Motif ID: FEV.p2

Z-value: 4.651


Transcription factors associated with FEV.p2:

Gene SymbolEntrez IDGene Name
FEV 54738 FEV (ETS oncogene family)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FEVhg19_v1_chr2_-_219850273_219850378-0.232.0e-01Click!


Activity profile for motif FEV.p2.

activity profile for motif FEV.p2


Sorted Z-values histogram for motif FEV.p2

Sorted Z-values for motif FEV.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FEV.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_198608216 12.503 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_-_72362513 12.366 NM_001083116
NM_005041
 PRF1

perforin 1 (pore forming protein)

chr10_-_72362441 11.538 PRF1
perforin 1 (pore forming protein)
chr1_+_198608244 11.478 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_-_51875790 10.771 NM_005601
 NKG7
natural killer cell group 7 sequence
chr1_-_157789832 10.700 NM_001159397
NM_001159398
NM_052938
 FCRL1


Fc receptor-like 1


chr6_-_32160289 10.636 GPSM3
G-protein signaling modulator 3
chr1_+_198608136 10.450 NM_002838
NM_080921
NM_080923
 PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_-_57871631 10.109 NM_001080156
 ARHGAP9
Rho GTPase activating protein 9
chr8_-_82395401 10.054 NM_001442
 FABP4
fatty acid binding protein 4, adipocyte
chr3_-_183273407 10.009 NM_130446
 KLHL6
kelch-like 6 (Drosophila)
chr19_-_39826625 9.822 GMFG
glia maturation factor, gamma
chr1_-_157522151 9.534 NM_001195388
NM_031281
 FCRL5

Fc receptor-like 5

chr12_-_123201319 9.442 NM_006018
 HCAR3
hydroxycarboxylic acid receptor 3
chr4_+_40198526 9.432 NM_004310
 RHOH
ras homolog gene family, member H
chr6_-_32160637 9.322 GPSM3
G-protein signaling modulator 3
chr7_+_106505739 9.282 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_123187842 8.597 NM_177551
 HCAR2
hydroxycarboxylic acid receptor 2
chr2_+_98330030 8.571 NM_001079
 ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr12_+_69742130 8.335 NM_000239
 LYZ
lysozyme

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 219 entries
Enrichment   P-value GO Accession GO Term
18.57 1.13e-07 GO:0042100 B cell proliferation
18.57 2.32e-04 GO:0043368 positive T cell selection
16.51 6.71e-04 GO:0030889 negative regulation of B cell proliferation
15.64 1.41e-09 GO:0050853 B cell receptor signaling pathway
14.57 3.43e-07 GO:0045058 T cell selection
13.51 3.44e-03 GO:0045061 thymic T cell selection
11.65 2.51e-04 GO:0050869 negative regulation of B cell activation
11.43 1.19e-02 GO:0045086 positive regulation of interleukin-2 biosynthetic process
11.08 4.64e-11 GO:0030888 regulation of B cell proliferation
10.61 6.08e-07 GO:0001910 regulation of leukocyte mediated cytotoxicity
10.61 2.02e-02 GO:0046640 regulation of alpha-beta T cell proliferation
10.20 4.85e-03 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
10.20 4.85e-03 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
9.91 2.29e-09 GO:0045582 positive regulation of T cell differentiation
9.91 3.24e-02 GO:0050854 regulation of antigen receptor-mediated signaling pathway
9.73 1.04e-05 GO:0030890 positive regulation of B cell proliferation
9.63 7.66e-03 GO:0030593 neutrophil chemotaxis
9.59 2.52e-06 GO:0031341 regulation of cell killing
9.57 8.81e-10 GO:0045621 positive regulation of lymphocyte differentiation
9.12 1.17e-02 GO:0045076 regulation of interleukin-2 biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
Enrichment   P-value GO Accession GO Term
24.76 1.71e-02 GO:0019814 immunoglobulin complex
24.76 1.71e-02 GO:0019815 B cell receptor complex
24.76 1.71e-02 GO:0042105 alpha-beta T cell receptor complex
18.57 1.41e-08 GO:0042101 T cell receptor complex
11.43 1.50e-03 GO:0001772 immunological synapse
8.74 9.38e-03 GO:0045335 phagocytic vesicle
5.98 3.19e-02 GO:0008305 integrin complex
5.56 1.02e-12 GO:0009897 external side of plasma membrane
4.25 1.05e-06 GO:0043235 receptor complex
4.02 9.96e-03 GO:0022626 cytosolic ribosome
3.50 1.13e-02 GO:0005925 focal adhesion
3.33 1.96e-02 GO:0005924 cell-substrate adherens junction
3.21 2.97e-02 GO:0030055 cell-substrate junction
2.99 2.40e-08 GO:0009986 cell surface
2.93 1.13e-02 GO:0044445 cytosolic part
2.85 2.69e-02 GO:0045121 membrane raft
2.14 7.25e-11 GO:0005887 integral to plasma membrane
2.10 2.29e-10 GO:0031226 intrinsic to plasma membrane
1.90 1.92e-13 GO:0044459 plasma membrane part
1.90 7.43e-04 GO:0005615 extracellular space

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
Enrichment   P-value GO Accession GO Term
24.76 2.69e-02 GO:0004911 interleukin-2 receptor activity
24.76 2.69e-02 GO:0019976 interleukin-2 binding
8.26 8.76e-07 GO:0004715 non-membrane spanning protein tyrosine kinase activity
8.08 7.16e-08 GO:0008009 chemokine activity
8.05 1.25e-06 GO:0003823 antigen binding
7.77 3.41e-08 GO:0042379 chemokine receptor binding
7.54 9.78e-03 GO:0001608 nucleotide receptor activity, G-protein coupled
7.54 9.78e-03 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
7.43 4.18e-02 GO:0001637 G-protein chemoattractant receptor activity
7.43 4.18e-02 GO:0004950 chemokine receptor activity
5.56 1.29e-03 GO:0005070 SH3/SH2 adaptor activity
5.37 2.54e-04 GO:0035591 signaling adaptor activity
3.96 2.21e-08 GO:0005125 cytokine activity
3.85 3.58e-07 GO:0005126 cytokine receptor binding
3.67 2.82e-03 GO:0019955 cytokine binding
3.60 3.58e-03 GO:0017124 SH3 domain binding
3.52 5.33e-06 GO:0005529 sugar binding
3.33 9.85e-03 GO:0030674 protein binding, bridging
3.12 2.22e-02 GO:0060090 binding, bridging
2.98 3.89e-05 GO:0005096 GTPase activator activity