Motif ID: FOX{C1,C2}.p2

Z-value: 1.744


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXC2hg19_v1_chr16_+_86600856_866008560.192.9e-01Click!
FOXC1hg19_v1_chr6_+_1610680_16106800.125.1e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_64225496 9.099 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_+_138612894 7.780 NM_000133
F9
coagulation factor IX
chr9_-_104198045 7.710 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr14_+_95047758 7.367 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr2_+_74120132 6.940 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_74120092 6.789 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr14_+_95047730 6.379 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_+_74281884 6.216 ALB
albumin
chr12_+_100867550 5.961 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr2_+_189839078 5.116 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_234621637 4.717 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr4_-_100140330 4.614 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr2_+_189839113 4.473 COL3A1
collagen, type III, alpha 1
chr3_-_149095413 4.462 TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095333 4.378 TM4SF1
transmembrane 4 L six family member 1
chr10_+_7745325 4.311 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_+_234637772 4.195 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr10_+_7745341 4.009 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_+_100867739 3.966 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr2_+_189839132 3.921 COL3A1
collagen, type III, alpha 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
157.83 2.74e-02 GO:0001915 negative regulation of T cell mediated cytotoxicity
10.69 1.12e-04 GO:0006805 xenobiotic metabolic process
10.69 1.12e-04 GO:0071466 cellular response to xenobiotic stimulus
10.61 1.20e-04 GO:0009410 response to xenobiotic stimulus
7.22 8.68e-04 GO:0008202 steroid metabolic process
3.84 2.24e-02 GO:0042060 wound healing
2.41 1.31e-03 GO:0042221 response to chemical stimulus
1.67 1.28e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
19.74 4.92e-02 GO:0034364 high-density lipoprotein particle
8.01 2.96e-03 GO:0009897 external side of plasma membrane
6.20 5.70e-05 GO:0005578 proteinaceous extracellular matrix
6.13 6.86e-06 GO:0031012 extracellular matrix
5.20 3.60e-04 GO:0009986 cell surface
3.27 2.58e-04 GO:0044421 extracellular region part
2.99 6.92e-08 GO:0005576 extracellular region
2.18 5.16e-03 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
Enrichment   P-value GO Accession GO Term
157.83 6.53e-03 GO:0018675 (S)-limonene 6-monooxygenase activity
157.83 6.53e-03 GO:0018676 (S)-limonene 7-monooxygenase activity
157.83 6.53e-03 GO:0019113 limonene monooxygenase activity
157.83 6.53e-03 GO:0033767 4-hydroxyacetophenone monooxygenase activity
67.65 1.39e-03 GO:0031210 phosphatidylcholine binding
47.36 4.71e-03 GO:0050997 quaternary ammonium group binding
29.60 2.14e-02 GO:0008395 steroid hydroxylase activity
17.55 1.51e-03 GO:0019825 oxygen binding
17.07 1.40e-02 GO:0005504 fatty acid binding
14.10 4.48e-03 GO:0004896 cytokine receptor activity
14.10 4.48e-03 GO:0033293 monocarboxylic acid binding
10.89 3.04e-03 GO:0004867 serine-type endopeptidase inhibitor activity
10.33 8.46e-04 GO:0019838 growth factor binding
8.78 1.04e-02 GO:0019955 cytokine binding
7.42 7.32e-03 GO:0031406 carboxylic acid binding
5.23 9.35e-03 GO:0004857 enzyme inhibitor activity
4.55 2.10e-03 GO:0008289 lipid binding
4.33 1.74e-02 GO:0030246 carbohydrate binding