Motif ID: ESRRA.p2

Z-value: 3.366


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESRRAhg19_v1_chr11_+_64073040_640730960.569.6e-04Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_144994908 14.008 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_42744318 10.927 NM_020707
HHATL
hedgehog acyltransferase-like
chr3_+_186435097 10.742 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr5_+_149569519 10.645 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr1_-_144994839 9.807 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_230849847 9.734 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230849863 9.717 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230849936 9.268 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr20_-_62130390 9.240 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr5_+_218441 9.037 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_218355 8.801 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_218447 8.666 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_218428 8.633 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr19_+_589849 7.910 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr1_+_159557615 7.409 NM_001639
APCS
amyloid P component, serum
chr10_+_81107242 7.318 PPIF
peptidylprolyl isomerase F
chr1_-_230850335 6.988 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_-_55668956 6.925 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr5_-_1594617 6.585 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr1_+_236849753 6.575 NM_001103
ACTN2
actinin, alpha 2
chr2_-_74374998 6.510 NM_001035505
NM_212552
BOLA3

bolA homolog 3 (E. coli)

chr8_-_100905910 6.106 COX6C
cytochrome c oxidase subunit VIc
chr15_-_83621350 5.998 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr1_-_173886464 5.963 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_19217384 5.951 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr10_+_81107259 5.917 PPIF
peptidylprolyl isomerase F
chr1_+_207226594 5.748 NM_001018053
NM_006212
PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

chrX_+_49047887 5.730


chr19_-_4535202 5.674 NM_001013706
PLIN5
perilipin 5
chr8_+_86376130 5.659 NM_000067
CA2
carbonic anhydrase II
chr1_-_173886401 5.597 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr3_+_133465098 5.586 TF
transferrin
chr6_-_135271206 5.470 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chrX_-_21776158 5.411 NM_014332
SMPX
small muscle protein, X-linked
chr10_-_91404901 5.327 PANK1
pantothenate kinase 1
chr2_+_26467615 5.015 NM_000183
HADHB
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
chr22_-_36019363 4.991 NM_203377
MB
myoglobin
chr22_-_24110054 4.986 NM_213720
CHCHD10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr16_+_21964677 4.978 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr8_-_100905865 4.894 COX6C
cytochrome c oxidase subunit VIc
chr3_+_159557745 4.854 SCHIP1
schwannomin interacting protein 1
chr18_-_43678233 4.781 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr8_+_145149985 4.749 CYC1
cytochrome c-1
chr16_+_21964608 4.745 NM_003366
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr3_+_133465250 4.704 TF
transferrin
chr3_+_133464883 4.697 NM_001063
TF
transferrin
chr10_+_88428167 4.687 NM_001171610
LDB3
LIM domain binding 3
chr15_-_42783293 4.660 ZFP106
zinc finger protein 106 homolog (mouse)
chr16_+_21964700 4.498 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr2_-_176046120 4.478 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr10_-_105156186 4.402 NM_001206426
NM_001206427
NM_032747
USMG5


up-regulated during skeletal muscle growth 5 homolog (mouse)


chr14_-_70546863 4.370 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr10_-_101190201 4.334 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr12_-_57039785 4.265 NM_001686
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr12_-_57039736 4.240 ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr3_+_108855560 4.196 FLJ22763
uncharacterized LOC401081
chr8_-_17658711 4.170


chr3_+_159557649 4.139 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr10_+_81107228 4.120 PPIF
peptidylprolyl isomerase F
chr1_-_33338081 4.096 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr10_+_81107219 4.084 NM_005729
PPIF
peptidylprolyl isomerase F
chr11_+_66059335 4.027 TMEM151A
transmembrane protein 151A
chr11_-_790103 3.976 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr1_-_16399936 3.974 NM_182623
FAM131C
family with sequence similarity 131, member C
chr3_+_181417387 3.940 SOX2-OT
SOX2 overlapping transcript (non-protein coding)
chr1_-_17380486 3.908 NM_003000
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr16_+_8814567 3.898 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr1_-_151798552 3.878 NM_001001523
RORC
RAR-related orphan receptor C
chr16_-_75150664 3.872 NM_153486
NM_194436
LDHD

lactate dehydrogenase D

chr3_+_133465204 3.863 TF
transferrin
chr7_-_95225802 3.860 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr17_-_27948345 3.859 NM_032854
CORO6
coronin 6
chr11_+_34938112 3.842 PDHX
pyruvate dehydrogenase complex, component X
chr11_+_66059364 3.778 NM_153266
TMEM151A
transmembrane protein 151A
chr15_-_41694619 3.774 NM_016013
NDUFAF1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
chr17_+_37821598 3.739 NM_003673
TCAP
titin-cap (telethonin)
chr1_-_154164551 3.724 NM_152263
TPM3
tropomyosin 3
chr11_-_47470687 3.697 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr2_-_179672056 3.686 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr1_+_165600433 3.630 MGST3
microsomal glutathione S-transferase 3
chr10_+_88426538 3.619 LDB3
LIM domain binding 3
chr1_+_161172174 3.606 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr14_-_102976096 3.601 NM_152326
ANKRD9
ankyrin repeat domain 9
chr18_-_43678195 3.572 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr7_-_87104974 3.533 NM_000443
NM_018849
NM_018850
ABCB4


ATP-binding cassette, sub-family B (MDR/TAP), member 4


chr18_-_43678230 3.532 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr1_+_161172125 3.524 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr14_-_102975996 3.523 ANKRD9
ankyrin repeat domain 9
chr4_+_84457390 3.504 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr10_-_76995685 3.498 NM_144589
COMTD1
catechol-O-methyltransferase domain containing 1
chr16_+_691827 3.484 NM_138418
FAM195A
family with sequence similarity 195, member A
chr12_+_121163570 3.483 NM_000017
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr1_-_241683011 3.464 FH
fumarate hydratase
chr10_-_27529263 3.439 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr1_+_161172163 3.365 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr18_-_43678251 3.349 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr3_-_42845946 3.342 NM_001099669
NM_014056
HIGD1A

HIG1 hypoxia inducible domain family, member 1A

chr3_-_10749715 3.338 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr11_-_64528186 3.334 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chrX_-_150067127 3.212 NM_001184808
NM_001242614
NM_031462
NM_134445
NM_134446
CD99L2




CD99 molecule-like 2




chrX_-_129299680 3.203 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr1_-_144994943 3.202 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr1_+_6094342 3.198 NM_001199860
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr18_-_47339854 3.197 ACAA2
acetyl-CoA acyltransferase 2
chr6_-_97345760 3.182 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chrX_-_150067062 3.175 CD99L2
CD99 molecule-like 2
chr3_-_42845911 3.169 NM_001099668
HIGD1A
HIG1 hypoxia inducible domain family, member 1A
chr5_-_150727088 3.148 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr8_-_124553253 3.147 FBXO32
F-box protein 32
chr3_-_38691118 3.123 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr17_+_46970128 3.119 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr19_+_54606141 3.095 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr11_-_132812870 3.077 NM_002545
OPCML
opioid binding protein/cell adhesion molecule-like
chr13_-_42535066 3.073 KIAA0564
KIAA0564
chrX_-_129299629 3.068 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr6_-_146056896 3.058 NM_001018041
NM_005670
EPM2A

epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

chr20_+_58179601 3.053 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr8_+_145149936 3.045 NM_001916
CYC1
cytochrome c-1
chr10_-_120938276 3.027 PRDX3
peroxiredoxin 3
chrX_-_46618471 3.021 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr8_-_100906241 3.001 NM_004374
COX6C
cytochrome c oxidase subunit VIc
chr6_+_29913400 2.994


chr5_+_161274196 2.991 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chrX_-_129299803 2.966 NM_001130847
NM_004208
NM_145812
NM_145813
AIFM1



apoptosis-inducing factor, mitochondrion-associated, 1



chr9_-_112191105 2.964 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr16_+_691901 2.957 FAM195A
family with sequence similarity 195, member A
chr15_+_78441737 2.957 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr3_-_48647085 2.936 NM_003365
UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr13_-_114103452 2.932 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr3_+_179322572 2.923 NM_001199957
NM_001199958
NM_002492
NDUFB5


NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa


chr12_+_6976694 2.893 TPI1
triosephosphate isomerase 1
chr5_+_175084984 2.887 NM_001131055
HRH2
histamine receptor H2
chr22_+_24309025 2.862 NM_001084393
DDTL
D-dopachrome tautomerase-like
chr6_-_97345747 2.856 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr15_-_89010607 2.836 NM_022163
MRPL46
mitochondrial ribosomal protein L46
chr2_-_26467501 2.816 NM_000182
HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr15_-_40630272 2.800 C15orf52
chromosome 15 open reading frame 52
chr7_+_56032065 2.794 NM_001202469
NM_001483
GBAS

glioblastoma amplified sequence

chr22_-_29711650 2.794 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr8_+_145149978 2.791 CYC1
cytochrome c-1
chr14_-_104387837 2.786 C14orf2
chromosome 14 open reading frame 2
chr7_-_123197824 2.785 NM_005000
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
chr9_+_17578952 2.765 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr11_+_22696318 2.754 NM_005256
GAS2
growth arrest-specific 2
chr16_+_56685810 2.741 NM_005947
MT1B
metallothionein 1B
chr12_-_54070108 2.733 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr3_-_48647052 2.727 UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr16_-_75150617 2.709 LDHD
lactate dehydrogenase D
chr4_+_44680408 2.706 NM_021927
GUF1
GUF1 GTPase homolog (S. cerevisiae)
chr2_-_26467463 2.695 HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr8_-_143858436 2.679 NM_177476
NM_177477
LYNX1

Ly6/neurotoxin 1

chr17_+_13972841 2.674 COX10
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
chr10_-_50970321 2.665 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr15_-_83735892 2.662 BTBD1
BTB (POZ) domain containing 1
chr5_-_45696219 2.659 NM_021072
HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr12_+_58176527 2.656 NM_001172695
NM_001172696
NM_001172697
NM_005726
TSFM



Ts translation elongation factor, mitochondrial



chr12_+_6976583 2.635 NM_001159287
NM_000365
TPI1

triosephosphate isomerase 1

chr22_+_31518923 2.627 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr19_+_35629727 2.616 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_1383904 2.616 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr7_+_116451073 2.610 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr15_+_78441733 2.603 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr19_-_12912602 2.603 NM_005809
NM_181738
PRDX2

peroxiredoxin 2

chr20_-_633808 2.590 SRXN1
sulfiredoxin 1
chr16_-_1877140 2.580 NM_001040427
NM_005326
HAGH

hydroxyacylglutathione hydrolase

chr22_+_30821610 2.580 NM_001003704
NM_016498
MTFP1

mitochondrial fission process 1

chr11_-_45307617 2.578 NM_001247987
NM_020826
SYT13

synaptotagmin XIII

chr16_+_56623266 2.578 NM_005954
MT3
metallothionein 3
chr19_+_1383898 2.573 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr18_-_12377168 2.553 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr18_-_43678273 2.516 NM_004046
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr12_+_25348194 2.512 LYRM5
LYR motif containing 5
chr11_+_22696381 2.508 GAS2
growth arrest-specific 2
chr20_+_37434294 2.507 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr4_-_140216951 2.506 NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr3_+_184038050 2.494 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr6_-_97345676 2.494 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr3_-_50608421 2.482 NM_001171741
C3orf18
chromosome 3 open reading frame 18
chr15_+_89010683 2.482 NM_022839
NM_176805
MRPS11

mitochondrial ribosomal protein S11

chr17_-_2614926 2.476 NM_015229
KIAA0664
KIAA0664
chr11_-_132813531 2.475 OPCML
opioid binding protein/cell adhesion molecule-like
chr18_+_11981457 2.467 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr10_-_120938337 2.461 NM_006793
NM_014098
PRDX3

peroxiredoxin 3

chr12_+_6647339 2.458 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr22_+_24373107 2.454 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr5_-_137911005 2.423 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr15_+_78441678 2.421 NM_005530
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr17_+_13972718 2.414 NM_001303
COX10
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
chr19_+_1383877 2.411 NM_024407
NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr6_-_46293628 2.406 NM_005822
RCAN2
regulator of calcineurin 2
chr9_-_130889993 2.399 PTGES2
prostaglandin E synthase 2
chr18_-_12377248 2.394 NM_006796
AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr16_+_85833315 2.390 COX4I1
cytochrome c oxidase subunit IV isoform 1
chr16_+_85833172 2.374 NM_001861
COX4I1
cytochrome c oxidase subunit IV isoform 1
chr12_-_111020752 2.374 PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr2_+_182850550 2.336 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr17_+_4981754 2.326 ZFP3
zinc finger protein 3 homolog (mouse)
chr4_-_170947428 2.321 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr11_-_34379526 2.317 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr20_-_633844 2.295 NM_080725
SRXN1
sulfiredoxin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
18.36 3.34e-29 GO:0022904 respiratory electron transport chain
15.14 8.46e-29 GO:0045333 cellular respiration
7.11 1.00e-24 GO:0006091 generation of precursor metabolites and energy
8.66 2.50e-24 GO:0015980 energy derivation by oxidation of organic compounds
13.20 4.75e-24 GO:0022900 electron transport chain
4.38 1.30e-22 GO:0055114 oxidation-reduction process
19.39 4.23e-16 GO:0006119 oxidative phosphorylation
20.39 1.50e-15 GO:0042773 ATP synthesis coupled electron transport
20.39 1.50e-15 GO:0042775 mitochondrial ATP synthesis coupled electron transport
19.06 5.02e-11 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
1.94 1.49e-08 GO:0006810 transport
1.92 3.56e-08 GO:0051234 establishment of localization
15.99 3.29e-07 GO:0009060 aerobic respiration
23.46 5.69e-07 GO:0015985 energy coupled proton transport, down electrochemical gradient
23.46 5.69e-07 GO:0015986 ATP synthesis coupled proton transport
1.39 3.64e-05 GO:0008152 metabolic process
1.66 7.16e-05 GO:0051179 localization
1.43 7.49e-05 GO:0044237 cellular metabolic process
1.95 3.39e-04 GO:0044281 small molecule metabolic process
2.09 4.23e-04 GO:0009056 catabolic process
2.64 6.18e-04 GO:0042180 cellular ketone metabolic process
2.94 6.19e-04 GO:0044282 small molecule catabolic process
2.61 1.15e-03 GO:0019752 carboxylic acid metabolic process
2.61 1.15e-03 GO:0043436 oxoacid metabolic process
8.19 1.33e-03 GO:0015992 proton transport
7.92 1.79e-03 GO:0006818 hydrogen transport
9.38 1.79e-03 GO:0019395 fatty acid oxidation
9.38 1.79e-03 GO:0034440 lipid oxidation
2.55 1.88e-03 GO:0006082 organic acid metabolic process
20.30 2.70e-03 GO:0042776 mitochondrial ATP synthesis coupled proton transport
3.41 3.61e-03 GO:0032787 monocarboxylic acid metabolic process
3.29 6.15e-03 GO:0015672 monovalent inorganic cation transport
4.35 1.01e-02 GO:0006936 muscle contraction
6.17 1.47e-02 GO:0006839 mitochondrial transport
8.40 1.73e-02 GO:0009062 fatty acid catabolic process
1.18 2.41e-02 GO:0009987 cellular process
3.99 2.51e-02 GO:0003012 muscle system process
5.13 2.59e-02 GO:0009260 ribonucleotide biosynthetic process
9.90 2.65e-02 GO:0006635 fatty acid beta-oxidation
39.58 2.67e-02 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
7.86 2.71e-02 GO:0072329 monocarboxylic acid catabolic process
6.50 3.02e-02 GO:0006754 ATP biosynthetic process
2.17 4.75e-02 GO:0016310 phosphorylation
4.34 4.97e-02 GO:0016054 organic acid catabolic process
4.34 4.97e-02 GO:0046395 carboxylic acid catabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.23 2.85e-36 GO:0044429 mitochondrial part
4.29 7.14e-36 GO:0005739 mitochondrion
9.21 8.54e-33 GO:0005743 mitochondrial inner membrane
7.40 5.04e-32 GO:0031966 mitochondrial membrane
8.61 6.47e-32 GO:0019866 organelle inner membrane
7.08 6.14e-31 GO:0005740 mitochondrial envelope
14.96 2.37e-28 GO:0044455 mitochondrial membrane part
4.74 2.42e-22 GO:0031975 envelope
4.74 5.81e-22 GO:0031967 organelle envelope
1.80 4.86e-20 GO:0044444 cytoplasmic part
17.59 1.23e-19 GO:0070469 respiratory chain
18.17 4.95e-19 GO:0005746 mitochondrial respiratory chain
1.51 2.58e-15 GO:0005737 cytoplasm
2.44 3.70e-14 GO:0031090 organelle membrane
18.95 1.31e-12 GO:0005747 mitochondrial respiratory chain complex I
18.95 1.31e-12 GO:0030964 NADH dehydrogenase complex
18.95 1.31e-12 GO:0045271 respiratory chain complex I
5.07 1.73e-08 GO:0005759 mitochondrial matrix
24.84 7.32e-08 GO:0005753 mitochondrial proton-transporting ATP synthase complex
22.22 2.20e-07 GO:0045259 proton-transporting ATP synthase complex
26.39 8.49e-06 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
1.45 2.67e-05 GO:0044422 organelle part
1.43 1.18e-04 GO:0044446 intracellular organelle part
1.19 1.98e-04 GO:0005622 intracellular
1.32 2.25e-04 GO:0016020 membrane
1.19 2.43e-04 GO:0044424 intracellular part
9.82 2.84e-04 GO:0016469 proton-transporting two-sector ATPase complex
15.08 4.32e-04 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
1.21 4.45e-03 GO:0043229 intracellular organelle
1.21 5.16e-03 GO:0043226 organelle
39.58 6.07e-03 GO:0005749 mitochondrial respiratory chain complex II
39.58 6.07e-03 GO:0045257 succinate dehydrogenase complex (ubiquinone)
39.58 6.07e-03 GO:0045273 respiratory chain complex II
39.58 6.07e-03 GO:0045281 succinate dehydrogenase complex
39.58 6.07e-03 GO:0045283 fumarate reductase complex
9.32 8.69e-03 GO:0042645 mitochondrial nucleoid
9.05 1.03e-02 GO:0009295 nucleoid
31.67 1.50e-02 GO:0005750 mitochondrial respiratory chain complex III
31.67 1.50e-02 GO:0045275 respiratory chain complex III
1.21 2.66e-02 GO:0043231 intracellular membrane-bounded organelle
1.21 2.87e-02 GO:0043227 membrane-bounded organelle
26.39 2.95e-02 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.95 2.04e-14 GO:0016491 oxidoreductase activity
18.54 2.43e-11 GO:0003954 NADH dehydrogenase activity
18.54 2.43e-11 GO:0008137 NADH dehydrogenase (ubiquinone) activity
18.54 2.43e-11 GO:0050136 NADH dehydrogenase (quinone) activity
15.96 2.25e-10 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
9.78 8.95e-09 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
8.71 1.22e-08 GO:0015078 hydrogen ion transmembrane transporter activity
1.57 5.35e-08 GO:0003824 catalytic activity
5.02 7.45e-08 GO:0048037 cofactor binding
5.51 5.93e-07 GO:0015077 monovalent inorganic cation transmembrane transporter activity
4.31 3.37e-05 GO:0022890 inorganic cation transmembrane transporter activity
4.97 4.95e-05 GO:0050662 coenzyme binding
2.62 6.69e-05 GO:0015075 ion transmembrane transporter activity
2.31 1.12e-04 GO:0022892 substrate-specific transporter activity
2.86 1.35e-04 GO:0008324 cation transmembrane transporter activity
4.66 2.79e-04 GO:0009055 electron carrier activity
2.32 2.94e-04 GO:0022857 transmembrane transporter activity
2.37 3.31e-04 GO:0022891 substrate-specific transmembrane transporter activity
21.99 5.40e-04 GO:0048038 quinone binding
52.77 2.16e-03 GO:0048039 ubiquinone binding
9.24 2.88e-03 GO:0016836 hydro-lyase activity
2.00 3.51e-03 GO:0005215 transporter activity
39.58 8.53e-03 GO:0000104 succinate dehydrogenase activity
6.72 2.45e-02 GO:0016835 carbon-oxygen lyase activity
26.39 4.14e-02 GO:0004300 enoyl-CoA hydratase activity
9.78 4.36e-02 GO:0051539 4 iron, 4 sulfur cluster binding