Motif ID: FOSL2.p2

Z-value: 2.486


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOSL2hg19_v1_chr2_+_28615771_28615794-0.057.8e-01Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_23040394 19.818 IGL@
immunoglobulin lambda locus
chr2_-_89292396 17.226 IGKC
immunoglobulin kappa constant
chr2_-_89513056 16.964 IGKC
immunoglobulin kappa constant
chr2_-_89442551 15.739 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr22_+_22735134 14.744 CYAT1
immunoglobulin lambda light chain-like
chr22_+_22735207 13.523 IGLJ3
immunoglobulin lambda joining 3
chr22_+_23063107 12.857 IGLJ3
immunoglobulin lambda joining 3
chr22_+_22758538 12.809


chr22_+_22735202 12.484


chr2_-_89619820 11.605 IGKC
immunoglobulin kappa constant
chr22_+_22723972 11.518


chr22_+_22569155 11.261


chr22_+_23165273 11.182


chr17_-_38721701 10.535 NM_001838
 CCR7
chemokine (C-C motif) receptor 7
chr7_+_73245192 9.918 NM_001305
 CLDN4
claudin 4
chr2_+_90077732 9.045


chr16_+_31366529 8.865 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr22_+_23029175 8.317 IGLV3-25
immunoglobulin lambda variable 3-25
chr4_-_71532341 8.268 NM_144646
 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr16_+_31366468 8.105 NM_000887
 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 84 entries
Enrichment   P-value GO Accession GO Term
38.97 3.50e-02 GO:0071731 response to nitric oxide
7.91 3.28e-02 GO:0032680 regulation of tumor necrosis factor production
6.41 1.37e-02 GO:0050671 positive regulation of lymphocyte proliferation
6.32 1.53e-02 GO:0032946 positive regulation of mononuclear cell proliferation
6.24 1.71e-02 GO:0070665 positive regulation of leukocyte proliferation
6.00 9.68e-04 GO:0070663 regulation of leukocyte proliferation
5.85 2.90e-02 GO:0006959 humoral immune response
5.78 1.76e-08 GO:0051249 regulation of lymphocyte activation
5.72 4.51e-03 GO:0050670 regulation of lymphocyte proliferation
5.71 3.73e-06 GO:0051251 positive regulation of lymphocyte activation
5.66 4.97e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
5.66 4.97e-03 GO:0032944 regulation of mononuclear cell proliferation
5.64 2.51e-04 GO:0032496 response to lipopolysaccharide
5.57 4.31e-02 GO:0050730 regulation of peptidyl-tyrosine phosphorylation
5.49 1.32e-04 GO:0002237 response to molecule of bacterial origin
5.47 2.60e-03 GO:0042110 T cell activation
5.45 7.28e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
5.43 4.03e-04 GO:0050870 positive regulation of T cell activation
5.32 1.15e-05 GO:0002696 positive regulation of leukocyte activation
5.32 2.94e-05 GO:0050863 regulation of T cell activation

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
3.46 2.87e-05 GO:0031012 extracellular matrix
3.40 4.13e-04 GO:0005578 proteinaceous extracellular matrix
2.93 8.15e-08 GO:0005615 extracellular space
2.90 2.71e-10 GO:0044421 extracellular region part
2.40 4.45e-13 GO:0005576 extracellular region
2.25 8.50e-06 GO:0031226 intrinsic to plasma membrane
2.25 1.21e-05 GO:0005887 integral to plasma membrane
1.89 8.30e-06 GO:0044459 plasma membrane part
1.64 5.17e-07 GO:0005886 plasma membrane
1.61 1.28e-06 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
14.85 3.56e-02 GO:0030228 lipoprotein particle receptor activity
13.86 4.78e-02 GO:0005161 platelet-derived growth factor receptor binding
13.86 4.78e-02 GO:0008329 pattern recognition receptor activity
12.99 9.69e-07 GO:0003823 antigen binding
9.17 1.52e-04 GO:0042379 chemokine receptor binding
9.04 7.43e-04 GO:0008009 chemokine activity
5.78 3.55e-04 GO:0019955 cytokine binding
4.62 1.32e-04 GO:0005126 cytokine receptor binding
4.38 2.74e-04 GO:0005529 sugar binding
4.02 1.73e-03 GO:0005125 cytokine activity
3.56 1.44e-05 GO:0030246 carbohydrate binding
2.07 5.64e-03 GO:0005102 receptor binding
1.91 3.66e-04 GO:0004872 receptor activity