Motif ID: EWSR1-FLI1.p2

Z-value: 1.163


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FLI1hg19_v1_chr11_+_128563955_1285639680.383.2e-02Click!
EWSR1hg19_v1_chr22_+_29663997_29664098-0.038.6e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_1401570 10.511 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chrY_+_1351570 10.161 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr12_-_117175634 5.434 NM_024738
C12orf49
chromosome 12 open reading frame 49
chr11_+_73357222 3.879 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_-_42307661 3.765 NM_000729
CCK
cholecystokinin
chr12_-_117175844 3.441 C12orf49
chromosome 12 open reading frame 49
chrX_-_148586666 2.997 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr19_-_47551881 2.817 NM_017854
TMEM160
transmembrane protein 160
chr5_-_142000899 2.764 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr5_+_175108463 2.714 NM_022304
HRH2
histamine receptor H2
chr9_+_135854097 2.242 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr8_+_133879202 2.119 NM_003235
TG
thyroglobulin
chr8_-_110986923 2.059 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr1_-_31230594 1.984 LAPTM5
lysosomal protein transmembrane 5
chr1_-_169680677 1.978 NM_000655
SELL
selectin L
chr1_-_31230673 1.931 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr5_-_101631965 1.853 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr2_+_37571752 1.831 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr5_+_156887026 1.807 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chrX_+_585078 1.736 NM_000451
NM_006883
SHOX

short stature homeobox

chr18_+_43405544 1.620 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr1_+_167599329 1.613 NM_052862
RCSD1
RCSD domain containing 1
chr4_-_57522059 1.601 HOPX
HOP homeobox
chr22_+_39966757 1.549 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr5_+_152870083 1.541 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr12_-_16759939 1.511 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_226926875 1.497 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr8_+_104152876 1.418 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr20_+_42187705 1.397 SGK2
serum/glucocorticoid regulated kinase 2
chr1_+_248020481 1.351 NM_015431
TRIM58
tripartite motif containing 58
chr12_-_49351263 1.331


chr21_+_45719953 1.313 PFKL
phosphofructokinase, liver
chr1_+_248020607 1.299 TRIM58
tripartite motif containing 58
chr19_-_39826625 1.295 GMFG
glia maturation factor, gamma
chr7_-_99573637 1.258 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr1_+_167599503 1.253 RCSD1
RCSD domain containing 1
chr3_+_115342302 1.242 GAP43
growth associated protein 43
chr12_-_49351297 1.232 ARF3
ADP-ribosylation factor 3
chr2_-_105467912 1.225 LOC100506421
uncharacterized LOC100506421
chr19_-_51472816 1.213 NM_002774
KLK6
kallikrein-related peptidase 6
chr4_-_57522469 1.197 NM_001145459
NM_139211
HOPX

HOP homeobox

chr15_-_79298001 1.197 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr12_-_49351129 1.183 ARF3
ADP-ribosylation factor 3
chr12_+_66583029 1.161 IRAK3
interleukin-1 receptor-associated kinase 3
chr12_-_49351245 1.146 ARF3
ADP-ribosylation factor 3
chr12_-_49351240 1.134 ARF3
ADP-ribosylation factor 3
chr6_+_36916038 1.115 NM_001199159
PI16
peptidase inhibitor 16
chr12_+_66583004 1.110 IRAK3
interleukin-1 receptor-associated kinase 3
chr3_-_192445344 1.082 NM_004113
FGF12
fibroblast growth factor 12
chrY_+_535078 1.025 NM_000451
NM_006883
SHOX

short stature homeobox

chr3_-_192126837 1.005 NM_021032
FGF12
fibroblast growth factor 12
chr18_-_5630629 0.998 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr1_-_152009490 0.967 NM_005620
S100A11
S100 calcium binding protein A11
chr10_-_90611675 0.966 NM_144590
ANKRD22
ankyrin repeat domain 22
chr12_-_49351251 0.956 NM_001659
ARF3
ADP-ribosylation factor 3
chr1_-_152009467 0.943 S100A11
S100 calcium binding protein A11
chr21_+_45719921 0.931 NM_002626
PFKL
phosphofructokinase, liver
chr1_-_152009406 0.925 S100A11
S100 calcium binding protein A11
chr1_+_223889253 0.924 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr19_-_33716609 0.923 NM_019849
SLC7A10
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
chr12_+_90103470 0.915 LOC338758
uncharacterized LOC338758
chr10_+_83637442 0.914 NM_001165973
NRG3
neuregulin 3
chr7_+_36429388 0.908 NM_018685
ANLN
anillin, actin binding protein
chr4_-_85887543 0.900 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr1_-_152009440 0.899 S100A11
S100 calcium binding protein A11
chr1_+_153330329 0.897 NM_002965
S100A9
S100 calcium binding protein A9
chr5_-_81046943 0.896 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr1_-_157069599 0.878 NM_001004341
ETV3L
ets variant 3-like
chrX_+_48644961 0.871 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr1_-_204463512 0.871 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr20_-_62284701 0.871 NM_015894
STMN3
stathmin-like 3
chr11_-_118123001 0.866 NM_198275
MPZL3
myelin protein zero-like 3
chr19_-_11494882 0.865 NM_000121
EPOR
erythropoietin receptor
chr6_-_143266283 0.862 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr11_+_63974190 0.859 FERMT3
fermitin family member 3
chr17_-_73389708 0.858 GRB2
growth factor receptor-bound protein 2
chr21_+_45719964 0.857 PFKL
phosphofructokinase, liver
chr17_+_2497233 0.841 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr9_+_115513050 0.841 NM_001012994
SNX30
sorting nexin family member 30
chr21_+_39628663 0.841 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_130536417 0.793 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr8_-_145701717 0.782 NM_003923
FOXH1
forkhead box H1
chr8_-_145701139 0.773 FOXH1
forkhead box H1
chr19_-_39826676 0.750 NM_004877
GMFG
glia maturation factor, gamma
chr13_+_114145307 0.748 NM_017905
TMCO3
transmembrane and coiled-coil domains 3
chr7_+_8474016 0.722 NXPH1
neurexophilin 1
chr15_-_59041812 0.708 ADAM10
ADAM metallopeptidase domain 10
chr10_+_104221144 0.699 TMEM180
transmembrane protein 180
chr20_+_42187634 0.699 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_233431458 0.695 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr7_+_138482696 0.688 NM_001085429
TMEM213
transmembrane protein 213
chr12_+_10331556 0.686 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr7_+_16793320 0.667 NM_014399
TSPAN13
tetraspanin 13
chr12_+_66582914 0.662 NM_001142523
NM_007199
IRAK3

interleukin-1 receptor-associated kinase 3

chr11_-_2323066 0.649 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr19_-_39368889 0.649 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chrX_-_62974987 0.648 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr11_+_2323236 0.635 NM_139022
TSPAN32
tetraspanin 32
chr3_-_131753757 0.628 NM_130808
CPNE4
copine IV
chr11_-_77122877 0.626 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr7_+_8473584 0.608 NM_152745
NXPH1
neurexophilin 1
chr19_-_17958814 0.608 NM_000215
JAK3
Janus kinase 3
chr7_+_143412938 0.595 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr19_-_6591136 0.571 NM_001252
CD70
CD70 molecule
chr14_-_64009546 0.565 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr7_+_24323806 0.564 NM_000905
NPY
neuropeptide Y
chr19_-_10679620 0.548 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr15_-_59041933 0.537 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chrX_+_56589961 0.537 NM_013444
UBQLN2
ubiquilin 2
chr11_+_10524398 0.536 AMPD3
adenosine monophosphate deaminase 3
chr15_+_41523465 0.515 CHP
calcium binding protein P22
chr2_+_182756665 0.511 SSFA2
sperm specific antigen 2
chr12_+_46123476 0.507 ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr13_+_114145394 0.500 TMCO3
transmembrane and coiled-coil domains 3
chr20_+_2844688 0.493 NM_002836
PTPRA
VPS16
protein tyrosine phosphatase, receptor type, A
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr15_-_59041777 0.487 ADAM10
ADAM metallopeptidase domain 10
chr12_+_57522429 0.487 LRP1
low density lipoprotein receptor-related protein 1
chr4_-_39367905 0.486 NM_001204747
NM_002913
RFC1

replication factor C (activator 1) 1, 145kDa

chr1_-_6546013 0.476 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr4_+_174089889 0.474 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr8_-_22550057 0.470 NM_001199881
EGR3
early growth response 3
chr12_-_49365545 0.468 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr9_+_125796845 0.449 NM_005294
GPR21
G protein-coupled receptor 21
chr11_+_17757494 0.448 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr11_+_62475165 0.429 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr4_+_183065111 0.425 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr19_-_51487070 0.424 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr20_+_62526453 0.419 NM_025219
DNAJC5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr19_-_17958773 0.412 JAK3
Janus kinase 3
chr2_+_182756468 0.409 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr1_-_157670280 0.408 NM_052939
FCRL3
Fc receptor-like 3
chr1_+_110168048 0.407 NM_203404
AMPD2
adenosine monophosphate deaminase 2
chr5_-_148442606 0.405 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr3_+_33155559 0.398 CRTAP
cartilage associated protein
chrX_-_153191686 0.395 ARHGAP4
Rho GTPase activating protein 4
chr19_+_52901101 0.393 NM_032423
ZNF528
zinc finger protein 528
chr19_-_42759279 0.389 NM_006494
ERF
Ets2 repressor factor
chr7_-_138482848 0.386 NM_020632
NM_130840
ATP6V0A4

ATPase, H+ transporting, lysosomal V0 subunit a4

chr3_-_107809754 0.385 NM_001777
NM_198793
CD47

CD47 molecule

chr7_-_127670995 0.379 NM_022143
LRRC4
leucine rich repeat containing 4
chr5_+_175084984 0.373 NM_001131055
HRH2
histamine receptor H2
chr5_+_86563819 0.372


chr12_-_81331487 0.371 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr5_-_71803119 0.369 NM_152625
ZNF366
zinc finger protein 366
chr1_-_87380008 0.369 NM_004261
NM_203341
SEP15

15 kDa selenoprotein

chr12_-_81331449 0.365 LIN7A
lin-7 homolog A (C. elegans)
chr11_+_10476665 0.363 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr11_+_2323356 0.357 TSPAN32
tetraspanin 32
chrX_-_78623006 0.353 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr3_-_50378238 0.352 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chr10_+_104221158 0.341 NM_024789
TMEM180
transmembrane protein 180
chr1_-_173176314 0.339 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr2_+_106361404 0.337 NM_001004722
NM_003581
NCK2

NCK adaptor protein 2

chr6_+_139013551 0.337 FLJ46906
uncharacterized LOC441172
chr11_+_9685650 0.337 SWAP70
SWAP switching B-cell complex 70kDa subunit
chrX_-_153191644 0.337 ARHGAP4
Rho GTPase activating protein 4
chr1_-_26232890 0.335 NM_001145454
NM_005563
STMN1

stathmin 1

chr1_+_202163117 0.335 NM_001017403
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr11_+_10477480 0.334 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr2_-_60780767 0.330 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chrX_+_123095555 0.329 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr5_-_81046858 0.329 SSBP2
single-stranded DNA binding protein 2
chr14_-_94595925 0.326 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr2_-_60780404 0.324 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr2_-_99917638 0.322 NM_174898
LYG1
lysozyme G-like 1
chr10_+_114710785 0.321 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr11_+_63974144 0.319 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr7_-_107204705 0.317 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr5_+_35856990 0.315 NM_002185
IL7R
interleukin 7 receptor
chr3_-_157221362 0.310 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chrX_+_123095598 0.308 STAG2
stromal antigen 2
chr11_+_68857483 0.294


chr6_-_24719286 0.291 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr19_-_4916814 0.287


chr3_-_157221127 0.285 NM_001167911
NM_001167912
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr1_-_47655603 0.283 PDZK1IP1
PDZK1 interacting protein 1
chr16_-_74734687 0.283 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr6_+_26383323 0.281 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr19_-_42759151 0.279 ERF
Ets2 repressor factor
chr1_+_154975201 0.278 NM_001252406
ZBTB7B
zinc finger and BTB domain containing 7B
chr11_+_9685606 0.277 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr12_-_1703330 0.276 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr17_-_34122547 0.274 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr7_-_99527242 0.272 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr22_+_31644314 0.271 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr16_-_2908105 0.270 NM_022119
PRSS22
protease, serine, 22
chr1_+_87380437 0.268 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr14_-_64009971 0.267 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr16_+_12995454 0.266 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr1_+_87380317 0.266 NM_001134492
NM_012262
HS2ST1

heparan sulfate 2-O-sulfotransferase 1

chrX_-_62975005 0.266 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr15_+_41523401 0.256 NM_007236
CHP
calcium binding protein P22
chr11_+_62475113 0.255 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr13_+_47127312 0.254 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr16_-_74640997 0.252 GLG1
golgi glycoprotein 1
chr17_-_8063946 0.251 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr9_-_107666046 0.248 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr12_+_57522247 0.248 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr19_-_6591082 0.244 CD70
CD70 molecule
chr10_+_106014467 0.243 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.