Motif ID: ESRRA.p2

Z-value: 3.366


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESRRAhg19_v1_chr11_+_64073040_640730960.569.6e-04Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_144994908 14.008 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_42744318 10.927 NM_020707
 HHATL
hedgehog acyltransferase-like
chr3_+_186435097 10.742 NM_000893
NM_001102416
NM_001166451
 KNG1


kininogen 1


chr5_+_149569519 10.645 NM_014228
 SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr1_-_144994839 9.807 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_230849847 9.734 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230849863 9.717 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230849936 9.268 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr20_-_62130390 9.240 NM_001958
 EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr5_+_218441 9.037 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_218355 8.801 NM_004168
 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_218447 8.666 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_218428 8.633 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr19_+_589849 7.910 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr1_+_159557615 7.409 NM_001639
 APCS
amyloid P component, serum
chr10_+_81107242 7.318 PPIF
peptidylprolyl isomerase F
chr1_-_230850335 6.988 NM_000029
 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_-_55668956 6.925 NM_000363
 TNNI3
troponin I type 3 (cardiac)
chr5_-_1594617 6.585 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr1_+_236849753 6.575 NM_001103
 ACTN2
actinin, alpha 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 45 entries
Enrichment   P-value GO Accession GO Term
39.58 2.67e-02 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
23.46 5.69e-07 GO:0015985 energy coupled proton transport, down electrochemical gradient
23.46 5.69e-07 GO:0015986 ATP synthesis coupled proton transport
20.39 1.50e-15 GO:0042773 ATP synthesis coupled electron transport
20.39 1.50e-15 GO:0042775 mitochondrial ATP synthesis coupled electron transport
20.30 2.70e-03 GO:0042776 mitochondrial ATP synthesis coupled proton transport
19.39 4.23e-16 GO:0006119 oxidative phosphorylation
19.06 5.02e-11 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
18.36 3.34e-29 GO:0022904 respiratory electron transport chain
15.99 3.29e-07 GO:0009060 aerobic respiration
15.14 8.46e-29 GO:0045333 cellular respiration
13.20 4.75e-24 GO:0022900 electron transport chain
9.90 2.65e-02 GO:0006635 fatty acid beta-oxidation
9.38 1.79e-03 GO:0019395 fatty acid oxidation
9.38 1.79e-03 GO:0034440 lipid oxidation
8.66 2.50e-24 GO:0015980 energy derivation by oxidation of organic compounds
8.40 1.73e-02 GO:0009062 fatty acid catabolic process
8.19 1.33e-03 GO:0015992 proton transport
7.92 1.79e-03 GO:0006818 hydrogen transport
7.86 2.71e-02 GO:0072329 monocarboxylic acid catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
Enrichment   P-value GO Accession GO Term
39.58 6.07e-03 GO:0005749 mitochondrial respiratory chain complex II
39.58 6.07e-03 GO:0045257 succinate dehydrogenase complex (ubiquinone)
39.58 6.07e-03 GO:0045273 respiratory chain complex II
39.58 6.07e-03 GO:0045281 succinate dehydrogenase complex
39.58 6.07e-03 GO:0045283 fumarate reductase complex
31.67 1.50e-02 GO:0005750 mitochondrial respiratory chain complex III
31.67 1.50e-02 GO:0045275 respiratory chain complex III
26.39 8.49e-06 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
26.39 2.95e-02 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
24.84 7.32e-08 GO:0005753 mitochondrial proton-transporting ATP synthase complex
22.22 2.20e-07 GO:0045259 proton-transporting ATP synthase complex
18.95 1.31e-12 GO:0005747 mitochondrial respiratory chain complex I
18.95 1.31e-12 GO:0030964 NADH dehydrogenase complex
18.95 1.31e-12 GO:0045271 respiratory chain complex I
18.17 4.95e-19 GO:0005746 mitochondrial respiratory chain
17.59 1.23e-19 GO:0070469 respiratory chain
15.08 4.32e-04 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
14.96 2.37e-28 GO:0044455 mitochondrial membrane part
9.82 2.84e-04 GO:0016469 proton-transporting two-sector ATPase complex
9.32 8.69e-03 GO:0042645 mitochondrial nucleoid

Gene overrepresentation in function category:

Showing 1 to 20 of 26 entries
Enrichment   P-value GO Accession GO Term
52.77 2.16e-03 GO:0048039 ubiquinone binding
39.58 8.53e-03 GO:0000104 succinate dehydrogenase activity
26.39 4.14e-02 GO:0004300 enoyl-CoA hydratase activity
21.99 5.40e-04 GO:0048038 quinone binding
18.54 2.43e-11 GO:0003954 NADH dehydrogenase activity
18.54 2.43e-11 GO:0008137 NADH dehydrogenase (ubiquinone) activity
18.54 2.43e-11 GO:0050136 NADH dehydrogenase (quinone) activity
15.96 2.25e-10 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
9.78 8.95e-09 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
9.78 4.36e-02 GO:0051539 4 iron, 4 sulfur cluster binding
9.24 2.88e-03 GO:0016836 hydro-lyase activity
8.71 1.22e-08 GO:0015078 hydrogen ion transmembrane transporter activity
6.72 2.45e-02 GO:0016835 carbon-oxygen lyase activity
5.51 5.93e-07 GO:0015077 monovalent inorganic cation transmembrane transporter activity
5.02 7.45e-08 GO:0048037 cofactor binding
4.97 4.95e-05 GO:0050662 coenzyme binding
4.66 2.79e-04 GO:0009055 electron carrier activity
4.31 3.37e-05 GO:0022890 inorganic cation transmembrane transporter activity
3.95 2.04e-14 GO:0016491 oxidoreductase activity
2.86 1.35e-04 GO:0008324 cation transmembrane transporter activity