Motif ID: FOXA2.p3

Z-value: 2.624


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
FOXA2 3170 forkhead box A2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXA2hg19_v1_chr20_-_22565050_225651000.682.0e-05Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_26697224 18.557 VTN
vitronectin
chr17_-_26697310 16.880 VTN
vitronectin
chr1_-_57431620 15.620 NM_000066
 C8B
complement component 8, beta polypeptide
chr17_-_26697358 13.182 NM_000638
 VTN
vitronectin
chr17_-_26697293 12.495 VTN
vitronectin
chr17_-_64225496 11.786 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_-_6462129 11.559 NM_000613
 HPX
hemopexin
chr2_-_21225640 11.366 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_-_72671236 10.426 NM_001204306
 GC
group-specific component (vitamin D binding protein)
chr1_+_207277577 10.354 NM_000715
 C4BPA
complement component 4 binding protein, alpha
chr11_-_116663106 10.112 NM_001166598
NM_052968
 APOA5

apolipoprotein A-V

chr4_-_70361578 10.050 NM_021139
 UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr22_+_21128378 9.950 NM_000185
 SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr3_+_52811601 9.881 NM_002215
 ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr2_-_21230572 9.608 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_+_51549552 9.580 NM_002443
NM_138634
 MSMB

microseminoprotein, beta-

chr4_+_187148624 9.507 NM_000892
 KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr6_+_131148544 9.291 NM_001195597
 LOC100507203
uncharacterized LOC100507203
chr10_-_54531394 9.241 NM_000242
 MBL2
mannose-binding lectin (protein C) 2, soluble
chr3_-_148939784 9.192 NM_000096
 CP
ceruloplasmin (ferroxidase)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 51 entries
Enrichment   P-value GO Accession GO Term
39.83 3.04e-02 GO:0009804 coumarin metabolic process
39.83 3.04e-02 GO:0031639 plasminogen activation
39.83 3.04e-02 GO:0051919 positive regulation of fibrinolysis
23.24 8.86e-06 GO:0015721 bile acid and bile salt transport
19.31 4.25e-02 GO:0006067 ethanol metabolic process
19.31 4.25e-02 GO:0006069 ethanol oxidation
19.31 4.25e-02 GO:0009698 phenylpropanoid metabolic process
19.31 4.25e-02 GO:0034308 primary alcohol metabolic process
15.93 1.51e-03 GO:0072378 blood coagulation, fibrin clot formation
15.62 1.36e-02 GO:0007597 blood coagulation, intrinsic pathway
15.18 3.68e-05 GO:0030195 negative regulation of blood coagulation
14.65 5.00e-05 GO:0050819 negative regulation of coagulation
14.36 1.21e-06 GO:0008206 bile acid metabolic process
13.28 4.93e-03 GO:0017144 drug metabolic process
13.06 3.36e-10 GO:0072376 protein activation cascade
11.80 1.04e-02 GO:0019439 aromatic compound catabolic process
11.38 7.75e-05 GO:0006956 complement activation
10.90 6.08e-04 GO:0030193 regulation of blood coagulation
10.28 2.42e-02 GO:0006958 complement activation, classical pathway
10.12 1.11e-03 GO:0050818 regulation of coagulation

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
17.70 9.70e-03 GO:0042627 chylomicron
11.24 4.65e-07 GO:0031983 vesicle lumen
10.62 4.45e-06 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
10.17 3.37e-05 GO:0031093 platelet alpha granule lumen
9.96 4.08e-05 GO:0034774 secretory granule lumen
9.32 1.66e-05 GO:0031091 platelet alpha granule
4.77 5.94e-07 GO:0005792 microsome
4.71 5.22e-11 GO:0031012 extracellular matrix
4.69 4.59e-09 GO:0005578 proteinaceous extracellular matrix
4.61 1.09e-06 GO:0042598 vesicular fraction
4.25 2.17e-04 GO:0030141 stored secretory granule
3.84 6.18e-21 GO:0044421 extracellular region part
3.78 5.70e-15 GO:0005615 extracellular space
3.25 1.24e-03 GO:0044433 cytoplasmic vesicle part
2.93 1.82e-23 GO:0005576 extracellular region
2.29 1.34e-03 GO:0005624 membrane fraction
2.22 2.60e-03 GO:0005626 insoluble fraction
2.09 3.39e-02 GO:0044432 endoplasmic reticulum part
2.05 2.02e-03 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
26.56 4.10e-02 GO:0051636 Gram-negative bacterial cell surface binding
16.60 2.70e-03 GO:0051635 bacterial cell surface binding
15.18 1.02e-05 GO:0015020 glucuronosyltransferase activity
14.16 4.60e-02 GO:0008514 organic anion transmembrane transporter activity
12.07 2.13e-06 GO:0043498 cell surface binding
10.22 3.49e-02 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
7.29 1.42e-02 GO:0003707 steroid hormone receptor activity
6.89 2.07e-02 GO:0004879 ligand-dependent nuclear receptor activity
6.11 1.69e-03 GO:0004867 serine-type endopeptidase inhibitor activity
5.42 3.67e-05 GO:0005539 glycosaminoglycan binding
5.01 1.03e-04 GO:0001871 pattern binding
5.01 1.03e-04 GO:0030247 polysaccharide binding
4.79 1.47e-02 GO:0008201 heparin binding
4.75 6.55e-03 GO:0043176 amine binding
4.64 1.53e-03 GO:0031406 carboxylic acid binding
4.00 3.18e-02 GO:0004866 endopeptidase inhibitor activity
3.85 4.56e-02 GO:0061135 endopeptidase regulator activity
3.49 3.49e-05 GO:0030246 carbohydrate binding
3.13 1.88e-02 GO:0004857 enzyme inhibitor activity
2.93 1.34e-03 GO:0008289 lipid binding