Motif ID: GATA6.p2

Z-value: 2.273


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA6hg19_v1_chr18_+_19749403_197495500.281.2e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_116708334 8.393 NM_000039
 APOA1
apolipoprotein A-I
chr10_-_99531712 7.782 NM_003015
 SFRP5
secreted frizzled-related protein 5
chr4_+_155484131 7.218 NM_001184741
NM_005141
 FGB

fibrinogen beta chain

chr2_+_102927961 7.003 NM_016232
 IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr3_+_148583042 6.807 NM_001870
 CPA3
carboxypeptidase A3 (mast cell)
chr7_-_100239136 6.703 NM_003227
 TFR2
transferrin receptor 2
chr8_-_86290333 6.530 NM_001128829
NM_001128830
NM_001128831
NM_001738
 CA1



carbonic anhydrase I



chr12_-_54689536 6.398 NM_006163
 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_-_27240430 6.106 NM_021969
 NR0B2
nuclear receptor subfamily 0, group B, member 2
chr10_-_48416692 5.854 NM_016204
 GDF2
growth differentiation factor 2
chr17_+_4675175 5.547 NM_003963
 TM4SF5
transmembrane 4 L six family member 5
chr17_-_64225496 5.181 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_+_7741934 5.129 NM_174918
 C19orf59
chromosome 19 open reading frame 59
chr11_-_47374221 4.892 NM_000256
 MYBPC3
myosin binding protein C, cardiac
chr2_-_44065888 4.735 NM_022436
 ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_88427535 4.626 NM_001443
 FABP1
fatty acid binding protein 1, liver
chr11_+_75428864 4.578 NM_025098
 MOGAT2
monoacylglycerol O-acyltransferase 2
chr9_-_100700422 4.523 NM_197978
 HEMGN
hemogen
chr12_-_70004941 4.466 NM_201550
 LRRC10
leucine rich repeat containing 10
chr2_-_69098502 4.372 NM_014482
 BMP10
bone morphogenetic protein 10

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 84 entries
Enrichment   P-value GO Accession GO Term
47.98 2.31e-02 GO:0030300 regulation of intestinal cholesterol absorption
41.13 4.01e-02 GO:0046487 glyoxylate metabolic process
22.58 2.60e-02 GO:0050892 intestinal absorption
20.00 4.48e-03 GO:0006691 leukotriene metabolic process
20.00 4.48e-03 GO:0043449 cellular alkene metabolic process
14.12 2.69e-02 GO:0046456 icosanoid biosynthetic process
13.71 7.51e-04 GO:0042632 cholesterol homeostasis
13.71 7.51e-04 GO:0055092 sterol homeostasis
12.97 4.12e-02 GO:0006636 unsaturated fatty acid biosynthetic process
12.80 5.78e-06 GO:0002576 platelet degranulation
11.75 1.21e-02 GO:0006690 icosanoid metabolic process
11.64 4.35e-04 GO:0055088 lipid homeostasis
11.08 1.72e-02 GO:0033559 unsaturated fatty acid metabolic process
11.02 3.43e-03 GO:0010951 negative regulation of endopeptidase activity
10.67 2.14e-02 GO:0051591 response to cAMP
9.44 4.33e-02 GO:0072376 protein activation cascade
9.38 1.42e-06 GO:0006805 xenobiotic metabolic process
9.38 1.42e-06 GO:0071466 cellular response to xenobiotic stimulus
9.31 1.56e-06 GO:0009410 response to xenobiotic stimulus
8.96 1.38e-02 GO:0002699 positive regulation of immune effector process

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
63.97 4.84e-02 GO:0042629 mast cell granule
41.13 5.69e-03 GO:0005577 fibrinogen complex
23.99 3.44e-02 GO:0005833 hemoglobin complex
16.61 4.48e-07 GO:0031983 vesicle lumen
16.34 3.99e-06 GO:0031093 platelet alpha granule lumen
16.00 4.75e-06 GO:0034774 secretory granule lumen
15.36 6.64e-06 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
13.47 1.92e-05 GO:0031091 platelet alpha granule
6.24 2.71e-05 GO:0030141 stored secretory granule
5.03 5.07e-15 GO:0005615 extracellular space
4.93 9.75e-04 GO:0005792 microsome
4.76 1.37e-03 GO:0042598 vesicular fraction
4.07 1.06e-12 GO:0044421 extracellular region part
3.02 2.12e-04 GO:0005624 membrane fraction
2.92 3.71e-04 GO:0005626 insoluble fraction
2.87 8.07e-12 GO:0005576 extracellular region
2.87 1.46e-05 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
34.90 7.96e-04 GO:0017127 cholesterol transporter activity
29.53 1.70e-03 GO:0015248 sterol transporter activity
14.93 8.66e-05 GO:0019825 oxygen binding
13.18 2.10e-04 GO:0042379 chemokine receptor binding
12.52 1.75e-03 GO:0008009 chemokine activity
10.29 5.57e-03 GO:0033293 monocarboxylic acid binding
9.29 1.00e-02 GO:0005319 lipid transporter activity
8.83 7.74e-04 GO:0004867 serine-type endopeptidase inhibitor activity
8.47 1.69e-02 GO:0016597 amino acid binding
7.73 1.17e-05 GO:0031406 carboxylic acid binding
7.11 3.87e-03 GO:0019955 cytokine binding
7.03 1.26e-03 GO:0020037 heme binding
6.60 2.12e-03 GO:0046906 tetrapyrrole binding
6.32 9.88e-04 GO:0061135 endopeptidase regulator activity
6.06 3.64e-02 GO:0008201 heparin binding
5.92 5.06e-03 GO:0004866 endopeptidase inhibitor activity
5.61 7.72e-03 GO:0030414 peptidase inhibitor activity
5.34 4.38e-03 GO:0005126 cytokine receptor binding
5.22 5.29e-03 GO:0061134 peptidase regulator activity
4.95 8.32e-03 GO:0005125 cytokine activity