Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 2.377


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOSL1hg19_v1_chr11_-_65667858_656678590.803.4e-08Click!
JUNDhg19_v1_chr19_-_18392048_183921630.541.3e-03Click!
JUNBhg19_v1_chr19_+_12902295_129023320.402.4e-02Click!
FOSBhg19_v1_chr19_+_45971249_459712900.327.2e-02Click!
FOShg19_v1_chr14_+_75745480_757456850.222.3e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_73245192 17.168 NM_001305
 CLDN4
claudin 4
chr2_+_170366211 15.828 NM_006063
 KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr8_-_82395401 14.649 NM_001442
 FABP4
fatty acid binding protein 4, adipocyte
chr10_-_76868853 12.299 NM_001007271
NM_001007272
NM_001007273
 DUSP13


dual specificity phosphatase 13


chr17_-_39768939 10.936 NM_005557
 KRT16
keratin 16
chr13_-_38172862 10.730 NM_001135934
NM_001135935
NM_001135936
NM_006475
 POSTN



periostin, osteoblast specific factor



chr5_+_150020201 10.472 NM_001109974
NM_007286
 SYNPO

synaptopodin

chr11_-_102714240 9.896 NM_002422
 MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr18_+_21452981 9.575 NM_000227
NM_001127718
 LAMA3

laminin, alpha 3

chr10_-_88730928 9.419 LOC100133190
uncharacterized LOC100133190
chr3_-_9920633 8.781 NM_022094
 CIDEC
cell death-inducing DFFA-like effector c
chr2_+_27505296 8.774 NM_032546
NM_187841
 TRIM54

tripartite motif containing 54

chr12_+_13349601 8.690 NM_001423
 EMP1
epithelial membrane protein 1
chr12_+_13349716 8.596 EMP1
epithelial membrane protein 1
chr11_+_394199 8.455 NM_007183
 PKP3
plakophilin 3
chr1_-_95007139 8.409 NM_001178096
NM_001993
 F3

coagulation factor III (thromboplastin, tissue factor)

chrX_+_99899162 8.203 NM_014467
 SRPX2
sushi-repeat containing protein, X-linked 2
chr7_+_30960914 7.816 NM_001185060
NM_001185061
NM_001185062
 AQP1


aquaporin 1 (Colton blood group)


chr1_+_183155393 7.815 LAMC2
laminin, gamma 2
chr1_+_183155173 7.646 NM_005562
NM_018891
 LAMC2

laminin, gamma 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 37 entries
Enrichment   P-value GO Accession GO Term
20.15 3.42e-03 GO:0031581 hemidesmosome assembly
12.67 1.91e-04 GO:0032963 collagen metabolic process
12.67 7.52e-03 GO:0030574 collagen catabolic process
11.82 3.45e-04 GO:0044259 multicellular organismal macromolecule metabolic process
10.64 2.27e-02 GO:0018149 peptide cross-linking
9.85 1.59e-03 GO:0044236 multicellular organismal metabolic process
9.85 3.66e-02 GO:0044243 multicellular organismal catabolic process
9.50 4.65e-04 GO:0031424 keratinization
6.93 2.27e-03 GO:0030216 keratinocyte differentiation
6.59 1.14e-03 GO:0009913 epidermal cell differentiation
6.07 2.47e-10 GO:0008544 epidermis development
4.28 7.69e-03 GO:0030335 positive regulation of cell migration
4.28 7.69e-03 GO:2000147 positive regulation of cell motility
4.14 1.14e-02 GO:0040017 positive regulation of locomotion
4.01 1.66e-02 GO:0051272 positive regulation of cellular component movement
3.62 2.80e-02 GO:0007517 muscle organ development
3.08 3.75e-02 GO:0061061 muscle structure development
3.01 1.93e-02 GO:0001501 skeletal system development
2.91 9.41e-09 GO:0009888 tissue development
2.81 2.07e-02 GO:0060429 epithelium development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
Enrichment   P-value GO Accession GO Term
19.70 6.42e-03 GO:0043256 laminin complex
19.00 7.02e-08 GO:0001533 cornified envelope
11.67 1.12e-02 GO:0030057 desmosome
7.39 2.35e-03 GO:0031674 I band
7.06 1.64e-08 GO:0044449 contractile fiber part
7.00 4.16e-02 GO:0030018 Z disc
6.50 2.11e-07 GO:0030016 myofibril
6.49 6.92e-08 GO:0043292 contractile fiber
6.33 9.04e-06 GO:0030017 sarcomere
5.10 3.54e-04 GO:0044420 extracellular matrix part
4.35 3.27e-09 GO:0005578 proteinaceous extracellular matrix
4.05 2.05e-09 GO:0031012 extracellular matrix
3.49 2.13e-02 GO:0070161 anchoring junction
3.39 8.83e-03 GO:0005911 cell-cell junction
2.61 5.55e-09 GO:0044421 extracellular region part
2.26 5.44e-04 GO:0005615 extracellular space
2.14 1.75e-10 GO:0005576 extracellular region
2.10 7.61e-07 GO:0005856 cytoskeleton
1.52 4.65e-02 GO:0044459 plasma membrane part
1.43 1.55e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
5.62 8.77e-03 GO:0005200 structural constituent of cytoskeleton
2.47 8.17e-04 GO:0005198 structural molecule activity