Motif ID: GLI1..3.p2

Z-value: 2.511


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GLI3hg19_v1_chr7_-_42276793_422767970.383.0e-02Click!
GLI1hg19_v1_chr12_+_57853917_578539670.355.0e-02Click!
GLI2hg19_v1_chr2_+_121554866_1215549200.202.8e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_22569155 6.737


chr6_-_32784727 5.647 NM_002120
 HLA-DOB
major histocompatibility complex, class II, DO beta
chr19_-_15575333 5.100 NM_022904
 RASAL3
RAS protein activator like 3
chr14_-_106791054 4.855 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr5_-_44388666 4.624 NM_004465
 FGF10
fibroblast growth factor 10
chr5_+_169659945 4.573 NM_001102609
 C5orf58
chromosome 5 open reading frame 58
chr22_-_19512001 4.198 CLDN5
claudin 5
chr7_-_100171269 3.905 NM_001168682
 SAP25
Sin3A-associated protein, 25kDa
chr15_+_39873276 3.826 NM_003246
 THBS1
thrombospondin 1
chr22_-_19511777 3.739 CLDN5
claudin 5
chr22_+_23229959 3.575 NM_001178126
 IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr5_-_157002739 3.569 NM_033274
 ADAM19
ADAM metallopeptidase domain 19
chr19_-_44285012 3.549 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_+_13263890 3.540 IER2
immediate early response 2
chr17_-_3819692 3.520 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr19_-_41859519 3.516 TGFB1
transforming growth factor, beta 1
chr2_-_136875629 3.499 NM_003467
 CXCR4
chemokine (C-X-C motif) receptor 4
chr14_-_106829736 3.413 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr11_-_66084501 3.343 NM_020404
 CD248
CD248 molecule, endosialin
chr16_+_29674282 3.280 NM_001030288
 SPN
sialophorin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 72 entries
Enrichment   P-value GO Accession GO Term
25.48 1.64e-02 GO:0051150 regulation of smooth muscle cell differentiation
18.44 7.46e-03 GO:0010718 positive regulation of epithelial to mesenchymal transition
17.52 9.83e-03 GO:0010770 positive regulation of cell morphogenesis involved in differentiation
14.60 2.57e-02 GO:0002260 lymphocyte homeostasis
14.02 3.18e-02 GO:0001776 leukocyte homeostasis
14.02 3.18e-02 GO:0048730 epidermis morphogenesis
11.68 1.44e-02 GO:0002573 myeloid leukocyte differentiation
9.84 1.86e-03 GO:0050680 negative regulation of epithelial cell proliferation
6.33 6.58e-05 GO:0051272 positive regulation of cellular component movement
6.29 2.18e-04 GO:0030335 positive regulation of cell migration
6.29 2.18e-04 GO:2000147 positive regulation of cell motility
6.08 3.24e-04 GO:0040017 positive regulation of locomotion
5.21 1.23e-02 GO:0050900 leukocyte migration
5.17 8.20e-04 GO:0008544 epidermis development
4.92 2.49e-04 GO:0002694 regulation of leukocyte activation
4.82 2.57e-02 GO:0030155 regulation of cell adhesion
4.78 1.17e-02 GO:0002696 positive regulation of leukocyte activation
4.74 2.29e-03 GO:0051249 regulation of lymphocyte activation
4.73 4.21e-04 GO:0050865 regulation of cell activation
4.70 1.39e-02 GO:0050867 positive regulation of cell activation

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
5.59 8.60e-04 GO:0009897 external side of plasma membrane
4.04 1.25e-05 GO:0009986 cell surface
2.54 1.62e-03 GO:0005615 extracellular space
2.25 3.96e-03 GO:0044421 extracellular region part
1.94 4.66e-02 GO:0005887 integral to plasma membrane
1.91 5.73e-04 GO:0005576 extracellular region
1.86 8.31e-04 GO:0044459 plasma membrane part
1.53 2.33e-03 GO:0071944 cell periphery
1.53 2.45e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
15.77 1.02e-06 GO:0003823 antigen binding
7.90 1.95e-03 GO:0005200 structural constituent of cytoskeleton
2.13 2.65e-02 GO:0005102 receptor binding
2.04 3.96e-05 GO:0004871 signal transducer activity
2.04 3.96e-05 GO:0060089 molecular transducer activity
2.00 1.36e-03 GO:0004872 receptor activity
1.33 6.47e-03 GO:0005515 protein binding