Motif ID: ETS1,2.p2

Z-value: 3.676


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ETS1hg19_v1_chr11_-_128391888_1283920380.714.3e-06Click!
ETS2hg19_v1_chr21_+_40177847_40177907-0.105.8e-01Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_137809710 16.247 NM_002003
 FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr16_+_29674282 12.485 NM_001030288
 SPN
sialophorin
chr3_-_183273407 11.539 NM_130446
 KLHL6
kelch-like 6 (Drosophila)
chrX_+_65235279 11.395


chr10_-_72362513 10.625 NM_001083116
NM_005041
 PRF1

perforin 1 (pore forming protein)

chr16_-_29757264 10.522 NM_175900
 C16orf54
chromosome 16 open reading frame 54
chr13_-_46756295 10.134 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_49838734 9.990 CD37
CD37 molecule
chr10_+_81370694 9.702 NM_001093770
NM_001164644
NM_001164645
NM_001164646
NM_001164647
NM_005411
 SFTPA1





surfactant protein A1





chr19_+_49838700 9.515 CD37
CD37 molecule
chr10_-_72362441 9.425 PRF1
perforin 1 (pore forming protein)
chr7_-_3083346 9.273 NM_032415
 CARD11
caspase recruitment domain family, member 11
chr9_+_137772653 9.227 NM_004108
NM_015837
 FCN2

ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)

chr14_-_94856926 8.885 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
 SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr6_+_31553955 8.836 NM_205838
NM_205839
 LST1

leukocyte specific transcript 1

chr3_+_32993065 8.714 NM_005508
 CCR4
chemokine (C-C motif) receptor 4
chr16_+_29674568 8.652 NM_003123
 SPN
sialophorin
chr19_+_49838673 8.540 NM_001040031
NM_001774
 CD37

CD37 molecule

chr10_+_49893514 8.359 NM_020945
 WDFY4
WDFY family member 4
chr16_+_30483959 8.296 NM_001114380
NM_002209
 ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 166 entries
Enrichment   P-value GO Accession GO Term
20.62 2.51e-02 GO:0045586 regulation of gamma-delta T cell differentiation
20.62 2.51e-02 GO:0045588 positive regulation of gamma-delta T cell differentiation
19.33 2.93e-03 GO:0002532 production of molecular mediator involved in inflammatory response
16.28 1.36e-07 GO:0050853 B cell receptor signaling pathway
12.89 3.72e-02 GO:0002825 regulation of T-helper 1 type immune response
12.89 3.72e-02 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
12.89 3.72e-02 GO:0045577 regulation of B cell differentiation
12.89 3.72e-02 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation
12.74 8.58e-04 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
12.74 8.58e-04 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
12.03 1.37e-03 GO:0002702 positive regulation of production of molecular mediator of immune response
10.92 1.66e-02 GO:0045058 T cell selection
10.55 5.95e-09 GO:0045621 positive regulation of lymphocyte differentiation
10.31 1.67e-04 GO:0046637 regulation of alpha-beta T cell differentiation
10.05 3.32e-07 GO:0045582 positive regulation of T cell differentiation
9.84 6.53e-03 GO:0046638 positive regulation of alpha-beta T cell differentiation
9.84 6.53e-03 GO:0050848 regulation of calcium-mediated signaling
9.77 2.43e-06 GO:0046634 regulation of alpha-beta T cell activation
9.31 1.07e-16 GO:0050851 antigen receptor-mediated signaling pathway
9.17 1.31e-08 GO:0006968 cellular defense response

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
30.93 7.74e-03 GO:0019814 immunoglobulin complex
30.93 7.74e-03 GO:0019815 B cell receptor complex
18.04 5.70e-06 GO:0042101 T cell receptor complex
11.90 8.34e-03 GO:0001772 immunological synapse
7.47 6.95e-03 GO:0008305 integrin complex
6.69 4.47e-03 GO:0032587 ruffle membrane
5.77 2.60e-10 GO:0043235 receptor complex
4.71 8.37e-07 GO:0009897 external side of plasma membrane
4.35 4.77e-02 GO:0031256 leading edge membrane
2.94 1.72e-02 GO:0031252 cell leading edge
2.80 2.63e-05 GO:0009986 cell surface
2.09 1.10e-07 GO:0005887 integral to plasma membrane
2.05 2.61e-07 GO:0031226 intrinsic to plasma membrane
1.93 2.78e-11 GO:0044459 plasma membrane part
1.88 4.63e-24 GO:0071944 cell periphery
1.87 2.61e-23 GO:0005886 plasma membrane
1.41 3.02e-07 GO:0016021 integral to membrane
1.40 3.91e-07 GO:0031224 intrinsic to membrane
1.39 1.41e-12 GO:0016020 membrane
1.38 2.10e-08 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
23.20 1.10e-05 GO:0019864 IgG binding
13.53 1.18e-04 GO:0019865 immunoglobulin binding
10.31 2.96e-02 GO:0008329 pattern recognition receptor activity
10.05 7.54e-08 GO:0003823 antigen binding
7.73 7.34e-07 GO:0004896 cytokine receptor activity
7.14 1.21e-03 GO:0004715 non-membrane spanning protein tyrosine kinase activity
6.31 1.14e-03 GO:0005070 SH3/SH2 adaptor activity
6.30 1.52e-09 GO:0019955 cytokine binding
6.19 1.49e-04 GO:0035591 signaling adaptor activity
4.23 2.01e-07 GO:0005529 sugar binding
3.38 4.71e-02 GO:0030674 protein binding, bridging
2.88 1.31e-05 GO:0030246 carbohydrate binding
2.85 1.71e-03 GO:0032403 protein complex binding
2.73 7.91e-03 GO:0005096 GTPase activator activity
2.58 5.80e-05 GO:0030695 GTPase regulator activity
2.51 1.13e-04 GO:0060589 nucleoside-triphosphatase regulator activity
2.29 1.73e-02 GO:0008047 enzyme activator activity
2.12 1.23e-11 GO:0004872 receptor activity
2.08 4.75e-14 GO:0004871 signal transducer activity
2.08 4.75e-14 GO:0060089 molecular transducer activity