Motif ID: GATA6.p2

Z-value: 2.273


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA6hg19_v1_chr18_+_19749403_197495500.281.2e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_116708334 8.393 NM_000039
APOA1
apolipoprotein A-I
chr10_-_99531712 7.782 NM_003015
SFRP5
secreted frizzled-related protein 5
chr4_+_155484131 7.218 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr2_+_102927961 7.003 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr3_+_148583042 6.807 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr7_-_100239136 6.703 NM_003227
TFR2
transferrin receptor 2
chr8_-_86290333 6.530 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr12_-_54689536 6.398 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_-_27240430 6.106 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr10_-_48416692 5.854 NM_016204
GDF2
growth differentiation factor 2
chr17_+_4675175 5.547 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr17_-_64225496 5.181 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_+_7741934 5.129 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr11_-_47374221 4.892 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr2_-_44065888 4.735 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_88427535 4.626 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_+_75428864 4.578 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr9_-_100700422 4.523 NM_197978
HEMGN
hemogen
chr12_-_70004941 4.466 NM_201550
LRRC10
leucine rich repeat containing 10
chr2_-_69098502 4.372 NM_014482
BMP10
bone morphogenetic protein 10
chr6_-_30128688 4.325 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr2_-_40739570 4.273 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_199996729 4.197 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr2_+_241808161 4.155 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chr16_+_31539202 4.061 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr14_-_65409445 4.033 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr14_-_94849552 3.990 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr4_+_100495972 3.905 MTTP
microsomal triglyceride transfer protein
chr12_+_69742130 3.824 NM_000239
LYZ
lysozyme
chr3_-_187009469 3.779 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chrX_-_55057408 3.717 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr3_+_137717657 3.632 NM_001002026
CLDN18
claudin 18
chr2_+_44066102 3.541 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr6_-_49604524 3.485 NM_000324
RHAG
Rh-associated glycoprotein
chr19_-_48389514 3.411 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr9_+_97521930 3.247 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr18_+_19749403 3.219 NM_005257
GATA6
GATA binding protein 6
chr3_+_186383770 3.200 NM_000412
HRG
histidine-rich glycoprotein
chr12_-_120765555 3.126 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr3_-_52864687 3.052 NM_001166449
NM_002218
ITIH4

inter-alpha-trypsin inhibitor heavy chain family, member 4

chr19_-_48389571 3.011 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chrX_+_65235279 2.987


chr4_-_74853819 2.976 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr7_-_99381703 2.965 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr12_-_14996381 2.918 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr20_+_43029865 2.870 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr10_-_129691047 2.863


chrX_+_106161589 2.812 NM_001171095
CLDN2
claudin 2
chr6_-_49712055 2.778 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chrX_-_105282714 2.776 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr6_+_31674639 2.764 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr19_-_55668956 2.762 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr4_+_69962191 2.756 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr13_+_24144402 2.742 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr12_-_96390002 2.698 NM_002108
HAL
histidine ammonia-lyase
chr16_-_67977956 2.692 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr10_-_52645430 2.669 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr19_+_10397642 2.641 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr16_-_53405040 2.641 NM_001207030
LOC643802
u3 small nucleolar ribonucleoprotein protein MPP10-like
chr7_-_44180911 2.624 NM_021223
MYL7
myosin, light chain 7, regulatory
chr2_+_90077732 2.616


chr9_-_71590754 2.597


chr10_-_129691202 2.574 NM_152311
CLRN3
clarin 3
chr12_-_114841702 2.526 NM_080718
TBX5
T-box 5
chr1_+_202431870 2.518 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr19_-_48547180 2.454 NM_019855
CABP5
calcium binding protein 5
chr16_-_20338808 2.429 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr4_+_78432905 2.421 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr18_-_64271215 2.415 NM_021153
CDH19
cadherin 19, type 2
chr2_-_89442551 2.405 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr2_-_21225640 2.359 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_+_71560022 2.348 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr4_-_72649734 2.316 NM_000583
GC
group-specific component (vitamin D binding protein)
chr2_+_234526290 2.281 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr5_-_135290521 2.271 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr16_+_27341305 2.268 IL4R
interleukin 4 receptor
chr4_+_169013687 2.244 NM_007193
ANXA10
annexin A10
chr2_+_113885145 2.224 IL1RN
interleukin 1 receptor antagonist
chr12_-_10562744 2.208 NM_001199805
KLRC4-KLRK1
KLRC4-KLRK1 readthrough
chr20_+_43029973 2.204 HNF4A
hepatocyte nuclear factor 4, alpha
chr4_-_144940439 2.199 NM_002100
GYPB
glycophorin B (MNS blood group)
chr2_-_179914785 2.149 NM_173648
CCDC141
coiled-coil domain containing 141
chr19_-_39303520 2.121 LGALS4
lectin, galactoside-binding, soluble, 4
chr12_+_113344738 2.114 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr12_+_113344811 2.106 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr5_+_156607847 2.101 NM_005546
ITK
IL2-inducible T-cell kinase
chr12_+_8666135 2.073 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr1_+_63063186 2.072 NM_014495
ANGPTL3
angiopoietin-like 3
chr3_+_108541544 2.067 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr16_-_89043215 2.063 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr12_+_9980076 2.028 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr18_-_28742744 2.023 NM_004948
NM_024421
DSC1

desmocollin 1

chr1_-_120354058 1.977 NM_001159352
NM_001159353
NM_032044
REG4


regenerating islet-derived family, member 4


chr16_-_67978422 1.964 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr4_+_68424444 1.959 NM_012108
STAP1
signal transducing adaptor family member 1
chr12_-_10542616 1.956 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr3_+_46395574 1.954 CCR2
chemokine (C-C motif) receptor 2
chr2_-_216248184 1.951 FN1
fibronectin 1
chr7_-_99332715 1.951 NM_000765
CYP3A7
CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 7
cytochrome P450, family 3, subfamily A, polypeptide 5
chr5_+_145316120 1.874 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr22_+_23229959 1.866 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr19_+_35940616 1.850 NM_005306
FFAR2
free fatty acid receptor 2
chr19_+_15751706 1.841 NM_000896
NM_001199208
NM_001199209
CYP4F3


cytochrome P450, family 4, subfamily F, polypeptide 3


chr9_-_95244634 1.812 ASPN
asporin
chr2_+_138721807 1.801 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr4_-_100140330 1.789 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr11_-_57158103 1.781 NM_001243245
NM_002728
PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

chr5_-_176935877 1.718 DOK3
docking protein 3
chr13_+_31309644 1.717 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_+_90211704 1.712


chr11_+_10326618 1.706 NM_001124
ADM
adrenomedullin
chr19_-_13213973 1.704 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr19_-_12997956 1.687 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr15_+_49715374 1.678 NM_002009
FGF7
fibroblast growth factor 7
chr3_-_137851123 1.667 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr17_-_3819692 1.656 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr2_+_211458078 1.645 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr9_+_33240165 1.641 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr22_-_37545944 1.638 NM_000878
IL2RB
interleukin 2 receptor, beta
chr21_-_35899046 1.635 NM_203418
RCAN1
regulator of calcineurin 1
chr8_+_120079423 1.601 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr9_+_118916069 1.592 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr9_+_35673852 1.587 NM_001216
CA9
carbonic anhydrase IX
chr19_-_39303739 1.556 NM_006149
LGALS4
lectin, galactoside-binding, soluble, 4
chr8_+_76452202 1.515 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr2_+_234637772 1.514 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr1_+_26644458 1.508 CD52
CD52 molecule
chr1_-_120311466 1.502 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr10_-_52645384 1.477 A1CF
APOBEC1 complementation factor
chrX_-_15402469 1.470 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr8_+_22019167 1.465 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr17_-_3819959 1.422 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr4_-_70626429 1.412 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr13_-_28543423 1.410 CDX2
caudal type homeobox 2
chr18_+_3447607 1.396 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr8_-_20040612 1.395 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr1_+_154293568 1.373 NM_080429
AQP10
aquaporin 10
chr13_-_28543143 1.367 CDX2
caudal type homeobox 2
chr22_+_22550159 1.355 IGLV6-57
immunoglobulin lambda variable 6-57
chr1_+_26644380 1.350 NM_001803
CD52
CD52 molecule
chr20_+_43835637 1.349 NM_003007
SEMG1
semenogelin I
chr15_-_50558161 1.324 NM_002112
HDC
histidine decarboxylase
chr17_-_39092714 1.315 KRT23
keratin 23 (histone deacetylase inducible)
chr11_+_71927818 1.315 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr6_-_52668599 1.309 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr19_-_13213513 1.303 LYL1
lymphoblastic leukemia derived sequence 1
chrX_+_106163605 1.296 NM_020384
CLDN2
claudin 2
chr14_+_76071804 1.295 NM_001195283
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr20_+_31870940 1.290 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr12_-_121476770 1.280 NM_003733
NM_198213
OASL

2'-5'-oligoadenylate synthetase-like

chr8_+_124194751 1.279 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr5_-_35048239 1.274 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr11_-_5255712 1.274 NM_000519
HBD
hemoglobin, delta
chr1_+_192127591 1.260 NM_130782
RGS18
regulator of G-protein signaling 18
chr11_+_118754474 1.253 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr17_-_73840495 1.250 UNC13D
unc-13 homolog D (C. elegans)
chr11_+_59856136 1.250 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr1_-_157811491 1.248 NM_005894
CD5L
CD5 molecule-like
chr7_-_76829109 1.243 NM_006682
FGL2
fibrinogen-like 2
chr19_-_11494882 1.238 NM_000121
EPOR
erythropoietin receptor
chr1_-_11907741 1.231 NM_006172
NPPA
natriuretic peptide A
chr4_+_151503076 1.229 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr1_+_206317458 1.226 NM_001910
NM_148964
CTSE

cathepsin E

chr6_-_2840683 1.219 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr12_-_53600999 1.218 NM_000889
ITGB7
integrin, beta 7
chr9_-_97402556 1.212 FBP1
fructose-1,6-bisphosphatase 1
chr3_+_100328432 1.211 NM_032787
GPR128
G protein-coupled receptor 128
chr5_+_179220985 1.209 NM_145867
LTC4S
leukotriene C4 synthase
chr17_-_73840587 1.207 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr11_+_63974190 1.205 FERMT3
fermitin family member 3
chr8_-_143833924 1.205 NM_205545
LYPD2
LY6/PLAUR domain containing 2
chr9_+_125137600 1.203 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_-_168513201 1.193 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr4_-_76928601 1.192 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr10_+_7745354 1.192 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_128779609 1.183 NM_000174
GP9
glycoprotein IX (platelet)
chr14_-_107013122 1.180 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_119379269 1.179 NM_022135
POPDC2
popeye domain containing 2
chr21_+_43823970 1.178 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chr11_-_115088628 1.160 CADM1
cell adhesion molecule 1
chr3_-_42917632 1.142 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr19_-_40228611 1.128 NM_001828
CLC
Charcot-Leyden crystal protein
chr10_+_7745284 1.127 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr13_-_28543290 1.126 NM_001265
CDX2
caudal type homeobox 2
chrX_+_135730335 1.124 NM_000074
CD40LG
CD40 ligand
chr1_+_168545710 1.122 NM_002995
XCL1
chemokine (C motif) ligand 1
chr21_-_35828038 1.119 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr20_-_7921068 1.117 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_+_74606222 1.113 NM_000584
IL8
interleukin 8
chr10_+_70847857 1.111 SRGN
serglycin
chrX_+_44703248 1.100 NM_022076
DUSP21
dual specificity phosphatase 21
chr1_-_173886464 1.080 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chrX_+_38211735 1.077 NM_000531
OTC
ornithine carbamoyltransferase
chr2_-_188419049 1.075 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr6_+_118869441 1.066 NM_002667
PLN
phospholamban
chr6_-_133078894 1.063 NM_001242350
NM_004665
VNN2

vanin 2

chr16_+_202853 1.057 NM_005332
HBZ
hemoglobin, zeta
chr14_-_94854910 1.045 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr22_+_23213671 1.037 IGLV4-3
immunoglobulin lambda variable 4-3
chr4_+_39408541 1.028 KLB
klotho beta

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.37 2.30e-11 GO:0009611 response to wounding
2.83 1.02e-10 GO:0065008 regulation of biological quality
2.74 2.50e-10 GO:0042221 response to chemical stimulus
2.61 1.18e-09 GO:0006950 response to stress
1.79 1.22e-09 GO:0050896 response to stimulus
3.28 6.25e-08 GO:0002376 immune system process
3.68 7.24e-08 GO:0006629 lipid metabolic process
3.63 2.06e-07 GO:0070887 cellular response to chemical stimulus
3.77 7.12e-07 GO:0006952 defense response
4.30 8.75e-07 GO:0048878 chemical homeostasis
3.63 8.78e-07 GO:0042592 homeostatic process
9.38 1.42e-06 GO:0006805 xenobiotic metabolic process
9.38 1.42e-06 GO:0071466 cellular response to xenobiotic stimulus
9.31 1.56e-06 GO:0009410 response to xenobiotic stimulus
4.71 1.86e-06 GO:0007596 blood coagulation
4.71 1.86e-06 GO:0050817 coagulation
4.68 2.11e-06 GO:0007599 hemostasis
1.52 3.62e-06 GO:0065007 biological regulation
12.80 5.78e-06 GO:0002576 platelet degranulation
4.13 9.31e-06 GO:0042060 wound healing
3.27 9.52e-06 GO:0032879 regulation of localization
6.55 1.10e-05 GO:0030168 platelet activation
4.43 1.28e-05 GO:0001775 cell activation
5.78 2.08e-05 GO:0006954 inflammatory response
4.10 2.34e-05 GO:0050878 regulation of body fluid levels
4.53 4.77e-05 GO:0046903 secretion
1.69 5.30e-05 GO:0032501 multicellular organismal process
2.43 7.13e-05 GO:0044281 small molecule metabolic process
3.69 7.45e-05 GO:0044255 cellular lipid metabolic process
6.14 7.82e-05 GO:0008202 steroid metabolic process
2.78 7.91e-05 GO:0010033 response to organic substance
5.23 8.38e-05 GO:0032787 monocarboxylic acid metabolic process
3.53 1.69e-04 GO:0019752 carboxylic acid metabolic process
3.53 1.69e-04 GO:0043436 oxoacid metabolic process
2.33 2.18e-04 GO:0048513 organ development
3.45 2.50e-04 GO:0042180 cellular ketone metabolic process
3.44 2.57e-04 GO:0006082 organic acid metabolic process
4.20 3.41e-04 GO:0050776 regulation of immune response
2.66 3.54e-04 GO:0051239 regulation of multicellular organismal process
8.35 3.63e-04 GO:0051384 response to glucocorticoid stimulus
11.64 4.35e-04 GO:0055088 lipid homeostasis
6.13 7.01e-04 GO:0003013 circulatory system process
6.13 7.01e-04 GO:0008015 blood circulation
3.25 7.21e-04 GO:0006955 immune response
7.74 7.34e-04 GO:0031960 response to corticosteroid stimulus
13.71 7.51e-04 GO:0042632 cholesterol homeostasis
13.71 7.51e-04 GO:0055092 sterol homeostasis
7.56 9.15e-04 GO:0051346 negative regulation of hydrolase activity
5.38 1.05e-03 GO:0051241 negative regulation of multicellular organismal process
3.48 1.44e-03 GO:0009725 response to hormone stimulus
4.62 2.43e-03 GO:0032940 secretion by cell
3.20 2.89e-03 GO:0002682 regulation of immune system process
3.79 2.98e-03 GO:0072358 cardiovascular system development
3.79 2.98e-03 GO:0072359 circulatory system development
4.90 3.00e-03 GO:0048545 response to steroid hormone stimulus
11.02 3.43e-03 GO:0010951 negative regulation of endopeptidase activity
6.53 3.47e-03 GO:0002697 regulation of immune effector process
5.71 4.14e-03 GO:0006887 exocytosis
20.00 4.48e-03 GO:0006691 leukotriene metabolic process
20.00 4.48e-03 GO:0043449 cellular alkene metabolic process
3.10 4.82e-03 GO:0051049 regulation of transport
4.35 4.87e-03 GO:0044057 regulation of system process
3.17 5.91e-03 GO:0009719 response to endogenous stimulus
3.77 6.37e-03 GO:0002684 positive regulation of immune system process
2.12 9.59e-03 GO:0048583 regulation of response to stimulus
1.66 1.06e-02 GO:0051716 cellular response to stimulus
3.59 1.16e-02 GO:0050801 ion homeostasis
11.75 1.21e-02 GO:0006690 icosanoid metabolic process
8.96 1.38e-02 GO:0002699 positive regulation of immune effector process
11.08 1.72e-02 GO:0033559 unsaturated fatty acid metabolic process
3.31 1.79e-02 GO:0051336 regulation of hydrolase activity
10.67 2.14e-02 GO:0051591 response to cAMP
1.81 2.19e-02 GO:0048731 system development
47.98 2.31e-02 GO:0030300 regulation of intestinal cholesterol absorption
1.40 2.37e-02 GO:0050789 regulation of biological process
22.58 2.60e-02 GO:0050892 intestinal absorption
4.30 2.68e-02 GO:0001944 vasculature development
14.12 2.69e-02 GO:0046456 icosanoid biosynthetic process
41.13 4.01e-02 GO:0046487 glyoxylate metabolic process
12.97 4.12e-02 GO:0006636 unsaturated fatty acid biosynthetic process
9.44 4.33e-02 GO:0072376 protein activation cascade
1.64 4.54e-02 GO:0032502 developmental process
4.42 4.57e-02 GO:0009617 response to bacterium
5.44 4.71e-02 GO:0010876 lipid localization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.03 5.07e-15 GO:0005615 extracellular space
4.07 1.06e-12 GO:0044421 extracellular region part
2.87 8.07e-12 GO:0005576 extracellular region
16.61 4.48e-07 GO:0031983 vesicle lumen
16.34 3.99e-06 GO:0031093 platelet alpha granule lumen
16.00 4.75e-06 GO:0034774 secretory granule lumen
15.36 6.64e-06 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.87 1.46e-05 GO:0000267 cell fraction
13.47 1.92e-05 GO:0031091 platelet alpha granule
6.24 2.71e-05 GO:0030141 stored secretory granule
3.02 2.12e-04 GO:0005624 membrane fraction
2.92 3.71e-04 GO:0005626 insoluble fraction
4.93 9.75e-04 GO:0005792 microsome
4.76 1.37e-03 GO:0042598 vesicular fraction
41.13 5.69e-03 GO:0005577 fibrinogen complex
23.99 3.44e-02 GO:0005833 hemoglobin complex
63.97 4.84e-02 GO:0042629 mast cell granule

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
7.73 1.17e-05 GO:0031406 carboxylic acid binding
3.02 1.20e-05 GO:0005102 receptor binding
4.15 8.56e-05 GO:0008289 lipid binding
14.93 8.66e-05 GO:0019825 oxygen binding
13.18 2.10e-04 GO:0042379 chemokine receptor binding
8.83 7.74e-04 GO:0004867 serine-type endopeptidase inhibitor activity
34.90 7.96e-04 GO:0017127 cholesterol transporter activity
6.32 9.88e-04 GO:0061135 endopeptidase regulator activity
7.03 1.26e-03 GO:0020037 heme binding
29.53 1.70e-03 GO:0015248 sterol transporter activity
12.52 1.75e-03 GO:0008009 chemokine activity
6.60 2.12e-03 GO:0046906 tetrapyrrole binding
7.11 3.87e-03 GO:0019955 cytokine binding
5.34 4.38e-03 GO:0005126 cytokine receptor binding
5.92 5.06e-03 GO:0004866 endopeptidase inhibitor activity
5.22 5.29e-03 GO:0061134 peptidase regulator activity
10.29 5.57e-03 GO:0033293 monocarboxylic acid binding
4.24 6.52e-03 GO:0004857 enzyme inhibitor activity
3.69 6.68e-03 GO:0030246 carbohydrate binding
5.61 7.72e-03 GO:0030414 peptidase inhibitor activity
4.95 8.32e-03 GO:0005125 cytokine activity
9.29 1.00e-02 GO:0005319 lipid transporter activity
8.47 1.69e-02 GO:0016597 amino acid binding
6.06 3.64e-02 GO:0008201 heparin binding
2.56 3.78e-02 GO:0042802 identical protein binding