr17_-_4643162 1.224 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr5_-_176836535 1.221 NM_000505
F12
coagulation factor XII (Hageman factor)
chr22_-_37545944 1.218 NM_000878
IL2RB
interleukin 2 receptor, beta
chr1_-_161039413 1.213 ARHGAP30
Rho GTPase activating protein 30
chr6_+_25727004 1.211 NM_170610
HIST1H2BA
histone cluster 1, H2ba
chr6_+_116782555 1.197 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr6_-_41006927 1.197 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr12_-_18890917 1.180 NM_033123
PLCZ1
phospholipase C, zeta 1
chr11_-_124180661 1.174 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr10_-_72362441 1.164 PRF1
perforin 1 (pore forming protein)
chr13_+_52436116 1.161 NM_031290
CCDC70
coiled-coil domain containing 70
chrX_+_49593905 1.160 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr2_+_204801453 1.158 NM_012092
ICOS
inducible T-cell co-stimulator
chrX_-_47489703 1.152 NM_002621
CFP
complement factor properdin
chr14_-_23588819 1.141 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr12_-_95945226 1.139 NM_032147
USP44
ubiquitin specific peptidase 44
chr19_-_14169970 1.135 NM_001145028
PALM3
paralemmin 3
chr19_-_4302381 1.126 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr1_+_212209129 1.115 DTL
denticleless homolog (Drosophila)
chr6_+_161123224 1.115 NM_000301
NM_001168338
PLG

plasminogen

chr3_-_120400957 1.113 HGD
homogentisate 1,2-dioxygenase
chr1_+_159259503 1.112 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr6_-_87804773 1.111 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr5_+_175108463 1.107 NM_022304
HRH2
histamine receptor H2
chr1_+_34326075 1.093 NM_145205
HMGB4
high mobility group box 4
chr12_+_113344811 1.081 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_-_152086555 1.080 NM_007113
TCHH
trichohyalin
chr2_+_234668914 1.078 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr18_+_72201799 1.072 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr7_-_38389575 1.062 TRGV5
T cell receptor gamma variable 5
chr16_+_67381252 1.052 NM_001161575
LRRC36
leucine rich repeat containing 36
chrX_-_127186339 1.051 NM_138289
ACTRT1
actin-related protein T1
chr2_+_79347610 1.050 REG1A
regenerating islet-derived 1 alpha
chr9_-_104145800 1.047 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr12_-_55378455 1.047 NM_001136030
KIAA0748
KIAA0748
chr9_+_105757592 1.043 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr11_-_47399986 1.042 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr1_-_108231122 1.037 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr11_-_26743545 1.033 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr15_-_34629044 1.031 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr17_+_43922255 1.028 NM_175882
IMP5
intramembrane protease 5
chr1_+_212209112 1.028 DTL
denticleless homolog (Drosophila)
chr5_-_135701163 1.011 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr6_-_52628272 1.000 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr20_+_34556528 0.999 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr1_+_16348365 0.999 NM_001042704
NM_004070
CLCNKA

CLCNKB
chloride channel Ka

chloride channel Kb
chr11_+_118764100 0.997 NM_032966
CXCR5
chemokine (C-X-C motif) receptor 5
chr17_-_47286742 0.995 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr11_+_122709205 0.989 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr12_-_10542616 0.972 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr6_+_14117857 0.968 NM_001040280
NM_004233
CD83

CD83 molecule

chr2_+_88824168 0.968 NM_152670
C2orf51
chromosome 2 open reading frame 51
chr20_-_44175995 0.961 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr7_-_115670811 0.960 TFEC
transcription factor EC
chr10_+_45406629 0.956 NM_001123376
TMEM72
transmembrane protein 72
chrX_+_107288199 0.954 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_+_118892363 0.953 NM_006952
UPK1B
uroplakin 1B
chr19_+_10959105 0.951 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr1_+_212797788 0.947 NM_153606
FAM71A
family with sequence similarity 71, member A
chr12_-_123201319 0.945 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr1_-_205391180 0.944 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr22_-_37215516 0.940 NM_002854
PVALB
parvalbumin
chr1_-_27701302 0.939 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr19_-_54327428 0.936 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr11_+_118215058 0.917 NM_000073
CD3G
CD3g molecule, gamma (CD3-TCR complex)
chr12_-_9885859 0.911 NM_001253748
NM_001253750
NM_172004
CLECL1


C-type lectin-like 1


chr8_-_87755880 0.910 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr8_+_32785485 0.907


chr6_-_133084585 0.903 NM_078488
VNN2
vanin 2
chr3_+_52813936 0.901 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr1_+_244214552 0.900 NM_205768
ZNF238
zinc finger protein 238
chr4_+_186350543 0.888 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr6_-_51952368 0.883 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_+_159442865 0.883 NM_001253727
NM_001253728
NM_001253729
NM_001253730
NM_001253732
NM_001253733
NM_021634
RXFP1






relaxin/insulin-like family peptide receptor 1






chr11_+_5968576 0.882 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr18_-_58040000 0.881 NM_005912
MC4R
melanocortin 4 receptor
chr2_+_87144737 0.880 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr5_-_176326314 0.878 NM_002115
HK3
hexokinase 3 (white cell)
chr1_-_76397975 0.876 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chrY_+_16168097 0.874 NM_181880
NM_004679
VCY1B
VCX3A
VCY
variable charge, Y-linked 1B
variable charge, X-linked 3A
variable charge, Y-linked
chr22_+_23054862 0.874 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr14_+_95027760 0.871 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr22_+_50986461 0.865 NM_138433
KLHDC7B
kelch domain containing 7B
chr10_-_48416692 0.862 NM_016204
GDF2
growth differentiation factor 2
chr4_-_74847669 0.857 NM_002619
PF4
platelet factor 4
chr1_+_111742946 0.853


chr16_+_57050985 0.851 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr1_-_161601752 0.850 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr12_+_8608521 0.847 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chrX_+_49226137 0.841 NM_001472
NM_001098407
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr12_-_11548485 0.841 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr4_-_74853819 0.833 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr11_-_45928832 0.828 NM_001080446
C11orf94
chromosome 11 open reading frame 94
chr1_-_161039703 0.825 ARHGAP30
Rho GTPase activating protein 30

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.92 6.32e-09 GO:0002376 immune system process
5.01 1.07e-08 GO:0006955 immune response
4.43 3.50e-07 GO:0006952 defense response
5.35 2.74e-05 GO:0002684 positive regulation of immune system process
6.15 3.41e-04 GO:0006954 inflammatory response
6.04 4.15e-04 GO:0050778 positive regulation of immune response
3.89 4.34e-04 GO:0002682 regulation of immune system process
4.64 1.12e-03 GO:0050776 regulation of immune response
13.40 3.27e-03 GO:0072376 protein activation cascade
6.97 3.46e-03 GO:0002696 positive regulation of leukocyte activation
6.86 3.97e-03 GO:0050867 positive regulation of cell activation
16.62 7.10e-03 GO:0050871 positive regulation of B cell activation
10.90 1.09e-02 GO:0002699 positive regulation of immune effector process
2.07 1.48e-02 GO:0006950 response to stress
6.65 1.64e-02 GO:0051251 positive regulation of lymphocyte activation
5.38 2.72e-02 GO:0002694 regulation of leukocyte activation
19.46 2.97e-02 GO:0030195 negative regulation of blood coagulation
1.52 3.01e-02 GO:0050896 response to stimulus
12.17 3.32e-02 GO:0002706 regulation of lymphocyte mediated immunity
12.17 3.32e-02 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
18.79 3.43e-02 GO:0050819 negative regulation of coagulation
11.95 3.62e-02 GO:0002819 regulation of adaptive immune response
5.18 3.67e-02 GO:0050865 regulation of cell activation
11.36 4.64e-02 GO:0050864 regulation of B cell activation
34.05 4.91e-02 GO:0051917 regulation of fibrinolysis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
8.89 6.80e-05 GO:0009897 external side of plasma membrane
2.36 1.29e-04 GO:0005576 extracellular region
3.48 1.63e-04 GO:0005615 extracellular space
13.10 3.41e-03 GO:0031983 vesicle lumen
2.68 6.46e-03 GO:0044421 extracellular region part
4.11 6.67e-03 GO:0009986 cell surface
11.60 3.44e-02 GO:0031093 platelet alpha granule lumen
11.36 3.73e-02 GO:0034774 secretory granule lumen
10.90 4.36e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
15.48 2.21e-03 GO:0043498 cell surface binding
14.81 2.76e-03 GO:0008009 chemokine activity
13.36 4.59e-03 GO:0042379 chemokine receptor binding