Motif ID: EOMES.p2

Z-value: 1.222


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EOMEShg19_v1_chr3_-_27764197_27764205-0.125.2e-01Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92680784 4.754 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_-_150652861 3.852 NM_001204798
NM_172057
 KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr12_-_111358353 3.634 NM_000432
 MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr8_+_1993157 3.493 NM_003970
 MYOM2
myomesin (M-protein) 2, 165kDa
chr1_-_11907741 3.404 NM_006172
 NPPA
natriuretic peptide A
chr1_+_228395740 3.296 NM_001098623
NM_052843
 OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr4_-_65275000 3.131 NM_001010874
 TECRL
trans-2,3-enoyl-CoA reductase-like
chr10_-_92681025 2.853 NM_014391
 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_116311161 2.661 CASQ2
calsequestrin 2 (cardiac muscle)
chr5_+_150040402 2.464 NM_001122853
NM_133371
 MYOZ3

myozenin 3

chr15_-_35087748 2.313 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr3_-_62861012 2.304 NM_003716
NM_183393
NM_183394
 CADPS


Ca++-dependent secretion activator


chr21_+_40823779 2.227 NM_007341
 SH3BGR
SH3 domain binding glutamic acid-rich protein
chr8_-_72268720 2.125 NM_172058
NM_172059
NM_172060
 EYA1


eyes absent homolog 1 (Drosophila)


chr7_+_110731061 2.092 NM_001099658
NM_001099660
NM_018334
 LRRN3


leucine rich repeat neuronal 3


chr20_+_43343523 2.045 WISP2
WNT1 inducible signaling pathway protein 2
chr7_-_123673486 2.045 NM_001136002
 TMEM229A
transmembrane protein 229A
chr11_+_73358593 2.024 NM_001130034
NM_001130035
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr2_-_74753311 1.996 NM_133637
 DQX1
DEAQ box RNA-dependent ATPase 1
chr10_-_29754478 1.950 SVIL
supervillin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
110.75 4.25e-02 GO:0030240 skeletal muscle thin filament assembly
103.83 8.19e-04 GO:0055003 cardiac myofibril assembly
63.90 4.13e-03 GO:0055006 cardiac cell development
63.90 4.13e-03 GO:0055013 cardiac muscle cell development
39.56 1.88e-02 GO:0030239 myofibril assembly
36.13 2.49e-02 GO:0055007 cardiac muscle cell differentiation
30.78 4.07e-02 GO:0031032 actomyosin structure organization
29.94 3.04e-03 GO:0006941 striated muscle contraction
29.94 3.04e-03 GO:0030049 muscle filament sliding
29.94 3.04e-03 GO:0033275 actin-myosin filament sliding
29.16 3.39e-03 GO:0070252 actin-mediated cell contraction
21.73 1.11e-02 GO:0030048 actin filament-based movement
14.03 2.98e-05 GO:0006936 muscle contraction
12.89 5.75e-05 GO:0003012 muscle system process
7.46 4.83e-02 GO:0007507 heart development

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
138.43 8.04e-05 GO:0031430 M band
63.90 1.13e-03 GO:0031672 A band
28.85 7.00e-05 GO:0031674 I band
25.44 5.87e-09 GO:0030017 sarcomere
24.52 6.80e-10 GO:0044449 contractile fiber part
23.88 8.87e-10 GO:0030016 myofibril
22.52 1.60e-09 GO:0043292 contractile fiber
21.87 3.12e-02 GO:0030018 Z disc
6.79 6.47e-03 GO:0015629 actin cytoskeleton
4.41 1.60e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
38.64 7.94e-07 GO:0008307 structural constituent of muscle
4.85 7.39e-03 GO:0008092 cytoskeletal protein binding