Motif ID: EP300.p2

Z-value: 1.444


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EP300hg19_v1_chr22_+_41488607_41488645-0.327.1e-02Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_95007139 7.909 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_+_153651050 3.883 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr13_+_37248048 2.739 NM_203451
SERTM1
serine-rich and transmembrane domain containing 1
chr19_-_46916825 2.564 NM_032040
CCDC8
coiled-coil domain containing 8
chr4_-_121993568 2.558 NM_024574
NDNF
neuron-derived neurotrophic factor
chr1_+_157963310 2.529 KIRREL
kin of IRRE like (Drosophila)
chr16_+_66400524 2.526 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr8_+_106331146 2.524 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr12_-_48152180 2.498 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr2_+_217498082 2.497 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr11_-_63258410 2.465 NM_001146728
NM_001146729
NM_054108
HRASLS5


HRAS-like suppressor family, member 5


chr11_-_2160199 2.454 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_72427535 2.402 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr15_-_23932410 2.396 NM_002487
NDN
necdin homolog (mouse)
chr15_+_71184781 2.338 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr1_+_57110745 2.319 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr2_-_110371669 2.293 NM_144710
NM_178584
SEPT10

septin 10

chr1_-_156647088 2.292 NM_006617
NES
nestin
chr15_-_23932364 2.254


chr13_-_40177355 2.250 NM_005780
LHFP
lipoma HMGIC fusion partner
chrX_-_17879355 2.147 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr2_-_110371404 2.107 SEPT10
septin 10
chr4_-_5890142 2.100 CRMP1
collapsin response mediator protein 1
chr18_-_24765178 2.068 NM_031422
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr10_-_30348433 2.051 NM_020848
KIAA1462
KIAA1462
chr9_-_129884961 2.038 ANGPTL2
angiopoietin-like 2
chr12_-_53298765 2.019 NM_002273
KRT8
keratin 8
chr10_-_21462987 2.017 NEBL
nebulette
chr4_-_186456580 2.008 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr12_+_6937764 1.973 LEPREL2
leprecan-like 2
chr8_+_15397761 1.972 TUSC3
tumor suppressor candidate 3
chr4_+_106816627 1.952 NPNT
nephronectin
chr16_+_66400585 1.936 CDH5
cadherin 5, type 2 (vascular endothelium)
chr8_+_17434700 1.931 PDGFRL
platelet-derived growth factor receptor-like
chr8_+_15397595 1.922 NM_006765
NM_178234
TUSC3

tumor suppressor candidate 3

chr4_-_142054431 1.902 NM_020724
RNF150
ring finger protein 150
chr4_-_16900348 1.876 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr13_-_40177200 1.854 LHFP
lipoma HMGIC fusion partner
chr1_-_153585504 1.850 NM_080388
S100A16
S100 calcium binding protein A16
chr16_+_80574853 1.807 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr13_-_40177304 1.777 LHFP
lipoma HMGIC fusion partner
chr6_-_112575766 1.776 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr12_-_6484389 1.769 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_-_225840660 1.752 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr20_+_34680569 1.748 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr9_-_117880411 1.709 NM_002160
TNC
tenascin C
chr14_+_53019865 1.700 NM_001099652
GPR137C
G protein-coupled receptor 137C
chr7_+_128470462 1.695 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr2_+_110371887 1.690 NM_023016
ANKRD57
ankyrin repeat domain 57
chr17_+_39969205 1.683 FKBP10
FK506 binding protein 10, 65 kDa
chr15_-_68724434 1.678 NM_001004439
ITGA11
integrin, alpha 11
chr17_+_37844325 1.662 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr7_-_117513527 1.656 NM_033427
CTTNBP2
cortactin binding protein 2
chr13_-_114567011 1.655 GAS6
growth arrest-specific 6
chr17_-_46692300 1.653 NM_024016
HOXB8
homeobox B8
chr13_-_114567034 1.650 GAS6
growth arrest-specific 6
chr5_-_10307873 1.649 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr5_-_41510627 1.645 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr14_-_61190458 1.643 NM_017420
SIX4
SIX homeobox 4
chr9_-_129884885 1.636 ANGPTL2
angiopoietin-like 2
chr11_+_125034558 1.618 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr1_-_68516311 1.612 NM_004675
DIRAS3
DIRAS family, GTP-binding RAS-like 3
chr19_+_46843961 1.606 HIF3A
hypoxia inducible factor 3, alpha subunit
chr10_-_21463019 1.604 NM_001173484
NM_213569
NEBL

nebulette

chr15_+_74466024 1.583 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr13_-_114566951 1.575 GAS6
growth arrest-specific 6
chr13_-_114567040 1.568 NM_000820
GAS6
growth arrest-specific 6
chr1_-_33366838 1.556 NM_033504
TMEM54
transmembrane protein 54
chr12_-_6484557 1.551 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr19_+_50030874 1.548 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr13_+_51796363 1.545 NM_001242312
NM_145019
FAM124A

family with sequence similarity 124A

chr5_+_40909558 1.538 NM_000587
C7
complement component 7
chr5_+_40909617 1.531 C7
complement component 7
chr13_-_114103452 1.512 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr2_+_47596447 1.512 EPCAM
epithelial cell adhesion molecule
chr22_+_35937351 1.495 NM_014310
RASD2
RASD family, member 2
chr11_-_46722115 1.495 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr22_-_44708730 1.493 NM_001099294
KIAA1644
KIAA1644
chr16_-_66959418 1.492 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr13_-_61989209 1.476 PCDH20
protocadherin 20
chr11_+_114167197 1.467 NNMT
nicotinamide N-methyltransferase
chr12_-_26277807 1.458 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr8_-_122653493 1.456 NM_005328
HAS2
hyaluronan synthase 2
chrX_+_37208527 1.455 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr1_+_38022514 1.453 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr11_-_46722139 1.448 ARHGAP1
Rho GTPase activating protein 1
chr3_+_159481880 1.440 SCHIP1
schwannomin interacting protein 1
chr6_-_110500803 1.438 WASF1
WAS protein family, member 1
chr11_+_101980736 1.438 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr11_+_125034604 1.436 PKNOX2
PBX/knotted 1 homeobox 2
chr9_+_2622099 1.427 VLDLR
very low density lipoprotein receptor
chr14_-_38064440 1.424 NM_004496
FOXA1
forkhead box A1
chr11_-_46722160 1.424 ARHGAP1
Rho GTPase activating protein 1
chr19_-_36246206 1.423 HSPB6
heat shock protein, alpha-crystallin-related, B6
chrX_-_140271293 1.390 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr5_-_33891967 1.387 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr12_-_59314069 1.386 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_-_173638970 1.384 NM_198493
ANKRD45
ankyrin repeat domain 45
chr2_-_160919120 1.382 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr9_+_2621740 1.381 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chr17_-_74533623 1.373 NM_134268
CYGB
cytoglobin
chr21_+_47401644 1.368 NM_001848
COL6A1
collagen, type VI, alpha 1
chr16_+_66400559 1.355 CDH5
cadherin 5, type 2 (vascular endothelium)
chr6_-_32076997 1.351 NM_019105
TNXB
tenascin XB
chr1_+_156084579 1.349 LMNA
lamin A/C
chr14_-_38064176 1.340 FOXA1
forkhead box A1
chr12_+_27677044 1.339 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr16_+_2083264 1.335 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chr1_+_180882312 1.334 NM_020950
KIAA1614
KIAA1614
chr19_+_50031232 1.333 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr5_-_443168 1.324 NM_138464
C5orf55
chromosome 5 open reading frame 55
chr15_+_74466171 1.320 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr2_-_229046313 1.313 NM_001142644
NM_030623
SPHKAP

SPHK1 interactor, AKAP domain containing

chr11_+_66824308 1.309 RHOD
ras homolog gene family, member D
chr12_+_54519836 1.308 LOC400043
uncharacterized LOC400043
chr7_-_120498128 1.304 NM_012338
TSPAN12
tetraspanin 12
chr14_-_27066959 1.296 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr11_-_100999793 1.294 NM_001202474
PGR
progesterone receptor
chr7_+_37960162 1.291 NM_001242946
NM_017549
EPDR1

ependymin related protein 1 (zebrafish)

chr1_+_200860619 1.289 NM_018265
C1orf106
chromosome 1 open reading frame 106
chr11_+_12399024 1.289 NM_018222
PARVA
parvin, alpha
chrX_-_140271205 1.288 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140271275 1.288 LDOC1
leucine zipper, down-regulated in cancer 1
chr11_-_2159472 1.286 IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_-_45128492 1.273 NM_001146334
NACAD
NAC alpha domain containing
chr6_+_43043944 1.273 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr2_-_170550859 1.273 NM_001085447
C2orf77
chromosome 2 open reading frame 77
chr8_+_121137297 1.272 NM_021110
COL14A1
collagen, type XIV, alpha 1
chr3_+_46923738 1.271 NM_001184744
PTH1R
parathyroid hormone 1 receptor
chr7_-_150038689 1.267 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr2_+_46524901 1.264 EPAS1
endothelial PAS domain protein 1
chr12_+_6309475 1.259 NM_001769
CD9
CD9 molecule
chr12_+_53443834 1.259 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chrX_-_128788913 1.253 NM_017413
APLN
apelin
chr12_-_123214882 1.247 NM_032554
HCAR1
hydroxycarboxylic acid receptor 1
chr17_+_60705051 1.245 MRC2
mannose receptor, C type 2
chr4_-_40859081 1.244 NM_001166051
NM_001166052
NM_001166053
NM_001166054
APBB2



amyloid beta (A4) precursor protein-binding, family B, member 2



chr9_+_35792405 1.239 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr12_-_57634474 1.238 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr7_+_37960920 1.237 NM_001242948
EPDR1
ependymin related protein 1 (zebrafish)
chrX_-_15511710 1.237 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr20_+_56136136 1.231 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr1_-_1590403 1.231 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr19_-_54984341 1.230 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr1_-_155162633 1.224 NM_001018016
NM_001018017
NM_001044390
NM_001044391
NM_001044392
NM_001044393
NM_001204285
NM_001204286
NM_001204287
NM_001204288
NM_001204289
NM_001204290
NM_001204291
NM_001204292
NM_001204293
NM_001204294
NM_001204295
NM_001204296
NM_001204297
NM_002456
MUC1



















mucin 1, cell surface associated



















chr7_-_100493481 1.217 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr5_-_149535309 1.213 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr17_+_37783202 1.202 PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr1_-_85930610 1.199 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr7_+_45197366 1.198 NM_005856
RAMP3
receptor (G protein-coupled) activity modifying protein 3
chr12_+_58003962 1.194 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr1_+_44444986 1.192 B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr2_+_217498205 1.182 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr19_+_41725277 1.180 AXL
AXL receptor tyrosine kinase
chr6_-_110501164 1.179 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr9_+_132934685 1.177 NM_014286
NCS1
neuronal calcium sensor 1
chr19_+_47759802 1.173 CCDC9
coiled-coil domain containing 9
chr20_-_22564893 1.164 FOXA2
forkhead box A2
chr12_-_48152860 1.164 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr19_+_13105970 1.162 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_149375584 1.156 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr7_-_120498009 1.154 TSPAN12
tetraspanin 12
chr12_-_105629790 1.150 NM_001251904
NM_018171
APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr1_+_157963062 1.144 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr10_+_81892497 1.142 PLAC9
placenta-specific 9
chrX_-_3264680 1.140 NM_015419
MXRA5
matrix-remodelling associated 5
chr2_-_230579198 1.135 NM_139072
DNER
delta/notch-like EGF repeat containing
chr7_+_116164838 1.129 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr15_+_23810808 1.124 MKRN3
makorin ring finger protein 3
chr12_-_9268513 1.121 A2M
alpha-2-macroglobulin
chr22_-_29075708 1.120 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chrX_-_99891690 1.118 NM_003270
TSPAN6
tetraspanin 6
chr1_-_59042827 1.116 TACSTD2
tumor-associated calcium signal transducer 2
chr2_+_56411123 1.116 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr12_+_3068442 1.114 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr19_-_18902077 1.114 NM_000095
COMP
cartilage oligomeric matrix protein
chr9_+_87283453 1.113 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr13_-_44361032 1.110 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr12_-_115121939 1.101 NM_005996
NM_016569
TBX3

T-box 3

chr1_+_170633312 1.100 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr11_+_129245834 1.096 NM_003658
BARX2
BARX homeobox 2
chr2_+_47596286 1.091 NM_002354
EPCAM
epithelial cell adhesion molecule
chr6_+_43738757 1.083 VEGFA
vascular endothelial growth factor A
chr10_-_71176567 1.083 NM_001057
TACR2
tachykinin receptor 2
chr4_+_113739203 1.081 NM_001127493
ANK2
ankyrin 2, neuronal
chr11_+_46402333 1.080 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr11_+_46403205 1.078 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr1_-_46598250 1.076 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr7_+_94536926 1.074 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chrX_-_125300079 1.074 NM_001013628
DCAF12L2
DDB1 and CUL4 associated factor 12-like 2
chr10_+_81892429 1.070 PLAC9
placenta-specific 9
chr2_+_192109879 1.067 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr3_-_116164363 1.067 NM_002338
LSAMP
limbic system-associated membrane protein
chr11_-_107582733 1.067 NM_003063
SLN
sarcolipin
chr15_-_37390372 1.065 NM_172315
MEIS2
Meis homeobox 2
chr7_+_116165089 1.062 CAV1
caveolin 1, caveolae protein, 22kDa
chr6_-_28303910 1.055 NM_001135216
NM_001243243
ZNF323

zinc finger protein 323

chr7_+_116165043 1.052 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr8_-_74005379 1.049 NM_153225
C8orf84
chromosome 8 open reading frame 84
chr17_-_19265882 1.045 NM_001243473
NM_015681
B9D1

B9 protein domain 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.10 8.14e-06 GO:0048856 anatomical structure development
1.97 8.71e-06 GO:0032502 developmental process
1.99 2.98e-05 GO:0007275 multicellular organismal development
2.09 8.20e-05 GO:0048731 system development
2.66 1.01e-04 GO:0009653 anatomical structure morphogenesis
1.87 2.24e-04 GO:0023052 signaling
1.66 4.33e-04 GO:0032501 multicellular organismal process
2.17 1.93e-03 GO:0048869 cellular developmental process
2.90 2.21e-03 GO:0042127 regulation of cell proliferation
4.30 4.26e-03 GO:0043009 chordate embryonic development
4.25 4.87e-03 GO:0009792 embryo development ending in birth or egg hatching
4.84 6.34e-03 GO:0061061 muscle structure development
1.44 1.34e-02 GO:0050794 regulation of cellular process
2.06 1.68e-02 GO:0030154 cell differentiation
1.75 1.81e-02 GO:0007165 signal transduction
1.41 2.30e-02 GO:0050789 regulation of biological process
2.90 2.58e-02 GO:0007155 cell adhesion
2.90 2.58e-02 GO:0022610 biological adhesion
6.47 2.82e-02 GO:0060537 muscle tissue development
1.38 3.09e-02 GO:0065007 biological regulation
3.32 4.14e-02 GO:0008284 positive regulation of cell proliferation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.21 7.46e-04 GO:0016324 apical plasma membrane
4.95 5.42e-03 GO:0045177 apical part of cell
3.76 6.75e-03 GO:0031012 extracellular matrix
1.90 1.26e-02 GO:0044459 plasma membrane part
1.58 1.27e-02 GO:0071944 cell periphery
1.58 1.64e-02 GO:0005886 plasma membrane
1.92 1.66e-02 GO:0005576 extracellular region
2.38 2.11e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
9.93 5.30e-03 GO:0004714 transmembrane receptor protein tyrosine kinase activity
104.25 1.58e-02 GO:0005019 platelet-derived growth factor beta-receptor activity
7.73 2.20e-02 GO:0019199 transmembrane receptor protein kinase activity
69.50 4.70e-02 GO:0004992 platelet activating factor receptor activity
69.50 4.70e-02 GO:0005017 platelet-derived growth factor receptor activity
69.50 4.70e-02 GO:0016941 natriuretic peptide receptor activity